Sleep-wake disorder

This study tests whether a device can detect when a patient's breathing slows after surgery and then play a recorded voice telling them to breathe. The device uses standard monitors already used in hospitals. The study includes patients who have or may have sleep apnea and are st…

This study tests whether involving patients in managing CPAP machine alerts—using a connected watch and app—can improve how often they use the device. It includes 556 adults with sleep apnea who are at risk for heart problems and likely to struggle with CPAP adherence. The goal i…

This study tests whether an oral drug called PXS-4728A can reduce brain inflammation in 40 adults aged 50-80 with isolated REM sleep behavior disorder (iRBD), a condition often leading to Parkinson's disease. Participants receive either the drug or a placebo for 12 weeks, and bra…

This study tests a device that stimulates a nerve in the neck to keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot use a CPAP machine. The goal is to see if the device is safe and improves breathing and sleep quality.

This study tests a device that delivers mild electrical stimulation to muscles in the throat to strengthen them and keep the airway open during sleep. It includes 5 healthy volunteers and 12 people with mild to severe obstructive sleep apnea. The goal is to see if using the devic…

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This study follows 110 adults with moderate to severe obstructive sleep apnea who have the Genio® device implanted. The device stimulates a nerve to keep the airway open during sleep. Researchers will track safety and effectiveness over 5 years, including changes in breathing pau…

This study looks at whether terazosin, a drug usually used for high blood pressure, can slow the progression of Parkinson's disease. Researchers are tracking changes in heart and brain scans of 15 people who are either in early stages or at high risk for Parkinson's. The goal is …

This phase 2 trial tests whether carvedilol, a drug usually used for heart conditions, can slow the loss of dopamine transporters in the brain and delay Parkinson's symptoms. It follows 15 people with REM sleep behavior disorder and other early Parkinson's risk factors over three…

This study tests whether using a CPAP machine to treat sleep apnea shortly after an ischemic stroke can reduce the risk of another stroke, heart attack, or death within 6 months. It also looks at whether CPAP improves overall recovery and brain function. Over 3,000 participants a…

This study looks at whether using a CPAP machine to treat obstructive sleep apnea can help improve insulin resistance and hormone levels in women with Polycystic Ovary Syndrome (PCOS). Researchers will measure changes in fat production, testosterone, and insulin in 20 women aged …

This study looks at whether using a CPAP machine at night can reduce the chance of atrial fibrillation (an irregular heartbeat) returning in people who have both sleep apnea and a history of AF. Researchers will follow 91 adults for 12 months, tracking how often they use CPAP and…

This study tests whether the sleep medication trazodone can slow memory loss in people with mild cognitive impairment and obstructive sleep apnea. Researchers will measure changes in blood markers and thinking skills over one year. 134 participants are enrolled in this double-bli…

This study tests whether a personalized lifestyle plan focused on improving diet, exercise, and sleep according to the body's natural rhythms can lower blood sugar levels in older adults. Sixteen participants aged 50-80 with elevated blood sugar and a long daily eating window wil…

This study follows children with hypotonia (low muscle tone) who have obstructive sleep apnea. They use a flexible silicone nasal tube called ssNPA at night to keep the airway open. Researchers will check how well it works and if children can tolerate it over a year.

This study tests whether the drug idebenone can slow or prevent the progression of a sleep disorder called iRBD into Parkinson's disease or similar brain conditions. About 142 adults aged 40-75 with iRBD will receive either idebenone or a placebo for 5 years. Researchers will tra…

This study tests whether a time-efficient breathing exercise program can help lower blood pressure in adults aged 50 and older who have moderate to severe sleep apnea but cannot or will not use a CPAP machine. Researchers will measure blood pressure changes over 36 weeks in 122 p…

This phase 3 trial tests whether a once-daily pill called orforglipron can improve sleep apnea in 600 adults with moderate-to-severe sleep apnea who are also obese or overweight. Participants are split into two groups: those who cannot or will not use a CPAP machine, and those wh…

