Respiratory tract infectious disorder

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

This phase 2b trial tests several versions of an experimental flu vaccine that includes an adjuvant (MF59) to strengthen the immune response. The vaccine is made from cells, not eggs, and targets four flu strains. Around 1,000 adults aged 50 and older receive a single shot and ar…

This phase 3 study tested a single dose of an investigational RSV vaccine in 751 adults aged 60 and older, and those 50-59 at increased risk for severe RSV. The goal was to see how well the vaccine boosts the immune system and whether it is safe. Participants received either the …

This early-stage trial is testing a new mRNA flu vaccine in 50 healthy adults aged 18 to 49. The vaccine uses mRNA technology to target a specific flu strain. Researchers will compare its safety and immune response to a standard seasonal flu shot. The goal is to see if the new va…

This early-stage trial tests a single dose of a new mRNA flu vaccine (VRC H1ssF-3928) in 50 healthy adults aged 18 to 49. The vaccine aims to teach the body to fight a stable part of the flu virus. Researchers are checking for side effects and measuring immune responses, comparin…

This study tested an mRNA vaccine (mRNA-1345) against respiratory syncytial virus (RSV) in 360 pregnant women. The goal was to see if the vaccine is safe for mothers and their babies, and whether it triggers an immune response that could protect infants after birth. Participants …

This early-stage study tests a new mRNA vaccine designed to protect against avian influenza (bird flu) in 80 healthy adults aged 18-49. The vaccine uses mRNA technology to teach the body to recognize and fight the H5 flu virus. The main goal is to check the vaccine's safety and s…

Pfizer completed a study testing a new modified RNA (mRNA) flu vaccine in 1,202 healthy adults aged 18 and older. The goal was to see if the vaccine is safe and triggers a strong immune response. Participants received either the experimental mRNA vaccine or a licensed flu shot, a…

This study tested an experimental RSV vaccine in adults who had a lung or kidney transplant, as well as in healthy adults over 50. The goal was to see if the vaccine could safely boost their immune response against RSV, a common and potentially serious respiratory virus. Research…

This study tested a new mRNA-based flu vaccine in over 1,100 adults aged 50 and older. The vaccine targets multiple flu virus proteins to potentially provide stronger protection. Researchers compared it to standard flu shots and monitored safety and immune response for six months…

This large, final-stage study tested a new combination vaccine that aims to protect against both COVID-19 and the flu with a single shot. About 9,300 adults aged 65 and older took part, receiving either the combo vaccine or a standard high-dose flu vaccine. Researchers checked ho…

This study tested a new vaccine called Pn-MAPS30plus to see if it is safe and helps the body fight pneumonia-causing bacteria. It involved 127 healthy adults aged 50 to 64. The vaccine is designed to protect against more types of the bacteria than current vaccines.

This study tested new mRNA-based seasonal flu vaccines in 776 healthy adults aged 18 and older. The goal was to see how safe the vaccines are and how well they boost the immune system. Researchers measured side effects and immune responses to find the best vaccine candidate.

This study tested an experimental RSV vaccine in adults aged 60 and older in China. The goal was to see if the vaccine produces a strong immune response similar to that seen in older adults from other countries, where the vaccine already proved effective. About 2,620 participants…

This completed Phase 3 trial tested whether an adjuvanted flu vaccine (FLUAD Quadrivalent) triggers a stronger immune response than a standard flu vaccine (FluQuadri) in 192 healthcare workers in Lima, Peru. Participants received one dose of either vaccine, and researchers measur…

This study tested a new nasal spray vaccine for respiratory syncytial virus (RSV), a common cause of serious breathing problems in babies and young children. The vaccine was given as nose drops to 88 healthy children aged 4 months to 5 years, including those who had and had not b…

This study tested a booster vaccine for H5N6 bird flu in about 260 adults. Some had previously received an H5N1 bird flu vaccine, while others had not. The goal was to see if the booster was safe and triggered a strong immune response. Participants received one or two doses of th…

This completed Phase 4 trial tested whether the Butantan Institute's seasonal flu vaccine is as safe and effective as the Sanofi vaccine. A total of 632 Brazilian adults aged 18 to 69 received one of the two vaccines. Researchers measured immune response through blood tests and t…

This study tested a single combination vaccine that aims to protect against both COVID-19 and influenza at the same time. About 980 adults aged 50 and older received either the combo shot, a flu shot alone, a COVID-19 shot alone, or both shots separately. Researchers monitored sa…

This study tested a single combination vaccine that targets both COVID-19 and influenza in adults aged 50 and older. About 980 participants received either the combo shot, the flu vaccine alone, the COVID-19 vaccine alone, or separate shots in each arm. Researchers monitored safe…

This early-stage study tested six different mRNA vaccine formulations against respiratory syncytial virus (RSV) in 240 healthy adults aged 18 to 49. The goal was to check safety and how well the vaccines trigger an immune response. Each participant received a single shot and was …

This study tested a new mRNA vaccine designed to protect against H5 pandemic flu strains. Researchers gave 276 healthy adults one of three doses or a placebo to check safety and immune response. The goal is to find the right dose for future studies.

