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Why do some joint replacements get infected? moscow study hunts for clues

NCT ID NCT07813832

Knowledge-focused Sponsor: People's Friendship University of Russia Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers in Moscow are studying patients who have knee or hip replacement surgery to learn why some develop serious infections around the implant. The study will follow 750 adults aged 45 and older, checking their immune status, mineral metabolism, and tissue samples before and after surgery. By comparing these markers with outcomes, the team aims to build tools that help doctors predict, diagnose, and prevent these complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the study identifies which patients face the highest risk, doctors could screen and prepare them better before surgery, potentially lowering the rate of painful, costly joint infections.
What could go wrong
This is an observational study, so it can only find links, not prove cause and effect. The findings may not apply to patients outside Moscow or to other types of joint replacement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 750 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

residents of the city of Moscow and the region

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients 45 years and older * Clinical diagnosis: Idiopathic coxarthrosis stage 3 * Clinical diagnosis: Secondary coxarthrosis stage 3 (ANFH, post-traumatic coxarthrosis, rheumatoid arthritis, etc.) * Clinical diagnosis: Idiopathic gonarthrosis stage 3 * Clinical diagnosis: Secondary gonarthrosis stage 3 (aseptic necrosis, post-traumatic gonarthrosis, rheumatoid arthritis, etc.) Exclusion Criteria: * Patients with knee and/or hip joint infection * Patient refusal to participate in the study * Inability to follow up for 3 years * History of psychiatric illness * Decompensated somatic illness

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Conditions

The condition(s) this trial relates to.

disease osteoarthritis, hip osteoarthritis, knee periprosthetic joint infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diagnostic Periprosthetic hip infection Periprosthetic joint infection (PJI) Periprosthetic knee infection Prediction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • City clinical Hospital №31

    RECRUITING

    Moscow, Russia

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