Sleep-wake disorder

This study looks at whether the shape of a person's face influences how Botox injections change bite force in people who grind their teeth (bruxism). Participants with different facial structures receive Botox into the jaw muscle, and bite force is measured before and after treat…

This study tested whether adding a telerehabilitation program (using a mobile app, video calls, and online coaching) to standard CPAP therapy helps obese adults with severe sleep apnea. 180 participants were followed for 6 months to see if the program improved daytime sleepiness,…

This completed study tested a remote, self-guided lifestyle program for 696 veterans with obesity and obstructive sleep apnea. Participants watched videos, completed handouts, and tracked their eating and activity, with optional coaching. The goal was to see if this low-cost appr…

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This study tested the Inspire system, a device that stimulates a nerve in the neck to keep the airway open during sleep. It involved 44 adults in Singapore with moderate-to-severe obstructive sleep apnea who could not use CPAP. The main goal was to confirm the device works proper…

This study tested whether getting a sleep doctor appointment within one month helps people with obstructive sleep apnea use their CPAP machine more regularly. About 100 adults participated. The goal was to see if faster care leads to better treatment adherence and improved sleepi…

This study looked at whether a diabetes drug called empagliflozin, combined with a breathing machine (CPAP), can improve sleep and heart function in 70 adults with both heart failure and obstructive sleep apnea. Participants were randomly assigned to take empagliflozin or not, an…

This study involved 155 adults with narcolepsy who were already taking a high-sodium oxybate medication. They switched to Xywav, a low-sodium version, to see if their blood pressure would improve. The goal was to provide doctors and patients with useful information about the impa…

This study tested whether a 3-year physical activity program could help prevent colon cancer from coming back in 889 patients who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. Participants were randomly assigned to either the exercise program plus…

This completed phase 4 trial tested three different drug combinations to treat obstructive sleep apnea in 45 adults. The drugs aim to improve how the airway stays open during sleep. Participants took either a drug combo or a placebo before bed, and their sleep was monitored overn…

This early-stage study tested whether a brief therapy program plus a mobile app could help pregnant and postpartum women stay on their buprenorphine medication for opioid use disorder. Fifteen pregnant women took part, attending therapy sessions and using the app for up to 9 mont…

This completed trial tested whether a low-level laser device (Alesis OSA-1) can reduce breathing pauses in adults with obstructive sleep apnea. 35 participants received six 12-minute light treatments over three weeks. Researchers measured apnea events before and after treatment, …

This study looked at whether weight-loss surgery (sleeve gastrectomy) is better than diet and medication for adults aged 65 and older with severe obesity and related health problems like type 2 diabetes, high blood pressure, sleep apnea, and knee arthritis. Sixty patients chose e…

This study tested if transplanting healthy gut bacteria (fecal microbiota) can help people with chronic insomnia. 80 adults received either the bacteria or a placebo in capsules. Researchers measured sleep quality using sleep tests and questionnaires to see if the treatment impro…

This study looked at 61 night workers aged 20-55 to understand how their sleep patterns relate to attention and heart rate. Participants took ramelteon (Rozerem), a drug similar to melatonin, for two weeks. Researchers measured changes in sleep quality, anxiety, and depression us…

This study tested whether managing sleep apnea remotely with a breathing device (APAP) can lower blood pressure as well as traditional in-person care. Researchers enrolled 344 adults with suspected sleep apnea in Beijing. Participants were randomly assigned to either telemedicine…

This study looked at whether using a CPAP machine at night can reduce episodes of atrial fibrillation (a type of irregular heartbeat) in people who also have obstructive sleep apnea. Twenty-five adults with both conditions were enrolled. Half used CPAP while the other half were o…

This phase 2 trial tested a drug called lorundrostat in 48 adults with moderate-to-severe obstructive sleep apnea and high blood pressure. Participants took either the drug or a placebo for four weeks to see if it improved breathing during sleep and lowered blood pressure. The st…

This study looked at 19 people with sleep apnea and mild high blood pressure. It compared a drug called bosentan to the standard CPAP machine to see if the drug could lower blood pressure just as well. The goal was to find a simpler way to manage heart risks in sleep apnea patien…

This completed trial tested a device called AesyBite Active, which uses gentle vibrations to reduce teeth grinding (sleep bruxism) during the night. 26 adults who grind their teeth wore the device while sleeping. The main goal was to see if it could cut grinding activity by at le…

This study looked at whether using a CPAP machine to treat sleep apnea soon after a stroke can improve heart health. 71 people with acute stroke and moderate-to-severe sleep apnea were randomly assigned to CPAP or usual care. Researchers measured changes in heart structure and bl…

This study looks at the long-term safety and effectiveness of pitolisant in adults with idiopathic hypersomnia, a condition causing excessive daytime sleepiness. Participants had already completed a previous study. The goal is to see if pitolisant remains safe and helps control s…

This study tested whether acetazolamide, a cheap and well-tolerated water pill, can reduce sleep apnea severity and lower blood pressure in young adults (18–50 years old) who cannot or will not use a CPAP mask. 54 participants received either the drug or a placebo for two weeks e…

This study tested whether a special oral appliance called myTAP, combined with a mouth shield and deep dental cleaning, can reduce gum disease in people who snore and breathe through their mouth. 43 adults with mild to moderate gum disease completed the 12-week trial. The device …

This study tested a personalized surgical approach for children with obstructive sleep apnea who have small tonsils or Down syndrome. Instead of the standard tonsil and adenoid removal, doctors used a sleep endoscopy to see exactly where the airway collapses and chose surgeries b…

This study tested two doses (250 mg and 500 mg daily) of acetazolamide, a drug usually used for altitude sickness, in 91 adults with moderate to severe obstructive sleep apnea. The goal was to see if the drug could reduce breathing pauses during sleep by improving breathing contr…

This study tested a personalized treatment plan called VitalCare for people with obstructive sleep apnea who were starting CPAP therapy. The plan included remote monitoring and tailored follow-up to help patients use their CPAP machine more regularly. Researchers enrolled 113 par…

This study tested whether personalized sleep or nutrition advice could help night shift workers sleep better and improve their health. 57 rotating or night shift workers wore smart devices, did alertness tests, and gave blood samples. Researchers compared those who got tailored a…

This study tested a new, low-cost device called Apne-Scan to see if it can accurately detect sleep apnoea compared to standard home tests. Forty adults referred to a sleep clinic wore the Apne-Scan mask alongside their usual test overnight. The goal was to see if the simpler, che…

This study looked at whether monitoring oxygen levels at home for 14 nights gives a more accurate diagnosis of obstructive sleep apnea than the standard single-night test in a hospital. Researchers enrolled 130 adults with suspected sleep apnea. They compared results from home mo…

This study tested a wearable device called SUNRISE to see if it can accurately screen for obstructive sleep apnea in people with diabetes or chronic lung disease. Researchers compared its results to standard sleep testing in 37 adults. The goal is to make sleep apnea screening ea…

This study tested a wearable ring device (Belun Ring) to see if it can accurately screen for obstructive sleep apnea. 70 adults wore the ring during a standard overnight sleep test. The ring measures oxygen levels, pulse, and movement to estimate breathing disruptions. Researcher…

This study looked at whether a portable sleep monitor used during a short hospital stay can accurately diagnose sleep apnea in people with multiple system atrophy (MSA), compared to the standard overnight lab test. Thirty adults with probable MSA took part. The goal was to see if…

This study tested whether a Samsung Galaxy Watch can reliably detect moderate to severe obstructive sleep apnea (OSA) in adults. Researchers enrolled 152 people who were at high risk or already diagnosed with OSA. The watch's readings were compared to standard sleep tests to see …

