Sleep-wake disorder

This trial tests a device called C-Lift, a neck brace with sensors that detect breathing pauses and low oxygen during sleep. When a problem is sensed, the brace inflates or deflates to open the airway. Researchers will enroll 10 adults with moderate to severe obstructive sleep ap…

This phase 3 trial tests whether UBT251, an investigational drug given as a weekly injection, can reduce breathing pauses during sleep in adults with moderate-to-severe obstructive sleep apnea who also have obesity. Participants continue their usual positive airway pressure (PAP)…

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This trial tests whether four weeks of supervised aerobic exercise can improve sleep and nervous system function in adults with mild to moderate obstructive sleep apnea. Researchers will compare an exercise group with a sleep-education-only group, measuring changes in sleep apnea…

This trial tests whether an investigational drug called HDM1005, given as a weekly injection, can help people with obstructive sleep apnea and obesity. Participants will receive either HDM1005 or a placebo for 52 weeks, alongside lifestyle counseling on diet and physical activity…

This phase 3 trial is testing whether an investigational drug called HDM1005, given as a once-weekly injection, can improve obstructive sleep apnea and reduce body weight in people with obesity who do not use positive airway pressure (PAP) therapy. About 200 adults aged 18 to 75 …

This phase 3 trial is testing whether an investigational drug called UBT251 can reduce the severity of obstructive sleep apnea in people who are obese and do not use positive airway pressure (PAP) therapy. Participants will receive weekly injections of UBT251 or a placebo for 52 …

This study compares three treatments for obstructive sleep apnea: positive airway pressure (CPAP), a dental device that moves the jaw forward, and a combination of two medications (atomoxetine and oxybutynin). About 2,400 adults with sleep apnea will be randomly assigned to one o…

This study looks at whether a newer opioid painkiller, oliceridine, is less likely than the standard sufentanil to cause breathing problems after surgery in people at high risk of obstructive sleep apnea. About 851 adults with known or suspected sleep apnea will receive one of th…

This study tests whether a new auto-adjusting positive airway pressure (APAP) device with a feature called Kairos PAP (KPAP) works better than a standard APAP device with expiratory pressure relief (EPR) for people with obstructive sleep apnea. Participants, who already use PAP t…

This study looks at people with COMISA, a condition where obstructive sleep apnea and insomnia occur together. Many people with this combination struggle to use CPAP, a standard treatment for sleep apnea, consistently. The study will compare those who take daridorexant, a sleep a…

This trial tests whether a miniscrew-assisted rapid palatal expander (MARPE) can reduce obstructive sleep apnea severity in people aged 16 to 60. Participants are randomly assigned to receive either standard care alone or standard care plus the expander, which widens the upper ja…

This trial tests whether removing the tonsils at the same time as implanting a hypoglossal nerve stimulator improves treatment for obstructive sleep apnea in adults whose airway collapses from the side during sleep. Participants are randomly assigned to receive the nerve stimulat…

This trial tests a cryotherapy procedure that freezes and destroys excess fat in the upper airway to reduce airway collapse during sleep. It enrolls adults with moderate-to-severe obstructive sleep apnea who cannot use standard treatments like CPAP. The study measures whether the…

This UK trial tests a device that uses mild electrical pulses to keep the airway open during sleep in people with obstructive sleep apnoea. It is for adults who cannot use standard CPAP therapy. The study will compare the device to usual CPAP care over three months to see if it i…

This pilot study tests an implantable device that stimulates the hypoglossal nerve to keep the airway open during sleep. It is for adults with moderate-to-severe obstructive sleep apnea who have tried but cannot tolerate a CPAP machine. The goal is to see if the device is safe an…

This trial investigates whether lemborexant, a sleep medication, can reduce the number of breathing pauses in adults with moderate obstructive sleep apnea who have a low arousal threshold (wake up easily). Participants take either lemborexant or a placebo daily for 30 days in thr…

This study compares two common treatments for moderate obstructive sleep apnea: a custom mouth device that moves the jaw forward (MAD) and a machine that blows air through a mask (CPAP). Researchers want to see how well each treatment improves breathing during sleep and reduces d…

This study compares two types of tonsil surgery for adults with obstructive sleep apnea and enlarged tonsils. One surgery removes the tonsils completely, while the other removes only part of them. The goal is to see if the less invasive approach works just as well at improving br…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study tests whether a high-flow nasal cannula (HFNC) — a soft tube that delivers warm, humidified air through the nose — works as well as the standard CPAP mask for children with moderate-to-severe obstructive sleep apnea. About 258 children aged 2 to 18 will use one of the …

This study tests whether combining a nerve-stimulating implant with two medications (atomoxetine and oxybutynin) can improve breathing during sleep more than either treatment alone. Twenty-four adults with obstructive sleep apnea who already have the implant will try each combina…