This study tested whether a vaccine called VPM1002 could help healthcare workers miss fewer days of work due to respiratory illnesses, including COVID-19. About 1,200 doctors, nurses, and other hospital staff received either the vaccine or a placebo. The goal was to see if the va…

This Phase 1 study tests a new vaccine that aims to protect against three respiratory viruses at once: RSV, hMPV, and PIV3. The trial involves 390 adults aged 60 and older and will check if the vaccine is safe and helps the body produce antibodies. Different combinations and dose…

This early-stage trial tested a new universal influenza vaccine called fH1/DSP-0546LP in 144 healthy adults aged 18 to 40. The goal was to check safety and how well the vaccine triggers an immune response. Participants received two shots three weeks apart, with different doses or…

This completed study in Japan checked the safety of the RSV vaccine Abrysvo in 497 pregnant women and their infants. Researchers tracked side effects in mothers for 28 days after vaccination and in babies from birth to 28 days old. The goal was to confirm the vaccine's safety in …

This early-stage trial tested a new self-amplifying mRNA vaccine (ARCT-2304) designed to protect against pandemic influenza. 212 healthy adults aged 18-80 received either two doses of the experimental vaccine or one dose of a licensed flu vaccine plus placebo. Researchers monitor…

This study tested a new vaccine for H7N9 bird flu, given through a small patch with tiny needles instead of a shot. Researchers wanted to see if it was safe and how the body reacted. The trial involved 267 healthy adults aged 18 to 50, who received two doses of the vaccine either…

Pfizer is testing a new type of flu vaccine called a self-amplifying RNA (saRNA) vaccine. This early study involves 440 healthy adults aged 18 to 49. Participants receive either the saRNA vaccine, a licensed flu shot, or a placebo. The main goal is to check safety and side effect…

This study tested a new vaccine designed to protect against two respiratory viruses: RSV and hMPV. It involved 646 healthy adults aged 60 and older who received either the vaccine or a placebo. The goal was to see if the vaccine is safe and triggers a strong immune response, with…

This study tested the safety and immune response of several Moderna mRNA vaccines for COVID-19, seasonal flu, RSV, and CMV in 308 healthy adults aged 18 to 75. Researchers monitored side effects and measured antibody levels after vaccination. The goal was to ensure the vaccines a…

This early-stage trial tested an experimental mRNA-based flu vaccine in 324 healthy younger (18-45) and older (60-80) adults. The main goal was to check safety and how well the vaccine triggers an immune response. Participants received one of several dose levels or a placebo, and…

This study tested a new mRNA-based flu vaccine from GSK in 845 healthy adults aged 18 to 85. The goal was to find the best dose and check how well it triggers the immune system and whether it is safe. Results will help decide if larger studies should move forward.

This study tested an experimental RSV vaccine in about 4500 adults aged 60 and older. Half received the vaccine and half received a placebo shot. The goal was to see if the vaccine could prevent lower respiratory tract disease caused by RSV, a common virus that can be serious in …

This study tested a higher dose of a new nasal vaccine (BPZE1) for whooping cough in 54 healthy adults aged 18-32. The goal was to see if the higher dose is safe and helps the vaccine take hold in the nose to trigger protection. Researchers monitored side effects and checked if t…

This study tested a new mRNA vaccine designed to protect against a future flu pandemic. Healthy adults aged 18-49 and 65-84 received either the experimental vaccine, a licensed flu shot, or a placebo. Researchers monitored safety and immune responses for about 13 months to see if…

This study tested an inactivated H1N1 flu vaccine in 122 kidney transplant recipients who were at least 6 months post-transplant and on triple immunosuppression. The goal was to see if the vaccine could safely trigger an immune response. Researchers measured antibody levels and t…

This early-stage study tested two experimental RSV vaccines given as nose drops in 60 children. Some children already had RSV antibodies (ages 1-5) and some did not (ages 6 months-2 years). The main goals were to check safety and whether the vaccines triggered an immune response.

This study tested an RSV vaccine in 378 older adults (60+) in Korea to see if it is safe and helps the body fight the virus. Participants received either the vaccine or a placebo and were monitored for side effects and immune response. The results showed the vaccine was well tole…

This study tested a new mRNA vaccine designed to protect against a potential pandemic of H5 bird flu. Nearly 1,000 healthy adults aged 18 to 85 received different doses to find the safest and most effective one. Researchers monitored side effects like pain, fever, and fatigue, an…

This study tested new modified RNA vaccines that target both influenza and COVID-19, given as a single shot. Over 2,600 healthy adults aged 18 and older took part, receiving either a flu vaccine, a COVID-19 vaccine, or a combination of both. The main goal was to check safety and …

This study tested a live, weakened RSV vaccine given as a nasal spray to infants and toddlers aged 6 to 24 months in Puerto Rico. The main goal was to see if the vaccine virus spreads from vaccinated children to others in the same household or daycare, and to check how long the v…

This early-stage study tested the safety and immune response of new vaccines that combine protection against flu, RSV, hMPV, and PIV3 in healthy adults aged 18 to 49. Participants received a single shot of one of several vaccine formulas. The goal was to see if these combination …

