Narcolepsy patients may see blood pressure benefits by switching to Low-Sodium oxybate
NCT ID NCT05869773
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study involved 155 adults with narcolepsy who were already taking a high-sodium oxybate medication. They switched to Xywav, a low-sodium version, to see if their blood pressure would improve. The goal was to provide doctors and patients with useful information about the impact of sodium content in narcolepsy treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Xywav (low-sodium oxybate)
What this could lead to
If successful, this study could show that switching to a low-sodium oxybate lowers blood pressure, offering a safer option for managing narcolepsy.
What could go wrong
This is a small, completed Phase 4 study with no placebo group, so results may not apply to everyone. Blood pressure changes may vary and not be clinically significant.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Abington Neurological Associates, LTD
Abington, Pennsylvania, 19001, United States
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Advanced Respiratory and Sleep Medicine, PLLC
Huntersville, North Carolina, 28078, United States
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Antwerp University Hospital (UZA)
Edegem, 2650, Belgium
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Azienda Ospedaliera Universitaria Policlinico Tor Vergata
Roma, 00133, Italy
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Bogan Sleep Consultants, LLC
Columbia, South Carolina, 29201, United States
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Bryan Medical Center
Lincoln, Nebraska, 68506, United States
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CHU Nantes - Hôtel Dieu
Nantes, Loire Atlantique, 44093, France
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CHU de Grenoble - Hôpital Albert Michallon
Grenoble, Isere, 38043, France
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Clinical Research of Rock Hill
Rock Hill, South Carolina, 29732, United States
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FWD Clinical Research
Boca Raton, Florida, 33486, United States
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Florida Pediatric Research Institute, LLC
Orlando, Florida, 32804, United States
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FutureSearch Trials of Neurology
Austin, Texas, 78731, United States
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Henderson Clinical Trials LLC
Henderson, Nevada, 89052, United States
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Hopital Gui de Chauliac
Montpellier, Herault, 34295, France
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Hospital General de Castellon
Castellon, 12004, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario Araba - Sede Santiago
Vitoria-Gasteiz, Alava, 01004, Spain
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Hospital Universitario Clinico San Carlos
Madrid, 28040, Spain
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IRCCS Istituto de Scienze Neurologiche di Bologna (ISNB)
Bologna, 40139, Italy
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Intrepid Research, LLC
Cincinnati, Ohio, 45245, United States
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Long Beach Research Institute
Lakewood, California, 90805, United States
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M3 Wake Research
Encino, California, 91436, United States
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Meris Clinical Research, LLC
Brandon, Florida, 33511, United States
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Neurocare, Inc
Newton, Massachusetts, 02459, United States
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OHSU Hospital
Portland, Oregon, 97239, United States
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Ocean Wellness Center
Miami, Florida, 33169, United States
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Ohio Sleep Medicine and Neuroscience
Dublin, Ohio, 43017, United States
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Ospedale San Raffaele (San Raffaele Turro)
Milan, 20127, Italy
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Private Practice RESPISOM Namur
Namur, 5101, Belgium
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SDS Clinical Trials, Inc.
Santa Ana, California, 92705, United States
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Saltzer Medical Group
Nampa, Idaho, 83686, United States
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Science 37
Culver City, California, 90230, United States
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Serenity Research Center LLC
Miami, Florida, 33176, United States
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Sleep Practitioners, LLC
Macon, Georgia, 31210, United States
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Sleep Therapy & Research Center
San Antonio, Texas, 78229, United States
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So Cal Clinical Research
Huntington Beach, California, 92647, United States
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Sparrow Health System
Lansing, Michigan, 48911, United States
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Stanford School of Medicine
Redwood City, California, 94063, United States
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TriValley Sleep Center
San Ramon, California, 94583, United States
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University of Louisville
Louisville, Kentucky, 40202, United States
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University of Maryland Medical Center
Baltimore, Maryland, 21201, United States
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Velocity Clinical Research, Greenville
Greenville, South Carolina, 29615, United States