This study tests a device that stimulates a nerve in the neck to treat sleep apnea in 57 teens and young adults (ages 10-21) with Down syndrome. The goal is to see if better sleep leads to improvements in thinking, attention, and language skills over 12 months. Participants must …

This study tests a device called the Genio® System, which is implanted under the chin and stimulates a nerve to keep the airway open during sleep. It is for people with obstructive sleep apnea who have not been helped by CPAP machines and have a specific type of airway collapse. …

This study tests whether a millimeter-wave radar system can accurately diagnose type 1 narcolepsy by monitoring sleep without physical contact. Forty patients will use the radar alongside standard sleep tests (PSG/MSLT) to see if the radar matches the standard results. If it work…

This study checks how well a new home sleep test system called SleepView+ can diagnose moderate to severe obstructive sleep apnea in people ages 12 and older. About 200 participants will first use the device during an overnight lab sleep study to compare results, then try it at h…

This study is testing whether a wearable ring and a small body sensor can accurately diagnose sleep-disordered breathing, including sleep apnea. About 79 adults with suspected sleep apnea will wear the devices during an overnight sleep lab test. The goal is to see if the ring's r…

This study explores whether parents can use their smartphones to record short videos of their child sleeping to screen for obstructive sleep apnea (OSA). Children with Down syndrome are at higher risk for OSA, but standard sleep studies can be hard to access. Parents will rate th…

This study planned to test a new wearable wireless device that wraps around a child's abdomen to monitor central sleep apnea. It would have involved 15 children aged 1 month to 5 years already undergoing standard sleep studies. The device's accuracy and comfort would have been co…

This study uses a special brain scan called DaTscan to look at how certain brain diseases affect the brain. Researchers will scan 500 adults with conditions like Parkinson's disease, dementia, mild cognitive impairment, or REM sleep behavior disorder. The goal is to see if DaTsca…

This study tests whether Withings bathroom scales can accurately measure pulse wave velocity (PWV), a key indicator of vascular stiffness. Researchers will compare readings from the scales with a standard medical device in 176 adults, including those with high blood pressure, sle…

This study checks if a special mouthpiece that measures oxygen levels during sleep is as accurate as the standard sleep lab test. Thirty adults with obstructive sleep apnea will wear the device overnight in a sleep lab. If it works well, it might offer a simpler way to track oxyg…

This study checks if a Withings smartwatch can accurately detect sleep apnea compared to a full hospital sleep test. About 220 adults who are already scheduled for a sleep test will wear the watch overnight. The goal is to see if the watch can help screen more people for sleep ap…

This study tests whether a non-contact device placed under the mattress can accurately detect sleep apnea. Researchers will compare the device's readings to standard sleep tests in 200 adults suspected of having sleep apnea. If proven reliable, this could offer a simple, low-cost…

This study tests a new 'intelligent duvet' called Easy Sleep Monitoring (ESM) that uses built-in sensors to detect movement and estimate sleep. Researchers will compare its accuracy to standard sleep lab tests (video-polysomnography) in 50 people, including those with sleep disor…

This study looks at whether adding CPAP (a machine that helps you breathe at night) to a healthy lifestyle program can lower the risk of diabetes in people with prediabetes and sleep apnea. About 174 overweight or obese adults with both conditions will be followed for 6 months. T…

This study tests whether inhaling or massaging with lavender, marjoram, and vetiver oils can help people with bruxism (teeth grinding). Sixty-four adults aged 18-25 will use the oils twice daily for a period. Researchers will measure changes in jaw muscle elasticity and thickness…

This study tests whether drinking a ketone supplement (Ketone-IQ) before bed can improve sleep quality and reduce sleep apnea severity in 30 adults who already use a CPAP machine. Participants will try two different doses and compare effects to a placebo. The goal is to find a si…

