Can a clotting boost make surgery safer for hemophilia patients?

NCT ID NCT05695391

Terminated Disease control Sponsor: Laboratoire français de Fractionnement et de Biotechnologies Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests whether a medication called eptacog beta can safely prevent excessive bleeding in people with hemophilia A or B who have inhibitors and need major surgery. Participants receive the drug during and after their operation, and doctors measure how well bleeding is controlled. The goal is to find a reliable option for this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Eptacog beta (activated), a recombinant clotting factor VIIa
What this could lead to: If successful, this could offer a reliable way to control bleeding during major surgery for people with hemophilia who have developed inhibitors, making operations safer.
What could go wrong: This is a small, single-arm study, so results may not be definitive. There is also a risk of blood clots or the treatment not being effective enough in all patients.

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Conditions

The condition(s) this trial relates to.

hemophilia hemophilia A hemophilia B

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMOPHILIA

Contacts and locations

Locations

Acibadem Adana Hospital

Seyhan, Adana, 01130, Turkey (Türkiye)
Charlotte Maxeke Johannesburg Academic Hospital

Johannesburg, Gauteng, 2196, South Africa
Chiang Mai University

Chiang Mai, 50200, Thailand
Children's Healthcare of Atlanta

Atlanta, Georgia, 30322, United States
Hacettepe Üniversitesi Rektörlüğü Sihhiye

Altındağ, Ankara, 06230, Turkey (Türkiye)
Hospital Ampang

Ampang, Selangor Province, 68000, Malaysia
Hospital Queen Elisabeth - Kota Kinabalu

Kota Kinabalu, Sabah Province, 88586, Malaysia
Hospital Universitario Dr. José Eleuterio González de Nuevo León

Monterrey, Nuevo León, 64460, Mexico
Istanbul Üniversitesi Onkoloji Enstitusu

Fatih, Istanbul, 34093, Turkey (Türkiye)
Karadeniz Teknik Üniversitesi

Trabzon, Trabzon, 61080, Turkey (Türkiye)
M Health Fairview Center for bleeding and Clotting disorders

Minneapolis, Minnesota, 55455, United States
Maharaj Nakorn Chiangmai Hospital, Chiangmai University

Chiang Mai, 50200, Thailand
Orthopaedic Institute for Children - Orthopaedic Hemophilia Treatment Center

Los Angeles, California, 90007, United States
Tulane Univertsity School of Medecine

New Orleans, Louisiana, 70112, United States
University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States

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