Disease

Researchers are piloting REACH, a service model that connects families, schools, and healthcare providers to improve asthma care for children. The study enrolls parents and children in partner school districts, along with school nurses and providers. REACH combines asthma educati…

This study tests personalized phage therapy in people with serious infections that have not responded to antibiotics or surgery. Researchers will collect data before, during, and after treatment to see how safe and effective phage therapy is, and how it affects different body sit…

This early-phase trial tests a new type of cell therapy called BCMA-CD19-IL-15/IL15sushi compound CAR T cells in 20 people with severe lupus that hasn't improved with standard treatments. The therapy aims to reset the immune system by targeting and eliminating faulty immune cells…

This study is testing a milder type of stem cell transplant for people with non-cancerous blood, immune, or metabolic disorders. The goal is to safely get donor cells to grow in the patient's body while reducing harsh side effects. About 220 participants will receive a reduced-in…

This trial tests an experimental drug called SKB575 in adults with asthma. The goal is to see if it is safe and whether it can improve asthma control and lung function. Participants receive either SKB575 or a placebo as a shot under the skin, and researchers monitor side effects …

This trial tests whether a rapid multiplex PCR test on lung fluid can help doctors choose the right antibiotic faster for patients with ventilator-associated pneumonia. The study involves 265 adults in intensive care who have been on a ventilator for at least 48 hours and are sus…

This study tests an experimental drug called ATV-1601 in people with moderate to severe HHT, a condition that causes frequent nosebleeds and anemia. The trial has two parts: first, participants receive either the drug or a placebo to check safety and effectiveness; then, all elig…

This study tests a specially engineered donor graft called Orca-Q in children and young adults with blood cancers who need a stem cell transplant. The graft is designed to help the new cells take hold and reduce complications. The trial is currently on hold, but aims to enroll 40…

This phase II trial tests whether adding paclitaxel directly into the abdomen, alongside standard systemic chemotherapy, is feasible for people with gastrointestinal cancers that have spread to the peritoneal lining. The study includes patients with gastric, colorectal, appendice…

This early-stage trial tests a new gene therapy called KLN-1010 for people with multiple myeloma that has come back or stopped responding to treatment. Instead of removing cells and engineering them in a lab, this therapy works inside the body to create special immune cells that …

This study tests two types of targeted radiation therapy (177Lu-PSMA-617 and 225Ac-PSMA-617) in 45 men with high-risk prostate cancer who are scheduled for prostate removal surgery. The goal is to see which therapy delivers more radiation to the tumor and how it affects the immun…

This study looks at whether supervised exercise can improve recovery in people who have had surgery for esophageal or gastric cancer. About 171 participants will be assigned to high-intensity interval training, low-intensity continuous training, or usual care for 8 weeks. The goa…

This study tests whether a hyaluronic acid gel can help regrow bone lost to severe gum disease, compared to the standard enamel matrix derivative gel or no gel at all. All treatments use a minimally invasive, non-surgical technique. Sixty adults with advanced periodontitis will b…

This study tests whether a new combination inhaler, containing beclometasone dipropionate and formoterol, works as well as an existing treatment (FOSTER®) for people with asthma. About 416 adults with asthma will use one of the two inhalers twice daily for four weeks. Researchers…

This phase 3 trial tests whether less intense drug combinations can control relapsed or refractory acute myeloid leukemia (AML) as well as high-dose chemotherapy. About 339 adults whose AML has returned or not responded to initial treatment will be randomly assigned to either a l…

This study tests whether early referral to a cardio-oncology specialist can lower heart risks in prostate cancer patients receiving long-term hormone therapy (ARPI). About 80 men with high-risk or advanced prostate cancer and additional heart risk factors will be assigned to eith…

This study offers a special stem cell transplant to people with cancer or other disorders who lack a perfectly matched donor. Doctors use a device to purify stem cells from a partially matched donor, removing immune cells that can cause rejection or attack the patient's body. The…

This study tests whether a 6-week walking and running program with sound feedback can improve ankle stability in 100 physically active adults who have chronic ankle instability. Participants will train three times a week and be followed for up to a year. The goal is to reduce ank…

This phase 2 trial is testing a new treatment called Orca-T for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Orca-T is a personalized cell therapy made from a donor's blood that includes stem cells and immune cells. The goal is to see if it can impr…

This study provides unlicensed cord blood units for transplant to children and adults with blood cancers, immune disorders, and other serious diseases. The goal is to see how well patients recover their white blood cells after the transplant. By making more cord blood units avail…

This study looks at the long-term safety and effectiveness of an oral drug called KT-621 in people with asthma. Participants have already completed a previous KT-621 asthma study. The goal is to see how well the drug works over time and if any side effects appear with longer use.

This study tests a dog allergy immunotherapy called Alutard SQ Dog in 40 adults with moderate-to-severe dog allergy. Participants receive increasing doses over 13 weeks, then maintenance shots every 6-8 weeks for a year. Their symptoms and lung function are measured before and af…

This study tests whether a single dose of a nasal spray called ETH47 can reduce asthma symptoms caused by a common cold virus (rhinovirus). Fifty adults with stable asthma will receive either the spray or a placebo and then be exposed to the virus in a controlled setting. Researc…

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This phase 2 trial tests whether delivering FOLFOX chemotherapy directly into the arteries feeding the tumor can help control advanced stomach or gastroesophageal junction cancer. The study includes 31 adults who cannot have surgery due to frailty or other health issues. The main…

This early-phase study is testing a new drug called 131I-apamistamab, which combines an antibody with radioactive iodine, to prepare people with severe sickle cell disease for a bone marrow transplant. The goal is to find the smallest effective dose that allows the donor stem cel…

This trial investigates whether giving a personalized dose of alemtuzumab (a drug that calms the immune system) before a stem cell transplant can improve outcomes for people with non-malignant diseases. Researchers aim to find the right dose that balances effectiveness and safety…

This study is testing a new prosthetic implant for the elbow joint in people with arthritis, instability, or limited motion. The implant replaces the damaged joint to reduce pain and improve function. About 84 participants will be followed for two years to see if the device is sa…

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal …

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This clinical trial is testing different combinations of antibiotics to find the best way to treat a lung infection caused by Mycobacterium abscessus, a bacteria that is hard to kill. About 300 adults and children with this infection will receive various drug regimens, including …

This study is testing a procedure called MRI-guided cryoablation, which uses extreme cold to freeze and destroy small prostate cancer tumors. The goal is to see if this targeted approach can safely control the cancer while avoiding the side effects of surgery or radiation. About …

This study compares two surgeries for a common type of hip fracture in older adults: a metal nail inside the bone versus a full hip replacement. The goal is to see which approach leads to better mobility, fewer complications, and higher quality of life. About 170 people aged 65 a…

This study tests whether GLP-1 receptor agonists, a class of diabetes medications including semaglutide, can improve heart nerve damage in people with type 2 diabetes. 60 adults will receive either standard care or standard care plus a weekly injection for 6 months. Researchers w…

This study looks at whether giving early, tailored COPD treatment to people being evaluated for lung cancer can improve their breathing and overall health. About 280 participants will receive either standard care or extra COPD consultations focusing on medication, smoking cessati…

This study tests whether giving the immune-suppressing drug tacrolimus earlier than usual can lower the risk of cytokine release syndrome (CRS), a severe inflammatory reaction, in patients receiving a half-matched stem cell transplant for blood cancer. About 20 adults will receiv…

This study tests two new drugs: one to help spot liver cancer cells (RYZ811) and another to deliver treatment directly to them (RYZ801). It is for people with a type of liver cancer called GPC3-positive hepatocellular carcinoma that cannot be removed by surgery. The goal is to se…

This study tests whether astaxanthin, a natural antioxidant supplement, can improve lung function and reduce airway inflammation in adults with mild-to-moderate asthma. Participants will take astaxanthin and a placebo in random order for 4 weeks each, with a break in between. The…

This study tests whether adding special immune cells from the mother to standard antiviral medicine can safely and more effectively treat moderate to severe CMV infection in newborns. Babies up to 21 days old with confirmed CMV disease may join. All receive antiviral drugs, and s…

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This early-stage trial tests the safety of combining two drugs, ONC201 and atezolizumab, in 58 women with advanced or recurrent endometrial cancer. The study includes both obese and non-obese participants to see if body weight affects treatment. The goal is to find the best dose …

This study tests whether L-serine, a natural amino acid taken as a supplement, can improve overall functioning in children and young adults (ages 2-30) with GRIN-related neurodevelopmental disorders caused by certain gene variants. Each participant will receive both L-serine and …

