New shot aims to tame COPD Flare-Ups in inflammatory subtype

NCT ID NCT06940154

Ongoing Disease control Sponsor: Connect Biopharm LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This Phase 2 trial tests whether rademikibart, an injected drug, can help adults with COPD who are having a sudden flare-up and have a specific type of inflammation (type 2). The study will compare the drug to a placebo in 160 participants, looking at whether it reduces treatment failure—like hospital readmission or needing more steroids—within 28 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rademikibart (also called CBP-201), a drug given as a shot
What this could lead to: If it works, this could point toward a new add-on treatment to reduce hospital visits and treatment failure during COPD flare-ups.
What could go wrong: This is an early Phase 2 trial with only 160 people, so results may not apply to everyone. The drug is experimental and may not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD ACUTE EXACERBATION

Contacts and locations

Locations

Acad. Chapidze Emergency Cardiology Center LLC

Tbilisi, 0159, Georgia
Acad. G. Chapidze Emergency Cardiology Center

Tbilisi, 0159, Georgia
Amicis Research Center

Valencia, California, 91355, United States
Bendigo Health

Bendigo, Victoria, 3550, Australia
CEMER - Centro Medico de Enfermedades Respiratorias

Florida, Buenos Aires, B1602, Argentina
Campbelltown Hospital

Campbelltown, New South Wales, 2560, Australia
Carilion Medical Center / Carilion Roanoke Memorial Hospital

Roanoke, Virginia, 24014, United States
Caucasus Medical Center

Tbilisi, 0159, Georgia
Centro Medico Ipam S.A

Rosario, Santa Fe Province, S2000, Argentina
Centro de Diagnostivo y Rehabilitación S.A. - CEDIR

Santa Fe, S3000, Argentina
Centro de Investigaciones Médicas Mar del Plata

Mar del Plata, Buenos Aires, B7600FYK, Argentina
Clinical Hospital Center "Dragisa Misovic - Dedinje"

Belgrade, 11040, Serbia
Clinical Research of Rock Hill

Rock Hill, South Carolina, 29732, United States
Columbus Clinical Services, LLC

Miami, Florida, 33125, United States
DCT- McAllen Primary Care Research, LLC dba Discovery Clinical Trials

McAllen, Texas, 78503, United States
Duke Asthma, Allergy, and Airway Center

Durham, North Carolina, 27705, United States
Guy's and St Thomas NHS Foundation Trust

London, SE1 7EH, United Kingdom
Health Center Uzice

Užice, 31000, Serbia
Health Synergy Clinical Research, LLC

West Palm Beach, Florida, 33407, United States
Hospital Italiano de Buenos Aires

CABA, Buenos Aires, C1199, Argentina
Hospital Universitario Austral

Pilar, Buenos Aires, 1629, Argentina
Inquest Clinical Research

Baytown, Texas, 77521, United States
Institute for Pulmonary Diseases and Tuberculosis Nis

Niš, 18108, Serbia
Institute for Pulmonary Diseases of Vojvodina

Kamenitz, 21204, Serbia
Institute for Respiratory Health

Nedlands, Western Australia, 6009, Australia
Instituto Ave Pulmo-Fundacion Enfisema

Mar del Plata, Buenos Aires, 7600, Argentina
Investigaciones en Patologias Respiratorias SRL

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
JSC "National Center for Lung Health"

Tbilisi, 0101, Georgia
LLC "Israel-Georgian Medical Research Clinic Healthycore"

Tbilisi, 0112, Georgia
LLC Diacor

Tbilisi, 0159, Georgia
Leland Stanford Junior University, Stanford Hospital

Palo Alto, California, 94304, United States
Medicines Evaluation Unit Ltd.

Wythenshawe, Greater Manchester, M23 9QZ, United Kingdom
National Jewish Health

Denver, Colorado, 80206, United States
Ochsner Medical Complex - The Grove

Baton Rouge, Louisiana, 70836, United States
Pharmax Research of South Florida, Inc.

Miami, Florida, 33175, United States
Pivotal Research Solutions

Stonecrest, Georgia, 30038, United States
Premier Pulmonary Critical Care and Sleep Medicine

Denison, Texas, 75020, United States
Primeway Clinical Research Group

Fayetteville, Georgia, 30214, United States
Queen Elizabeth hospital Birmingham

Birmingham, B15 2GW, United Kingdom
Salford Royal Hospital - Northern Care Alliance NHS Foundation Trust Barnes Clinical Research Facility

Salford, M6 8HD, United Kingdom
St. Vincent's Hospital Sydney

Darlinghurst, New South Wales, 2010, Australia
Stony Brook University Hospital

Stony Brook, New York, 11733, United States
Sunshine Coast University Hospital

Birtinya, Queensland, 4575, Australia
The Canberra Hospital

Garran, Australian Capital Territory, 2605, Australia
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
University Clinical Center Kragujevac

Kragujevac, 34000, Serbia
University Hospitals Birmingham NHS Foundation Trust Birmingham Heartlands Hospital

Birmingham, B9 5SS, United Kingdom
University of Alabama at Birmingham Lung Health Center

Birmingham, Alabama, 35233, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
Vermont Lung Center

Colchester, Vermont, 05446, United States
Westmead Hospital

Westmead, New South Wales, 2145, Australia

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