Could a pill replace your CPAP machine for sleep apnea?

NCT ID NCT06295562

Completed Disease control Sponsor: China Medical University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed phase 4 trial tested three different drug combinations to treat obstructive sleep apnea in 45 adults. The drugs aim to improve how the airway stays open during sleep. Participants took either a drug combo or a placebo before bed, and their sleep was monitored overnight. The main goal was to see if the drugs reduced the number of breathing pauses per hour.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atomoxetine, oxybutynin, venlafaxine, trazodone
What this could lead to: If successful, these drug combinations could offer a new medication option for people with obstructive sleep apnea who cannot use CPAP machines.
What could go wrong: This is a small, early-phase trial with only 45 participants. The drugs may not work for everyone and could cause side effects like dry mouth or dizziness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTRUCTIVE SLEEP APNEA OF ADULT

Contacts and locations

Locations

China Medical University Hospital

Taichung, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.