Scientists hunt for hidden antibodies in Kids' kidney disease

NCT ID NCT07516964

Recruiting now Knowledge-focused Sponsor: Meyer Children's Hospital IRCCS Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is investigating whether certain autoantibodies, especially those targeting a protein called nephrin, play a role in nephrotic syndrome, a kidney condition that causes swelling and protein loss in urine. Researchers will analyze blood and kidney tissue from 50 children and adults with the disease using advanced lab techniques. The goal is to better understand the disease mechanisms and pave the way for more personalized, effective treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could lead to better diagnostic tests and more personalized treatments for children with nephrotic syndrome, reducing unnecessary steroid use.
What could go wrong: This is an observational study, not a treatment trial. It is small (50 participants) and early-stage, so findings may not apply to all patients or lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

disease focal segmental glomerulosclerosis idiopathic membranous glomerulonephritis lipoid nephrosis nephrotic syndrome nephrotic syndrome, type 4 sporadic idiopathic steroid-resistant nephrotic syndrome with collapsing glomerulopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOCAL SEGMENTAL GLOMERULOSCLEROSIS (FSGS) MINIMAL CHANGE NEPHROTIC SYNDROME NEPHROTIC SYNDROME DUE TO IDIOPATHIC MEMBRANOUS NEPHROPATHY NEPHROTIC SYNDROME WITH EDEMA (DIAGNOSIS)

Contacts and locations

Locations

Azienda Ospedaliero Universitaria Careggi
NOT_YET_RECRUITING

Florence, Italy
Azienda Ospedaliero Universitaria Pisana
NOT_YET_RECRUITING

Pisa, Italy
Azienda Ospedaliero-Universitaria di Parma
NOT_YET_RECRUITING

Parma, Italy
Azienda USL - IRCCS
NOT_YET_RECRUITING

Reggio Emilia, Italy
Bellvitge University Hospital
NOT_YET_RECRUITING

Barcelona, Spain
Hospital General de México, Mexico City
NOT_YET_RECRUITING

Mexico City, Mexico
IRCCS Azienda Ospedaliero - Universitaria
NOT_YET_RECRUITING

Bologna, Italy
IRCCS Istituto Giannina Gaslini
NOT_YET_RECRUITING

Genova, Italy
Ludwig-Maximilians Universitat
NOT_YET_RECRUITING

München, Germany
Mayo Clinic
NOT_YET_RECRUITING

Rochester, Minnesota, 55902, United States
Meyer Children's Hospital IRCCS
RECRUITING

Florence, FIRENZE, 50139, Italy
Ospedale S. Giovanni di Dio
NOT_YET_RECRUITING

Florence, Italy
Ospedale Santa Maria Annunziata
NOT_YET_RECRUITING

Bagno a Ripoli, Firenze, Italy
Ospedale Santo Stefano
NOT_YET_RECRUITING

Prato, Italy

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