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Second chance: milder prep for stem cell transplants may help when first fails

NCT ID NCT01666080

Recruiting now Disease control Sponsor: Masonic Cancer Center, University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This trial tests a second stem cell transplant using a gentler conditioning regimen of busulfan, fludarabine, and low-dose total body irradiation. It is for people with blood disorders, hemoglobin diseases, or immune deficiencies whose first transplant did not achieve enough donor cell engraftment. The goal is to see if this approach can successfully establish donor cells and restore healthy blood and immune function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Busulfan, Fludarabine, total body irradiation, and stem cell transplant
What this could lead to
If successful, this approach could offer a second chance at a working transplant for people whose first one failed, potentially controlling their blood disorder or immune deficiency.
What could go wrong
This is a small, early-stage guideline study, not a large controlled trial. Risks include graft failure, infection, and side effects from the conditioning regimen.

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Conditions

The condition(s) this trial relates to.

hematologic disorder hemoglobinopathy immunodeficiency disease inborn error of immunity inherited hemoglobinopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOLOGIC DISORDERS HEMOGLOBINOPATHIES IMMUNODEFICIENCIES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Masonic Cancer Center, University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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