This study tests a new device called Elara APAP for people with obstructive sleep apnea. The device delivers air pressure to keep the airway open during sleep. About 55 adults who already use an APAP machine will have one night of sleep monitoring to see if the device reduces bre…

This study tests whether a traditional Chinese herbal formula (Tiaoshen Anti-cancer granules) combined with cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and possibly extend survival in 360 women with advanced ovarian cancer. Participants will receive either…

This study tests an injection called GZR18 in 140 obese adults with moderate-to-severe obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug improves breathing during sleep, reduces weight, and boosts quality of life compared to a place…

This study tests an injection called GZR18 in 140 obese adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. The goal is to see if the drug improves breathing during sleep and helps with weight loss over 52 weeks. Participants will rec…

This study tests if a mouthpiece worn during sleep can help people with both heart failure and obstructive sleep apnea. The device keeps the airway open, which may reduce stress on the heart and improve quality of life. 328 participants will use either the real device or a sham o…

This early trial tests a new wearable PAP mask system for people with obstructive sleep apnea. Fifteen participants will use the device for up to 7 nights to rate its comfort, seal, and usability. The goal is to improve the user experience, not to measure treatment effectiveness.

This study tests whether injecting botulinum toxin (like Botox) into a throat muscle can help people with moderate to severe obstructive sleep apnea. The goal is to reduce breathing pauses during sleep and improve oxygen levels and daytime sleepiness. The trial involves 20 adults…

This study tests whether a Garmin smartwatch that shows health data can help people with moderate to severe sleep apnea use their CPAP machine more regularly. 80 adults who are new to CPAP will be split into two groups: one can see their wearable data, the other cannot. The main …

This study tests whether eating meals at times that match your body's internal clock can help people who have had weight-loss surgery keep the weight off and improve their health. About 246 adults who had sleeve gastrectomy at least six months ago will either follow standard diet…

This trial tests whether an artificial intelligence model can assess the severity of obstructive sleep apnea in children using noninvasive sensors instead of a standard sleep study. Researchers will compare signals from a fingertip pulse oximeter, pressure-sensing mattresses, and…

This study tests whether a machine-learning model can automatically detect pauses in breathing, called apnoea, in preterm infants born before 32 weeks of gestation. The model uses signals from the diaphragm muscle, along with airway pressure and oxygen levels, recorded over eight…

This study will test several new wearable devices and a mobile app to see how well they diagnose obstructive sleep apnea (OSA) compared to the standard overnight sleep test. About 90 adults will wear devices like a finger sensor, wristband, ring, patches, and an eye mask while al…

This trial tests whether performing a sleep study at home through primary care is more cost-effective than the standard hospital-based approach for diagnosing obstructive sleep apnea. Adults with suspected apnea will be randomly assigned to either home testing via their local hea…

This study compares a new home sleep apnea screening device to the gold-standard in-lab sleep test. Researchers will measure how well the home device detects breathing pauses and oxygen drops in adults referred for a sleep study. The goal is to see if the home test is accurate en…

This study compares a new software, C. Santé, to the standard sleep test (polysomnography) to see if it can accurately measure sleep quality. The software uses sensors on a bed to track breathing and heart rate without disturbing sleep. If successful, it could allow people to mon…

This study will develop and test artificial intelligence (AI) to automatically classify sleep stages from overnight sleep recordings (polysomnography). The goal is to see if the AI can match or beat expert manual scoring, with the aim of supporting diagnosis of chronic insomnia a…

This study will test whether a smart mattress with built-in sensors can accurately diagnose obstructive sleep apnea (OSA) compared to the standard hospital sleep test (polysomnography). Researchers plan to enroll 500 people and have them sleep on the mattress while also undergoin…

This study tests a smart mask that uses AI to detect sleep stages and breathing-related arousals in adults with sleep apnea. About 150 participants will wear the mask during an overnight sleep study, and its results will be compared to standard lab tests. If accurate, the mask co…

This study tests whether a digital program that combines cognitive behavioral therapy for insomnia with circadian rhythm coaching can prevent depressive symptoms from worsening in college students aged 18-24 who have trouble falling asleep and tend to be night owls. Participants …

This study tests whether a special pacifier, called CURAPROX, can reduce the severity of obstructive sleep apnea (OSA) in infants with Down syndrome. Fifty infants will be enrolled at one month old, with half using the pacifier and half not. At six months, sleep tests will measur…

This study tests whether a 6-month program combining exercise, Mediterranean diet, sleep counseling, and cognitive training can help people with early Parkinson's or a sleep disorder (RBD) stick to healthy habits. Researchers will track how well 99 participants follow the program…

This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve sleep quality in adults undergoing surgery for lung cancer. Participants with poor sleep before surgery will receive either active rTMS or a sham (inactive) treatment over five …