This study tested two different H5N8 bird flu vaccines in 1380 healthy adults to see how safe they are and how well they trigger the immune system. Participants received different doses of the vaccine with either AS03 or MF59 adjuvant. The goal is to find the best dose and adjuva…

This early-stage study tested an experimental flu vaccine called FluMos-v2 in 30 healthy adults aged 18 to 50. The vaccine is designed to protect against multiple flu strains at once, unlike current vaccines that target only one. Participants received two shots four months apart …

This study tested a new seasonal flu vaccine made from animal cells instead of eggs in over 3,200 adults aged 50 and older. Participants received either the new vaccine or a standard egg-based flu shot, and researchers measured their immune response and side effects. The goal was…

This early-stage trial tested a new 23-valent pneumococcal polysaccharide vaccine in 144 healthy people aged 2 and older. Participants received one dose of either the experimental or a control vaccine. The study checked for side effects and measured immune response through blood …

This large Phase 3 trial tested a new quadrivalent flu vaccine in over 2,700 healthy children aged 6 to 35 months. The study compared two doses of the experimental vaccine against a standard flu vaccine to see how well it triggers an immune response and whether it is safe. Resear…

This phase 3 study tested an mRNA vaccine called mRNA-1345 to protect against respiratory syncytial virus (RSV) in adults aged 50 and older. Over 3,300 participants received the vaccine alone, with a flu shot, or with a COVID-19 booster. The trial also looked at a booster dose on…

This completed phase 3 trial tested whether giving an RSV vaccine and a COVID-19 mRNA vaccine at the same time is as safe and effective as giving them separately. About 841 adults aged 50 and older took part. Researchers measured immune responses and side effects one month after …

This early-stage trial tested several experimental mRNA vaccines that aim to protect against both influenza and SARS-CoV-2 in a single injection. About 1,758 healthy adults aged 18 to under 80 took part. The main goals were to check safety and measure the immune response, with re…

This phase 2 study tested a non-adjuvanted H1N1 flu vaccine in 110 pregnant women to see if it is safe and triggers a good immune response. Participants received two doses of the vaccine and were monitored for side effects. The goal is to protect both mothers and their babies fro…

This study tested a new vaccine called IVX-A12 that targets two respiratory viruses: RSV and hMPV. It involved 264 healthy adults aged 60 to 85. The goal was to see if the vaccine is safe and boosts the immune system to fight these viruses.

This study tested a single combined vaccine that aims to protect against both COVID-19 and influenza. About 8,800 healthy adults received either the combo shot or separate vaccines. Researchers checked for side effects and measured immune responses over six months to see if the c…

This study tested a new combination vaccine called mRNA-1083 that aims to protect against both COVID-19 and the flu with a single shot. It involved 2,457 healthy adults aged 50 and older in Japan, Taiwan, and South Korea. The main goals were to check how well the vaccine triggers…

This study tested a new mRNA-based flu vaccine (mRNA-1010) in 172 healthy adults aged 18-50 and 65-80. The goal was to check its safety and how well it triggers the immune system compared to standard flu vaccines. Results help determine if the vaccine is safe and effective enough…

This study tested whether a new flu vaccine made in cells (instead of eggs) can prevent the flu. About 7,250 adults received either the vaccine or a placebo shot. Researchers then checked for flu infections over 6 months. The goal was to see if the vaccine protects against flu st…

This early-stage trial tested a new vaccine designed to protect against both RSV and hMPV, two common respiratory viruses. 385 healthy adults aged 60 to 75 received a single injection of different doses. The main goals were to check safety and measure the immune response. Results…

This study compared how well egg-based and non-egg-based flu vaccines trigger the immune system in adults aged 18 to 64. Researchers wanted to see if egg adaptation weakens the vaccine's effectiveness. Over two flu seasons, 366 participants received one of three vaccines: a stand…

This large phase 3 study tested an experimental RSV vaccine in over 25,000 adults aged 60 and older. The goal was to see if a single shot could prevent lower respiratory tract disease caused by RSV, a common virus that can be dangerous for seniors. Participants received either th…

This study tested whether giving the RSV vaccine (Abrysvo) and the shingles vaccine (Shingrix) at the same doctor's visit is safe and works as well as giving them separately. About 526 adults aged 50 and older took part. Researchers measured immune responses and tracked side effe…

This study compared three different flu vaccines: one made using eggs, one using cells, and one using a lab-made protein. The goal was to see which vaccine triggers the strongest antibody response, especially against a tricky flu strain called H3N2. 366 adults who hadn't had a fl…

This completed study looked at how well licensed RSV vaccines (Pfizer's Abrysvo or GSK's Arexvy) trigger an immune response in adults over 60 living in long-term care facilities compared to those living independently in the community. Researchers measured antibody levels before a…

This completed study looked at how effective the Prevnar 13 (PCV13) vaccine is at preventing pneumonia and related infections in adults with HIV. Researchers analyzed health records of over 350,000 people with HIV to compare those who got the vaccine with those who did not. The g…