This study is testing whether a 6-month program of online exercise classes, guided meditation, and nutrition advice can improve thinking, sleep, and overall health in people with Parkinson's disease. 60 participants aged 40 to 85 will take part, with some starting the program rig…

This study aimed to see if taking branched-chain amino acids (BCAAs) could improve oxygen levels during sleep in people with sleep apnea. The researchers planned to include adults with confirmed sleep apnea but exclude those with severe cases. However, the study was withdrawn bef…

This study compares listening to Holy Qur'an recitation versus calming music before bed in children aged 6 to 10 who are undergoing chemotherapy. Sleep problems are common in these children, and the goal is to find a safe, non-medication way to improve sleep quality. Ninety child…

This phase 2 trial tests whether combining cognitive behavioral therapy, a stimulant (methylphenidate), melatonin, and light therapy can improve sleep in cancer patients. About 68 patients currently on cancer treatment who have sleep problems will participate. The study measures …

This Phase 2A study tests three drugs—sivopixant, acetazolamide, and SASS-001—in 60 adults with sleep apnea that has a central component (where the brain fails to signal breathing). The goal is to see if these drugs can reduce the number of breathing pauses during sleep. Particip…

This study tests two different mouthpieces (mandibular advancement devices) for people with obstructive sleep apnea who cannot use a CPAP machine. Twenty-eight participants will wear one of the two devices for a year, and researchers will track comfort, side effects like jaw pain…

This study tests whether a numbing injection near the glossopharyngeal nerve, combined with topical anesthesia, can help people recover faster after surgery for obstructive sleep apnea. The trial involves 80 adults with moderate to severe sleep apnea who are scheduled for palatop…

This study tests whether a special type of talk therapy for insomnia (CBT-I) that is customized for shift workers can improve sleep, mental health, and quality of life. About 84 healthcare workers who work rotating shifts including nights will either receive this tailored therapy…

This study tests a combination of two medicines (atomoxetine and oxybutynin) given at bedtime for 6 months to children aged 6-17 with Down syndrome and obstructive sleep apnea. The goal is to see if the treatment improves sleep quality and thinking skills. About 36 children will …

This study aimed to see if an educational game called Yapouni could help children aged 3 to 16 use their CPAP or NIV breathing machines more consistently. The game was designed to motivate children by linking machine use to a hot air balloon's flight. However, the study was withd…

This study tests whether a breathing training program can improve sleep in people whose insomnia is linked to anxiety or depression. Researchers will monitor sleep quality and heart activity in 188 adults. The goal is to find a simple, drug-free way to ease sleep problems and und…

This study tests whether high-flow oxygen therapy can prevent low oxygen levels (hypoxemia) in patients at higher risk during sedated digestive endoscopy. The trial includes 326 adults with obesity, sleep apnea, or stable lung or heart conditions. Researchers will compare high-fl…

This study aimed to see if using a special nasal mask that provides positive airway pressure (PAP) during colonoscopy sedation could reduce the frequency, length, and severity of low oxygen levels compared to standard oxygen through a nasal cannula. The study planned to enroll hi…

This study tests whether combining two sedatives, remimazolam and propofol, works better than propofol alone or with midazolam during a procedure called drug-induced sleep endoscopy (DISE) for people with obstructive sleep apnea. The goal is to see if the combo leads to more succ…

This study tests whether doing simple mouth, tongue, and throat exercises using a mobile app can improve snoring and sleep apnea better than following a paper guide. The 34 participants are adults with mild to severe obstructive sleep apnea who could not or would not use a CPAP m…

This study looked at whether sunlight exposure therapy could improve sleep problems in people with Alzheimer's disease. Sixty participants with mild Alzheimer's and sleep issues received a health education plan on sun exposure and were followed for 14 days. The goal was to see if…

This study tests whether showing people with sleep apnea how their CPAP machine use compares to other patients helps them use it more consistently. About 186 adults who have been on CPAP for at least three months will be split into two groups: one gets routine feedback on their o…

