Charles University, Czech Republic

This study looks at how well and how safely a new catheter-based treatment (pulsed-field ablation) can stop abnormal electrical signals in the heart's left upper chamber and nearby areas in people with persistent atrial fibrillation. About 50 adults with non-paroxysmal AFib will …

This study tests a new automated insulin delivery system (the Medtrum TouchCare Nano with APGO algorithm) in 200 adults with type 1 diabetes. The system automatically adjusts insulin based on blood sugar levels, aiming to keep glucose in a healthy range. Researchers will measure …

This study compares a newer surgical method (transobturator cystocele repair) with the standard native tissue repair for fixing a bladder prolapse (cystocele) in women aged 50 and older. About 592 participants will be followed to see which approach better corrects the prolapse an…

This study tests if using magnetic brain stimulation right before electroconvulsive therapy (ECT) can make ECT work better for people with hard-to-treat depression. About 50 adults with severe depression will receive both treatments, and researchers will measure changes in seizur…

This study looks at whether a program of exercise, nutrition advice, and mental support before surgery (called prehabilitation) can help people with ovarian or endometrial cancer recover faster and feel better. About 64 patients will be randomly assigned to either standard care o…

This study aims to understand and improve how patients with COPD and asthma use their inhalers. Researchers will assess 1000 patients and their healthcare providers using a special tool and artificial intelligence. The goal is to find common mistakes and help patients get the ful…

This study looks at whether military medics who have little experience with intubation can successfully use the SaCoVLM™ video laryngeal mask to manage a patient's airway. The study has two parts: first, training on a simulator, then using the device on sedated patients having el…

This study follows 209 children and adults hospitalized with tick-borne encephalitis (TBE) in the Czech Republic for one year after they leave the hospital. Researchers check on participants at several points to see which symptoms like tiredness, headaches, or memory problems las…

This study looks at how a new procedure called pulse field ablation affects the heart's upper chambers in people with a type of irregular heartbeat called paroxysmal atrial fibrillation. Researchers will measure changes in heart function using ultrasound during the procedure. The…

This study reviews data from 500 women who donated breast milk to a hospital milk bank between 2021 and 2025. Researchers will measure how much milk was donated and check its quality, looking at factors like the mother's age, weight, and how she gave birth. The goal is to learn w…