This study tested whether a ring-shaped device worn on the finger can accurately diagnose obstructive sleep apnea compared to the standard overnight sleep lab test. 136 adults suspected of having sleep apnea wore the Belun Ring while also undergoing standard lab testing. The goal…

This study tested whether a special algorithm in a pacemaker can accurately diagnose sleep apnea in people with heart problems. Researchers compared the pacemaker's readings to a standard overnight sleep test in 66 participants. They also looked for a link between sleep apnea sev…

This study tested a headband called Dreem 3S that people wear at home to monitor sleep and wake patterns. The goal was to see if it can help diagnose narcolepsy, a condition that causes extreme daytime sleepiness. 78 adults took part, and researchers checked how well the device w…

This completed study tested a new radioactive tracer called [18F] - FD17 for PET imaging to detect clumps of a protein called alpha-synuclein in the brain. These clumps are linked to Parkinson's disease, multiple system atrophy, and a sleep disorder that often precedes Parkinson'…

This study tested a new device called the BRUXENSE occlusal splint to see if it can help diagnose sleep bruxism (teeth grinding). Seven adults with bruxism tried wearing the splint for 10 nights. The goal was to see if they could use it comfortably and if it collected enough data…

This study looked at whether a home sleep apnea test can accurately detect obstructive sleep apnea in children aged 5-12 who have already had their tonsils and adenoids removed. 62 children completed both a home test and an overnight in-lab sleep study. The goal was to see how we…

This study tested whether a smartphone app called Apneal can accurately diagnose sleep apnea. 491 adults wore the app on their chest during an overnight sleep test, and the app's results were compared to the standard hospital sleep test. The goal is to see if the app can reliably…

This study tested a behavioral sleep program for 16 depressed teenagers who slept less than 7 hours on school nights or had irregular sleep schedules. The program included one session with a provider and used smartphone tools to help teens create a plan for longer and more regula…

This study tested whether taking hydrocortisone (a cortisol-like hormone), melatonin, or both could reduce jet lag symptoms after long eastward flights. Fifty-seven healthy adults aged 18-65 who flew across 6-8 time zones took the pills for 4 days after arrival and reported their…

This study tested a combination of two drugs, atomoxetine and oxybutynin (called AtoOxy), as a potential pill-based treatment for obstructive sleep apnea (OSA). 117 adults with OSA who were not using CPAP took the medication for one month. The goal was to see if the drug combo co…

This completed pilot study tested whether shining a low-level laser into the blood (intravenous laser therapy) can improve sleep and reduce pain in people with chronic sciatica. Sixty-six adults with sciatica and poor sleep received either electroacupuncture alone or electroacupu…

This study tests an oral drug called SDX (serdexmethylphenidate) to see if it safely reduces excessive daytime sleepiness in adults with idiopathic hypersomnia, a condition where people feel extremely sleepy during the day despite getting enough sleep at night. Participants will …

This study tests two behavioral therapies—imagery rehearsal therapy (IRT) and targeted dream control (TDC)—to reduce nightmares in adults with narcolepsy. Participants attend therapy sessions, keep a daily sleep log, and complete questionnaires. Some Chicago-area participants als…

This study looked at whether extra family support helps children with Down syndrome and obstructive sleep apnea use their positive airway pressure (PAP) machine more regularly. 27 children aged 6-18 were split into two groups: one received standard care, the other got a family-in…

This trial investigates whether jaw exercises (Rocabado programme) work better when guided by a physiotherapist through online video sessions versus doing them at home with written instructions alone. Adults aged 18-60 with jaw-joint pain and teeth grinding are randomly assigned …

This study tested two simple treatments for snoring in people with mild sleep apnea: low-level laser therapy applied to the mouth and soft palate, and oropharyngeal exercises (like tongue and throat workouts). 180 adults aged 40-55 took part. The goal was to see which approach re…

This study tested whether a mild electrical current applied to the head (called transcranial electrostimulation, or TES) can help control pain after major sleep apnea surgery. 45 patients received TES along with standard care. The goal was to see if TES reduces pain and the need …

This Phase 2 trial tested AXS-12 (reboxetine) in 21 adults with narcolepsy and cataplexy. Participants received either the drug or a placebo for three weeks, then switched. The goal was to see if AXS-12 could reduce weekly cataplexy attacks and improve excessive daytime sleepines…

This study tested a 12-week remotely-supervised rehabilitation program for 60 men aged 25-65 with moderate to severe obstructive sleep apnea. The goal was to see if the program could improve breathing pauses during sleep, daytime sleepiness, and overall quality of life. Participa…

This study tested a new medicine called ALKS 2680 in 92 adults with narcolepsy type 1, a condition that causes severe daytime sleepiness and sudden muscle weakness (cataplexy). Participants stopped their usual narcolepsy medications and received either ALKS 2680 or a placebo for …

This study tested whether a herbal supplement called Redormin 500 (made from valerian and hop extracts) can help people with occasional sleep problems think more clearly during the day and feel better overall. Forty healthy adults with mild sleep issues took either the supplement…

This study tested a six-session behavioral sleep program, called Apnea and Insomnia Relief (AIR), in 118 Gulf War veterans with Gulf War Illness. The program combined sleep education, motivation for using a breathing machine, and insomnia therapy, all done via telehealth. Researc…

This study tests whether repeated acupressure can help reduce agitation, pain, and sleep disturbances in intensive care unit (ICU) patients who are on mechanical ventilators. Participants receive either real acupressure or a light touch (sham) twice daily for four days. Researche…

This study looked at whether a swaddle blanket with a gentle abdominal band can reduce acid reflux, breathing pauses, heart rate drops, and low oxygen levels in premature infants. About 50 babies in the NICU were observed to see if the blanket helped. The goal was to find a simpl…

This study tested whether a drug called acetazolamide can improve sleep-disordered breathing in women traveling to high altitude (3600 m). 303 healthy adults participated in a randomized, placebo-controlled trial. The main goal was to see if the drug reduced drops in oxygen level…

This study looked at whether surgery to fix a blocked nose can improve snoring and sleep apnea in adults. Thirty people with nasal obstruction and sleep apnea had surgery. The main goal was to see if their breathing pauses during sleep (measured by the apnea-hypopnea index) got b…

This study tested different treatments to help with sleep problems caused by Long COVID. It involved 361 adults and looked at improving daytime sleepiness and overall sleep quality. The goal was to find which treatments work best for these specific sleep issues.

This study tested whether a 14-day course of the sleep medication eszopiclone could help people with both insomnia and obstructive sleep apnea use their CPAP machine more consistently. Sixty participants were randomly assigned to receive either eszopiclone or a placebo. The resea…

This study tested whether a Persian-language internet program called Omid, based on cognitive behavioral therapy, can improve sleep in adults with insomnia. Thirty participants were randomly assigned to use the program or receive usual care. The program includes weekly online les…

This study tested a six-session behavioral therapy that teaches people with narcolepsy type 1 how to become aware during dreams (lucid dreaming) and control frightening images. Ninety-eight adults took part, with half receiving the therapy and half getting standard care. The goal…

This study tested an experimental drug called AXS-12 (reboxetine) in 90 people with narcolepsy who experience cataplexy (sudden muscle weakness) and excessive daytime sleepiness. Participants took either the drug or a placebo twice daily for several weeks. The main goal was to se…

This study tested whether using a CPAP machine (a device that helps you breathe during sleep) can also improve oral frailty (weakness in the mouth) and dysphagia (trouble swallowing) in people with obstructive sleep apnea. Researchers followed 450 adults aged 50 and older for six…

This study tested three treatments for chronic teeth grinding (bruxism): dry needling and two types of botulinum toxin (Botox). 72 adults with severe jaw pain were split into three groups. Researchers measured pain levels and jaw muscle thickness before treatment and up to 3 mont…

