Gentler transplant offers hope for blood disorders without cancer

NCT ID NCT00920972

Recruiting now Disease control Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a milder type of stem cell transplant for people with non-cancerous blood, immune, or metabolic disorders. The goal is to safely get donor cells to grow in the patient's body while reducing harsh side effects. About 220 participants will receive a reduced-intensity treatment before transplant, and researchers will monitor engraftment and toxicities for 100 days.

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Conditions

The condition(s) this trial relates to.

disease hemoglobinopathy inherited hemoglobinopathy metabolic disease thalassemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOLOGIC, IMMUNE, OR BONE MARROW DISORDERS HEMOGLOBINOPATHIES METABOLIC DISORDERS NON MALIGNANT DISORDERS

Contacts and locations

Locations

All Children's Hospital
COMPLETED

St. Petersburg, Florida, 33701, United States
BC Children's Hospital
COMPLETED

Vancouver, British Columbia, V6H 3N1, Canada
Carolinas Medical Center
COMPLETED

Charlotte, North Carolina, 28232, United States
Children's Hospital of New Orleans
COMPLETED

New Orleans, Louisiana, 70118, United States
Children's Hospital of Orange County
RECRUITING

Orange, California, 92868, United States
Children's Memorial Hospital
COMPLETED

Chicago, Illinois, 60614, United States
Children's Mercy
COMPLETED

Kansas City, Missouri, 64108, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Cook Children's Hospital
COMPLETED

Forth Worth, Texas, 76104, United States
Duke Children's Hospital
COMPLETED

Durham, North Carolina, 27705, United States
George Washington University School of Medicine
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Hackensack University Medical Center
COMPLETED

Hackensack, New Jersey, 07601, United States
Indiana University School of Medicine
RECRUITING

Indianapolis, Indiana, 46202, United States
Miami Children's Hospital
COMPLETED

Miami, Florida, 33155, United States
Nemours Children's Health
COMPLETED

Jacksonville, Florida, 32207, United States
Phoenix Children's Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
St. Louis University
RECRUITING

St Louis, Missouri, 63104, United States
Texas Transplant Institute
COMPLETED

San Antonio, Texas, 78229, United States
The University of Oklahoma
COMPLETED

Oklahoma City, Oklahoma, 73104, United States
University of Calgary
COMPLETED

Calgary, Canada
University of California
RECRUITING

San Diego, California, 92123, United States
University of Manitoba
COMPLETED

Winnipeg, Manitoba, MB R3E 0T4, Canada
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Pittsburg
COMPLETED

Pittsburgh, Pennsylvania, 15224, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States
Washington University School of Medicine (in St. Louis)
RECRUITING

St Louis, Missouri, 63110, United States
Yale School of Medicine
RECRUITING

New Haven, Connecticut, 06510, United States

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