Proton beam therapy plus chemo aims to improve Post-Surgery treatment for advanced endometrial cancer
NCT ID NCT04527900
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This phase 2 trial tests a new approach called UPPROACH for people with loco-regionally advanced endometrial cancer who have had surgery. The treatment combines intensity-modulated proton beam therapy (IMPT) with standard chemotherapy (carboplatin and paclitaxel) given at the same time. The main goal is to see if more people can complete all six cycles of chemotherapy alongside the radiation compared to historical results. The study also tracks side effects, especially in the gut and urinary system.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- carboplatin, paclitaxel, and proton beam therapy
- What this could lead to
- If successful, this approach could offer a more tolerable way to deliver combined radiation and chemotherapy after surgery for advanced endometrial cancer, potentially improving treatment completion rates.
- What could go wrong
- This is a small, early-phase study with only 2 participants, so results may not apply broadly. The combination may still cause side effects like gastrointestinal or urinary issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baltimore Washington Medical Center
Glen Burnie, Maryland, 21061, United States
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Central Maryland Radiation Oncology
Columbia, Maryland, 21044, United States
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Maryland Proton Treatment Center
Baltimore, Maryland, 21201, United States
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UMMC
Baltimore, Maryland, 21201, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A safer first cut? trial tests two laparoscopic entry points for endometrial cancer surgery
- Could a common Weight-Loss drug help hormone therapy work better for young women with endometrial cancer?
- New biologic drug DBC-664 takes aim at Hard-to-Treat cancers
- New imaging tool could help surgeons detect hidden cancer cells during surgery
- Could a simple diet replace an enema before endometrial cancer surgery?
- Scientists probe hidden clues to immunotherapy success in endometrial cancer