This early-stage study tests whether a harmless bacterium called Lactobacillus crispatus, when placed directly into the bladder, is safe and can help prevent urinary tract infections (UTIs) in adults with spinal cord injury who use a catheter. Forty participants will receive two …

This phase 2 trial tests whether taking abiraterone 250 mg with food and prednisone can lower testosterone to castration levels in prostate cancer patients, without using standard hormone-blocking injections or surgery. The study enrolls 60 men with prostate cancer who need hormo…

This study follows adults aged 30-65 who previously tried a fasting-mimicking diet (FMD) to see if they can maintain fat loss and heart health improvements for one more year. Participants will continue FMD cycles every three months. The goal is to check if these benefits last and…

This study is testing a new drug called ABT-301 combined with two other drugs (tislelizumab and bevacizumab) in people with advanced colorectal cancer that has not responded to at least two prior treatments. The goal is to see if the combination is safe and can shrink tumors. Abo…

This study compares a new radiation technique called total lymphoid irradiation (TLI) to the standard total body irradiation (TBI) for children aged 0-18 who need a stem cell transplant from a half-matched donor. The goal is to see if TLI reduces complications like graft-versus-h…

This study is testing two new blood tests designed to help doctors detect cancer in people who have symptoms that might be cancer. The study will involve 1,650 adults aged 45 and older who are already undergoing medical tests for possible cancer. The goal is to see how well these…

Researchers at Turku University Hospital are testing a PET imaging tracer called Al[18F]F-NOTA-folate to see how well it detects two heart conditions: cardiac sarcoidosis, an inflammatory disease of the heart muscle, and infective endocarditis, an infection of the heart valves. T…

Researchers are testing whether MRI scans can accurately show whether bladder tumors have grown into the muscle wall, a key factor in choosing treatment. The trial enrolls 150 adults with bladder tumors who are scheduled for a transurethral resection (TURB), a surgical biopsy. Do…

This study is testing whether a set of five simple physical exam maneuvers can accurately diagnose infrapatellar fat pad impingement, a common cause of front knee pain. Researchers will compare the results of these clinical tests to MRI scans in 50 adults with anterior knee pain.…

Doctors often use a methacholine challenge to help diagnose asthma in children, but the standard breathing test requires strong cooperation and can fail if a child cannot blow hard enough. This study tests whether a gentler method called forced oscillation, which measures how the…

This study explores whether a low-dose CT scan without contrast dye can accurately detect pulmonary embolism (blood clots in the lungs). Researchers will enroll 750 adults suspected of having a clot and add two very low-radiation CT scans to their standard dye-based scan. The goa…

Researchers are studying whether thromboelastography, a blood test that measures clot formation, can predict outcomes for people having surgery for glial brain tumors. The trial enrolls about 100 adults who are scheduled for tumor removal or biopsy. By tracking clotting measureme…

Researchers are testing a device called the CARE phantom system to see if it can make prostate MRI measurements more consistent across different scanners. The study includes men aged 18 and older who are undergoing prostate cancer investigation and have suspicious lesions on MRI.…

This study is testing whether a blood test can accurately identify colorectal cancer or polyps in adults referred for suspected lower GI cancer. Participants provide a blood sample during their routine diagnostic visit, and their results are compared to their final diagnosis. The…

This trial compares two established biopsy methods for small lung nodules (≤2 cm): CT-guided percutaneous biopsy and shape-sensing robotic-assisted bronchoscopy with cone-beam CT. The goal is to see which approach is more effective at diagnosing cancer and which has fewer complic…

This study aims to improve how doctors diagnose Cushing's syndrome, a condition caused by too much cortisol. Researchers will test the accuracy of the desmopressin stimulation test in 140 people aged 18-70 who have or may have Cushing's, plus healthy volunteers. Participants will…

This trial tests a fluorescent probe called TTP-ICG that targets Trop2, a protein often found on oral cancer cells. Researchers will soak tissue samples from people with oral tumors in the probe and use near-infrared imaging to see if it can distinguish cancer from benign growths…

This study looks at whether a physiotherapist can accurately diagnose subacute knee injuries (lasting 1 week to 3 months) using a video consultation instead of an in-person exam. Researchers will compare three types of assessments: video-based, in-person without special knee test…

This study tests a new radioactive tracer called 68Ga-DOTA-BPP, which targets a protein (ACE) found on some cancer cells. Researchers want to see if it can improve PET/CT imaging for people with triple-negative breast cancer, a type that can be harder to detect. The trial involve…

This study is testing a new blood test called PROSTest to see if it can accurately detect prostate cancer in men with high PSA levels. Researchers will compare the test results with standard prostate biopsy findings in 1,500 men. If the test works well, it could help many men avo…

This phase 3 trial is testing a new radioactive imaging agent called 68Ga-NYM032, given as an injection before a PET/CT scan, in 365 men newly diagnosed with prostate cancer. The goal is to see if this scan can accurately detect whether the cancer has spread to pelvic lymph nodes…

This trial is testing whether a special PET/CT scan using 18F-fluorocholine, along with a liquid biopsy, can predict how well patients with inoperable liver cancer (hepatocellular carcinoma) will respond to immunotherapy. The study enrolls adults with this type of liver cancer wh…

This trial is testing a new blood test that measures tiny molecules called microRNAs to help doctors tell the difference between prostate cancer and benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate. The study will include 500 men who are scheduled f…

This study is testing a new device called a nitride-based Raman biochip that analyzes blood samples using light to detect molecular patterns linked to lung cancer. Researchers will compare results from 2,000 people with lung cancer and 1,000 without to see if the test can accurat…

This trial is evaluating whether a new PET/CT imaging tracer, 68Ga-MY6349, can detect recurrent or metastatic thyroid cancer more effectively than the standard 68Ga-FAPI tracer. Adults with a history of treated thyroid cancer who show signs of possible recurrence will receive bot…

This study is testing a new blood test called HeLP™ that looks at proteins in platelets to diagnose prostate cancer. Researchers want to see if it can be a safe and accurate alternative to current tests like PSA, MRI, and biopsy. The study will enroll 300 men suspected of having …

This study uses ultrasound to see if people with hand injuries also have shoulder problems that might be missed. Researchers will examine 60 adults with hand injuries to check for issues like tendon tears or bursitis. The goal is to find out whether shoulder exams should be part …

This study compares two methods for quickly analyzing lung tissue samples during a bronchoscopy: confocal laser endomicroscopy (CLE), which uses a laser to scan the tissue, and rapid on-site evaluation (ROSE), where a cytologist examines cells under a microscope. The goal is to s…

This study tests whether a lab technique called polyethylene glycol (PEG) precipitation can tell the difference between a true heart attack and a harmless condition called macrotroponin, where troponin molecules clump together and falsely signal heart damage. Researchers will com…

This study tests a new PET scan that uses a special tracer to find blood clots inside the heart. It involves 20 people with cardiac amyloidosis and atrial fibrillation. The goal is to see if this scan can spot clots better than current methods, which could help prevent strokes.

This study tests whether a special type of chest X-ray, called dynamic chest radiography, can help diagnose chronic obstructive pulmonary disease (COPD). Currently, COPD is diagnosed with lung function tests that require strong patient effort and may not be possible during a resp…

This study looks at whether blood clots in the lungs (pulmonary embolism) are often missed in people hospitalized with acute heart failure. About 740 patients across multiple hospitals will take part. In half the hospitals, doctors will follow their usual approach; in the other h…

This study is testing a new test called FlowPath Lung that looks for signs of lung cancer in sputum (phlegm). It involves over 2,000 high-risk individuals aged 50-80 who have lung nodules found on CT scans. The goal is to see if this non-invasive test can accurately detect early-…

This study investigates whether a specialized bone scan (bone scintigraphy) can more accurately diagnose cervical pseudarthrosis — a condition where neck bones fail to fuse after surgery. About 100 adults who had neck fusion surgery and still have symptoms will receive a bone sca…

This study looks at whether spontaneous eye blinking can help doctors tell the difference between two types of consciousness disorders: unresponsive wakefulness syndrome and minimally conscious state. Researchers will measure blinking patterns in 70 patients across 8 European cen…

This study tests whether a more precise lab technique (mass spectrometry) can improve the captopril test used to diagnose primary aldosteronism, a common but treatable cause of high blood pressure. Researchers will measure aldosterone and renin levels in blood samples from health…

This study is enrolling 200 adults with asthma or COPD to see if combining chest CT scans with blood, sputum, and microbiome tests can more accurately tell the two diseases apart. Researchers will also look for clues that predict how well a patient will respond to treatment. No e…

This study looks at a new genetic test called Caris Chromoseq for people with certain blood cancers (acute myeloid leukemia, myelodysplastic syndrome, or myeloproliferative neoplasms). The test scans the entire genome to help classify the cancer and guide risk assessment. Researc…

This study is testing whether a urine test can accurately detect urothelial carcinoma, a type of cancer that includes bladder cancer. Researchers are comparing the test results to standard tissue biopsies in 800 adults with blood in their urine and suspicious imaging findings. If…

This study aims to create a detailed database of how healthy, precancerous, and cancerous skin interacts with light. Researchers will collect optical data from 140 patients with skin carcinomas or actinic keratoses. The goal is to identify unique light patterns (spectroscopic sig…

This study will test a new type of PET/CT scan that uses a special tracer to find BCMA, a protein on myeloma cells. The goal is to see if this scan can more accurately detect active myeloma throughout the body compared to standard methods. About 300 people with suspected or known…

This study compares the standard flashlight pupil exam to a precise, automated pupillometer in 50 adults with suspected brain death. The goal is to see if the device catches details the human eye might miss. If it works, it could improve accuracy in declaring brain death.