This study tested a new combination vaccine called mRNA-1083 that aims to protect against both flu and COVID-19 in a single shot. About 1,320 adults aged 18 to 64 took part. Researchers measured the immune response and checked for side effects to see if the combo vaccine works as…

This study looked at whether adding special ingredients called adjuvants to two standard flu vaccines (Fluzone and Flublok) could make them work better. About 240 healthy adults aged 18 to 45 received either a regular flu shot or one with an adjuvant. Researchers checked for side…

This study tested a single shot that aims to protect against both COVID-19 and the flu. About 932 adults aged 50 to 64 received the experimental mRNA-1083 vaccine. Researchers checked for side effects and measured antibody levels one month after vaccination to see how well the va…

This early-stage trial tested a new type of flu vaccine called ARCT-2138, which uses self-amplifying mRNA technology to potentially provide stronger and longer-lasting protection. The study involved 139 healthy adults aged 18-49 and 65-85, who received either the experimental vac…

This Pfizer trial tested whether a single injection combining an updated COVID-19 vaccine and a flu vaccine is safe and triggers a strong immune response. The study involved 644 healthy adults aged 50 and older. Researchers measured side effects and antibody levels to see if the …

This study tested two different doses of an experimental H7 flu vaccine with an added booster (adjuvant) against a version without the booster. About 581 healthy adults aged 18 and older took part. The goal was to see which dose produced the strongest immune response and was safe…

This study tested an RSV vaccine in 453 healthy women aged 18-49. It compared a multidose vial with a preservative to a single-dose vial without one. The goal was to see if both versions are safe and produce a similar immune response. Participants received one shot and were follo…

This study tested an experimental RSV vaccine in about 1,500 adults. It compared the immune response and safety in younger adults (18-49 years) who are at increased risk for RSV disease to older adults (60 years and older). The goal was to see if the vaccine works as well in the …

This early-stage study tested a 'prime-boost' approach for a universal flu vaccine. Researchers gave an inactivated H5N1 flu shot to 32 healthy adults, some of whom had previously received other experimental flu vaccines. The goal was to see if this method could trigger broad imm…

This completed Phase 3 trial tested a quadrivalent (four-strain) influenza vaccine from Instituto Butantan in over 1,300 healthy infants and children aged 6 to 35 months. The study compared the immune response and safety of two doses (0.25ml and 0.50ml) against standard trivalent…

This Phase 1 study tested several versions of a quadrivalent recombinant influenza vaccine, some with an adjuvant, in 210 healthy adults aged 18-30 and 50+. The main goals were to check safety and measure antibody responses against flu strains. Researchers compared different H3 a…

This study tested a new COVID-19 booster vaccine called SpiN-Tec in 432 healthy adults aged 18 to 85 who had already received full vaccination and at least one booster. The vaccine was compared to approved boosters like Covishield and Comirnaty. The goal was to check safety and w…

This study tested a quadrivalent influenza vaccine in 652 healthy children aged 3-8 years. Researchers compared immune responses after one dose versus two doses, and also checked for side effects. The goal was to find the best way to protect children against flu.

This early-stage trial tested a new mRNA-based flu vaccine in 233 healthy adults aged 18 and older. The study compared three different doses of the experimental vaccine to a standard high-dose flu shot. Researchers monitored safety and immune responses over time to see if the new…

This large Phase 3 trial tested an experimental mRNA-based flu vaccine (mRNA-1010) against standard flu shots in over 40,000 adults aged 50 and older. The goal was to see if the new vaccine is safer and better at preventing flu-like illness caused by influenza A or B. Researchers…

This study tested a seasonal flu vaccine made with a modified manufacturing process in healthy adults aged 18 and older. The goal was to see if the new process produces a vaccine that works as well as the current version and is as safe as a licensed flu vaccine. About 1,928 parti…

This study tested a new vaccine called VAX-24, which targets 24 types of pneumococcal bacteria, in 802 healthy infants. The babies received four doses at 2, 4, 6, and 12-15 months old, alongside routine vaccines. The goal was to check safety and how well the vaccine triggers an i…

This completed Phase 1 trial tested a new flu vaccine that includes an extra H3 strain, aiming to improve protection against influenza. The study involved 400 healthy adults aged 18-49 and 60+, comparing the new vaccine to standard flu shots. Researchers checked for side effects …

This early-stage trial tested an experimental mRNA vaccine designed to protect against two respiratory viruses: RSV and hMPV. Healthy adults aged 18 to 49 and 60 years and older received a single injection of the vaccine at different doses. The main goals were to check safety and…

This early-stage trial tested a new mRNA vaccine that combines protection against seasonal flu and COVID-19 in a single shot. Researchers gave the vaccine to 106 healthy adults aged 18-64 to check for side effects and measure immune responses. The goal is to see if a combined vac…

This early-stage trial tests a new mRNA-based flu vaccine in 159 adults aged 18-49 and 60+. The vaccine uses modified mRNA to target a specific flu strain (H3N2). Researchers compare its safety and immune response to a standard flu shot. The goal is to gather data to improve futu…

This phase 3 trial tested a new recombinant flu vaccine (RIV4) against a standard inactivated flu vaccine (IIV4) in 301 healthy adults aged 18 and older in South Korea. The study measured antibody levels and safety over 29 days. The goal was to see if the new vaccine triggers a s…

