Could a quick quiz end millions of unnecessary penicillin allergies?

NCT ID NCT05464615

First seen Jul 17, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study tests whether a short questionnaire can identify hospitalized patients who were incorrectly labeled as allergic to penicillin. Those deemed low-risk receive a supervised dose of amoxicillin to confirm they can tolerate it. If they do, the allergy label is removed from their medical records, potentially improving their future treatment options.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
amoxicillin
What this could lead to
If successful, this approach could safely remove penicillin allergy labels for many hospitalized patients, allowing them to receive more effective antibiotics.
What could go wrong
This is a small early-phase study, and the questionnaire may not accurately identify all low-risk patients, leading to allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Geisinger Community Medical Center

    Scranton, Pennsylvania, 18510, United States

  • Geisinger Lewistown Hospital

    Lewiston, Pennsylvania, 17044, United States

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822, United States

  • Geisinger Wyoming Valley

    Wilkes-Barre, Pennsylvania, 18711, United States

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