This study is testing a new radioactive probe called PFD3, used with a PET/CT scan, to see if it can better find and assess small cell lung cancer (SCLC) by targeting a protein called DLL3 found on cancer cells. About 30 adults with SCLC will receive both a standard FDG scan and …

This study tests whether an artificial intelligence (AI) tool can help radiologists more accurately determine the stage of stomach cancer from CT scans. Fifty-four radiologists will review 60 scans each, first without AI help and then with AI assistance, to see if the AI improves…

This study tests whether computer analysis of 3D dental scans can accurately detect gum disease, gingivitis, and cavities, compared to traditional manual exams. About 30 adults with at least one gum recession will participate. If successful, this approach could make dental diagno…

This study compares two biopsy methods in 572 men who have multiple suspicious spots on MRI but have never had a prostate biopsy. One method combines targeted biopsy with a wider sampling around each spot (perilesional biopsy), while the other combines targeted biopsy with standa…

This study compares a new wearable armband called HeartWatch to the standard Holter monitor for detecting heart rhythm problems like atrial fibrillation. About 300 adults who need a Holter test will wear both devices at the same time. The goal is to see if the HeartWatch can accu…

This study is testing a more accurate way to diagnose primary aldosteronism, a common but often missed cause of high blood pressure that can be cured with surgery. Researchers will measure urine aldosterone using a precise lab method (LC-MS/MS) in 800 healthy volunteers and patie…

This study tests a decision-support tool called MyCMV that helps doctors interpret blood test results for cytomegalovirus (CMV) infection during pregnancy. CMV is a common virus that can cause hearing loss and developmental problems in babies if the mother catches it for the firs…

This study checks if the HiCardi M350 patient monitor gives accurate blood pressure readings compared to the traditional cuff method. About 100 adults will have their blood pressure measured with both devices. The goal is to see if the new monitor is reliable enough for everyday …

This study is testing whether a simple blood test, combined with artificial intelligence (AI), can help find lung cancer early in people with COPD who are current or former smokers. About 1,000 participants will give a blood sample, and those flagged as high-risk by the AI will g…

The NIMBLE study is testing whether blood-based biomarkers can accurately distinguish between cancerous and non-cancerous lung nodules. Researchers will analyze blood samples from 1,800 patients referred with a lung nodule, looking at protein markers, epigenetic smoking markers, …

This study aims to find better, non-invasive tests to diagnose and predict the course of interstitial lung disease (ILD). Researchers will test blood and breath samples from 750 people, including pigeon fanciers at high risk for ILD and patients already diagnosed. The goal is to …

This study is testing whether an artificial intelligence (AI) model can accurately predict which prostate cancers are aggressive and need treatment. Researchers will combine MRI and ultrasound images with tissue samples from 3,000 men. The goal is to reduce unnecessary biopsies a…

This study is testing a new blood-based method to diagnose osteoporosis and predict fracture risk. Researchers will analyze the vitality and behavior of certain blood cells from 120 healthy, osteopenic, and osteoporotic adults aged 40 and older. The goal is to see if this approac…

This study is testing whether proteins in the blood can help detect liver cancer at an early stage. Researchers will compare blood samples from 600 people—some with liver cancer and some healthy—to find protein patterns that signal the disease. The goal is to create a simple, non…

This study follows 20,000 women who take a new saliva test (Endotest) to diagnose endometriosis. Researchers want to see how the test result—positive or negative—affects their quality of life, emotions, and care decisions. Participants fill out questionnaires and share medical da…

This study is testing whether measuring a natural immune marker called IFN-I in nasal swabs can help detect respiratory viral infections in older adults. Current PCR tests only look for a few viruses and can miss others or show old infections. The goal is to improve diagnosis, es…

This study aims to improve how doctors tell the difference between borderline ovarian tumors and early-stage invasive ovarian cancer before surgery. Researchers will test a panel of nine blood-based biomarkers in 400 women with suspicious ovarian cysts. If successful, this could …

This study is testing whether simple measurements like facial scans, videos of blinking and swallowing, and heart rate changes can help doctors diagnose obstructive sleep apnea (OSA). Researchers will collect this data from 800 adults who do not already have an OSA diagnosis. The…

This study aims to translate an English questionnaire used to diagnose carpal tunnel syndrome into Thai and check if it works well. Researchers will enroll 80 adults at Siriraj Hospital who have been diagnosed with carpal tunnel syndrome. Participants will answer the new Thai que…

This study tests a new radioactive tracer called 68Ga-NK224 that lights up PD-L1, a protein on cancer cells, during a PET/CT scan. Researchers want to see if the scan can accurately measure PD-L1 levels compared to standard tissue biopsy. One hundred adults with various cancers w…

This study will enroll 500,000 people with high myopia and cataracts to develop an artificial intelligence model that helps doctors calculate the correct lens power and grade cataracts more accurately. The goal is to improve vision outcomes and reduce complications after surgery.…

This study compares contrast-enhanced mammography (CEM) to the standard MRI plus digital mammography for screening women at high risk of breast cancer. About 2200 women aged 35-60 with a 5-year risk of 5% or higher will be randomly assigned to one of the two screening methods ove…

This study is testing a device called Inflammacheck that measures chemicals in a person's breath to see if it can help tell the difference between lung cancer, other lung diseases, and healthy lungs. Researchers will collect breath samples from 140 adults and use AI to build a di…

This study tests whether giving emergency department patients who are at high risk for lung cancer a direct referral to a screening program, plus text message reminders, increases the number who get screened. About 300 eligible adults will be randomly assigned to either basic inf…

This study is testing whether simpler methods like mouth photos, dental X-rays, saliva tests, and questionnaires can accurately detect gum disease (gingivitis and periodontitis) compared to a standard full-mouth exam. About 2,000 adults from five centers will participate. The goa…

This study is testing a new type of PET/CT scan that targets a protein called ACP3 to find prostate cancer tumors. Researchers will compare it to standard PSMA/FDG scans in 100 adults with newly diagnosed or recurrent prostate cancer. The goal is to see if the ACP3 scan is more a…

This study looks at whether measuring inflammation in the breath and blood can help doctors prioritize who gets lung tests first when asthma is suspected. About 1,500 people aged 6 and older will take part. The goal is to see if this approach reduces delays for those most at risk…

This study is testing new types of MRI scans to see if they can more accurately find and grade prostate cancer without using contrast dye. Researchers will compare these new scans with standard MRI results and tissue samples from surgery or biopsy. About 300 people with suspected…

This study aims to develop a blood test that detects RNA from tiny particles (exosomes) to predict if prostate cancer has spread to the bones. Researchers will analyze blood samples from 1,000 men with newly diagnosed prostate cancer and compare results with PSMA PET scans. The g…

This pilot study tests a new blood test that looks at markers on white blood cells to tell if a feverish baby under 3 months has a serious bacterial infection. Researchers will collect an extra small blood sample from 180 infants in the emergency department. The goal is to see if…

This study tests a new bedside tool called Adjust-Unlikely to safely reduce unnecessary imaging for pulmonary embolism (a blood clot in the lungs) in emergency patients. Researchers will enroll 4,000 adults in Canada to see if the tool accurately identifies who does not need a sc…

This study aims to find markers in menstrual blood that can diagnose endometriosis, a painful condition affecting many women. Researchers will compare menstrual blood from 250 women with and without endometriosis, and also look at changes after surgery. If successful, this could …

This study is testing whether taking a delayed PET/CT scan 2-3 hours after injection of a radioactive tracer can better detect aggressive prostate cancer compared to the standard 60-minute scan. Researchers will enroll 1,000 men with suspected prostate cancer who have not yet had…