This study tested a live-attenuated RSV vaccine given as a nasal spray in 259 infants and toddlers aged 6 to 18 months. The main goals were to check safety and measure the immune response. Researchers also looked at how much vaccine virus was shed and how well the vaccine worked …

This study tested a recombinant flu vaccine (RIV4) in over 1,300 people aged 9 to 49. The goal was to see if the immune response in children and teens (9-17) was as good as in adults (18-49). Researchers measured antibody levels before and 29 days after vaccination. The trial als…

This study tested a new universal flu vaccine (INFLUENZA G1 mHA) in 170 healthy adults aged 18-45. The goal was to check if it is safe and triggers an immune response. Participants received either the vaccine with or without an adjuvant, or a placebo. Results will show if this ap…

This Phase 1 trial tests the safety and how the body handles HRS-9813, an experimental oral drug for idiopathic pulmonary fibrosis (a lung-scarring disease). Healthy volunteers aged 18-45 take multiple doses to measure side effects and drug levels in the blood. The study does not…

This study tests whether special breathing techniques called neurophysiological facilitation of respiration can improve oxygen levels and shorten hospital stays in children aged 6 months to 2 years with pneumonia. The techniques involve gentle stretches and co-contraction of the …

This study tests two approaches to reduce the overuse of broad-spectrum antibiotics in adults hospitalized with community-acquired pneumonia. Researchers will compare rapid diagnostic testing and pharmacist-led de-escalation, alone or together, against usual care. The goal is to …

This study tested an inhaled drug called RSP-1502, which combines the antibiotic tobramycin with a substance called CaEDTA, in 71 people with cystic fibrosis who have chronic Pseudomonas lung infections. The goal was to check safety and find the right dose. Participants received …

This study tested whether a combination of small amounts of tube feeding plus extra nutrition through an IV could reduce pneumonia in people with severe stroke. The trial enrolled 546 adults who had trouble swallowing. Researchers compared this approach to standard full tube feed…

This study tests an inhaled drug called AGMB-447 in healthy volunteers and people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs. The main goal is to check safety and how the body processes the drug. 143 participants will receive either the drug or a pla…

This study tested the safety and effectiveness of the antifungal drug isavuconazole as a first treatment for Chinese patients with serious invasive fungal infections caused by Aspergillus or other molds. All 70 participants received the drug for up to 84 days (or 180 days for cer…

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked d…

This large, completed trial tested several potential COVID-19 treatments in over 1,500 hospitalized adults across Europe. Earlier drugs like remdesivir and hydroxychloroquine were dropped after showing no benefit. The current phase is testing a new antibody combination called AZD…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This completed Phase 2/3 trial tested whether adding baloxavir to standard oseltamivir treatment helps hospitalized flu patients clear the virus faster. Fifteen adults with confirmed influenza were randomly assigned to receive either the combination or oseltamivir alone. The main…

This study tested an experimental drug called GKT137831 in 58 people with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. The drug aims to reduce lung damage caused by harmful molecules called reactive oxygen species. Researchers measured cha…

This Phase 3 trial tested whether an inhaled drug called treprostinil (Tyvaso) could slow the loss of lung function in 598 adults with idiopathic pulmonary fibrosis (IPF), a progressive lung disease. Participants inhaled the drug or a placebo four times daily for 52 weeks. The ma…

This study tested a new mRNA booster shot (mRNA-1345) in 507 adults aged 60 and older who had already received a licensed RSV vaccine at least a year earlier. The goal was to see if the booster is safe and boosts the immune system's ability to fight RSV. Researchers measured side…

This study tested a new drug called opelconazole, given as a mist through a nebulizer, to prevent a serious fungal lung infection (aspergillosis) in people who had a lung transplant. The trial involved 102 participants and compared the drug to standard care. The main goal was to …

This early-stage trial tested a single inhaled dose of FLAMOD, a protein that mimics a bacterial signal to activate the immune system, in 46 healthy adults. The goal was to check safety and see if it triggers a local immune response in the lungs. If it works, this approach might …

This study tested a new flu medicine called ZX-7101A in 169 children aged 2 to 11. The medicine was given as a single oral dose, and researchers compared it to a standard 5-day treatment (oseltamivir). The main goal was to check safety and how well it relieved flu symptoms. The t…

This early-phase study tested a purified green tea extract called EGCG in 50 people with idiopathic pulmonary fibrosis (IPF) who were already taking standard medications. The main goal was to check if EGCG is safe and how it interacts with their usual drugs. Participants took EGC…

This study tested whether adding bedaquiline to two standard antibiotics (clarithromycin and ethambutol) helps clear a stubborn lung infection called MAC lung disease. 129 adults who had not responded to previous treatment took part. The main goal was to see if the new combinatio…

This study looked at the safety and how the body processes two doses of nirsevimab, a medicine to prevent RSV, given 5 to 6 months apart. It included 33 Japanese infants up to 12 months old with heart or lung disease, weak immune systems, Down syndrome, or who were born early. Re…