This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve sleep quality in adults recovering from a lung transplant. Participants with sleep problems during their hospital stay will receive either active rTMS or a sham (inactive) treat…

This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve sleep quality in adults with advanced non-small cell lung cancer who have trouble sleeping during hospital stays. Researchers will randomly assign 160 participants to receive ei…

This study tests a new, compact CPAP device worn on the head, designed to treat obstructive sleep apnea. Ten adults who already use CPAP will try the device during a supervised daytime nap to see how comfortable, stable, and easy it is to use. The goal is to gather feedback that …

This trial tests whether coloring mandalas—intricate circular patterns—can help reduce anxiety and improve sleep quality in female students who experience premenstrual syndrome (PMS). Participants will be asked to color mandalas, and researchers will measure changes in their anxi…

This trial tests whether connective tissue massage, given three times a week for four weeks, can reduce insomnia severity in adults with chronic insomnia. Participants also receive sleep hygiene education, and the control group gets education alone. The study measures sleep quali…

This study tests whether taking dronabinol (a cannabis-derived medication) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. Th…

This study tests whether AI-based cognitive training, using the Lumosity app, combined with a tailored physical-therapy program can improve sleep and quality of life in people with multiple sclerosis. Participants aged 25-40 with mild to moderate disability will undergo the train…

This study will compare two sedative drugs, remimazolam and dexmedetomidine, in 60 adults with obstructive sleep apnea undergoing drug-induced sleep endoscopy. The goal is to see which drug provides more stable sedation, fewer side effects like low heart rate or low blood pressur…

This study tests a 4-month personalized digital program (PASS) to help people with obstructive sleep apnea start and continue using positive airway pressure (PAP) therapy. Sixty overweight, inactive adults newly diagnosed with sleep apnea will be randomly assigned to either the P…

This study tests two different CPAP devices for people newly diagnosed with obstructive sleep apnea. One device uses a feature called KPAP, the other uses EPR. Researchers will compare how well each device controls breathing pauses during sleep and how patients feel about their s…

This study tests a digital, game-like exercise system called ApneaTheraPlay for people with obstructive sleep apnea. Participants will do a mix of breathing, aerobic, strengthening, and throat exercises three times a week for 12 weeks, either through the game or a structured prog…

This trial tests whether a concentrated beverage taken daily for 28 days can improve sleep quality in adults aged 18 to 60 with mild sleep issues. Participants keep sleep diaries and complete questionnaires on sleep quality and fatigue. The study uses a single-arm design, meaning…

This study looks at whether racism-related stress affects how well a digital cognitive behavioral therapy program (Sleepio) works for insomnia in Black adults. One hundred participants will use the app for 6-10 weeks while researchers track their sleep and stress levels. The goal…

This study tests a program to help adult patients sleep better in the intensive care unit (ICU) after surgery. The program includes sleep education, earplugs and eye masks, reducing noise and light at night, and grouping nursing tasks to avoid waking patients. Researchers will co…

This study looks at whether starting CPAP therapy early for people with suspected obstructive sleep apnea (OSA) can improve their daytime sleepiness and quality of life while they wait for a formal sleep study. Participants are adults with strong signs of OSA, such as loud snorin…

This study tests a special device that monitors sleep without any physical contact, designed for people with Alzheimer's or related dementias living in long-term care facilities. About 100 residents will use the device for four weeks. Researchers want to see if sharing sleep data…

This study tests whether a digital bite-force sensor can objectively measure bruxism (teeth grinding) and track how well Botox injections work. Thirty-six adults with bruxism will receive either Botox or a placebo in their jaw muscles. Researchers will use the sensor and patient …

This study tests whether learning progressive muscle relaxation and deep breathing exercises can improve sleep for cancer patients receiving chemotherapy. About 40 adults aged 40-60 with poor sleep will be split into two groups: one gets relaxation training plus usual care, the o…

This study compares two exercise approaches—short 'exercise snacks' spread throughout the day versus traditional aerobic exercise—in adults with moderate to severe obstructive sleep apnea. Researchers will measure sleep quality, daytime sleepiness, and physical function over 8 we…

This study tests a sleep treatment called TranS-C, adapted for veterans with PTSD and sleep problems. The goal is to improve sleep, reduce nightmares, and help veterans function better in daily life. 182 veterans will receive either the sleep treatment or usual care to see if it …

This study tests whether a decision-making tool can help veterans with sleep apnea choose and stick with a treatment that works for them. About 128 veterans will be randomly assigned to receive either a brief education program or the same program plus a personalized tool. The goa…

This study tests a small device called the Serene Sleep Palatal Implant, placed in the soft palate to reduce snoring and mild-to-moderate obstructive sleep apnea. About 26 adults will be split into two groups based on their condition. The main goal is to check safety, like whethe…