This study tests a non-invasive device that stimulates a nerve in the ear to see if it can improve movement, mood, sleep, and motivation in people with Parkinson's disease. Thirty participants will try three different stimulation patterns over several weeks. The goal is to find t…

This study tests whether a simplified behavioral relaxation program can improve sleep in pregnant women with insomnia. Twenty women in their second or third trimester will receive coaching calls and sleep hygiene tips. The goal is to see if this approach helps them fall asleep fa…

This study is testing whether special drug-free patches can help relieve acute back, shoulder, or other muscle pain and improve sleep. The patches use a gentle vibration technology instead of medication. 150 adults aged 18-64 will wear either an active patch or a sham (fake) patc…

This study compares two common surgical tools (monopolar and bipolar electrocautery) used during tonsil removal to see which one causes less pain and bleeding after surgery. It involves 74 people aged 5 to 40 who need their tonsils out due to chronic tonsillitis or other issues. …

This study looks at whether Tai Chi, a gentle moving meditation, can improve chronic insomnia in breast cancer survivors. About 90 women who have completed cancer treatment and have had trouble sleeping for at least 6 months will practice Tai Chi. Researchers will measure sleep q…

This study tests whether a gentle hand massage along the vagus nerve can quickly improve blood pressure, heart rate, and oxygen levels in people with moderate to severe sleep apnea. One hundred adults will either receive the 16-minute massage or rest quietly. Researchers will mea…

This study tests whether a program called the Model of Occupational Harmony (MOHar) can help people with sleep disorders sleep better and feel better. Forty adults with poor sleep will either get this program—which helps them redesign their daily routines with an occupational the…

This study looks at whether adding cognitive behavioral therapy for insomnia (CBT-I) to standard knee osteoarthritis care (education and exercise) helps reduce pain and improve function. About 128 adults aged 45+ with both knee osteoarthritis and insomnia will be followed for 6 m…

This study will survey directors of dental programs at Italian universities to find out if sleep medicine is part of the curriculum. The goal is to understand how much future dentists learn about sleep-disordered breathing like sleep apnea. About 70 program directors will answer …

This study examines how common obstructive sleep apnea (OSA) is in adult survivors of Hodgkin lymphoma who received chest radiation. Researchers will compare 220 survivors to matched controls using sleep tests, brain scans, and heart assessments. The goal is to understand links b…

This study looks at how continuous positive airway pressure (CPAP) therapy affects body signals like oxygen levels, heart rate, and breathing in adults with obstructive sleep apnea. Researchers will analyze data from 160 people who completed a previous trial, comparing signals be…

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This study looks at how common sleep breathing problems are in children with cerebral palsy across the UK, and how often they use breathing support like CPAP machines. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to im…

This Mayo Clinic study will follow 100 adults with narcolepsy or idiopathic hypersomnia who are starting a new treatment. Researchers will measure changes in blood pressure over 24 hours and track eye movements during a simple mental test before and after at least 3 months on med…

This study is testing whether a simple breath test, called fractional exhaled nitric oxide (FeNO), can help measure the severity of obstructive sleep apnea (OSA). Researchers will compare FeNO levels in 200 adults with different levels of sleep apnea to see if the test can predic…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study tests whether showing parents an infographic about obstructive sleep apnea (OSA) symptoms helps more children get diagnosed. About 200 parents of children with OSA symptoms will either see the infographic or receive usual care. Researchers will compare how many childre…

This study looks at how the body's internal clock (circadian rhythm) affects heart disease risk, especially in people with obesity. Researchers measured blood pressure and other heart markers in 17 lean and overweight adults over 5 days. The goal is to understand if obesity creat…

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

This study enrolls 500 adults with a sleep condition called REM sleep behavior disorder (RBD), which often leads to Parkinson's disease or related brain disorders. Researchers will track symptoms like thinking, movement, and smell to develop a rating scale. The goal is to prepare…