This phase 2 trial tested an experimental tablet called HSK44459 in 186 adults with idiopathic pulmonary fibrosis (IPF), a progressive lung-scarring disease. Participants took one of three doses of the drug or a placebo twice daily for 12 weeks. The main goal was to see if the dr…

This study looked at how safe and effective the drug Cresemba (isavuconazole) is for Korean patients with serious fungal infections like invasive aspergillosis or mucormycosis. Researchers tracked side effects and how well the drug worked in 94 adults. The goal was to confirm the…

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study tested a drug called Auxora in 314 people with severe COVID-19 pneumonia. The goal was to see if it could help patients recover faster and reduce the need for breathing machines. Participants received either Auxora or a placebo, along with standard treatments. Results …

This study tested whether the antioxidant N-acetylcysteine (NAC) can slow lung decline in people with idiopathic pulmonary fibrosis (IPF) who have a specific gene variant (TOLLIP TT). Over 200 participants took NAC or a placebo for 24 months. The goal was to see if NAC delays wor…

This study tested a new cell therapy called REGEND001 for people with idiopathic pulmonary fibrosis (IPF), a serious lung disease. The therapy uses special lung cells to try to repair damaged tissue. In this phase 2 trial, 23 participants received either the cell therapy or a pla…

This study tested an experimental drug called AON-D21 in 150 ICU patients with severe community-acquired pneumonia. The goal was to see if adding AON-D21 to standard care is safe and helps patients recover faster compared to a placebo. The trial focused on how quickly patients co…

This study tested whether a dietary supplement called Imunoglukan P4H® (made from pleuran, a mushroom extract, plus vitamin C) could help people with chronic sinusitis. 85 patients over age 12 took the supplement alongside standard treatments like nasal sprays and saline rinses. …

This study tested whether a probiotic called WecProB could help children with mycoplasma pneumonia get better faster. Sixty children aged 6 months to 12 years took either the probiotic or a placebo. The main goal was to see if the probiotic reduced the amount of pneumonia-causing…

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This completed trial tested whether a rapid MRSA nasal swab test could help doctors safely stop an antibiotic called vancomycin in adults with pneumonia in the intensive care unit. 277 participants were randomly assigned to have their swab results reported to their doctor or to r…

This study tested a combination of plasma exchange, rituximab, and intravenous immunoglobulin in 82 people with a sudden, severe worsening of idiopathic pulmonary fibrosis (IPF). The goal was to see if this treatment could improve survival compared to usual care with antibiotics …

This study looked at whether giving pomegranate seed oil supplements for 24 weeks could help prevent urinary tract infections and pneumonia in people with advanced dementia who are in palliative care. It also checked if the supplement helped reduce or stop antipsychotic medicatio…

This study tests an experimental oral drug, BI 1819479, in 322 adults with idiopathic pulmonary fibrosis (IPF). Participants receive one of three doses or a placebo for 6 to 12 months. The main goal is to see if the drug can slow the yearly decline in lung function, measured by b…

This early-phase study tested a new oral drug called CC-42344 in 80 healthy adults to see if it is safe and how the body processes it. The drug is designed to stop the influenza A virus from multiplying. The study did not treat actual flu patients, but the results will help decid…

This study looked at 279 adults with worsening idiopathic pulmonary fibrosis (IPF), a serious lung disease. It compared taking two antifibrotic drugs together (pirfenidone and nintedanib) versus switching to the other single drug. The goal was to see which approach better slows l…

This Phase 2 trial tested an experimental drug called BMS-986278 in 403 adults with pulmonary fibrosis, a condition that causes lung scarring and breathing difficulty. The study compared the drug to a placebo to see if it could improve lung function and was safe. Results will hel…

This study tested whether taking two antibiotics instead of three is just as effective for treating a lung infection called MAC, while causing fewer side effects. 474 adults with MAC lung disease were randomly assigned to receive either two or three drugs for 12 months. The goal …

This study tested a personalized approach for people with severe COPD. Doctors used a simple blood test (eosinophil count) to decide whether to reduce inhaled steroids, and some patients also received the antibiotic azithromycin. The goal was to see if this strategy could reduce …

This study tested an experimental drug called MN-001 (tipelukast) in 15 people with moderate to severe idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. Participants took either the drug or a placebo twice daily for six months, then everyone could take the drug for an…

This study looked at whether giving children a longer course of antibiotics (amoxicillin-clavulanic acid) after hospitalization for pneumonia leads to better recovery compared to a shorter course. It involved 314 children aged 3 months to 5 years in Australia. The goal was to see…

This study tested whether a daily probiotic drink (like Yakult) can reduce cold symptoms in triathletes before and after a competition. 80 healthy amateur triathletes drank either the probiotic or a placebo for 30 days before and 14 days after a race. Researchers tracked symptoms…

This study tested whether the antiviral drug Amizon (enisamium iodide) can help adults with colds or flu feel better faster. One hundred adults aged 18 to 60 took either Amizon or a placebo pill for 7 days, starting within a day of their first symptoms. Researchers tracked sympto…