This study is testing an artificial intelligence tool called DeepComp that uses CT scans and patient data to predict which stomach cancer patients are at high risk for major complications after surgery. Researchers will enroll 500 patients across five medical centers and compare …

This study is testing whether whole genome sequencing (a complete scan of a person's DNA) can help doctors identify the cause of atypical diabetes—unusual cases that don't fit typical type 1 or type 2 diabetes. Researchers will compare this advanced genetic test to the current st…

This study aims to make it easier for family doctors to detect early signs of Alzheimer's and other dementias. Researchers will test 1,200 adults with memory or thinking problems using blood tests and brain scans. The goal is to see if these tools can accurately identify who has …

This study compares two ways of reading mammograms for breast cancer screening. The standard method uses two radiologists to review each image. The new method uses one radiologist with the help of artificial intelligence (AI). The goal is to see if the AI-assisted single reading …

This study tests whether adding contrast-enhanced ultrasound to standard ultrasound can improve the diagnosis of thyroid cancer. Researchers are comparing two scoring methods in 800 participants with thyroid nodules. The goal is to see which method better identifies cancer and re…

This study tests whether a new type of ultrasound, called quantitative ultrasound (QUS), can find liver cancers that standard ultrasound often misses. About 328 adults at risk for liver cancer will receive both QUS and standard ultrasound, and results will be compared to MRI or b…

This study tests whether a simple, non-invasive nail microscope exam (capillaroscopy) can help doctors find connective tissue disease faster in people newly diagnosed with interstitial lung disease. 48 adults will get the exam alongside standard care. The goal is to see if this e…

This study tests a new way to decide who needs a prostate biopsy. Instead of relying only on MRI, it adds a blood test called Prostate Health Index (PHI) to better tell which men have dangerous prostate cancer. The goal is to safely skip biopsies in men with low-risk findings, re…

This study is testing an artificial intelligence system that reads medical images like X-rays and MRIs to diagnose and stage osteoporosis and osteoarthritis. Researchers aim to make diagnosis more accurate and consistent. The trial will enroll 2,000 adults who have already had im…

This study is testing whether an artificial intelligence (AI) system can accurately identify different types of lung cancer by analyzing PET/CT scans and patient information like age, smoking history, and tumor markers. Researchers aim to improve how doctors distinguish between s…

This study is testing whether measuring telomeres (parts of your DNA) in a blood sample can help doctors diagnose lung cancer. Researchers will collect blood from 1,200 people, including those with lung cancer and healthy volunteers, to build a predictive algorithm. The goal is t…

This study compares two prostate biopsy techniques to see which one better detects clinically significant prostate cancer. About 592 men with a suspicious MRI lesion will be randomly assigned to receive either targeted plus perilesional biopsy or targeted plus systematic biopsy. …

This study tests whether artificial intelligence (AI) can analyze routine heart tests (ECGs) to find hidden heart problems like weak heart muscle, valve issues, or high lung pressure. About 590 adults without a prior heart disease diagnosis will have ECGs taken with standard mach…

This study is testing a device called SenseToKnow that uses video and a caregiver survey to help detect autism in children aged 16 to 36 months. The goal is to see how accurate the device is compared to a doctor's diagnosis. About 350 children from Duke Health will take part.

This study follows 100 men who have suspicious spots on prostate MRI but no significant cancer on their first biopsy. Over one year, they will have repeat MRI scans and biopsies to see if changes in those spots predict the development of clinically significant prostate cancer. Th…

This study tests whether a specific ultrasound measurement can reliably detect superficial endometriosis on the uterosacral ligaments. Researchers will compare ultrasound findings with laparoscopic surgery results in 64 women undergoing gynecological surgery. If a clear cutoff th…

This study looks at whether doctors need to change the needle between taking samples from different lymph nodes when staging lung cancer. About 30 people with suspected or confirmed lung cancer will have two rounds of staging—one with a needle change and one without. The goal is …

This study is testing whether adding a PSMA PET scan to the usual MRI can better detect prostate cancer that has come back after focal therapy. Focal therapy treats only the cancerous part of the prostate, but cancer can sometimes return. The PSMA PET scan uses a radioactive dye …

This study tests a new way to create detailed 3D images of lung and colorectal cancer tissue. Researchers will use a special preprocessing system and 3D imaging to get a clearer picture of tumors. The goal is to improve how doctors diagnose and plan treatment for these cancers. T…

This study is testing a new blood test that looks at tiny pieces of DNA (cfDNA) to find out if lung nodules seen on CT scans are cancer or not. Researchers will study 240 adults with small lung nodules to see how accurate the test is. The goal is to avoid unnecessary biopsies or …

This early-phase study tests whether a special PET scan tracer, 18F-fluoroglutamine, can detect pulmonary arterial hypertension (PAH) earlier and more accurately. PAH is a serious disease of the lung's blood vessels that often goes undiagnosed for years. The study will scan 71 ad…

This study is testing a new device that measures how sensitive the throat is to help diagnose obstructive sleep apnea (OSA). Researchers will compare the results of this test with standard sleep studies in 117 adults. The goal is to see if this simpler, quicker test can accuratel…

This study tests whether an upright MRI (where you sit) can detect prostate cancer as well as the standard closed MRI and PSA blood test. About 550 men at risk for prostate cancer will get both types of MRI and answer comfort questionnaires. The goal is to see if the upright MRI …

This study tests whether an AI-powered app can help doctors more accurately diagnose ear infections in young children (6-24 months) with cold symptoms. Researchers will compare standard ear exams with the AI app's analysis of eardrum photos. The goal is to see if the AI reduces u…

This study is testing whether a small, portable ultrasound probe (echOpen) can help doctors diagnose patients faster. About 100 adults who need a quick diagnosis will be included. Researchers will compare how long it takes to get a diagnosis when doctors use the probe versus when…

This study aims to see if a protein test on bile fluid can accurately diagnose cholangiocarcinoma (bile duct cancer). Researchers will collect bile samples from 200 adults with bile duct narrowing during a routine scope procedure. They will compare the protein test results with s…

This early-stage trial tests a new robot and ultrasound probe, called ProBot, designed to make prostate biopsies more precise and comfortable. The study will enroll 60 men with suspected prostate cancer to see if the device is safe and works as intended. If successful, it could l…

This study tests whether combining PSMA PET scans with machine learning can accurately grade prostate cancer without invasive biopsies. Researchers will enroll 220 men with suspected or confirmed prostate cancer. If successful, this approach could reduce unnecessary biopsies and …

This study is testing how well two types of 3D ultrasound can detect a uterine septum (a wall inside the uterus) compared to MRI. About 145 women aged 18-45 with a suspected septum will get both an MRI and the ultrasound exams. The goal is to see if the ultrasounds are as good as…

This study tests three different ways of taking a lung tissue sample (needle biopsy) to see which one gives the best quality sample for diagnosing lung cancer. About 54 adults with suspected lung cancer will take part. The goal is to find the most accurate technique to help docto…

This study is checking how well a test called ColoSense finds colorectal cancer and pre-cancerous growths using stool samples. About 12,500 adults aged 45 and older will provide samples, and the test's accuracy will be measured against standard colonoscopy findings. The goal is t…

This study compares two step-by-step approaches to diagnose advanced liver fibrosis in people with NAFLD (fatty liver disease). Both methods start with a simple blood test, then use a more advanced test only if needed, aiming to avoid invasive liver biopsies. About 1,045 particip…

This study tests a community-based program to help underserved adults get screened for breast, lung, and prostate cancers. Researchers will work with local resource spots to offer screenings and follow-up care. The goal is to see if this approach increases screening rates and cat…

This study is testing a new tool that combines a blood test with a questionnaire to help primary care doctors correctly identify bipolar disorder in people who are currently experiencing depression. The goal is to see if this tool can accurately tell the difference between bipola…

This study explores whether measuring brain activity during a brief rectal balloon inflation can help doctors tell the difference between patients who are minimally conscious and those who are unresponsive. Researchers will record EEGs in 45 patients with disorders of consciousne…

This study looks at whether digital tools like intraoral scanners and cone-beam CT can help dentists spot cavities, plaque, and gum disease more accurately than a standard exam. About 350 adults will get both a regular check-up and digital imaging, and researchers will compare th…

This study compares two ways to use MRI images during prostate biopsy: software fusion (computer-assisted) and cognitive fusion (doctor's visual estimate). Over 1,300 men with suspicious prostate lesions will be randomly assigned to one method. The goal is to see which technique …

This study aims to improve how doctors diagnose polymyalgia rheumatica (PMR), a painful inflammatory condition common in older adults. Current methods often lead to misdiagnosis and unnecessary treatment with steroids, which have serious side effects. Researchers will use a new P…

