New injection aims to stop dangerous psoriasis flares in their tracks
NCT ID NCT07314060
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests an injection called TQH2929, a lab-made antibody that blocks inflammation, in 36 adults having a sudden, severe flare of generalized pustular psoriasis (GPP). Half get the drug, half get a placebo. The main goal is to see if the drug clears pustules within one week. Researchers also check for safety and longer-term skin clearing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TQH2929 injection (a lab-made antibody that blocks inflammation signals)
- What this could lead to
- If it works, this could point toward a fast-acting treatment for sudden, severe flare-ups of generalized pustular psoriasis.
- What could go wrong
- This is a small, early-phase trial with only 36 people. It may not show clear benefit, and side effects are still being studied.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Chengdu Second People's Hospital
NOT_YET_RECRUITINGChengdu, Sichuan, 610000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Henan Provincial People's Hospital
NOT_YET_RECRUITINGZhengzhou, Henan, 450003, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jiaxing First Hospital
NOT_YET_RECRUITINGJiaxing, Zhejiang, 314001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Peking University First Hospita
RECRUITINGBeijing, Beijing Municipality, 100034, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Peking University Third Hospital
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100191, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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People's Hospital of Xinjiang Uygur Autonomous Region
NOT_YET_RECRUITINGÜrümqi, Xinjiang, 830001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Renmin Hospital of Wuhan University
NOT_YET_RECRUITINGWuhan, Hubei, 430060, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shandong First Medical University Affiliated Dermatology Hospital
NOT_YET_RECRUITINGJinan, Shandong, 250022, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanghai Skin Disease Hospital
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200443, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shiyan Renmin Hospital
NOT_YET_RECRUITINGShiyan, Hubei, 442000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sichuan Provincial People' s Hospital
NOT_YET_RECRUITINGChengdu, Sichuan, 610000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Southern Medical University Dermatology Hospital
NOT_YET_RECRUITINGGuangzhou, Guangdong, 510091, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sun Yat-sen Memorial Hospital, Sun Yat-sen University
NOT_YET_RECRUITINGGuangzhou, Guangdong, 510120, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Hospital of Guizhou Medical University
NOT_YET_RECRUITINGGuiyang, Guizhou, 550004, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Hospital of Southwest Medical University
NOT_YET_RECRUITINGLuzhou, Sichuan, 646000, China
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The Affiliated Hospital of Southwest Medical University
NOT_YET_RECRUITINGLuzhou, Sichuan, 646000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Fujian Medical University
NOT_YET_RECRUITINGFuzhou, Fujian, 350000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Kunming Medical University
NOT_YET_RECRUITINGKunming, Yunnan, 650032, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Xinjiang Medical University
NOT_YET_RECRUITINGÜrümqi, Xinjiang, 830013, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Hospital of Hunan University of Chinese Medicine
NOT_YET_RECRUITINGChangsha, Hunan, 410007, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The General Hospital Of Hunan University Of Medicine
NOT_YET_RECRUITINGHuaihua, Hunan, 41800, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Affiliated Hospital of Henan University of science and technology
NOT_YET_RECRUITINGLuoyang, Henan, 471000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Affiliated Hospital of Xi'an Jiaotong University
NOT_YET_RECRUITINGXi’an, Shanxi, 710061, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Hospital Of Hebei Medical University
NOT_YET_RECRUITINGShijiazhuang, Hebei, 050000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The fifth Affiliated hospital of zhengzhou university
NOT_YET_RECRUITINGZhengzhou, Henan, 450052, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The first affiliated hospital of ningbo university
NOT_YET_RECRUITINGNingbo, Zhejiang, 315020, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The first hospital of china medical university
NOT_YET_RECRUITINGShenyang, Liaoning, 110001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The first hospital of jilin university
NOT_YET_RECRUITINGChangchun, Jilin, 130012, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital
NOT_YET_RECRUITINGTianjin, Tianjin Municipality, 300120, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tianjin Medical University General Hospital
NOT_YET_RECRUITINGTianjin, Tianjin Municipality, 300052, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Xiangya Hospital of Central South University
NOT_YET_RECRUITINGChangsha, Hunan, 410008, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zhengzhou Central Hospital
NOT_YET_RECRUITINGZhengzhou, Henan, 450000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Costa rica launches national registry to track rare skin disease
- New registry aims to unlock secrets of rare skin disease GPP
- New drug spesolimab under Real-World watch for rare skin disease
- Psoriasis flare drug study pulled before it began
- New pill shows promise for rare, severe psoriasis
- Can a single infusion stop GPP flares in their tracks?