Charles University, Czech Republic

This study compares a newer surgical method (transobturator cystocele repair) with the standard native tissue repair for fixing a bladder prolapse (cystocele) in women aged 50 and older. About 592 participants will be followed to see which approach better corrects the prolapse an…

This study tests a new automated insulin delivery system (the Medtrum TouchCare Nano with APGO algorithm) in 200 adults with type 1 diabetes. The system uses a patch pump to automatically adjust insulin based on blood sugar levels. Researchers will measure changes in blood sugar …

This study tests whether using magnetic brain stimulation (TMS) right before electroconvulsive therapy (ECT) can make ECT work better and faster for people with severe, treatment-resistant depression. About 50 adults will receive both treatments, and researchers will measure chan…

This study looks at whether a program of exercise, nutrition advice, and mental support before surgery (called prehabilitation) can help people with ovarian or endometrial cancer recover faster and feel better. About 64 patients will be randomly assigned to either standard care o…

This study looks at how a new procedure called pulse field ablation affects the heart's upper chambers in people with a type of irregular heartbeat called paroxysmal atrial fibrillation. Researchers will measure changes in heart function using ultrasound during the procedure. The…

This study aims to understand why many people with COPD and asthma do not use their inhalers correctly, and to test new ways to help them stick to their treatment. Researchers will work with 1,000 patients and their healthcare providers, using a special assessment tool and artifi…

This study follows 209 children and adults in the Czech Republic who were hospitalized with tick-borne encephalitis (TBE), a brain infection from tick bites. Researchers check on participants at several points over a year to see which symptoms—like tiredness, headaches, or memory…

This study reviews data from 500 women who donated breast milk to a hospital milk bank between 2021 and 2025. Researchers will measure how much milk was donated and check its quality, looking at factors like the mother's age, weight, and how she gave birth. The goal is to learn w…

This study looks at whether military medics who have little experience with intubation can safely use a special video laryngeal mask called SaCoVLM™. The study has two parts: first, training on a simulator, then using the device on sedated patients having elective surgery. The go…

This study looks at how well and how safely a new catheter (Varipulse) can treat atrial fibrillation by using pulsed-field energy to burn specific areas in the heart. About 50 adults with non-paroxysmal atrial fibrillation will take part. The main goals are to see if the burning …