This study tests a new microwave-based device, called MiWEndo, that is used during a standard colonoscopy to help doctors find polyps in the colon. About 50 people who already have a polyp in their rectum will take part. The goal is to see if the device is safe and can find more …

This study looks at two methods for finding cavities between baby molars in children aged 4 to 10: standard X-rays and a newer light-based technique. Researchers want to see which method is more accurate and which children prefer. About 174 children will participate, and their co…

This study tests whether emergency doctors using lung ultrasound in ambulances can better diagnose and treat severe shortness of breath. 40 adults with low oxygen and fast breathing will be included. Researchers will compare the treatment given before and after the ultrasound to …

This study tests whether watching moving patterns (like a spinning disk or VR display) can help doctors objectively diagnose visually induced dizziness. Researchers will measure balance and symptoms in 240 people, including those with concussion-related dizziness, non-concussion …

This study is testing a blood test that looks for DNA changes from tumors to help diagnose and manage biliary tract cancers, which are often found late and have a low survival rate. Researchers will enroll 1,800 participants with confirmed cancers to see how accurate the test is.…

This study is testing a new radioactive tracer called 68Ga-MY6349 to see if it can help diagnose craniopharyngioma, a rare brain tumor, using PET/CT scans. The tracer targets a protein called Trop-2, which is often found on these tumors. Twenty participants with suspected or conf…

This study is testing whether an augmented reality (AR) system can help doctors guide needles during MRI scans. The AR system overlays digital information onto the real world, potentially making procedures like biopsies or injections more precise. Researchers will enroll 25 peopl…

This study tests an artificial intelligence system called iPredict-DR that analyzes retinal photos to detect diabetic retinopathy, a leading cause of blindness. Researchers will enroll 922 adults with diabetes at primary care and endocrinology clinics. The AI's accuracy will be c…

This study is testing whether a set of blood markers can accurately rule out late-onset sepsis in newborns in intensive care. Researchers will enroll 358 babies with signs of infection and compare the markers against a panel of experts. If the markers work well, doctors could avo…

This trial tests whether methenamine hippurate, a non-antibiotic antiseptic, can prevent urinary tract infections (UTIs) as effectively as standard antibiotics in women receiving BOTOX-A injections for overactive bladder. Participants will be randomly assigned to take either meth…

This trial tests whether personalized health dialogues, combined with lifestyle screening and molecular profiling, can reduce the risk of cardiovascular disease, cancer, and other serious conditions. Adults aged 40, 50, 60, and 70 in Sweden's Skåne region will participate. They w…

This study tests a smartphone app designed to encourage mothers of children aged 4 and under to test their homes for radon, a radioactive gas that is the second leading cause of lung cancer. Participants receive a free radon test kit and use the app to learn about radon risks. Th…

This study tests whether a new sunscreen, Anthelios Fluide 100 KA+ UVMune 400, can help prevent actinic keratosis—rough, scaly patches that can turn into skin cancer—in people aged 60 and older who already have many of these spots. Eighty participants will be randomly assigned to…

Researchers are testing whether an AI-generated, personalized discharge plan improves the quality of discharge teaching and recovery for people who had lung cancer surgery. The trial enrolls 156 adults who had surgery for stage I to III lung cancer and are going home to recover. …

This study tested whether a portable robot-assisted device could improve knee rehabilitation better than traditional bodyweight exercises. Twelve people with knee injuries (like ACL tears) used either the device or standard rehab for 6 weeks. Researchers measured muscle strength,…

This trial tests whether low-intensity endurance exercise can reduce cancer-related fatigue and improve quality of life in lung cancer patients. Participants will either do continuous exercise or interval exercise for 30 minutes a day, five days a week, for 12 weeks. Researchers …

This study tests whether taking high-dose branched chain amino acids (BCAAs) can help teens and young adults recover from a concussion more quickly. Researchers will compare recovery rates at 28 days between those taking BCAAs and those taking a placebo. The trial aims to enroll …

This trial tests whether low-intensity endurance exercise can reduce cancer-related fatigue and improve sleep, stress, and quality of life in people with lung cancer. Researchers will compare two exercise styles: continuous and interval, both done for 30 minutes a day, five days …

This study looks at whether qigong or multicomponent exercise training can improve physical and mental health in people with panic disorder. Researchers will enroll 60 adults diagnosed with panic disorder and have them do 8 weeks of exercise. The goal is to see if these activitie…

This study tests whether a small device that sends mild electrical pulses through the skin (TENS) can reduce pain during a prostate biopsy. About 140 men will get either a real TENS device or a fake one, along with standard numbing medicine. The goal is to see if TENS makes the p…

This study compares two common steroids (dexamethasone and methylprednisolone) in children aged 3-17 hospitalized for severe asthma. The goal is to see which treatment reduces the need for more steroids after leaving the hospital and improves quality of life. The trial will help …

This study tests whether acupressure can reduce coughing and related symptoms like shortness of breath and fatigue in lung cancer survivors. Eighty participants will either perform acupressure for 8 weeks or receive an educational booklet. Researchers will track changes in cough …

This study compares two types of aerobic exercise for children with asthma: virtual reality-based games and treadmill walking. Thirty children aged 10-17 will exercise twice a week for 8 weeks. Researchers will measure lung function, exercise capacity, and quality of life to see …

This study tests whether yoga and mindfulness programs can improve quality of life, reduce inflammation, and even affect gene activity in people who have survived lung, colon, or non-Hodgkin's lymphoma cancer. One hundred survivors, at least six months past treatment, will be ran…

This early study tests whether a gel called Barrigel can stay unfrozen and protect the rectum during prostate cancer cryoablation (freezing treatment). About 20 men with localized or recurrent prostate cancer will receive the gel before the procedure. The main goal is to see if t…

This study tests whether a spinal cord stimulator, combined with physical therapy, can help people who have had a stroke regain arm and hand movement. Twenty adults with long-term arm weakness will first do therapy alone, then get a spinal implant and repeat therapy with stimulat…

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study looks at whether watching a cartoon or playing a mobile game for 10 minutes before surgery can lower anxiety and fear in children aged 7 to 12 who are hospitalized for appendicitis. About 69 children will be split into three groups: one watches a cartoon, one plays a m…

This study tests whether starting a structured exercise and education program within a month of a pulmonary embolism (a blood clot in the lungs) can prevent long-term problems like poor quality of life, shortness of breath, and reduced physical ability. About 160 hospitalized pat…

This study tests whether an 8-week online yoga program can improve recovery in lung cancer patients who had lung surgery. Forty participants will either do live yoga sessions three times a week or receive standard care. The goal is to see if tele-yoga boosts exercise capacity, br…

This study looks at two different ways to reach out to lung cancer patients who may need help with anxiety or depression. The goal is to see which method gets more people to start a telehealth counseling program. About 30 adults being treated for lung cancer at Penn Medicine will…

This study tests whether rinsing the sinuses with a probiotic (good bacteria) solution can reduce symptoms of chronic sinusitis better than a plain saltwater rinse. About 60 adults who have had sinus surgery in the past will use the rinse daily for a period and report changes in …

This study looks at whether giving the steroid dexamethasone near the nerves or through an IV can safely make pain relief last longer in children having hand or forearm surgery. About 150 children will be randomly assigned to one of three groups: dexamethasone near the nerve, dex…

This study tests a new early intervention program called SAFE for high-risk infants (3-12 months old) who may have developmental delays. The program focuses on activities to improve arm, hand, and fine motor skills through play and daily routines. Researchers will compare SAFE to…

This study tests whether a nerve block (superior hypogastric plexus block) can help people recover better after laparoscopic surgery for colorectal cancer. About 170 adults having this surgery will be randomly assigned to receive the nerve block or not. The main goal is to see if…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. About 600 adults with a STOP-Bang score of 5 or higher will b…

This early study tests whether ivacaftor, a drug used for cystic fibrosis, can help people with chronic sinusitis caused by hard-to-treat bacteria. Twenty adults will receive either ivacaftor plus standard care or standard care alone for 14 days. Researchers will check safety, sy…

This study tests a robotic system that lets surgeons perform abdominal and pelvic surgeries through just one small cut. The goal is to see if this approach reduces pain, complications, and recovery time. About 33 adults who need such surgeries will take part.