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive eit…

This study tests whether a culturally tailored text-message program can help Spanish-speaking Hispanic adults with obstructive sleep apnea use their positive airway pressure (PAP) machine more consistently. Fifty adults will receive automated texts that offer support, troubleshoo…

This study tests whether a drug called gamma-hydroxybutyrate (GHB) can help intensive care patients get better deep sleep. Sleep problems are very common in the ICU and can lead to serious issues like confusion and longer recovery. The trial will give GHB or a placebo to 24 adult…

This study tests whether taking inulin (a prebiotic fiber) and spirulina (a nutrient-rich algae), alone or together, can improve sleep in adults aged 18 to 60 with chronic insomnia. Over 12 weeks, 180 participants will take one of four options: inulin, spirulina, both, or a place…

This study tests whether a newer 'splintless' jaw surgery is more accurate and safer than the standard method for treating obstructive sleep apnea. About 66 adults with moderate to severe sleep apnea who cannot use CPAP will be randomly assigned to one of the two surgeries. Resea…

This study tests a special gel (HA35) applied to the jaw at night to relieve pain and muscle tightness from temporomandibular joint disorder (TMD). About 30 adults with TMD will use the gel nightly for 8-12 hours. Researchers will check how well it reduces pain and tension after …

This study tests a slow-release melatonin (PedPRM) in 120 children aged 6 to 18 who have anorexia nervosa and trouble sleeping. Participants take either melatonin or a placebo for 13 weeks. The goal is to see if it safely improves total sleep time and related symptoms like anxiet…

This study looks at whether giving people with obstructive sleep apnea (OSA) access to their nightly oxygen levels can improve their experience with a mouthpiece device (MAD). About 120 adults with mild to severe OSA will either get standard care or also see their oximetry data t…

This study tests whether taking steroids (dexamethasone) for a few days after sleep surgery helps reduce pain, allows patients to eat solid food sooner, and lowers the need for strong painkillers. About 120 adults with obstructive sleep apnea will receive either the steroid or a …

This study will test whether different massage techniques can reduce jaw pain and muscle stiffness in people with sleep bruxism (teeth grinding). Forty-two participants will receive either connective tissue massage, another massage method, or a standard mouthguard (occlusal splin…

This study compares a new device called KPAP to standard APAP for treating obstructive sleep apnea. The goal is to see if KPAP, which delivers lower pressure during breathing out, is more comfortable and used more each night. About 30 adults with sleep apnea will try both devices…

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study looks at people who have both sleep apnea and chronic insomnia. All 120 participants will receive standard CPAP therapy for sleep apnea. Half will also get a digital program to treat their insomnia starting at the same time as CPAP. The other half will follow usual car…

This study tests new parts for PAP machines (the devices that help people with sleep apnea breathe at night). Researchers want to see if the new masks, tubes, or machines are as comfortable and easy to use as current ones. About 30 adults who already use a PAP machine will try th…

This study looks at whether orofacial myofunctional therapy (OMT) – exercises for the mouth and tongue – can improve sleep apnea symptoms in adults with mild-to-moderate cases. It will compare OMT alone, CPAP alone, both together, and standard care in 168 participants over 12 wee…

This study compares how comfortable two different sleep apnea machines feel to people who have never used one before. Twenty-four adults with newly diagnosed obstructive sleep apnea will try each machine for 4 nights at home. The goal is to see which device people find more comfo…

This study tests a wearable smart eye-mask that combines gentle heat and massage with voice-guided sleep therapy to help people who have both insomnia and sleep apnea. The 4-year project will first explore how the condition works, then develop the device, and finally test it in 1…

This study tests whether a mobile app or virtual reality program that teaches mindfulness and breathing exercises can lower stress, burnout, and improve sleep and thinking in nurses who work rotating shifts. 300 nurses will be split into four groups: one gets health education onl…

This study tests whether doing progressive relaxation exercises at times matched to each patient's natural circadian rhythm can help manage symptoms, improve sleep quality, increase comfort, and boost mental well-being in people receiving hemodialysis. Researchers will enroll 75 …

This study tests whether 12 weeks of daily breathing exercises using a special device can reduce sleep apnea severity and improve sleep quality in 10 adults with severe obesity (BMI over 40) and obstructive sleep apnea. Participants will do progressively harder breathing workouts…

This study tests whether personalized lifestyle coaching can help emergency medicine residents stay alert and recover better during night shifts. Thirty residents will either receive one-on-one coaching or just a handout on sleep and nutrition. Researchers will track sleep, react…

This study compares standard fentanyl pain medicine to an opioid-free mix of acetaminophen, ibuprofen, ketamine, and dexamethasone in 64 children aged 5-10 with mild to moderate sleep apnea undergoing tonsil surgery. The goal is to see if the opioid-free option controls pain just…