This study tested an inhaled mixture of bacteria-killing viruses (phages) in 48 adults with bronchiectasis and chronic Pseudomonas lung infections. Participants received either the phage therapy or a placebo by inhalation. The goal was to see if the phages could safely reduce the…

This study tested whether adding rituximab (a drug that calms certain immune cells) to standard mycophenolate mofetil treatment helps people with interstitial lung disease whose lungs are not responding to initial therapy. 122 adults with various ILD types received either rituxim…

This early study tested whether injecting human umbilical cord stem cells into the lungs is safe for people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Seventeen patients received different doses through a bronchoscope. The m…

This study tested whether a daily supplement called Immulina, made from Spirulina, can help healthy people fight off upper respiratory viruses like the flu. Researchers measured natural killer cell activity and other immune markers in 492 healthy adults aged 18-59 and 65+. Partic…

This study tested whether low-dose hydrocortisone, a common steroid, can help people with severe community-acquired pneumonia survive. Over 950 critically ill adults in intensive care received either the steroid or a placebo, alongside standard antibiotics and support. The goal w…

This study tested whether using very small breaths (ultraprotective ventilation) on a breathing machine, without a heart-lung bypass machine, could improve survival and reduce time on the ventilator for COVID-19 patients with severe lung injury. About 220 adults with confirmed CO…

This study tested an experimental oral drug called INS018_055 in 71 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and makes breathing hard. The main goal was to see if the drug is safe and tolerable over 12 weeks compared to a placebo. Resea…

This study tested whether a special infant formula containing lactoferrin and human milk oligosaccharides (HMOs) could improve immunity in newborns. 240 healthy full-term babies were randomly assigned to receive either the test formula, a standard formula, or breast milk for 12 m…

This phase 2a trial tested a drug called PLN-74809 in 10 people with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. Participants took the drug or a placebo daily for 12 weeks. The study used a special PET/MRI scan to measure collagen (scar t…

This early-stage trial tested the safety and tolerability of a new drug called BI 1015550 (Nerandomilast) in 15 people with idiopathic pulmonary fibrosis (IPF). Participants took either the drug or a placebo twice daily for up to 12 weeks. The study aimed to see if the drug is sa…

This small pilot study tested whether a sustained-release ammonium chloride formula (with vitamin D) can reduce virus levels in adults with mild or moderate COVID-19 or influenza. 32 participants took either the active formula or a vitamin D-only control twice daily for 10 days. …

This completed Phase 2 trial tested whether inhaling a green tea extract called EGCG could help cancer patients with moderate-to-severe COVID-19 pneumonia. 111 participants received either EGCG mist or a placebo three times daily for 7 days. The study looked at lung CT scan impro…

This study tested whether using lung ultrasound to guide how nurses position ventilated newborns can prevent pneumonia better than standard repositioning every two hours. Researchers enrolled 80 full-term infants on breathing machines. The goal was to see if personalized position…

This early-phase trial tested an experimental drug called PMG1015 in 29 people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. The main goal was to check the drug's safety and how the body processes it, not whether it works. Participants received either PMG1015…

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This study looked at whether the flu vaccine can reduce inflammation in people with stable coronary artery disease. Inflammation plays a key role in heart disease progression. The trial involved 47 adults aged 60 and older with stable heart disease, who received the flu vaccine e…

This study tested two drugs, ruxolitinib and fostamatinib, in hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the disease from becoming severe. 185 patients were randomly assigned to receive one of the drugs or standa…

This study tested a new flu medicine called ZSP1273 in 72 children aged 2 to 17 with influenza A. The goal was to see how safe it is, how the body processes it, and whether it helps reduce flu symptoms. The trial took place in China and has already been completed.

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested an oral drug called GRI-0621 in 35 adults with idiopathic pulmonary fibrosis (IPF), a chronic lung disease that causes scarring and breathing difficulty. Participants took either the drug or a placebo daily for 12 weeks. The main goals were to check safety and m…

This large Phase 3 trial tested whether the drug BI 1015550 (nerandomilast) can help people with idiopathic pulmonary fibrosis (IPF), a serious lung disease that causes scarring and makes breathing hard. Over 1,100 adults aged 40 and older took either a low or high dose of the dr…

This study tested an inhaled drug called ARO-MMP7 in healthy volunteers and people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The main goal was to check safety and how the body handles the drug. About 105 participants took p…

This study tested an experimental drug called SPR720 in 25 adults with a chronic lung infection caused by Mycobacterium avium complex (MAC). The goal was to see if the drug can reduce bacteria in sputum and is safe compared to a placebo. Participants took the drug or placebo by m…

This study looked at how well the antibiotic Klacid SR works for adults with respiratory infections like bronchitis and mild pneumonia, especially in those who had taken it before. Over 3,000 participants were treated in regular doctor visits, and doctors checked if symptoms impr…

This study tested an experimental oral drug called EDP-323 in 142 healthy adults who were deliberately infected with RSV. The goal was to see if the drug is safe and can reduce the amount of virus in the nose compared to a placebo. Results will help determine if EDP-323 could be …

This Phase 2 study tested an experimental oral drug called TTI-101 in 100 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. Participants took either TTI-101 or a placebo daily for 12 weeks. The main goal was to check sa…