This study tested three ways to treat jaw pain caused by teeth grinding (bruxism): a custom mouthguard (occlusal splint), Botox injections, or both together. Sixty adults completed the 3-month trial. Researchers measured pain and jaw function changes to see which approach worked …

This study tested whether a mindfulness program could help teenagers with obstructive sleep apnea use their CPAP machine more regularly. 37 teens aged 13-18 with moderate to severe sleep apnea took part. The program taught skills like awareness and resilience, and the researchers…

This study tested whether a short course of the steroid dexamethasone can reduce the severity of obstructive sleep apnea in children aged 2 to 10. Ten children with moderate-to-severe sleep apnea received either the drug or a placebo for three days. The goal was to see if the ste…

This study tested a once-nightly extended-release form of sodium oxybate (FT218) in 157 adults with idiopathic hypersomnia, a condition causing excessive daytime sleepiness despite adequate sleep. Participants were already on stable doses of stimulants or other alerting agents. T…

This study looked at whether a deep dental cleaning (called subgingival instrumentation) can reduce jaw symptoms like pain, stiffness, and tension in people who grind their teeth (bruxers) and also have gum disease (periodontitis). Sixty adults aged 30-40 received the cleaning, a…

This study tested a dietary supplement called Speed Sleep in 60 adults aged 18-65 who have trouble sleeping. Participants took either the supplement or a placebo daily for 4 weeks. Sleep quality and quantity were measured using Fitbit trackers and questionnaires.

This study tested whether sleeping in a semi-upright position (45-degree angle) after surgery could prevent sleep apnea from getting worse. 164 adults with sleep apnea who were having elective inpatient surgery took part. Half slept semi-upright and half slept flat on their backs…

This study looked at whether wearing compression stockings during the day for 28 days could reduce the number of breathing pauses (apneas) per hour in people with moderate to severe sleep apnea. The idea is that stockings prevent fluid from building up in the legs and moving to t…

This study tested whether a self-help book could help healthcare workers with shift work disorder sleep better and feel less sleepy. 199 participants with symptoms of the disorder took part. The book provided tips on managing sleep, alertness, and health related to shift work.

This study tested a cognitive behavioral therapy (CBT) course for insomnia in 73 adults who also have a chronic physical illness like arthritis, heart disease, or cancer. The therapy focused on changing sleep habits and thoughts about sleep. Results showed that the course helped …

This study tested whether a desk lamp that gives off near-infrared light can help people who feel sleepy or down during the day. Eighty healthy adults aged 25 to 65 used the lamp at their desk for two weeks. Researchers checked changes in mood, drowsiness, sleep quality, and bloo…

This study looked at whether exercising in the morning or evening helps control blood sugar better in pregnant women with gestational diabetes or glucose intolerance. 39 women walked or stepped for 30 minutes either after breakfast or after dinner. The researchers measured blood …

This study tested a phone-based health coaching program to help people with sleep apnea use their positive airway pressure (PAP) device more often. 27 adults who were not using their device enough took part. The coaching aimed to improve device use and reduce daytime sleepiness.

This study looked at whether breathing exercises plus lavender essential oil can reduce job burnout and improve sleep in nurses who work rotating shifts. 70 nurses took part. The goal was to see if this simple, drug-free approach could help them feel less exhausted and sleep bett…

This study tested whether wearing a smart watch and using a health app could help people with obstructive sleep apnea use their CPAP machine more regularly. 46 adults who either had never used CPAP or used it less than 4 hours a night were given a smart watch and app for 90 days.…

This small study looked at 17 adults with bruxism (teeth grinding) who received Botox injections into their jaw muscle. Researchers used ultrasound to measure muscle thickness and texture before treatment, at 14 days, and at 90 days. They also tracked pain levels. The goal was to…

This completed study tested whether semaglutide, a drug used for type 2 diabetes and weight loss, could improve sleep apnea in 15 people with diabetes or obesity. Researchers measured breathing pauses during sleep (AHI) after 1 and 4 weeks of treatment. The goal was to see if the…

This study tested a program called SIESTA-Rehab to help stroke patients sleep better during their hospital stay. The program included training nurses to reduce nighttime disruptions and a plan to check for and treat sleep apnea. Researchers studied 400 adults in a rehab hospital …

This study tested whether a dental mouthpiece (mandibular advancement device) can reduce frequent nighttime urination in adults with obstructive sleep apnea. Eleven participants who woke up to pee at least twice a night used the device and tracked their bathroom visits. The goal …

This study looked at whether therapeutic touch—a gentle, non-invasive technique—can help people aged 65 to 85 who are in the hospital sleep better and feel less anxious. Researchers compared a group that received therapeutic touch to a control group. The goal was to see if this s…

This study looked at whether aromatherapy (lavender oil foot massage) and reflexology (pressing specific points on the feet) could reduce pain and improve sleep in 90 children with cerebral palsy, aged 6 to 12. Children were split into three groups: aromatherapy, reflexology, or …

This study looked at two treatments for jaw pain caused by teeth grinding (bruxism) and related muscle pain. Forty adults either got a custom mouth splint to wear most of the day or had thin needles inserted into their jaw muscles (dry needling) in three weekly sessions. Research…

This study tested a version of cognitive behavioral therapy for insomnia, specially adapted for night shift workers. 60 nurses who work night shifts and have insomnia took part. The goal was to see if the therapy is practical and helps improve sleep and reduce fatigue.

This study tested two programs to help older adults stop taking sleeping pills like lorazepam or zolpidem. One program focused on placebo effects—the power of believing a treatment works—while the other did not. Both included cognitive behavioral therapy and special pill packagin…

This small study tested whether wearing bright light glasses each morning could improve symptoms of irritable bowel syndrome (IBS) and reduce leaky gut. Five adults with IBS used the light device for two weeks. The goal was to see if the light therapy eases belly pain, bloating, …

This study tested a dietary supplement called NP-2006 in 48 healthy adults who had mild, ongoing sleep troubles (subclinical insomnia). Participants took either the supplement or a placebo pill daily before bed for 4 weeks. Researchers measured sleep quality and daytime sleepines…

This study looked at whether sucking on ice (oral cryotherapy) can reduce sore throat and improve daily life in people with sleep apnea after robotic surgery. 64 adults took part. The goal was to see if this simple, low-cost method could ease pain and help patients get back to no…

This study tested a behavioral sleep treatment in 36 veterans who have PTSD, insomnia, and sleep apnea. The goal was to see if improving sleep also improves quality of life and daily functioning. Participants attended therapy sessions and reported their sleep and well-being throu…

This study tested whether a daily mix of plant protein and two herbs (ashwagandha and rhodiola) could improve sleep in 100 adults aged 35-70 with sleep troubles. Participants took either the supplement or a placebo for 30 days and reported their sleep quality daily. The goal was …

This study tested whether the drug acetazolamide can improve sleep-disordered breathing in 39 adults with chronic pain who use opioids. Participants took either the drug or a placebo for one week each. The goal was to see if the pill could reduce sleep apnea events as an alternat…

This study tested different doses of light therapy to see which works best for improving sleep in people with Parkinson's disease. 203 participants used either bright-white or dim-red light boxes at different times of day. The goal was to find the most effective dose to ease slee…

This study tested whether the drug Lemborexant helps people with delayed sleep phase syndrome (a condition where your natural sleep time is much later than desired) fall asleep faster. 71 adults took either the drug or a placebo nightly for up to 2 years. The main goal was to see…

This phase 2 study tested an experimental drug called ALKS 2680 in 93 adults with narcolepsy type 2, a condition causing severe daytime sleepiness. Participants took either the drug or a placebo daily to see if it safely improved their ability to stay awake. The trial is now comp…

This study tested whether installing special LED lights that mimic sunlight in hospital rooms could help treat depression and improve sleep. Fifteen adults with major depression participated. The goal was to see if the lights were comfortable and if they could reduce depression s…

This early study tested a product called Chenghuang Circadian Rhythm Regulator in 15 adults with ongoing sleep problems. The goal was to see if it could improve sleep quality and immune markers. Results are not yet reported, but the study was small and had no comparison group.

