Can a laser microscope match the gold standard for spotting lung cancer during a biopsy?
NCT ID NCT07725510
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This study compares two methods for quickly analyzing lung tissue samples during a bronchoscopy: confocal laser endomicroscopy (CLE), which uses a laser to scan the tissue, and rapid on-site evaluation (ROSE), where a cytologist examines cells under a microscope. The goal is to see if CLE can accurately detect cancer in small lung lesions without destroying the tissue, potentially replacing ROSE. Thirty participants with suspicious lung nodules will have their biopsy samples analyzed by both methods, and the results will be checked against the final lab diagnosis.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If CLE proves as accurate as ROSE, it could offer a non-consumptive, real-time diagnostic method for lung biopsies, potentially speeding up diagnosis and preserving tissue for further testing.
- What could go wrong
- This is a small, early-stage study with only 30 participants, so results may not generalize. CLE requires specialized equipment and expertise, which could limit its widespread use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510163
RECRUITINGGuangzhou, Guangdong, 510100, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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