This study tests whether wearing blue-blocking glasses at night can help teenagers (ages 12-18) with insomnia or delayed sleep phase disorder who are already receiving psychiatric care. Forty participants will wear the glasses or use real darkness for one week. The goal is to see…

This study tests whether a single session of sleep hygiene education can improve sleep quality and reduce pain in 100 adults with migraine or chronic lower back pain. Participants will learn healthy sleep habits and follow them for four weeks, tracking changes through questionnai…

This study tests a new oral appliance called DPOA that gently and gradually moves the jaw forward during sleep to keep the airway open in people with mild to moderate obstructive sleep apnea. Forty adults aged 20 to 65 will be enrolled and monitored with sleep tests. The goal is …

This study tests whether an 8-week Mindfulness-Based Stress Reduction (MBSR) program can reduce hot flashes and improve sleep in menopausal women. 90 women aged 45-60 with hot flashes and poor sleep will be randomly assigned to either the MBSR program or no intervention. The prog…

This study tests a new software tool called Pressure Match that helps doctors set personalized minimum and maximum pressure levels on CPAP machines for people newly diagnosed with obstructive sleep apnea. The tool uses patient data like weight, gender, and severity of apnea to re…

This study tests a noninvasive device that stimulates a nerve in the leg to help people with restless legs syndrome who have developed complications from their usual medication. About 50 adults will use the device at home for 8 weeks. Researchers will measure changes in symptom s…

This study tests whether using a virtual reality headset for guided relaxation after night shifts can improve sleep quality in nurses and nursing assistants. Forty participants will either use the VR device for one month or receive standard care, then switch. Sleep quality, insom…

This study looks at whether teaching people with rotator cuff syndrome the best sleeping positions can improve their sleep quality while they undergo physical therapy. Researchers will compare two groups: one getting standard physical therapy, and another getting physical therapy…

This study tests a nasal device (iNAP) that uses gentle suction to keep the airway open during sleep. It includes 65 adults aged 50-75 with mild cognitive impairment and moderate-to-severe sleep apnea. Half will use the device nightly for 24 weeks, while the other half receive sl…

This study looks at whether 8 weeks of inspiratory muscle training can improve thinking, brain oxygen levels, and brain healing in 42 adults with moderate obstructive sleep apnea. Participants will do breathing exercises daily and be compared to those receiving a low-intensity ve…

This study looks at whether adding stress management and sleep education to standard physiotherapy can help people with temporomandibular disorders (TMD). TMD causes jaw pain, teeth grinding, and sleep problems. Forty adults with TMD will receive either physiotherapy alone or phy…

This early study tests a neck device that uses gentle suction to keep the airway open during sleep, which might help people with obstructive sleep apnea. Ten healthy volunteers will wear the device during one night of sleep and compare their breathing to a night without it. The g…

This study tests whether increasing ward rounds from twice to four times a day, with structured conversations and simple breathing exercises, can lower anxiety in hospitalized patients waiting for therapeutic gastrointestinal endoscopy. About 1,000 adults with mild anxiety will t…

This study tests whether a mobile app called SleepQ can reduce insomnia symptoms in adults. The app provides a 12-week digital cognitive behavioral therapy program, including sleep scheduling and relaxation techniques. Eighty participants will be randomly assigned to use the app …

This study tests whether a nerve block (injecting numbing medicine near the cheekbone) can control pain after tonsillectomy in children aged 3-9, reducing the need for opioids. Sixty kids having tonsil surgery for sleep apnea will be randomly assigned to get either the nerve bloc…

This study looks at two ways to improve sleep after breast cancer surgery: a nerve block injection or a mild ear stimulation device. About 136 women will be randomly assigned to one of the two treatments. Their sleep will be tracked with a wrist monitor and questionnaires for the…

This study looks at whether eating special healthy cookies high in linoleic acid (a type of fat) for 8 weeks can improve sleep quality in overweight adults who have trouble sleeping. Researchers will measure sleep changes, blood fat levels, and how well people stick to eating the…

This study tests whether myofunctional therapy—simple exercises for the tongue, face, and breathing muscles—can improve sleep in children aged 6-12 with obstructive sleep apnea. Half of the 174 participants will do these exercises for 24 weeks with remote coaching, while the othe…

This study looks at whether doing moderate resistance exercises in the morning can improve sleep quality in young adults aged 18-35. Over 8 weeks, 64 participants with different sleep patterns (morning or evening types) will follow an online exercise program. Researchers will mea…

This study looks at whether placing children in a specific position when their breathing tube is removed after sleep apnea surgery can reduce the risk of dangerously low oxygen levels. About 262 children aged 2-10 will take part. The goal is to find a simple, no-cost way to make …

This study tests whether drinking a ketone supplement (Ketone-IQ) before sleep can improve sleep quality and reduce breathing pauses in people with moderate-to-severe obstructive sleep apnea. Thirty adults who already use CPAP will try the ketone drink for two nights and a placeb…