This study followed 71 adults with narcolepsy who started taking LUMRYZ, a medication for excessive daytime sleepiness. Over 4 months, participants filled out questionnaires about their symptoms, how they felt about the drug, and their quality of life. The goal was to see if LUMR…

This study tested a mobile health (mHealth) program designed to help people who have had a stem cell transplant for blood cancer get better sleep. Researchers wanted to see if the program was easy to use and if participants liked it. About 30 survivors, caregivers, and doctors ga…

This study tested whether wearing a light-blocking eye mask at night (11 p.m. to 5 a.m.) could improve sleep quality and melatonin levels in 60 intensive care unit patients. Participants were randomly assigned to either wear the mask or receive standard care. Sleep quality was me…

This study tested whether a medication called lemborexant can help night shift workers sleep longer during the day. 29 full-time night shift workers who had trouble sleeping took either the drug or a placebo for two weeks. The goal was to see if the drug increased total daytime s…

This study tested whether two types of gentle exercise—stretching or traditional pregnancy exercises—could improve sleep quality in pregnant women during their third trimester. Sixty women with sleep troubles took part in guided sessions twice a week for three weeks. The goal was…

This study tested a new automatic setting (Auto-EPAP) on a ventilator to see if it could better manage airway blockages during sleep compared to the standard manual setting. It involved 23 adults with conditions like sleep apnea, COPD, or obesity-related breathing problems who al…

This study tested a drug called solriamfetol in 59 adults with obstructive sleep apnea who also had trouble thinking clearly and felt very sleepy during the day. The goal was to see if the drug could improve cognitive function, like attention and processing speed. Participants to…

This study tested whether a headband called Muse-S, which senses brain activity, could help midlife women with sleep problems like insomnia. Thirty-one women going through menopause wore the device at home. The goal was to see if it was practical and if it improved sleep quality …

This study tested whether custom mouthguards (splints) designed using a 3D jaw-tracking device called MODJAW work better than standard mouthguards for people with teeth grinding (bruxism) or jaw pain. 40 adults with mild-to-moderate symptoms wore either a personalized or standard…

This study tested whether an Apple Watch paired with a special app and weekly health coaching could help dementia caregivers improve their sleep and mood. Twenty-one caregivers wore the watch to track their activity and sleep, and received personalized feedback and motivational c…

This study tested three ways to manage sleep bruxism (teeth grinding) in 48 people with implant-supported dentures. One group got Botox injections into the jaw muscles, another used a custom mouth splint at night, and a third simply removed their dentures at night (control). Rese…

This early study tested whether the drug acetazolamide can reduce breathing pauses during REM sleep in people with obstructive sleep apnea who cannot use a CPAP machine. Eleven participants took either the drug or a placebo for a few nights. Researchers measured breathing events …

This small pilot study tested whether cannabis oil (with different ratios of CBD to THC) could help with insomnia in people who also have major depression. Fourteen adults took either a high-CBD oil, a low-CBD oil, or a placebo for a short time. The main goal was to see if a larg…

This study tested different treatments for sleep problems caused by Long COVID. It included 830 adults who had COVID-19 and now have trouble sleeping or feel very sleepy during the day. The goal was to see if treatments matched to specific sleep issues could help people feel bett…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tested whether giving children a single oral dose of steroid right after tonsillectomy can reduce pain and lower the need for strong painkillers. It involved 163 children aged 3 to 12 having outpatient tonsil surgery. Researchers measured pain scores and opioid use for…

This study tested whether orofacial myofunctional therapy (OMT) — simple tongue and throat exercises done during the day — can improve breathing during sleep in people with mild-to-moderate sleep apnea. 209 adults with sleep apnea participated, comparing OMT to a placebo exercise…

This study tested whether a combination of a specific jaw muscle technique and neck exercises could reduce pain and improve jaw function in people with temporomandibular disorder (TMD) and teeth grinding (bruxism). Sixty adults with TMD and bruxism were split into two groups: one…

This study tested a mobile app called SleepFix that provides digital behavioral therapy for insomnia in 128 older adults aged 50+ who also had mild memory concerns. Participants either used the app or received online sleep health education. The goal was to see if the app could re…

This study tested whether acupressure—a gentle finger-pressure technique on specific body points—could improve sleep in elderly people living in care homes. 75 residents took part, with half receiving 12 acupressure sessions over four weeks. The results showed that those who rece…

This study tested an online program called ALDER that teaches older adults skills to boost positive emotions and reduce anxiety. 33 people aged 65 and older who used benzodiazepines (anti-anxiety or sleep medications) at least twice a week took part. Over 5 weeks, they learned an…

This early-phase study tested a new slow-release form of pitolisant (HBS-201) in 46 adults with narcolepsy. The goal was to see if starting at a full dose is tolerable. Participants took the drug for 14 days, and researchers tracked side effects and dropouts.

This study tested a non-drug treatment called Personalized Integrated Chronotherapy (PIC) for depression during pregnancy and after childbirth. 120 pregnant women with major depression were randomly assigned to receive either usual care (medication or therapy) or PIC plus usual c…

This study tested a 16-week sensory-friendly physical activity program for autistic children aged 7-12 in special education schools. The program included predictable routines and calming cool-downs to help with sleep. Researchers measured sleep quality using wrist monitors and pa…

This study tested a special educational program based on motivational interviewing to help people with sleep apnea use their CPAP machine more regularly. 100 adults newly prescribed CPAP took part. The program aimed to improve adherence, motivation, quality of life, and daytime s…

This study looked at 558 adults with mild to moderate sleep apnea who also don't get enough sleep. Researchers compared two programs: one focused on improving use of a PAP machine, and another on sleep education. The goal was to see which works better for reducing daytime sleepin…

This study tested whether a high-flow nasal cannula (HFNC) can reduce the risk of low oxygen levels during sedated gastrointestinal endoscopy in 80 adults with high-risk obstructive sleep apnea. Participants had a STOP-Bang score of 5 or higher and were undergoing gastroscopy, co…

This study tested whether a safe sleep aid could help people with obstructive sleep apnea use their CPAP machine more each night. Many patients struggle to keep the mask on all night, often because they wake up easily. The trial gave a medication to raise the sleepers' arousal th…

This study tested whether a jaw-widening surgery (surgically assisted maxillary expansion) could improve quality of life in 9 adults with obstructive sleep apnea. Participants completed sleep questionnaires before surgery and again 3 months and 1 year after. The goal was to see i…

This study tested a new combination pill called AD109 for obstructive sleep apnea (OSA) in 646 adults who could not tolerate CPAP machines. The pill aims to reduce breathing pauses during sleep by targeting brain chemicals. Results will show if it improves the apnea-hypopnea inde…

This study tested a new medication called AD109 (a combination of two drugs) to treat obstructive sleep apnea in adults who cannot or will not use a CPAP machine. About 660 participants took either the pill or a placebo for one year. The main goal was to see if the pill reduces t…

This study tested whether doing special tongue and throat exercises for 12 weeks after surgery helps people with moderate-to-severe sleep apnea breathe better at night. 51 adults were split into two groups: one did the exercises after surgery, the other had surgery only. The exer…

This study tested a behavioral program to help older veterans with obstructive sleep apnea use their positive airway pressure (PAP) machine more consistently. About 100 veterans who had stopped using their PAP device worked with a sleep coach over several sessions. The goal was t…