This study compares two breathing exercises—alternate nostril breathing and Buteyko breathing—in 46 adults with mild to moderate asthma. The goal is to see which technique better improves breath control, reduces shortness of breath, and boosts lung function. Participants will pra…

This study tests whether adding mental tasks to treadmill walking (dual-task training) improves movement, thinking, and daily living skills more than walking alone. It involves 46 people with early-to-mid stage Alzheimer's who can already walk. The goal is to see if this combined…

This study is testing whether a structured exercise program called Indonesian Asthma Gymnastic can help adults with stable asthma breathe better and feel better day-to-day. Researchers will measure walking distance, lung function, and asthma control in 35 participants who continu…

This study looks at whether art therapy, delivered through virtual reality glasses or in person, can help reduce anxiety and improve sleep and well-being in people with colorectal cancer. 78 patients receiving chemotherapy will be randomly assigned to one of three groups: virtual…

This study tests whether a 6-day course of the steroid Medrol (methylprednisolone) can lower pain, nausea, and the need for opioid painkillers after foot or ankle surgery. About 180 adults having surgery at Emory will take either the steroid or a placebo, plus a small supply of h…

This study tests whether a food supplement called Doliral can improve quality of life and reduce pelvic pain in women with endometriosis. About 60 women with confirmed endometriosis and ongoing pelvic pain will take either Doliral or a placebo for 12 weeks. Researchers will track…

This study tests whether a team of a psychologist, speech therapist, and motor therapist can help children aged 2-7 with neurodevelopmental disorders eat more foods and have fewer mealtime struggles. 24 children will be split into two groups: one gets the team therapy, the other …

This study tests whether a digital exercise program with online group sessions can help prostate cancer patients on hormone therapy exercise more regularly. 160 participants will either get standard care or standard care plus the digital program. Adherence is tracked with a weara…

This study tests whether a special type of artificial light that changes throughout the day can improve sleep, body clock function, and overall well-being in frail older adults. Researchers will enroll 300 people over age 65 who are staying in hospital rooms equipped with this dy…

This study tests whether a supplement made from the Antrodia cinnamomea mushroom can improve quality of life for people with lung cancer who are receiving platinum-based chemotherapy. About 40 participants will take either the supplement or a placebo for 3 months, and researchers…

This study tests a smartphone system called ReACT that helps teens ages 13-17 with poorly controlled asthma. The app tracks medication use and symptoms, and offers personalized tips and goal-setting. 160 teens will be randomly assigned to use ReACT or a basic asthma app for six m…

This pilot study tests whether a non-invasive magnetic brain stimulation technique called TMS can improve brain connectivity and thinking skills in people with schizophrenia. Forty adults will receive either real or sham TMS daily for four weeks, and researchers will measure chan…

This study tests a 12-week prehabilitation program for 20 prostate cancer patients about to start hormone and radiation therapy. The program includes physical exercise and a 4-day residential session with education and activities. Researchers want to see if patients and their fam…

Researchers are studying whether a next-generation radiation delivery system can run a complete treatment workflow while patients hold their breath. The trial enrolls about 20 adults with tumors in the chest or upper abdomen who are already scheduled for stereotactic body radiati…

This study follows 400 adults diagnosed with pulmonary embolism (a blood clot in the lungs) at a Swedish hospital. Researchers will repeatedly check heart tests and blood markers during the first 48 hours to see if early changes can better predict who will worsen. The goal is to …

This trial tests whether a specially designed AI interface can help people without medical training assess the urgency of health scenarios and identify possible conditions. Participants use either a standard AI tool or one that prompts them with targeted questions before giving s…

Researchers are building a global registry to collect patient-reported surveys, genetic test results, and medical records from people with Charcot-Marie-Tooth disease and related inherited neuropathies. The study is open to children and adults with a confirmed or suspected diagno…

This study collects wisdom teeth and surrounding tissue that are normally thrown away after oral surgery. Researchers will use these samples to learn more about oral health and disease. Up to 3,000 people aged 16 to 50 who need their wisdom teeth removed can join. The study also …

This pilot study will test a smartphone app called Womb Watch that uses the phone's microphone to listen for fetal movements, like kicks, breathing, and hiccups. About 60 pregnant women between 28 and 40 weeks will record audio daily for 15 minutes. The goal is to see if the app …

This long-term study follows 24,000 mothers and their children born at Boston Medical Center to understand how early-life exposures—like pregnancy complications and birth outcomes—affect health later in life. Researchers will track conditions such as asthma, obesity, allergies, a…

Researchers in Moscow are studying patients who have knee or hip replacement surgery to learn why some develop serious infections around the implant. The study will follow 750 adults aged 45 and older, checking their immune status, mineral metabolism, and tissue samples before an…

This study follows 80 children aged 2-8 with cystic fibrosis to see how highly effective CF drugs (Kalydeco or Trikafta) impact sinus disease and sense of smell. Researchers will use MRI scans, smell tests, and quality-of-life surveys over two years. The goal is to understand whe…

This study follows 170 adults with cystic fibrosis and chronic sinusitis to see if sinus surgery improves lung function and quality of life compared to medical treatment alone. Participants either have surgery or continue with standard care. Researchers will track changes in brea…

This study looks at whether a structured program can help more high-risk smokers get a first lung cancer screening with a CT scan. About 500 people aged 50 to 74 who smoke or recently quit will join. The goal is to see if a dedicated network makes screening easier and more effect…

This study tests whether a digital chatbot can help more adolescents and young adults (AYA) with cancer get genetic counseling and testing compared to standard remote services. About 535 participants aged 18-39 will use either a chatbot or standard telehealth. The goal is to see …

This study tests whether tracking changes in infection markers and blood culture results over time can help detect sepsis earlier and monitor treatment in adults with cancer. Researchers will follow 100 patients with suspected sepsis during their hospital stay and for up to 30 da…

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This study looks at 100 adults with CADASIL, a genetic condition that affects small blood vessels in the brain and can lead to strokes and thinking problems. Researchers will collect genetic data, symptoms, and brain MRI images to see how these factors relate. The goal is to bett…

This study reviews data from about 25,000 patients who were checked for bowel cancer in Scotland between 2022 and 2025. The goal is to see how well the current two-step stool test works and find ways to make diagnosis faster and more accurate. Researchers hope to reduce delays an…

This study looks at whether people with long-term spinal cord injury who also have a condition called autonomic dysreflexia (sudden high blood pressure) have changes in their heart structure. Researchers will use MRI scans to compare two groups: 24 people with high-level injury a…

This study is testing a new type of dental MRI (ddMRI) to see if it can work as well as standard dental X-rays for diagnosing problems like crowded teeth, jaw pain, and infections. About 300 adults will get a ddMRI scan and then compare the results to their regular dental images.…

This study explores whether methane gas produced by gut microbes is linked to the progression of Parkinson's disease and related conditions like dementia. Researchers will measure breath methane levels in 200 adults—including those with Parkinson's, those at high risk (REM sleep …

This study follows 100 adults with blood disorders who receive an unrelated cord blood transplant. Researchers will measure levels of γδ T cells—a type of immune cell—in the blood at several time points over the first year. The goal is to see if the pattern of γδ T cell recovery …

This study is looking at why some people with advanced cancer lose weight and muscle, a condition called cachexia. Researchers will follow 800 patients with advanced lung, pancreatic, or colorectal cancer to see if there are distinct subtypes of cachexia based on symptoms, biomar…

This study looks at women who had surgery for deep endometriosis affecting the ureters, the tubes that carry urine from the kidneys to the bladder. The goal is to see how their kidney function and blood pressure fare years after the operation, and whether the type of surgery matt…

This study builds a large French cohort of 1,000 people experiencing a major depressive episode to examine their sleep and circadian rhythms. Researchers will use sleep recordings (polysomnography) and psychiatric evaluations to identify distinct patient subgroups and potential b…

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated within 72 hours of their procedure. The goal is to confirm the device is safe and works as intended.

This study looks at how sleep apnea measurements change from night to night. Current tests rely on a single night, which can be inaccurate. Researchers will track 192 people over multiple nights to find more reliable markers for diagnosis and treatment.