This study was designed to see if a new type of airway device can prevent dangerous drops in oxygen levels during anesthesia in patients who are at high risk, such as those with obesity or sleep apnea. Researchers planned to compare the new device with standard ones in adults und…

This study looks at why sleep apnea raises the risk of diabetes. Overweight adults with and without sleep apnea will have their blood sugar control measured. Some will receive CPAP, some will get extra oxygen at night, and others will get a sham treatment. The goal is to find out…

This study is testing a new type of clinic that screens people with prediabetes and type 2 diabetes for several hidden health problems at the same time, including fatty liver disease, sleep apnea, and heart failure. The goal is to see how common these undiagnosed conditions are a…

This study looks at whether bruxism (teeth grinding) is linked to changes in muscle function and a higher risk of injuries, especially in the shoulder, among amateur athletes. Researchers will measure muscle tone, stiffness, and strength in 120 swimmers and handball players. The …

This study looks at how sleep apnea might cause prediabetes to turn into diabetes. Researchers will use CPAP machines and niacin infusions in 300 overweight, prediabetic adults with sleep apnea to measure changes in blood chemicals. The goal is to understand the biological steps …

This small study tests whether the supplement N-acetylcysteine (NAC) can reduce oxidative stress and inflammation in people with obstructive sleep apnea who are already using standard PAP therapy. Researchers want to see if the effects differ between men and women. The study invo…

This pilot study aimed to see if personalized lifestyle coaching and a simple handout could help emergency medicine residents stay alert and perform better during night shifts. The study planned to compare coached residents to those receiving only a handout, measuring reaction ti…

This study compares two ways to predict heart and metabolic problems in people with mild-to-moderate obstructive sleep apnea: one based on inflammation in the body, and the other based on how severe the sleep apnea is. Researchers will measure things like waist size, blood pressu…

This study looks at whether measuring body water with a harmless device can help detect obstructive sleep apnea (OSA) in pregnant women with severe obesity. OSA is common but often missed in this group, and can be dangerous for both mother and baby. Researchers will enroll 52 wom…

This study looks at how age-related sleep changes and sleep apnea might increase the risk of Alzheimer's disease. Researchers will use brain scans and overnight sleep tests in 158 healthy adults aged 55-75 to measure amyloid buildup and sleep patterns over two years. The goal is …

This study looks at how mood disorders and insomnia interact by monitoring heart and brain activity. Researchers will measure signals like heart rate variability and brain waves in 200 people, including healthy volunteers and those with mood or sleep issues. The goal is to unders…

This study looks at whether treating obstructive sleep apnea (OSA) with a breathing device (CPAP) lowers blood pressure more in people who are very sleepy compared to those who are not. Researchers will analyze data from about 10,000 adults with OSA from previous studies. The goa…

This study aims to understand the genetic factors behind obstructive sleep apnea (OSA) and its related health issues. Researchers will enroll 5,000 adults who have been diagnosed with or are suspected of having sleep apnea. Participants will provide genetic samples and answer sle…

This study uses a 30-40 minute online survey to understand how being on call affects sleep in 1,000 medical trainees (students, residents, fellows). It looks at sleep quality, quantity, and disruption to body rhythms. The goal is to gather knowledge to improve sleep health for he…

This study is investigating whether bruxism (teeth grinding or clenching) is associated with pelvic pain, erectile dysfunction, and anxiety in young men aged 18-30. Researchers will use questionnaires and physical exams to assess 100 participants. The goal is to better understand…

This study explores whether bruxism (teeth grinding or clenching) is related to pelvic floor dysfunction in young women aged 18-30. Researchers will use questionnaires and physical exams to assess jaw function, pelvic floor symptoms, and anxiety in 100 participants. The goal is t…

This study examines the links between sleep bruxism (teeth grinding during sleep) and sleep quality, heart health, thyroid function, and mood. Researchers will give some participants opipramol, a drug that may reduce grinding activity, and monitor them with sleep tests. The goal …