This study tested whether a 4-week program of diaphragmatic breathing exercises before bed can reduce sleep bruxism (teeth grinding) in 100 adults. Participants learned deep breathing techniques and practiced them nightly, while a control group listened to neutral music. The goal…

This study looked at the long-term safety and effectiveness of a drug called AXS-12 for people with narcolepsy who also have sudden muscle weakness (cataplexy) and severe daytime sleepiness. 68 people who had already completed an earlier study took AXS-12 and were monitored for s…

This study tested a special water bottle nozzle designed to strengthen mouth and tongue muscles while you drink. 43 adults with mild to moderate sleep apnea used the nozzle daily for 8 weeks. Researchers measured changes in sleep quality, snoring, and apnea severity to see if thi…

This study tested a new CPAP mask (the Eclipse) against a traditional mask in 70 adults with obstructive sleep apnea. Participants tried each mask three times and reported how much they liked it and any technical issues. The goal was to see if the new design is easier and more pl…

This study tested how easy a new CPAP mask (the Eclipse) is to use compared to a traditional mask. 35 adults with sleep apnea tried both masks three times each. Researchers measured setup time, technical issues, and how often help was needed.

This study tested a new CPAP mask called DreamPort-Eclipse against a traditional nasal mask in 173 adults with obstructive sleep apnea. Participants used the mask for 6 hours a night over 60 days. The goal was to see if the new mask reduces air leaks, improves breathing scores, a…

This study tested a sleep and circadian treatment (TranS-C) for people with severe mental illness (SMI) in community mental health centers. The treatment was adapted to better fit these settings. Researchers looked at whether it improved sleep, daily functioning, and symptoms in …

This study tested whether the sleep medication suvorexant (Belsomra) can help older adults sleep better and reduce confusion after heart surgery. One hundred patients aged 60 and older received either suvorexant or a placebo for seven nights in the ICU. Researchers measured sleep…

This study tested whether adding the sleep medication eszopiclone (Lunesta) to brief behavioral therapy improves sleep quality and CPAP use in veterans with PTSD and complex insomnia. Fifty-three veterans who had trouble sticking with CPAP therapy for sleep apnea took part. The g…

This study tested two versions of a sleep treatment for people with severe mental illness in community mental health centers. One version was the standard treatment, and the other was adapted to better fit patients' needs. The goal was to see if training clinic staff to deliver t…

This study tested a group program for people with moderate-to-severe sleep apnea who were having trouble using their breathing machine (PAP). The program aimed to help them use the machine more often and for longer each night. Researchers compared the group program to usual care …

This study tested a home-based lifestyle program for people with severe obstructive sleep apnea and severe obesity. The program used a tablet and sensors to track sleep, diet, and exercise, along with regular calls from a health coach. The goal was to see if people could use the …

This study looked at whether giving iron supplements to children with ADHD, restless legs syndrome, and low iron levels could improve their symptoms. Twelve kids aged 10-15 took iron for 3 months. Researchers measured changes in brain iron, blood iron, and symptoms using sleep mo…

This study looked at ways to help people who had a stroke use a CPAP machine for sleep apnea during their rehab stay. Sleep apnea is common after stroke and can slow recovery. The researchers tested different approaches to improve how often patients used the CPAP machine over thr…

This study tested whether certain health and wellness products can help people sleep better. Over 1,600 adults who wanted better sleep took either a product or a placebo (fake product) without knowing which they got. The study measured changes in sleep, anxiety, and fatigue using…

This small pilot study tested custom 3D-printed masks for children with sleep apnea who use CPAP machines. Researchers took 3D pictures of each child's face to create a perfectly fitted mask. The goal was to see if the custom mask was more comfortable and used more often over 6 m…

This study tested a special candy containing tea theanine, casein hydrolysate, and saffron extract in 171 Chinese adults aged 20-55 with mild sleep problems. Participants took the candy or a placebo for 28 days, and researchers measured changes in sleep quality, stress, mood, and…

This study tested a new once-nightly medication called FT218 for people with narcolepsy who experience excessive daytime sleepiness and sudden muscle weakness (cataplexy). It included 184 participants, some already on a twice-nightly medication and some new to treatment. The goal…

This study tested a steroid nasal spray (mometasone furoate) in 130 children aged 3-12 who snore and have sleep-disordered breathing. The goal was to see if the spray could relieve symptoms enough to avoid surgery to remove tonsils or adenoids. Children used the spray daily for 6…

This study tested different doses of melatonin to see which one best improves sleep quality in autistic children aged 3 to 12 who have trouble sleeping. Researchers measured things like how long it takes to fall asleep, total sleep time, and number of night awakenings using sleep…

This study looked at whether adding special breathing muscle training to running programs helps 10-13-year-old male football players improve their agility, endurance, and lung function. 75 boys who had played football for at least two years took part. The training was tailored to…

This study tested a new nasal pillows mask called F&P Toffee for people with obstructive sleep apnea. Forty adults who already use PAP therapy tried the mask at home for 14 days. Researchers measured how well the mask controlled breathing pauses (AHI score) and how sleepy partici…

This study tested a new nasal mask called the F&P Caramel for people with obstructive sleep apnea. 45 adults who already use a similar mask tried it at home for 14 days. Researchers measured how well the mask controlled breathing pauses (AHI score) and daytime sleepiness. The goa…

This study tested a powdered sleep supplement called BEAM Dream Powder in 40 adults who had trouble sleeping. For two weeks, participants took a placebo, then switched to the real powder for four weeks. Researchers used sleep questionnaires and Fitbit trackers to see if the powde…

This study tested whether a remote patient monitoring platform (MonitAir) could help people with obstructive sleep apnea use their CPAP machine more consistently. 200 adults starting CPAP therapy were randomly assigned to receive standard coaching or enhanced monitoring with the …

This study compared two treatments for sleep bruxism (teeth grinding): botox injections and marjoram oil aromatherapy. Thirty adults with sleep bruxism were split into two groups, receiving either botox or marjoram oil. Researchers measured changes in jaw muscle thickness, pain, …

This small study tested whether the sleep medication lemborexant (Dayvigo) can help people with moderate-to-severe obstructive sleep apnea (OSA) who have a low arousal threshold—meaning they wake up easily during sleep. Ten untreated adults each took the drug or a placebo on two …

This study tested an experimental drug called TAK-861 in 105 adults with narcolepsy type 1, a condition causing severe daytime sleepiness and sudden muscle weakness (cataplexy). Participants took either TAK-861 or a placebo daily for 3 months. The main goal was to see if the drug…

This study tested two non-drug approaches for bruxism (teeth grinding) in 30 young adults. One group received hands-on manual therapy to the jaw and neck, while the other did home exercises. Both groups also learned about bruxism. The goal was to see if these treatments could red…

This study looks at whether a 90-minute afternoon nap, a moderate dose of caffeine, and a short recovery routine (stretching plus a snack) can improve evening athletic performance. Sixty elite university athletes (30 men, 30 women) will try different combinations of these strateg…

This study looks at a nerve in the neck called the ansa cervicalis, which controls muscles that help keep the airway open. Researchers will measure the nerve's size and shape in 50 adults having neck surgery for head and neck cancer. They will also test how stimulating the nerve …

This study looked at how children with cerebral palsy, their parents, and healthcare professionals experience sleep disordered breathing and its management. Researchers interviewed 24 participants to understand the challenges and what helps or hinders treatment. The goal was to g…

This study tested whether bright light in the afternoon, alone or with morning light, can shift teens' internal body clocks earlier. 84 adolescents aged 18-20 followed a stable sleep schedule and then lived in a lab for a week. Researchers measured melatonin levels to track clock…