This study tests whether a brain stimulation training can strengthen the connections between the brain, spinal cord, and muscles in people with chronic cervical spinal cord injury. Researchers will enroll 15 adults with incomplete injuries at or above C6 who are at least one year…

This study explores whether artificial intelligence can analyze MRI scans to detect, map, and characterize gliomas—a common type of brain tumor—without needing an invasive biopsy. Researchers will collect existing MRI and clinical data from about 700 patients across Italy to trai…

This study looks at how hyperbaric oxygen therapy (HBOT) affects symptoms and urine markers in people with chronic radiation cystitis, a bladder condition caused by past radiation treatment. Researchers will collect urine, blood, and tissue samples from 100 participants before, d…

This study is collecting blood and urine samples from 1,400 ICU patients in China to find new biological markers for sepsis. Researchers will analyze genes, proteins, and metabolites to build faster and more accurate diagnostic tests. The goal is to help doctors identify sepsis e…

This study tests whether advanced MRI and magnetic resonance spectroscopy (MRS) can identify specific genetic mutations in gliomas, the most common type of brain tumor. Researchers will scan about 110 people with suspected or confirmed low- or high-grade gliomas before surgery or…

This study looks at how often sleep apnea occurs in people with peripheral artery disease (blocked leg arteries). Researchers will monitor 295 adults with leg artery disease using a sleep test. The goal is to better understand the connection between these two conditions, which ma…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study tests whether giving oxygen to the lung that is not being ventilated during lung cancer surgery can reduce inflammation and improve oxygen levels. Researchers will measure inflammatory markers in lung tissue and blood from 56 adult patients. The goal is to see if this …

This study explores whether adenosine, a drug that affects heart rhythm, can help identify the mechanism behind premature ventricular contractions (PVCs). About 100 adults scheduled for a standard heart procedure will receive adenosine or verapamil to see how their extra beats re…

This observational study will follow 5000 people with pulmonary hypertension to understand a severe complication called pulmonary hypertension crisis. Researchers will collect medical data and samples to build a risk prediction tool. The goal is to identify who is at risk and imp…

This study is testing a new technique called EXPEL to find biomarkers for pancreatic cancer. Researchers will analyze the fluid used to preserve biopsy samples from 200 patients with suspected pancreatic cancer. The goal is to identify proteins and other molecules that could help…

This study aims to understand why breathlessness varies among people with different lung diseases like COPD, asthma, and ILD. Researchers will measure lung function, exercise ability, and breathing patterns in 75 participants (50 with lung disease and 25 healthy controls). The go…

This study is testing a new, simple questionnaire called SAPHIR to see if it can accurately measure how physically active people are. Researchers will compare the questionnaire results with data from an activity monitor worn by 118 adults. The goal is to create an easy tool for d…

This study looks at whether targeted cancer drugs called TKIs affect brain health and well-being in people with chronic leukemia. Researchers will compare 400 patients who receive TKI therapy to those who do not. The goal is to understand if these treatments cause cognitive chang…

This study tests a training program that teaches advanced practice providers (like nurse practitioners and physician assistants) in the emergency department how to use a portable ultrasound to check the heart. About 75 providers will take a simulation course, then use the ultraso…

This study looks at whether treating gestational diabetes early (before 24 weeks) is better than waiting until the standard 24-28 week screening. About 2,010 pregnant women with mild early high blood sugar will be randomly assigned to either start intensive treatment right away o…

This study is testing a new, low-dose food challenge given over several days to diagnose FPIES, a food allergy that causes vomiting and diarrhea. Researchers want to find the safest dose that can still trigger symptoms in people with FPIES. The study involves 72 people aged 1 to …

This study looks at how well a telehealth program called National TeleOncology works for veterans newly diagnosed with lung, colorectal, prostate, or breast cancer. Researchers will track how many veterans use telehealth visits and whether the program affects the quality of care …

This study looks at whether treating obstructive sleep apnea (OSA) with a CPAP machine can improve asthma control in people with difficult-to-treat asthma. Eighty adults will be randomly assigned to receive CPAP, no OSA treatment, or serve as a reference group without OSA. The go…

This study looks at whether lung ultrasound can detect emphysema (a type of lung damage) as well as CT scans do. About 1,600 people with or without emphysema will get both an ultrasound and a CT scan. The goal is to find patterns on ultrasound that match the damage seen on CT, wh…

This study follows 180 infants who had COVID-19 around birth to see if the infection affects hormone levels and development. Researchers focus on a temporary hormone surge called minipuberty, which is important for growth. By measuring hormones and developmental milestones, they …

This study aims to create better criteria for deciding when to operate on Chinese patients with degenerative cervical myelopathy, a condition where the spinal cord is compressed. Researchers will test 100 surgical candidates using simple physical performance tests like hand grip …

This study is testing whether a smartphone app can accurately measure how people walk, without needing special markers or equipment. Researchers will compare the app's measurements to a standard motion-capture system in 30 volunteers—some with neuromuscular diseases like SMA or m…

This study follows 100 people aged 55 and older who have clonal hematopoiesis (CH) or unexplained low blood counts. Researchers will monitor their health over time, assess risks for heart disease and blood cancers, and provide personalized support. The goal is to create a bluepri…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This study is gathering information from 10,000 people who have had a spontaneous brain hemorrhage. Researchers will collect medical history, brain scans, and blood samples to better understand the condition and find clues that help predict recovery. The goal is to improve how do…

This study looks at whether a special training and support program can help addiction clinics start using contingency management, a proven method that gives rewards to patients who stay off stimulants. Researchers will work with 76 clinics and track how many patients and counselo…

This study aims to understand why some people have unexplained bleeding that standard tests cannot diagnose. Researchers will study blood samples and ask participants about their symptoms and quality of life. The goal is to find the causes of this bleeding disorder and improve ca…

This study looks at how the chemotherapy drug treosulfan is processed in children getting a stem cell transplant. The goal is to find the right dose for each child to reduce side effects and improve outcomes. Researchers will measure drug levels in the blood and track how patient…

This study aims to describe the characteristics of prostate cancer in Algeria, including patient demographics, symptoms, diagnosis methods, and treatments. Researchers will collect data from 2,000 men aged 19 and older with confirmed prostate cancer. The goal is to better underst…

This study is building a large collection of biological samples and health information from up to 50,000 people, including both patients with various conditions and healthy volunteers. The goal is to help researchers better understand how diseases begin, change over time, and res…

This study follows 650 people with early Parkinson's disease or a sleep condition called idiopathic REM sleep behavior disorder (iRBD). Researchers use brain scans, heart tests, and fluid samples to track changes over time. The goal is to better understand how these conditions de…

This study uses ultrasound to measure blood inside the abdomen within 24 hours after gynecologic surgery. Researchers will check if the amount of blood relates to problems like anemia, need for transfusion, pain, infection, or longer hospital stay. About 250 women having major gy…

This study looks at how body composition (like weight and fat distribution) relates to airway tone and reactivity. Researchers will use a device called an oscillometer to measure airway resistance in 100 people who are already scheduled for a methacholine challenge test. The goal…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study is investigating whether certain autoantibodies, especially those targeting a protein called nephrin, play a role in nephrotic syndrome, a kidney condition that causes swelling and protein loss in urine. Researchers will analyze blood and kidney tissue from 50 children…

This study follows 500 men who had their prostate removed for cancer. Researchers check PSA levels soon after surgery to see if they can predict if the cancer will come back or spread. No new treatments are given—just standard care and observation.

This international registry collects data from 200 stomach cancer patients who undergo robot-assisted minimally invasive gastrectomy (RAMIG). The goal is to understand surgical techniques, outcomes, and the learning curve for surgeons. By standardizing data collection across cont…

This study is looking for early warning signs of Alzheimer's disease in 800 cognitively healthy adults aged 50 to 80. Researchers will use blood tests, brain scans, and memory assessments over about 4 years to see how Alzheimer's-related changes develop. The goal is to find a way…

This study follows nearly 3,000 people, including healthy adults and those with memory or movement problems, to learn how brain diseases like Alzheimer's and Parkinson's develop. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve ear…

This study is watching how lung cancer patients do when they get the drug tislelizumab in normal doctor visits, not in a strict research setting. About 240 people with small cell or non-small cell lung cancer will take part. The goal is to see how long they live, how the drug aff…

This study looks at whether a new, simpler guideline can safely reduce the number of tests, antibiotics, and hospital stays for infants under 2 months old with a fever. Researchers will compare hospitals using the new guideline to those using standard care. The goal is to find ou…

This observational study will follow 1,000 adults in Algeria who have been diagnosed with gastric cancer. Researchers will collect information on patient demographics, risk factors, symptoms, how the cancer is diagnosed, and what treatments are used. The goal is to better underst…

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants to find links between immune cell patterns and disease s…

This study tests whether a biomarker signature (BV score) can help doctors decide when to use antibiotics for ICU patients. About 1,200 adults in intensive care who started antibiotics within the past 72 hours will be randomly assigned to have their treatment guided by the biomar…

This observational study is investigating how patients with chronic airway diseases like COPD and asthma perceive breathing difficulty. Researchers will assess about 950 participants (800 patients and 150 healthy volunteers) using questionnaires, lung function tests, blood sample…

This study collects blood, tissue, and other samples from up to 10,000 people to create a biobank for research. The goal is to help scientists study the causes of diseases like cancer, heart disease, and diabetes. Participants provide samples and basic health data, but no treatme…