This study looks at whether carvedilol, a drug used for heart failure, can reverse early heart changes seen in people with a sleep disorder that puts them at high risk for Parkinson's disease. Fifteen participants with REM sleep behavior disorder or reduced sense of smell will ta…

This study looks at whether terazosin, a drug used for high blood pressure, can change heart nerve activity in people at high risk for Parkinson's disease. Researchers are studying 15 adults with REM sleep behavior disorder (a strong early sign of Parkinson's) to see if the drug …

This study looks at how working night shifts changes eating behaviors and appetite compared to day shifts. Researchers will measure food intake, hunger hormones, and fullness in 100 healthy adults who work either day or night shifts. The goal is to understand why night workers ar…

This study looks at whether sleep-disordered breathing, like obstructive sleep apnea, is linked to worsening spine curves in children with idiopathic scoliosis. Researchers will follow 405 children aged 6 to 15 with mild to moderate scoliosis. They will measure spine curves and s…

This study uses a small skin sample to measure levels of a protein linked to Parkinson's disease and REM sleep behavior disorder. Researchers will follow 100 participants for 18 months to see if changes in the protein match disease progression. The goal is to develop a simple bio…

This study looks at whether remote video visits (tele-visits) work as well as in-person home visits for people using a CPAP machine to treat sleep apnea. About 320 adults who have been using CPAP for at least a year will take part. The main goal is to see if tele-visits help peop…

This study looks at whether doing brain-training exercises in the morning or the afternoon helps older adults (60+) recover thinking skills after a stay in the intensive care unit. Forty participants will either train in the morning, in the late afternoon/evening, or receive usua…

This study looks at whether dopamine levels and certain genes affect the risk and severity of sleep breathing disorders like sleep apnea. Researchers will monitor 100 adults overnight and take blood samples to measure dopamine and check for genetic variations. The goal is to bett…

This study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will use sleep tests, blood samples, and questionnaires to find links between bruxism and other conditions. The goal i…

This study looks at how sleep and your internal body clock influence blood pressure at night. Researchers will monitor over 1,400 participants using a constant routine protocol—staying awake in a dim room for over 24 hours—to measure melatonin, body temperature, and blood pressur…

This study looks at whether leaving a breathing tube in for 24-48 hours after gastric cancer surgery can lower complications in patients who also have severe obstructive sleep apnea. Researchers will compare two groups of 240 patients: one with standard tube removal and one with …

This study looks at whether eating a high-carb or high-protein dinner 3-4 hours before bed can help medical residents sleep better. 90 participants will be assigned to one of three meal types for two weeks. Sleep quality will be measured using questionnaires and smartwatches, and…

This study looks at how stimulating two specific tongue muscles (palatoglossus and genioglossus) affects airway size during a sleep endoscopy procedure. Researchers will measure changes in the airway with and without stimulation in 60 adults with obstructive sleep apnea who canno…

This study was designed to see if stimulating both sides of a tongue nerve during sleep could improve airway collapse in people with obstructive sleep apnea who already have an Inspire device. It was withdrawn before enrolling anyone, so no results are available.

This study aimed to see if giving extra oxygen at night could improve blood sugar control in people living at high altitudes who have sleep-disordered breathing. It was designed for permanent residents of Puno, Peru, but was withdrawn before any participants were enrolled. No res…

This study follows 10,000 people with both obstructive sleep apnea and high blood pressure over many years. Researchers will track how well patients use CPAP machines and blood pressure medications, and whether this reduces the chance of heart attacks, strokes, heart failure, or …

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…

This study looks at children aged 10-15 who need braces for prominent upper front teeth. Some will have upper premolars removed as part of treatment, others will not. Researchers will use sleep studies before and after treatment to see if the extractions increase the risk of obst…