This study looked at jaw disorders and teeth grinding in 76 elite basketball referees compared to healthy people. Referees face high stress and often hold a whistle between their teeth, which may strain the jaw. Researchers used ultrasound to measure jaw muscle thickness and foun…

This study looked at how sleep quality and beliefs about sleep affect the risk of relapse in people recovering from alcohol dependence. Researchers followed 198 adults as they left inpatient rehab and returned home, measuring sleep with questionnaires and activity monitors. The g…

This study investigates why people develop obstructive sleep apnea (OSA) and whether the underlying cause affects how they respond to different treatments. Researchers will test three approaches—CPAP, a sleep medication (eszopiclone), and supplemental oxygen—in adults with OSA. T…

This study looks at how not getting enough sleep and being awake at odd hours affects your thinking, blood chemistry, and the helpful bacteria in your gut. Researchers gave 55 healthy adults a prebiotic supplement or a placebo to see if it could help counter the negative effects.…

This study looked at how sleep quality improves when people with obstructive sleep apnea start using a CPAP machine. Researchers used a special headband to track deep sleep at home for 7 nights before and 9 nights after starting treatment. The goal was to see how quickly sleep ge…

Sleep problems affect up to 90% of people with alcohol dependence and often lead to relapse. This study tests whether a short questionnaire called the Short Sleep Index (SSI) can reliably measure sleep quality compared to a longer, standard sleep questionnaire. Researchers will a…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study tested whether eating 28 grams of pistachios (about 40 nuts) one hour before bedtime could help regulate the body's internal clock in 28 overweight young adults. Researchers measured melatonin levels, antioxidant activity, and sleep-wake patterns. The goal was to see i…

This completed study looked at 1,740 newly married couples to see if the bacteria in their mouth, eyes, and gut are linked to sleep problems, vision issues, and mood. Participants provided samples and completed surveys about sleep, anxiety, depression, and dry eye symptoms. The g…

This study tested whether taking salt with breakfast versus dinner changes blood pressure patterns and nighttime salt excretion in 53 obese adults. Participants took salt tablets at different times of day. The goal was to see if timing affects blood pressure rhythms and related h…

This study explored sleep disorders in 37 adults with non-small cell lung cancer. Participants filled out questionnaires about their sleep, symptoms, mood, and quality of life. The goal was to create a guide to help doctors diagnose and treat sleep issues in this group, ultimatel…

This study tested whether helping people sleep longer (through sleep hygiene and extending sleep time) could lower their blood pressure during sleep. 66 adults who slept less than 7 hours per night took part. Researchers measured blood pressure during sleep and awake periods at t…

This early study tested whether a small electrode placed near the nerve that controls tongue movement could help people with obstructive sleep apnea. Fourteen adults who already needed surgery took part. The main goal was to see if the approach was safe and could make the tongue …

This study tested whether stimulating certain nerves or muscles in the throat can improve breathing in people with obstructive sleep apnea. Researchers placed temporary electrodes and measured airflow during sleep in 35 adults. The goal was to see if this approach is feasible and…

This early study tested whether a small electrode placed near the tongue nerve could be safely used in people with obstructive sleep apnea. 14 adults who could not use CPAP took part. The goal was simply to see if the nerve could be reached and stimulated, not yet to treat the co…

This study looked at the medical records of one person from a sleep clinic to see if their breathing problems were due to a condition called dysanapsis (where airways are smaller than normal) rather than true asthma. The goal was to better understand why some people with sleep ap…

This study looked at how sleeping at high altitude (3600 m) affects breathing in healthy women, and whether the phase of their menstrual cycle makes a difference. 91 women spent two nights at altitude while their oxygen levels and breathing patterns were measured. The goal was to…

This study looked at 103 adults with narcolepsy or obstructive sleep apnea to see if anxiety, social, or work factors affect their ability to stay awake during a standard test. Participants filled out an anxiety questionnaire before the test. The goal is to better understand why …

This study looked at 173 infants with myelomeningocele, a severe form of spina bifida, to see if the timing of their surgery (before or after birth) affects their risk for sleep-disordered breathing. Researchers used sleep studies to measure breathing problems and later checked t…

This study looked at 62 children with cerebral palsy (ages 2-18) and their primary caregivers to understand how the children's sleep problems relate to caregiver burden and mental health. Researchers used questionnaires to measure sleep quality in both children and caregivers, al…

This study looked at how eye pressure changes when breath-hold divers hold their breath. Forty divers had their eye pressure, oxygen levels, heart rate, and blood pressure measured before, during, and after holding their breath. The goal was to understand these changes and how th…

This study looked at whether a 15-minute meditation practice called Shoonya meditation can help people stay sharp after a night without sleep. Researchers compared regular meditators to people who nap regularly, measuring brain activity, heart rate, and cognitive performance. The…

This study looked at 395 adults with obstructive sleep apnea to see if a new tool called the Baveno classification agrees with the standard sleep test (polysomnography) for deciding treatment. Researchers compared symptoms and health records against sleep lab results. The goal is…

This study tested a new approach called DREAM, where Veterans at risk for sleep apnea could go straight to home sleep testing without an initial in-person clinic visit. Over 6,500 Veterans took part to see if this speeds up diagnosis and treatment. The goal is to make sleep apnea…

This completed study looked at whether chemicals in the blood (metabolomics) can help diagnose obstructive sleep apnea and track changes with treatment. Researchers analyzed stored blood samples from 388 people with and without sleep apnea, and also collected new samples from pat…

This study followed 59 nurses during their first year of work to see if night shifts harm bone health. Researchers measured bone density and markers of bone turnover in night shift nurses compared to day shift nurses. The goal was to understand if shift work increases the risk of…

This completed study looked at sleep problems in over 1,100 children and adults with specific learning disabilities (like dyslexia or dyspraxia), with or without ADHD. Participants filled out online questionnaires about their sleep habits. The goal was to find out how common diff…

This study looked at how the drug modafinil affects driving ability in 27 people with narcolepsy or hypersomnia. Participants took modafinil or a placebo for five days, then completed both simulated and real driving tests. The goal was to see if the drug improves alertness and re…

This completed Phase 1 study looked at whether obstructive sleep apnea (OSA) might contribute to Alzheimer's disease. Researchers studied 182 older adults aged 65-85 with and without OSA, using brain scans and breathing tests. The goal was to understand how sleep disruptions like…

This study looked at 89 people — some with bruxism (teeth grinding) and some healthy — to see if there is a connection between the body's 'automatic' nervous system and the tightness, stiffness, and elasticity of the chewing muscles. Participants wore a chest strap to measure hea…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study looked at 48 young adults (24 with bruxism, or teeth grinding, and 24 without) to understand how jaw function, posture, muscle stiffness, pain, stress, and sleep quality are connected. Researchers used special tools to measure posture, muscle tightness, and pain levels…

This completed study in Norway looked at whether delaying school start times by one to two hours on Mondays and Tuesdays helps high school students sleep longer, feel less sleepy during the day, and improve their mental health and grades. Over 580 first-year students participated…

This study looked at 38 adults who usually sleep less than 6 hours a night. Researchers helped them increase their sleep to the recommended 7 hours and measured changes in blood chemicals and insulin sensitivity. The goal was to find biological markers that can tell if someone is…

This study looked at whether veterans with traumatic brain injury (TBI) and insomnia can reliably measure their internal body clock at home. Thirty-one veterans wore a wrist device for a week and collected saliva samples to track melatonin levels. The goal was to see if these hom…

This study looked at whether a wearable device (Xiaomi Mi Band 8) can accurately detect sleep-related breathing disorders. About 300 adults wore the band during a standard overnight sleep test. Researchers compared the band's sleep-stage data with the hospital test to see if wear…