This study explores how the eyes' response to light relates to sleep patterns, circadian rhythms, and overall health. Researchers will measure pupil size under different lighting conditions and track sleep and melatonin levels in healthy volunteers and people with various medical…

This study will give the nasal flu vaccine to 25 people who are already scheduled to have their tonsils or adenoids removed for sleep apnea. Researchers will then study the removed tissue to see how the vaccine affects immune cells near the nose. The goal is to better understand …

This study looks at what happens when people who live above 2600 meters, in places like Quito, spend a week at sea level and then return to altitude. Researchers will measure sleep quality, oxygen levels during the night, and breathing patterns in healthy adults and in people wit…

Researchers are studying what happens when people with pulmonary arterial hypertension who live above 2600 meters spend a week at sea level. The trial compares their sleep, blood oxygen, and breathing during sleep at altitude and after seven days at sea level. It includes both pa…

Researchers at Massachusetts General Hospital are testing whether a single under-the-tongue dose of dexmedetomidine, a sedative, can safely alter sleep patterns, internal 24-hour rhythms, and daily cycles of a brain-aging protein in adults aged 65 and older. In this double-blind,…

This study tests whether a new questionnaire called PLATO can help dentists track how well oral appliance therapy works for people with obstructive sleep apnea. The questionnaire, developed by the American Academy of Sleep Medicine, measures patient-reported outcomes. Researchers…

This study evaluates whether several sleepiness questionnaires are reliable for children and adolescents aged 6 to 17. It includes three groups: children from the general population, those with sleep disorders or conditions like narcolepsy or ADHD, and healthy volunteers. The goa…

This observational study investigates whether cardiac autonomic neuropathy (nerve damage affecting the heart) changes the risk of death and cardiovascular events in people who have diabetes, coronary heart disease, and sleep apnea. Researchers will follow 326 participants, dividi…

This study investigates whether obstructive sleep apnea is linked to metabolic associated fatty liver disease (MAFLD) in adults. Researchers will measure sleep apnea severity using overnight sleep tests and liver fat using a special ultrasound-like scan. The goal is to see if wor…

This study looks at how the size of the upper airway might influence teeth grinding (bruxism) during sleep in people with obstructive sleep apnea. Researchers will use safe, low-radiation 3D scans and sleep tests to measure airway volume and bruxism in 80 adults. The goal is to b…

This study tests whether an artificial intelligence model can estimate a person's risk of developing Parkinson's disease. Participants aged 50 and older who have certain early warning signs—like REM sleep behavior disorder, drops in blood pressure upon standing, or reduced sense …

This study looks at whether having surgery in the morning versus the afternoon changes how well the sedative ciprofol works and how smoothly patients recover. Researchers will compare adults having non-emergency surgery starting between 8-11 AM or 2-5 PM. The goal is to see if th…

This study looks at how obstructive sleep apnea (OSA) affects thinking skills like attention and memory, and how those changes relate to quality of life. Adults newly diagnosed with OSA will take an overnight sleep test, followed by computer tasks and questionnaires. Their result…

This study looks at whether exercise can help protect the body from health problems caused by shift work, which disrupts natural sleep-wake cycles. Sixteen healthy but inactive adults will spend 5 days in a lab, simulating day shifts then night shifts, with some doing exercise. R…

This study looks at how mental health, especially stress, affects gum disease in people who grind their teeth. About 110 adults aged 30-50 with both teeth grinding and gum disease will answer mental health questions and get a dental check-up. The goal is to see if poor mental hea…

This study looks at how stress levels, sleep quality, and teeth grinding (bruxism) together affect gum disease in adults aged 30-45. Researchers will compare two groups of people with gum disease: those who grind their teeth and those who do not. The goal is to understand how the…

This study looks at whether psychological resilience — the ability to bounce back from stress — can reduce the harmful effects of stress on gums in people who grind their teeth (bruxers). Researchers will measure stress and resilience using questionnaires and check gum health in …

This study looks at how whole-body heat therapy (hyperthermia) changes body temperature, pain sensitivity, and pain during movement in 60 people—half with chronic widespread pain (like fibromyalgia) and half healthy. Participants will receive six heat sessions over three weeks. T…

This study will use a painless ultrasound to examine tongue stiffness, thickness, and other features in 80 adolescents aged 12-18 with obesity and sleep-disordered breathing. Participants are already enrolled in a weight-loss program. The goal is to better understand how the tong…

This study aims to find out how much dental interns in Egypt know about pediatric obstructive sleep apnea, a common but often missed sleep disorder in children. Researchers will survey 350 interns using a questionnaire to assess their knowledge, attitudes, and practices. The goal…

