Targeted drug shows promise for Hard-to-Treat lung cancer

NCT ID NCT03318939

Terminated Disease control Sponsor: Spectrum Pharmaceuticals, Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called poziotinib in 648 people with advanced non-small cell lung cancer that has specific genetic changes (EGFR or HER2 exon 20 mutations). The goal was to see if the drug could shrink tumors. The study was stopped early, but results showed some patients had their tumors shrink. Common side effects included skin rashes and diarrhea.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NSCLC

Contacts and locations

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Locations

Ambroise Pare University Hospital Center

Mons, Belgium
BC Cancer - Vancouver

Vancouver, British Columbia, V5Z 4E6, Canada
Baptist Cancer Center

Memphis, Tennessee, 38120, United States
CTCA - Eastern Regional Medical Center

Philadelphia, Pennsylvania, 19124, United States
CTCA - Midwestern Regional Medical Center

Zion, Illinois, 60099, United States
CTCA - Southeastern Regional Medical Center

Newnan, Georgia, 30265, United States
City of Hope

Duarte, California, 91010, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Duke University Medical Center

Durham, North Carolina, 27710, United States
Erasmus Medical Center

Rotterdam, Netherlands
Florida Hospital

Orlando, Florida, 32804, United States
General Hospital Delta

Roeselare, Belgium
Georgetown University Medical Center

Washington D.C., District of Columbia, 20007, United States
Gustave Roussy Oncology Institute, Department of Medical Oncology

Villejuif, France
H. Lee Moffitt Cancer Center & Research Institute

Tampa, Florida, 33612, United States
Hadassah Medical Center

Jerusalem, Israel
Hattiesburg Clinic Hematology/Oncology

Hattiesburg, Mississippi, 39401, United States
Hopital Larrey, CHU Toulouse, Unité d'Oncologie des Voies Respiratoires

Toulouse, France
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Baltimore, Maryland, 21287, United States
Kaiser Permanente Medical Center

Vallejo, California, 94589, United States
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
London Regional Cancer Program

London, Ontario, N6A 5W9, Canada
Los Angeles Hematology Oncology Medical Group

Los Angeles, California, 90017, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic Hospital

Phoenix, Arizona, 85054, United States
Minnesota Oncology Hematology, P.A.

Minneapolis, Minnesota, 55404, United States
Montefiore Einstein Medical Center for Cancer Care

The Bronx, New York, 10461, United States
NYU Langone Medical Center

New York, New York, 10016, United States
National Cancer Institute Regina Elena, IRCCS, Operative Unit of Medical Oncology A 1

Rome, Italy
National Cancer Institute, IRCCS, Department of Medical Oncology

Milan, Italy
North Shore Hematology Oncology Associates DBA New York Cancer and Blood Specialists

The Bronx, New York, 10469, United States
North Shore Hematology Oncology Associates P.C. DBA NY Cancer and Blood Specialists

Port Jefferson Station, New York, 11776, United States
Oklahoma Cancer Specialists and Research Institute, LLC

Tulsa, Oklahoma, 74146, United States
Oncology Physician's Network Inc./OPN Healthcare

Arcadia, California, 91007, United States
Pacific Shores Medical Group

Long Beach, California, 90813, United States
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
Rabin Medical Center

Petah Tikva, Israel
Rambam Healthcare Campus

Haifa, Israel
Rocky Mountain Cancer Center

Boulder, Colorado, 80303, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Saint Luc University Hospital

Brussels, Belgium
Santa Maria delle Croci Hospital

Ravenna, Italy
Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Soroka Medical Center

Beersheba, Israel
Texas Oncology- Austin

Austin, Texas, 78745, United States
The Bond & Steele Clinic, P.A. dba Bond Clinic, P.A.

Winter Haven, Florida, 33881, United States
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Torrance, California, 90502, United States
The Ohio State University

Columbus, Ohio, 43210, United States
UC Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
UCLA Hematology/Oncology

Santa Monica, California, 90404, United States
UCSD -Moores Cancer Center

La Jolla, California, 92093, United States
UCSF Helen Diller Comprehensive Cancer Center at Mt Zion

San Francisco, California, 94115, United States
USC/Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University Cancer & Blood Center, LLC

Athens, Georgia, 30607, United States
University Hospital 12 de Octubre

Madrid, Spain
University Hospital Germans Trias i Pujol, Department of Medical Oncology

Barcelona, Spain
University Hospitals Leuven

Leuven, Belgium
Virginia Cancer Specialists, PC

Fairfax, Virginia, 22031, United States
Weill Cornell Medical College

New York, New York, 10065, United States
Yale University, Yale Cancer Center Smilow Cancer Hospital at Yale

New Haven, Connecticut, 06510, United States