Charles University, Czech Republic

This study compares a new surgical technique called transobturator cystocele repair (TOCR) to the standard anterior repair for fixing a cystocele, a type of pelvic organ prolapse where the bladder bulges into the vagina. About 592 women aged 50 and older with at least stage 2 pro…

This study is testing a new automated insulin delivery system for adults with type 1 diabetes. The system uses a patch pump and a smart algorithm to adjust insulin automatically. Researchers will check if it improves blood sugar control and is safe to use in daily life. 200 parti…

This study tests whether a program of exercise, nutrition advice, and mental support before surgery helps gynecological cancer patients recover faster and feel better. About 64 women with ovarian or endometrial cancer will be randomly assigned to either standard care or the preha…

This study tests whether giving transcranial magnetic stimulation (TMS) right before electroconvulsive therapy (ECT) can lower the amount of electricity needed for ECT and speed up its antidepressant effects. Fifty adults with major depression that hasn't responded to other treat…

This study looks at the best way to treat a fluid pocket (pseudomeningocele) that can form under the scalp after brain surgery. It compares doing nothing active (just watching and caring for the wound) with doing a procedure like draining the fluid or another surgery. The goal is…

This study looks at whether military medics with limited experience can use the SaCoVLM™ video laryngeal mask to manage airways and perform intubation. The research has two parts: first, training on a simulator, then using the device on sedated patients having elective surgery. T…

This study looks at how a new procedure called pulse field ablation affects the heart's upper chambers in 50 people with paroxysmal atrial fibrillation (a type of irregular heartbeat). Researchers will use ultrasound images taken during the procedure to measure changes in heart f…

This study is looking back at five years of data from a single hospital milk bank to understand what factors affect the amount and quality of breast milk donated. Researchers will examine information from about 500 donors, including their age, weight, and how they gave birth. The…

This study follows 209 children and adults hospitalized with tick-borne encephalitis (TBE) in the Czech Republic for one year after discharge. Researchers track symptoms like fatigue, headaches, memory problems, and weakness to see how long they last and who needs extra support. …

This study looks at how well and how safely a new catheter (Varipulse) works for treating a type of irregular heartbeat called atrial fibrillation. About 50 adults with this condition will receive the procedure. Researchers will check if the treatment successfully blocks faulty e…

This study aims to understand and improve how patients with COPD and asthma use their inhalers. Researchers will assess patients' inhaler technique and provide education, while also evaluating healthcare professionals' knowledge. The goal is to boost adherence to treatment and re…