This study follows 60 adults who had jaw surgery (maxillomandibular advancement) for obstructive sleep apnea. Some develop central or mixed sleep apneas after surgery, and researchers want to see if these breathing issues get better, stay the same, or get worse over a year. Parti…

This study will test a new wearable device that monitors your body's internal clock (circadian rhythm) by tracking signals like heart rate and movement. Researchers will compare the device's readings to standard saliva tests in 30 adults who are either healthy, have sleep apnea, …

This study looks at how a disrupted body clock (like in night-shift workers) affects gum inflammation. Researchers will measure clock proteins and immune markers in the gum fluid of 116 people with and without gum disease. The goal is to understand the link between sleep-wake cyc…

This study will monitor 75 adults—natural short sleepers, normal sleepers, and people with idiopathic hypersomnia—over 32 continuous hours in a sleep lab. Using EEG and actigraphy, researchers will track brain wave patterns and blood sugar changes to understand how the body regul…

This study looks at how losing sleep and having a disrupted body clock (like shift workers) can make the body less responsive to insulin, a key step toward obesity and type 2 diabetes. Researchers will test 48 healthy adults aged 18-45 to see how the timing of the stress hormone …

This study looks at how abnormal proteins, like alpha-synuclein and tau, build up and affect brain function in people with Parkinson's disease. Researchers will use brain scans, blood tests, and skin biopsies to track these changes. The goal is to find better ways to diagnose and…

This study looks at whether children aged 6 to 12 with a specific teeth alignment issue (posterior crossbite) are more likely to have obstructive sleep apnea. Researchers will use a questionnaire to measure sleep apnea risk in 420 children. The goal is to understand if there is a…

This study looks at whether a quick, non-invasive breathing test called impulse oscillometry (IOS) can help doctors find the right pressure settings for sleep apnea machines. Currently, patients often need an overnight sleep study to determine the correct pressure. The study will…

This pilot study looks at how sleep, physical activity, and meal timing in early pregnancy relate to blood sugar patterns and the risk of gestational diabetes. Researchers will track 140 pregnant women using wearable devices and an AI food-logging app. The goal is to see if real-…

This study looks at why many people with obstructive sleep apnea still feel very sleepy during the day even after successful treatment with CPAP or other devices. Researchers will test 100 adults to see if the amount of oxygen drops during sleep before treatment predicts this lef…

This study looks at whether giving preterm babies their mother's breast milk at the same time of day it was expressed (like night milk at night) helps them sleep better and develop a healthy day-night rhythm. About 200 preterm infants will be split into two groups: one gets milk …

This study follows 60 adults with pulmonary hypertension (high blood pressure in the lungs) for 2 years. Researchers will measure breathing problems during sleep and heart rate changes to see how they relate to the disease. No new treatment is given; participants continue their u…

This study will test three ways of giving oxygen to 280 adults during colonoscopy sedation: standard continuous flow, breath-synchronized pulses via the Sovant device, and CPAP. Researchers will track how often patients have breathing pauses or low oxygen levels. The goal is to f…

This study looks at whether taking melatonin earlier in the evening (3 hours before bed) or at a higher dose (4 mg) helps healthy adults fall asleep faster and sleep better. Fourteen participants will try different combinations of melatonin and placebo while their sleep is measur…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This study looks at how often people develop speech or swallowing problems after a jaw-advancement surgery for obstructive sleep apnea. Researchers will measure nasality, speech, and swallowing in 28 adults before and after surgery at five different times. The goal is to better u…

This study looks at whether a simple arm exercise test, called the 6-Minute Pegboard and Ring Test, can reliably measure upper body function in adults with obstructive sleep apnea. Researchers will compare test results with sleep study data and questionnaires. The goal is to impr…

This study looks at how physical activity levels are linked to posture, sleep quality, depression, and muscle or joint pain in health science professors and researchers at Istanbul Aydin University. About 73 academics aged 23 to 65 will fill out questionnaires. The goal is to und…

This study looks at whether being male or female changes how the body handles hunger and blood sugar when sleep and eating are out of sync, like during night shifts. Researchers will compare 36 healthy adults in a controlled lab setting. Results could lead to personalized shift s…

This study explores whether stress in children and their parents is related to bruxism (teeth grinding) in kids aged 8-11. Researchers will compare 100 children with and without bruxism, using questionnaires to measure stress levels. The goal is to better understand the role of s…

This study looks at how the amount of deep sleep just before waking affects how alert people feel after a 2-hour nap taken at night. Researchers will monitor brain activity during sleep and test reaction times after waking. The goal is to understand sleep inertia and improve nap …

This study will collect health data from 5,000 adults with sleep-related breathing disorders like obstructive sleep apnea. Researchers will track symptoms and test results over time to better understand these conditions and improve patient monitoring. No new treatments are being …

