Can a single infusion stop GPP flares in their tracks?
NCT ID NCT06013969
First seen Nov 01, 2025
Summary
This study is testing whether the drug spesolimab can safely and effectively treat repeated flares of generalized pustular psoriasis (GPP), a serious skin condition. Adults with GPP who have had a flare will receive a single intravenous dose of spesolimab, with a possible second dose one week later. The main goal is to see if the treatment clears visible pustules within one week.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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ASST degli Spedali Civili di Brescia
Brescia, 25123, Italy
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Chang Gung Memorial Hospital, Linkou
Taoyuan, 330, Taiwan
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Cliniques Universitaires Saint-Luc
Brussels, 1200, Belgium
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Faculdade de Medicina do ABC
Santo André, 09060-870, Brazil
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Farhat Hached Hospital
Sousse, 4000, Tunisia
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HOP Saint-Louis
Paris, 75010, France
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HOP Trousseau
Chambray-lès-Tours, 37170, France
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Hedi Chaker Hospital, Department of Dermatology
Sfax, 1053, Tunisia
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Hospital Kuala Lumpur
Kuala Lumpur, 50586, Malaysia
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Hospital Pulau Pinang-Pulau Pinang-21953
Georgetown Pulau Pinang, 10990, Malaysia
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Hospital Putrajaya
Putrajaya, 62250, Malaysia
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Hospital Selayang
Batu Caves, 68100, Malaysia
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Hospital Sultan Ismail
Johor Bahru, 81100, Malaysia
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Hospital Sultanah Aminah
Johor Bahru, 80100, Malaysia
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario Evangelico Mackenzie
Curitiba, 80440-220, Brazil
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Hospital Universitario Ramon Y Cajal
Madrid, 28034, Spain
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Klinikum der Universität München AÖR
München, 80337, Germany
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Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
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Maharat Nakhonchiangmai Hospital
Muang Chiang Mai, 50200, Thailand
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National Taiwan University Hospital
Taipei, 100, Taiwan
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National University Hospital-Singapore-42005
Singapore, 119228, Singapore
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Nelson Mandela Academic Clinical Research Unit (NeMACRU)
Mthatha, Eastern Cape, 5099, South Africa
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Nkp Salve Institute of Medical Sciences and Lata Mangeshkar Hospital
Nagpur, 440019, India
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Red River Research Partners, LLC
Fargo, North Dakota, 58103, United States
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SP medical college and associated group of hospitals
Bikaner, 334003, India
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Seoul National University Hospital
Seoul, 03080, South Korea
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Shanghai Skin Disease Hospital
Shanghai, 200000, China
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Shanghai Tenth People's Hospital
Shanghai, 200072, China
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Southern Medical University Dermatology Hospital
Guangzhou, 510091, China
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Srinagarind Hospital
Khon Kaen, 40000, Thailand
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Sunway Medical Centre
Selangor Darul Ehsan, 47500, Malaysia
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University of California Irvine
Irvine, California, 92697, United States
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Universitätsklinikum Frankfurt
Frankfurt am Main, 60596, Germany
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Westmead Hospital
Westmead, New South Wales, 2145, Australia
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
spesolimab (Spevigo®)
What this could lead to
If successful, this could confirm that spesolimab is a safe and effective option for managing repeated GPP flares, offering patients a reliable treatment.
What could go wrong
This is a small, single-arm study with no placebo group, so results may be less conclusive. Side effects are possible, and the treatment may not work for everyone.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.