This study looked at 77 never-smokers newly diagnosed with lung cancer to see how many also have sleep apnea and whether sleep apnea affects their cancer outlook. Participants had a sleep test before starting cancer treatment. The goal is to understand if sleep apnea is a hidden …

This completed study tested two different PAP systems (machines, masks, and tubing) for obstructive sleep apnea. Thirty employees of the device maker used each system for a week and rated their experience. The goal was to gather feedback to guide future product improvements, not …

This study followed 520 French adults with central or mixed sleep apnea to see how a treatment called adaptive servo-ventilation (ASV) improved their sleep quality. Participants used a breathing device that adjusts pressure in real time. The goal was to measure changes in sleep q…

This study looked at 89 obese pregnant women to find out how common sleep apnea is and whether it is linked to high blood pressure, preeclampsia, or poor fetal outcomes. Participants had a sleep test (polysomnography) to detect apnea. The goal was to understand the connection and…

This study looked at how sleep health impacts recovery quality in 174 adults after hip or knee replacement surgery. Participants wore activity monitors and kept sleep diaries to track their sleep patterns. The goal was to see if poor sleep leads to worse recovery, helping doctors…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This study looked at how having fibromyalgia changes body measurements and sleep patterns in people with obstructive sleep apnea. Researchers measured neck, waist, and hip sizes, and used sleep tests and ultrasound to compare 77 participants. The goal was to better understand the…

This pilot study tested whether limiting food intake to an 8am-to-6pm window for four weeks could improve metabolic health and appetite regulation in 16 healthy adults. Participants ate freely during that window and fasted the rest of the time. The study measured changes in appet…

This study looked at whether treating obstructive sleep apnea (OSA) can also reduce pain and problems in the jaw and face, known as temporomandibular disorders (TMD). Forty-one adults with OSA but not yet on treatment were checked for TMD before starting therapy and again after a…

This study tested a website designed to help teenagers with narcolepsy or idiopathic hypersomnia and their families understand and improve social relationships. Twenty-five teens and their parents reviewed the website's content, which included animations, patient stories, and exp…

This completed study tested two different methods for positioning a dental sleep appliance used to treat obstructive sleep apnea. Eleven adults each tried both a standard forward-jaw technique and a technique based on saying certain sounds. The goal was to see if the speech-based…

This completed study enrolled 230 people with Parkinson's disease, a related sleep disorder, and healthy volunteers. Participants used a smartphone app to track their movements daily and underwent brain scans. Some also gave skin biopsies to test for a protein linked to Parkinson…

This study used smartwatches to compare sleep stages and total sleep time between 62 adults with sleep bruxism (teeth grinding) and healthy controls. Participants wore a smartwatch for 7 nights to collect sleep data. The goal was to see if smartwatches can help monitor sleep brux…

This study looked at 106 people with obesity who were scheduled for weight-loss surgery. Researchers measured how their upper airways behaved during sleep and used MRI scans to see if changes after surgery could explain why some develop obstructive sleep apnea and others do not. …

This study looked at whether a special camera test done during sleep (called drug-induced sleep endoscopy) can help doctors choose the right non-CPAP treatment for people with obstructive sleep apnea. 35 adults who could not use CPAP took part. The goal was to see if this approac…

This completed pilot study looked at whether a quick, non-invasive eye scan (OCT angiography) can detect early blood vessel changes in the retina of people with obstructive sleep apnea. Researchers compared 166 adults with and without sleep apnea. The goal was to see if retinal i…

This study looked at how the sleep hormone melatonin and a specific gene (MTNR1B) work together to control blood sugar. Researchers tested 23 healthy adults in a controlled lab setting. The goal was to understand why some people may have higher diabetes risk, which could lead to …

This study looked at how low oxygen levels (hypoxia) in people with obstructive sleep apnea affect the body's ability to use insulin. Researchers measured insulin resistance in the liver and fat tissue of 48 non-diabetic adults. The goal was to understand why some sleep apnea pat…

This study looked at 150 children and adults who had their tonsils removed using one of three surgical methods: BiZact, coblation, or bipolar. Researchers measured pain after surgery, how long the operation took, when patients could eat solid food again, and how much the devices …

This small study tested whether placing a nerve stimulation lead in a different spot during a sleep apnea device implant could improve breathing. 29 adults with moderate to severe central sleep apnea took part. The goal was to see immediate changes in breathing and airway functio…

This study looked at how well the diaphragm works in people with obstructive sleep apnea (OSA). Researchers used ultrasound to measure diaphragm movement in 60 adults with OSA. The goal was to see if diaphragm function is linked to how severe the sleep apnea is.

This completed study tracked 132 children with obstructive sleep apnea who had their tonsils removed. Researchers recorded how many had breathing problems after surgery, especially those with other health issues. The goal was to create a simple flowchart to help doctors decide wh…

This completed study looked at how consistently 300 obese adults (BMI over 30) used positive airway pressure therapy for sleep-disordered breathing. Researchers tracked whether patients used the device at least 4 hours per night for 70% of nights within the first 90 days and agai…

This study looked at 40 adults who had a blood clot in their lungs (pulmonary embolism). Researchers compared those who also had sleep-disordered breathing (like sleep apnea) with those who did not. The goal was to see if sleep problems affect short-term recovery and the chance o…

This study looked at 24 people with high-altitude pulmonary hypertension who live above 2500 meters. Researchers measured their sleep breathing at 3200 meters and again after moving to 760 meters. The goal was to see if lower altitude improves oxygen levels and reduces breathing …

This study looked at how well smartphone apps and a special ring (Belun Ring) can measure sleep quality in adults getting braces or other orthodontic treatment. 52 people from Case Western Reserve University's dental clinic took part. They answered sleep questionnaires and used t…

This study used a very powerful 7 Tesla MRI to look for tiny brain changes in 15 people with idiopathic REM sleep behavior disorder (iRBD) compared to 15 healthy volunteers. iRBD is a sleep condition that often leads to Parkinson's disease years later. The goal was to find early …

This study looked at how specific tongue muscles help keep the airway open during sleep in people with obstructive sleep apnea. Researchers used a special camera during sleep-like sedation to measure airway collapse. The goal was to understand the mechanisms behind airway obstruc…

This completed study looked at how blood sugar levels affect sleep in 30 adults with cystic fibrosis-related diabetes. Participants wore devices at home to track glucose and sleep for 10 days. The goal was to see if this kind of remote monitoring is practical and to gather early …

This study looked at whether a 25-minute or 45-minute nap helps teenage soccer players run faster and feel less tired. Sixteen male players tried both nap lengths and a no-nap day. Results showed that napping improved agility and made exercise feel easier, but did not help them k…

This completed study with 40 participants explored factors that might predict obstructive sleep apnea in people with Down syndrome. Researchers used a range of assessments, including sleep studies, heart monitoring, and exercise tests, to identify early warning signs. The goal is…

This study looked at how sleep quality, when people eat, and gut bacteria are linked to obesity. Researchers tested a mobile app to help people make healthier lifestyle changes. The study included 133 adults with different body weights, including some with sleep apnea. The goal w…

This study looked at whether a nutrition and behavior change program could help reduce sleep apnea in people who are overweight or obese. About 400 adults took part, and researchers measured changes in sleep apnea risk, daytime sleepiness, and weight loss. The goal was to see if …

This completed study looked at 825 adults with type 1 diabetes who use an insulin pump to see how many also have obstructive sleep apnea. Researchers used overnight oxygen tests and sleep studies to find cases. The goal was to understand if sleep apnea is linked to diabetes compl…

This study looked at 200 heart transplant patients to see if the time of day the donor heart was removed affects how well the patient does. Researchers compared hearts taken during the body's rest phase (midnight to noon) versus the active phase (noon to midnight). They tracked s…