This study will follow 1200 people who have had a heart attack or unstable angina and also have sleep apnea. Researchers will collect blood, urine, and stool samples to understand how sleep apnea affects metabolism and heart risk. The goal is to build an AI-based tool to better p…

This study looks at how the time of day and the menstrual cycle (specifically low vs. high progesterone phases) affect strength and thinking in female athletes. Thirty women aged 18-30 who train regularly will be tested at 7am, 12pm, and 6pm during two different phases of their c…

This study aims to understand how working night shifts in busy hospital settings like intensive care and emergency rooms affects what and when healthcare workers eat. Researchers will ask 245 adults who work night shifts in healthcare or other jobs to fill out an online questionn…

This study follows 160 adults in Hong Kong over time to see if disruptions in daily activity and sleep (rest-activity rhythms) can predict who develops major depressive disorder. Participants will wear activity monitors and complete questionnaires about mood and sleep. The goal i…

This study will give a single dose of morphine or a placebo to 26 adults (some healthy, some with obstructive sleep apnea) during a sleep study night. Researchers will measure how much their breathing changes. The goal is to understand why opioids can dangerously slow breathing d…

This study will follow 11,100 adults with sleep-disordered breathing for up to 5 years. Researchers will collect health data and samples to find better ways to predict risks and tailor treatments. No new drug or device is being tested; participants receive standard care like CPAP…

This study looks at how a device that stimulates a nerve in the tongue changes the way the upper airway collapses in people with obstructive sleep apnea. Researchers will measure airway collapsibility during a sleep endoscopy in 21 adults already using the therapy. The goal is to…

This study looks at why people with heart failure or those taking opioid painkillers develop central sleep apnea (pauses in breathing during sleep). Current treatments don't work well, so researchers will test combinations of breathing machines and medications in 200 Veterans. Th…

This study looks at how low oxygen levels during sleep (from obstructive sleep apnea) are connected to problems in the tiny blood vessels of the heart. Researchers will follow 560 adults with suspected heart issues to see if sleep apnea patterns can predict future heart events li…

This study will track 100 adults receiving a single dental implant to see if the implant moves between placement and the final crown, about 3-4 months later. Researchers will use 3D scans taken right after surgery and before loading the crown to measure any shifts in position or …

This study looks at whether exercising at different times of day changes how we feel pain. Fifty-six healthy adults will do a 12-minute high-intensity workout in both the morning and evening. Researchers will measure pain thresholds before and after exercise to see if time of day…

This study will test two different ways of using a breathing machine (CPAP) in 60 severely obese adults after they wake up from anesthesia. The goal is to see which setting better supports heart and lung function. Participants will be monitored with special sensors to measure lun…

This study looks at 50 children aged 3-7 with type 1 obstructive sleep apnea who are scheduled for adenotonsillectomy. Researchers want to see if changes in how much children open their mouths during sleep are linked to improvements in their quality of life. Parents will answer q…

This study looks at whether the natural drop in blood pressure during sleep (called 'dipping') is linked to changes in the heart's electrical activity in people with high blood pressure. Researchers will monitor 140 adults using a 24-hour blood pressure device and compare those w…

This study will observe 55 adults with obstructive sleep apnea to see if the severity of their breathing pauses during sleep is linked to higher blood pressure in the lungs. Researchers will use echocardiography to measure lung artery pressure. The goal is to better understand th…

This study will check for stress, anxiety, depression, sleep problems, and bad breath in 110 adults with obesity who are getting ready for weight-loss surgery. Participants will fill out questionnaires and use a portable breath tester. The goal is to learn more about these issues…

This study will use an overnight sleep test (polysomnography) to measure breathing problems during sleep in 30 adults with systemic sclerosis (scleroderma). The goal is to find out how common sleep-disordered breathing is in this group. No treatment is given—this is purely an obs…

This study looks at whether treating obstructive sleep apnea with CPAP can change how certain immune cells (neutrophils) behave. Researchers will collect blood from 120 people — 80 with moderate-to-severe sleep apnea and 40 healthy controls — to measure immune cell activity and r…

This study will check how common it is for obese people with sleep apnea to still have low breathing at night even when using a CPAP machine. About 139 adults will wear a special skin sensor that measures oxygen and carbon dioxide levels overnight. The goal is to find out how man…

Obesity-related sleep hypoventilation represents a continuum ranging from isolated nocturnal hypoventilation to obesity hypoventilation syndrome. Current diagnostic criteria rely mainly on dichotomous thresholds and may not adequately reflect cumulative nocturnal carbon dioxide e…

Sleep apnea-hypopnea syndrome (SAHS) is a frequent and largely under-diagnosed sleep-related breathing disorder. Adult prevalence is estimated between 9% and 38%. Untreated SAHS increases cardiometabolic and neurocognitive risk. Reference diagnostic methods (in-lab polysomnograph…