This study is observing 500 adults with severe pulmonary embolism (a dangerous blood clot in the lungs) to see if the timing of clot-busting treatments affects survival and complications. Researchers want to find the optimal time window to start treatment, similar to how heart at…

This study follows 900 people having lung cancer surgery to learn why some develop blood clots in their legs (deep vein thrombosis) within 30 days after surgery. Researchers will collect medical data and use machine learning to build a tool that predicts each person's risk. The g…

This study tests whether beetroot juice, which contains natural nitrates that relax blood vessels, can safely lower lung blood pressure in people with intermediate high-risk pulmonary embolism. 36 adult patients will receive either beetroot juice or a placebo for five days, along…

This study looks at how past sports injuries and a sedentary lifestyle may lead to chronic disease, pain, and disability in former athletes. Researchers will compare strength, function, physical activity, and heart health among current and former college athletes and non-athletes…

This study looks at how breast density affects mammogram accuracy in women aged 45 to 75. Dense breast tissue can make cancers harder to see, leading to missed tumors or unnecessary follow-up tests. Researchers will review past mammograms and test a software tool that automatical…

This study will use cardiac MRI to track changes in heart structure and function in 40 patients who have had endovascular repair for aortic disease. Researchers will compare heart measurements taken before surgery and again at 6 and 12 months afterward. The goal is to understand …

The TRIAD study is testing whether combining biological markers, psychological tests, and social factors can help diagnose Alzheimer's disease earlier and more accurately. Researchers will follow 80 patients with cognitive decline and their caregivers, collecting data through mem…

This pilot study tests whether telemedicine can help people living with HIV in Alabama who also struggle with opioid or stimulant misuse get follow-up care. Thirty participants will receive either telemedicine or standard care. The goal is to see if telemedicine is feasible and a…

This study looks at how often heart failure with preserved ejection fraction (HFpEF) occurs in people with COPD and how it affects their health over time. Researchers will follow 200 adults aged 50–70 in Russia who are hospitalized with COPD. They will use heart and lung tests to…

This study aims to find specific epigenetic markers in the blood of elderly patients with acute myeloid leukemia (AML). Researchers will analyze DNA from blood samples of 30 AML patients and compare them to samples from healthy older adults undergoing heart surgery. The goal is t…

This study looks at how immune cells behave in people with lung cancer, sarcoidosis, and COPD. Researchers will collect blood and tissue samples from 425 participants to analyze immune function. No experimental treatments are given. The goal is to understand why some patients don…

This study is creating a registry of 100 women with extramammary Paget's disease (EMPD) of the vulva or perianal area. Researchers will collect health information, tissue samples, and skin swabs to learn more about the disease and the bacteria living on affected skin. The goal is…

This study is testing whether a special 3D ultrasound technique can help doctors better monitor how liver tumors respond to treatment. About 80 adults with liver cancer that started in the colon or rectum will be scanned before and during therapy. The goal is to see if this imagi…

This study tests whether an AI tool can help doctors make more accurate diagnoses in kidney medicine. About 100 doctors will review up to 10 online patient cases. Some doctors will see AI suggestions before giving their final diagnosis, while others will not. Researchers will com…

This study is testing advanced heart MRI scans to better diagnose and predict risks for people with rare heart muscle diseases. Researchers will scan 1000 participants to see if these new imaging methods can identify conditions like Fabry disease and cardiac amyloidosis more accu…

This study is testing whether artificial intelligence can help doctors better classify and predict the behavior of rare smooth muscle tumors of the uterus, including those that are hard to diagnose (called STUMP). Researchers will train AI models on digital images of tumor tissue…

This study collects stool from 4 healthy adults to see how phages (viruses that eat bacteria) found in dairy products affect gut bacteria in a lab dish. Researchers will add antibiotics and dairy phages to the stool samples and watch how the bacterial community changes. The goal …

This study follows 150 adults for one year after ankle arthroscopy to record any complications that arise. Participants will be checked by their surgeon and physical therapist at 15 days, 3 months, 6 months, and 1 year after surgery. They will also fill out questionnaires and do …

This study is looking at genetic differences between the original lung cancer tumor and where it has spread in the body. Researchers will analyze DNA from stored tumor samples of 25 adults with non-small cell lung cancer. The goal is to better understand how lung cancer spreads, …

This early-stage study tests whether a new drug called J4 is safe for people. It is the first time J4 is given to humans, and only healthy adults aged 18 to 64 can join. The main goal is to check for side effects and how the drug moves through the body. This study does not treat …

This study looks at whether a small drop of blood from a finger-prick device can reliably detect tumor DNA in 35 adults with colorectal cancer that has spread to the liver. Researchers will compare results from the finger-prick sample to a standard arm-vein blood draw to see if t…

This study explores how traditional Chinese medicine tools, such as tongue and pulse diagnosis, can help identify unique features of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare 30 people with IBD to 30 healthy volun…

This study looks at whether tiny particles released by cells into the blood, called extracellular vesicles, can help detect a type of heart disease called ATTR amyloidosis earlier. The disease often goes unnoticed until serious damage occurs. Researchers will compare these partic…

This study looks at how well pelvic organs move in women with endometriosis using dynamic MRI. Researchers want to see if measuring this movement can help diagnose the disease better and explain why some treatments don't work. About 52 women with suspected endometriosis will take…

This study aims to understand why some people have complications after spinal surgery. Researchers will measure bone strength, muscle health, and other markers in 200 adults undergoing spine surgery. The goal is to find better ways to predict and prevent problems like pain or the…

This study looks at how the information given to mothers about labor induction affects their childbirth experience. Researchers will also examine if social media plays a role. The study involves 50 women with planned labor induction and uses questionnaires to measure their experi…

Researchers at the University of Michigan and Northwestern University are interviewing children, adults, and parents of young children about their experiences with swelling caused by Nephrotic Syndrome. The goal is to develop a survey that can be used in future clinical trials to…

This study looks back at medical records of about 59 ICU patients who used a low-flow carbon dioxide removal (ECCO2R) machine for breathing failure. The goal is to describe how the device was used and what happened to patients, including survival and side effects. It does not tes…

This study looks at how the immune system changes in men with prostate cancer who receive brachytherapy (internal radiation). Researchers will collect blood and tissue samples before, during, and after treatment to track immune cells and DNA. The goal is to better understand the …

This study tests whether a short educational video can encourage Hispanic current and former smokers to get screened for lung cancer. Researchers will enroll 2,000 people aged 50-80 who smoke or quit recently. Participants watch the video and answer surveys to identify barriers a…

This study tests if giving C-section babies bacteria from their mother can help restore their gut health to be more like babies born vaginally. About 100 healthy infants will receive a daily oral bacterial product for one or four weeks. Researchers will compare their gut bacteria…

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …

This study is for people with sickle cell disease or other rare anemias. Researchers want to use advanced genetic and blood tests to better understand each person's condition. The goal is to make diagnosis more precise so that treatments can be tailored to each patient. About 200…

This study looks at how aging changes the way your body uses energy and nutrients, and how that relates to physical and mental decline. Researchers will track 100 healthy and frail older adults using special tracer infusions to measure metabolism. The goal is to better understand…

This study aims to improve the accuracy of medical lab tests by creating better reference materials and quality controls. Researchers will compare how these materials behave compared to real patient samples in multiple labs. The goal is to ensure test results are consistent and t…

This study looks at how long it takes for people in Brazil to get a correct diagnosis of pulmonary arterial hypertension (PAH), a rare and serious lung disease. Researchers will review medical records of about 139 adults diagnosed in the last five years to find out what causes de…

This study is a large national registry that collects mammography data from radiology practices across the U.S. to help them compare their performance with national and regional benchmarks. It includes up to 8 million participants and provides feedback on key measures like cancer…

This study follows 250 adults with asthma over about 5 years to see how the disease varies from person to person and changes over time. Researchers will track lung function, symptoms, triggers, and flare-ups through annual clinic visits and home assessments. The goal is to better…

This study checks if a computer algorithm can correctly identify the cause of chronic pain, just like a pain specialist would. About 200 adults with pain lasting at least one month will have their symptoms and history analyzed by both the algorithm and a doctor. The goal is to se…

This study looks at medical records from 15,000 people to see how chronic liver diseases (like hepatitis, fatty liver, and cirrhosis) are linked to other health problems. Researchers will track new cases of liver cancer and complications over time. The goal is to better understan…

This study looks at the genetic causes of nephronophthisis, a rare kidney disease that leads to kidney failure before age 20. Researchers will collect urine and blood samples from 310 patients and healthy relatives to study cells and identify potential drug targets. The goal is t…