This early study at Mayo Clinic tests whether using a device that massages the legs at night can help the brain clear waste products better in people with obstructive sleep apnea. The study involves 12 adults aged 50 and older who already use CPAP therapy. Researchers will measur…

This study looks at whether measuring how hard you bite can help predict and prevent problems with dental implants. Researchers will follow 85 adults with dental implants for up to 10 years, measuring their bite force each year and checking for complications. The goal is to creat…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study looks at whether long-term use of a breathing device called adaptive servo-ventilation (ASV) can improve how the heart uses energy and how nerves work in people with heart failure and sleep apnea. Researchers will use PET scans to measure heart metabolism and nerve fun…

This study will enroll 20 children with a narrow upper jaw to see if their jaw shape is linked to sleep apnea. Researchers will use a home sleep monitor to measure breathing pauses during sleep and compare that to dental X-rays and exams. The goal is to understand how jaw develop…

This study looks at how problems with the body's internal clock (circadian rhythm) may contribute to REM sleep behavior disorder (RBD), a condition where people physically act out their dreams. Researchers will measure melatonin levels and sleep patterns in 30 adults recently dia…

This study tests a sleep-health program that uses habit-formation science to help young adults (ages 18-30) improve their sleep. Researchers want to see if adding text message reminders makes it easier for people to stick with healthy sleep routines. The goal is to find simple, e…

This observational study follows 10 adults with obstructive sleep apnea who are already receiving a cryotherapy treatment (the Cryosa Procedure). Researchers will use MRI and ultrasound before and after treatment to measure fat in the throat and nerve activity. The goal is to fin…

This study looks at how sleep problems like apnea, insomnia, and poor sleep quality are linked to heart disease and diabetes in rural southern areas. About 3,680 adults already in a larger health study will wear sleep trackers and answer questionnaires. The goal is to understand …

This study follows 1,545 adults over many years to understand how sleep-disordered breathing and other sleep problems develop and affect health. Participants were Wisconsin state employees aged 30-60 when the study began. Researchers use overnight sleep tests, questionnaires, and…

This study was designed to find out if treating obstructive sleep apnea with a CPAP machine could help improve insulin resistance and heart function in people with heart failure. It planned to enroll adults aged 18 to 75 with moderate to severe sleep apnea and reduced heart pumpi…

This study uses a wrist-worn activity watch to measure sleep quality in people with orthostatic intolerance (a condition where standing causes dizziness) compared to healthy volunteers. Researchers want to see if these patients have worse sleep, like taking longer to fall asleep.…

This study was designed to explore how the glossopharyngeal nerve varies in shape and size, and whether electrically stimulating it could open the airway during surgery. It planned to enroll adults with head and neck cancer or sleep apnea, but was withdrawn before any participant…

This study looks at sleep quality in 60 adults with non-cystic fibrosis bronchiectasis, a chronic lung condition. Researchers will measure how well participants sleep and see if poor sleep is linked to more severe lung disease, worse breathing tests, or more lung damage on CT sca…

This study aims to create a computer model that can predict how airway surgery will affect obstructive sleep apnea (OSA) in children with Down syndrome. Researchers will measure airway resistance during a sleep MRI to gather data for the model. The goal is to help doctors choose …

This study checks whether sleep questionnaires can reliably detect obstructive sleep apnea (OSA) in children with Down syndrome, who are at higher risk for the condition. Researchers will compare questionnaire results with overnight sleep studies (the gold standard) in about 81 c…

This study follows 2,000 adults aged 45-75 in Pennsylvania to better understand why some groups have higher heart disease risk. About 800 participants at higher risk will receive either usual care or a personalized program with nutrition, exercise, and stress management advice. T…

This study was designed to understand how obstructive sleep apnea (OSA) speeds up the natural drop in testosterone as men age. Researchers planned to use CPAP machines—one real, one placebo—to test hormone changes in men aged 30 to 70 with moderate to severe OSA. However, the stu…