Can a wakefulness drug make driving safer for sleepy patients?

NCT ID NCT00916253

Completed Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how the drug modafinil affects driving ability in 27 people with narcolepsy or hypersomnia. Participants took modafinil or a placebo for five days, then completed both simulated and real driving tests. The goal was to see if the drug improves alertness and reduces driving risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Modafinil
What this could lead to: If successful, this study could help doctors understand whether modafinil improves driving safety in people with sleep disorders.
What could go wrong: This is a small, early-stage study with only 27 participants, so results may not apply to everyone. It focuses on measuring driving ability, not on curing or treating the underlying condition.

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Conditions

The condition(s) this trial relates to.

Disorders of Excessive Somnolence hypersomnia narcolepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERSOMNIA NARCOLEPSY

Contacts and locations

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Locations

AP-HP - Hôpital de l'Hôtel-Dieu

Paris, 75181, France
GENNPHASS - CHU de Bordeaux

Bordeaux, 33076, France

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