Could a CO2-Removal device save lives in severe COPD attacks?
NCT ID NCT05546606
First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time
Summary
This trial investigates whether adding a device that removes carbon dioxide from the blood (ECCO2R) to standard care improves survival in people with very severe flare-ups of chronic obstructive pulmonary disease (COPD). The study includes patients at high risk of needing a breathing tube or already on a ventilator. Researchers compare outcomes between those receiving standard care alone and those also receiving ECCO2R therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ECCO2R therapy using the Xenios platform (a device that removes carbon dioxide from the blood)
- What this could lead to
- If effective, this approach could reduce the need for invasive ventilation and lower death rates during severe COPD flare-ups.
- What could go wrong
- This is a very small, early-stage study with only 17 participants, so results may not apply broadly. The device carries risks like bleeding, infection, and blood clots.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for COPD ACUTE EXACERBATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
CH Le Mans
Le Mans, 72000, France
-
CHD de Vendée
La Roche-sur-Yon, 85925, France
-
CHR Orléans
Orléans, 45067, France
-
CHRU Bretonneau
Tours, 37044, France
-
CHU Angers
Angers, 49933, France
-
CHU Besançon
Besançon, 25030, France
-
CHU Lapeyronie
Montpellier, 34295, France
-
CHU Pontchaillou
Rennes, 35033, France
-
CHU Rouen
Rouen, 76031, France
-
CHU la Milétrie
Poitiers, 86021, France
-
Centre Hospitalier de Saint Denis
Saint-Denis, 93200, France
-
Hôpital Avicennes, AP-HP
Bobigny, 93009, France
-
Hôpital Cochin - APHP
Paris, 75014, France
-
Hôpital La Pitié Salpêtrière, AP-HP
Paris, 75013, France
-
Hôpital Nord
Marseille, 13015, France
-
Hôpital Tenon
Paris, 75020, France
-
Hôpital d'Instruction des Armées Robert Picqué
Villenave-d'Ornon, 33882, France
-
Hôpital de la Croix-Rousse
Lyon, 69317, France
-
Hôpital européen Georges Pompidou - APHP
Paris, 75015, France
-
Nouvel Hôpital Civil Strasbourg
Strasbourg, 67091, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.