This study looked at whether working night shifts for just three nights in a row can disrupt bone health. Twenty healthy adults aged 20-40 either followed a normal sleep schedule or stayed awake at night and slept during the day. Researchers measured bone turnover markers to see …

This study looked at whether rotating shift workers can stick to a time-restricted eating plan, where they only eat during certain hours. Researchers wanted to see if this approach is practical and how it affects blood glucose levels during day and night shifts. 31 healthcare wor…

This study followed over 200 sleep apnea patients from a large European database to see how many developed heart problems, metabolic issues, cancer, or died over time. Researchers also checked whether using CPAP therapy (a common sleep apnea treatment) affected these risks. The g…

This study looked at how the timing of sleep affects what teenagers eat. Researchers wanted to understand why getting more sleep helps some teens eat less, but not others. They studied 190 healthy teens aged 14-18 to see if matching sleep to their natural body clock improves thei…

This study looked at whether people with bruxism (teeth grinding or clenching) have worse lung function, breathing muscle strength, balance, and sleep quality compared to healthy people. Researchers tested 34 adults using breathing tests, balance assessments, and sleep questionna…

This study looked at 24 children (ages 6-17) with narcolepsy or hypersomnia to see if changes in their metabolism explain why they often gain weight and become obese. Researchers measured energy use at home and in the hospital using activity trackers. The goal was to understand t…

This study looked at whether people with binge eating disorder have a disrupted body clock. Researchers compared 43 adults with and without the condition, measuring melatonin levels and activity patterns. The goal was to understand how the circadian system might be involved, whic…

This study looked at how two drugs, atomoxetine and oxybutynin, affect throat muscles in people with obstructive sleep apnea (OSA). The goal was to understand why the combination works better than either drug alone. 27 adults with OSA took part, and researchers measured muscle ac…

This study looked at 209 adults with moderate to severe sleep apnea to better understand how the condition affects the body. Instead of just counting breathing pauses, researchers used special measures like oxygen drops, heart rate changes, and sleep disruption. Participants used…

This study follows 202 people who were first checked for sleep apnea as children in 2003. Researchers want to see how their sleep apnea changed over 18 years and whether it is linked to heart problems or thinking difficulties. Participants will repeat sleep tests, blood pressure …

This study followed 113 adults with myotonic dystrophy (Steinert's disease) for 5 years to find out what factors lead to low breathing (hypoventilation). Researchers measured lung function, sleepiness, fatigue, and thinking skills. The goal is to better understand which patients …

This study looked at 27 adults with sleep bruxism (teeth grinding) who got Botox injections in their jaw muscles every six months for two years. Researchers used ultrasound to measure fat buildup in the muscle before each injection. The goal was to see if repeated Botox causes lo…

This study tested whether treating severe gum disease (periodontitis) with a deep cleaning procedure could also reduce teeth grinding (bruxism) during the day and night. Forty adults with advanced gum disease or healthy gums took part. Researchers measured grinding events before …

This study looked at 134 adults with chronic sinusitis to see if sleep problems and daytime tiredness predict declines in thinking skills and daily functioning. Participants filled out questionnaires about their symptoms and quality of life. The goal was to better understand how …

This study looked at how often sleep apnea occurs in adults with type 1 diabetes. Researchers monitored 53 participants overnight using standard sleep tests and continuous glucose monitors. The goal was to measure the link between sleep-disordered breathing and blood sugar contro…

This completed observational study looked at 72 men and women aged 20-50 who work rotating night and day shifts. Researchers measured blood sugar, weight, sleep patterns, and other health markers to understand how short-term circadian misalignment from shift work affects the body…

This study tested whether a thin, flexible tube with pressure sensors (high-resolution manometry) can pinpoint where the airway gets blocked during sleep in people with obstructive sleep apnea. 18 adults and children underwent both the standard scope test and the new tube method.…

This study looked at how sleep apnea might make brain problems worse after surgery. Researchers enrolled 32 adults with moderate-to-severe sleep apnea who were scheduled for surgery. They used brain scans and memory tests before surgery, two days after, and six months later to tr…

This study looked at how often children's oxygen levels drop after surgery for sleep apnea. 178 children who had their tonsils and adenoids removed were monitored with a continuous pulse oximeter. The goal was to better understand oxygen desaturation patterns in the hospital afte…

This study looked at whether having a higher body mass index (BMI) and using simple sleep apnea screening questionnaires can predict breathing or sedation-related problems during endoscopy. Researchers enrolled 350 adults with a BMI of 25 or higher who were scheduled for an upper…

This study looked at how a mix of home and on-site resistance training affects muscle loss and fatigue in people with chronic respiratory diseases like COPD, obstructive sleep apnea, or lingering COVID-19 symptoms. 72 adults aged 30-85 completed 18 exercise sessions. Researchers …

This completed study from Istanbul University looked at 64 obese adults to see if obesity hypoventilation syndrome (OHS) causes extra problems beyond obesity alone. Researchers measured exercise capacity, muscle strength, sleep quality, and quality of life. The goal was to unders…

This study looked at 28 people with both stable coronary artery disease and moderate sleep apnea. Researchers measured blood markers of oxidative stress (a type of cell damage) before and after 3 months of CPAP therapy. The goal was to see if CPAP could reduce oxidative stress, w…

This study looks at how disrupted sleep changes the way common drugs (like painkillers, stimulants, and sedatives) work in the body. Researchers will disturb the sleep of 148 healthy adults in a lab and then measure how their brains respond to these drugs, including pain relief a…

This completed study observed 563 patients who had weight-loss (bariatric) surgery and received extra oxygen during their first night in the hospital. Researchers tracked how often oxygen levels fell below 90% and what actions nurses took, like adjusting the oxygen flow or reposi…

This study looked at how sleep apnea and low oxygen levels affect muscle strength and breathing in people with chronic spinal cord injury. Thirty adults with neck-level spinal cord injuries were tested using hand grip strength and muscle activity measurements. The goal was to und…

This study measured dental movements in 180 adults with sleep apnea who use an oral appliance. Researchers used 3D photographs of teeth to track changes in tooth rotation and length. The goal was to better understand how these devices affect tooth position over time.

This study looked at 172 adults with obstructive sleep apnea to compare the risk of heart attacks, strokes, and eye problems between two common treatments: a CPAP machine and a dental mouthpiece. Researchers did not give any new treatment—they simply observed patients already usi…

This study looked at how moving an oral appliance forward by just one millimeter at a time affects sleep apnea severity and symptoms like daytime sleepiness. Twenty adults with moderate or severe sleep apnea took part. Researchers measured breathing pauses during sleep and used q…

This study followed 60 people who survived a severe breathing crisis in the ICU. Researchers wanted to learn about their health, sleep disorders, and why some need to return to the hospital. Participants had sleep tests three months after leaving the ICU and were tracked for a ye…

This completed study looked at 100 people with jaw deformities to see if they have sleep problems and how their body posture and breathing are connected. Participants had sleep tests and posture measurements before and after corrective jaw surgery. The goal was to better understa…

This completed study looked at whether people with advanced gum disease (periodontitis) also grind or clench their teeth more during sleep. Researchers used a small portable device to measure muscle activity in the jaw over 24 hours in 40 adults, half with severe gum disease and …

This study looked at how lack of sleep and evening light exposure affect the body clocks of teenagers aged 14 to 17. Researchers used morning bright light to try to shift teens' sleep schedules earlier. They measured changes in melatonin levels and sleep patterns to understand wh…

This study looked at how people with obstructive sleep apnea and their bed partners adapt to CPAP therapy, a common treatment that uses a machine to keep airways open during sleep. Researchers interviewed 24 patients and their partners to understand what helps or hinders consiste…