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Can surgery save the kidneys in deep endometriosis?

NCT ID NCT07776574

Knowledge-focused Sponsor: Charles University, Czech Republic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study looks at women who had surgery for deep endometriosis affecting the ureters, the tubes that carry urine from the kidneys to the bladder. The goal is to see how their kidney function and blood pressure fare years after the operation, and whether the type of surgery matters. Researchers will also test new ways to detect early kidney damage, which could help guide future treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could establish clear guidelines for when to operate on ureteral endometriosis and how to monitor kidney health afterward, potentially preventing irreversible kidney damage.
What could go wrong
This is a small, observational study, so its findings may not apply to all patients. It does not test a new treatment, and long-term outcomes may vary widely among individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

* Group F (postoperative follow-up) Expected number of participants: approximately 50 patients Control group: 15 women of reproductive age with no history of hydronephrosis, other renal disease, or endometriosis; they will be recruited from among patients evaluated for other benign conditions. As part of the study, they will undergo renal ultrasonography with assessment of renal morphology (parenchyma and Doppler perfusion characteristics), and the presence of arterial hypertension will be evaluated. * Group S (prospective pilot cohort) Expected number of participants: 15 women with ureteral endometriosis indicated for surgical treatment (ureterolysis, UCNA, ureteroureterostomy).

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:• age ≥ 18 years; * hydronephrosis caused by DE-related ureteral stenosis; * for Group F: a history of surgical treatment of ureteral endometriosis (ureterolysis, ureteroureterostomy, UCNA) at our center at least 24 months previously; * for Group S: indication for surgical treatment because of hydronephrosis or clinically significant ureteral stenosis; * signed informed consent. Exclusion Criteria:• pregnancy; * malignancy; * congenital uropathy; * other renal diseases; * inability to undergo dynamic renal scintigraphy (e.g., allergy to the radiopharmaceutical or severe comorbidities precluding the examination); * previous urinary tract surgery unrelated to ureteral endometriosis that could substantially confound the assessment of renal function.

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Conditions

The condition(s) this trial relates to.

disease endometriosis hydronephrosis urinary system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometriosis Endometriosis (diagnosis) Urinary tract diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • General University in Prague

    RECRUITING

    Prague, 120 00, Czechia

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