This study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…

This early-stage study tested a new drug called HuL001 in 24 people, including healthy volunteers and patients with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. The main goal was to check safety and how the body handles the drug. This is a first step to see if Hu…

This study tested whether taking vitamin D every day could reduce lung complications in children and teens with sickle cell disease. Lung problems like infections, asthma attacks, and acute chest syndrome are major causes of illness and death in this condition. Researchers gave d…

This study tested whether a salmon oil supplement called CARDIO® could help control asthma in adults. 70 participants took either the supplement or a placebo alongside their usual asthma medications. The goal was to see if the supplement reduced asthma attacks and improved breath…

This study tested a new flu medicine called ADC189 in 190 children aged 2 to 11 with influenza. The medicine is given as a single dose, either as a tablet or granules. The goal was to see if it is safe and works well in younger children, who currently have limited treatment optio…

This study tested whether giving children with pneumonia a daily oral rehydration solution (ORS) for three days could shorten their hospital stay. Researchers compared 140 children aged 1 month to 5 years who received ORS to those who did not. The goal was to see if this simple, …

This study tested a single dose of HLX6018, an experimental antibody, in 66 healthy adults to see if it is safe and how the body handles it. HLX6018 is designed to block a protein pathway involved in idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs. Because thi…

This study tested whether giving HIV-infected infants with severe pneumonia early treatment for cytomegalovirus (CMV) and tuberculosis (TB) could help them survive. Over 500 babies aged 1 month to 1 year were randomly assigned to receive either standard care or additional drugs f…

This study tested whether adding a procedure called fiberoptic bronchoscopy to standard care helps adults with severe ventilator-associated pneumonia. One hundred patients were split into two groups: one got usual treatment (antibiotics, suctioning), the other got the same plus d…

This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researc…

This study tested two new rapid tests that use a single nose swab to detect COVID-19, influenza A/B, and RSV. Researchers checked how accurate the tests are compared to standard lab methods and whether healthcare workers find them easy to use. The study involved 589 people with s…

This study collected nasal swabs, throat swabs, and saliva samples from 79 people with symptoms of flu, RSV, or COVID-19. The samples were used to help evaluate a point-of-care device called LumiraDx, which aims to quickly and accurately detect these viruses. The study focused on…

This study tested whether a simple mouth rinse could help diagnose Pneumocystis pneumonia, a serious lung infection in people with weakened immune systems. Researchers used a PCR test on the rinse sample to look for the fungus, aiming to find a threshold that indicates active inf…

This study checked how well a new rapid test (LumiraDx) detects COVID-19 and flu A/B from a simple nose swab. Over 1,000 people with symptoms took part at clinics. The test aims to give fast results at the point of care, helping doctors tell these illnesses apart quickly.

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study checked how accurate two rapid tests (LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV-2 & Flu A/B) are at detecting COVID-19 and flu in people with symptoms. 716 participants provided nasal swabs at clinics. The results were compared to standard lab tests to measure…

This study tested a new rapid test (LumiraDx Influenza A/B + RSV Test) that uses a nasal swab to quickly detect flu A, flu B, and RSV. Over 500 people with cold or flu-like symptoms took part. The test was performed by healthcare workers at point-of-care sites and compared to sta…

This study tested whether giving general practitioners a rapid C-reactive protein (CRP) test helps them decide when antibiotics are truly needed for patients with respiratory infections. 140 patients with symptoms like cough, fever, or sore throat took part. Doctors in the test g…

This study tested whether a special lung MRI can replace CT scans for diagnosing idiopathic pulmonary fibrosis (IPF), a scarring lung disease. Researchers compared MRI to standard CT in 60 patients to see if MRI could spot the same key signs of IPF without using radiation. The go…

This study looked at 173 adults on ventilators to see if combining advanced germ-detection tests with a patient's immune response can improve diagnosis of ventilator-associated pneumonia. Researchers compared several molecular tests and host-response markers to standard clinical …

This study looked at whether an artificial intelligence (AI) tool can help doctors diagnose ventilator-associated pneumonia (a serious lung infection) in ICU patients. Researchers analyzed chest X-rays from 119 adults on breathing machines, comparing the AI's readings to doctors'…

This study looked at whether measuring TB DNA in fluid from around the lungs (pleural fluid) can quickly and accurately diagnose tuberculosis. Researchers tested fluid from 329 adults with lung fluid buildup. The goal was to see if this DNA test works better than standard tests, …

This study checked how well a new test called VitaSIRO solo™ detects COVID-19, flu, and RSV in people with respiratory symptoms. Over 1,200 participants provided nose and throat swabs. The test's accuracy was compared to standard lab methods.

This study tested a rapid diagnostic test (BioFire Pneumonia Panel) in 40 ICU patients on ventilators with suspected pneumonia. Half got the rapid test, half got standard care. The goal was to see if the test helps doctors give the right antibiotics sooner. Results could lead to …

This study tested whether using a low-dose CT scan or lung ultrasound is more accurate than the usual chest X-ray for diagnosing pneumonia in people over 65. About 473 older adults with suspected pneumonia in the emergency room took part. The goal was to see if better imaging cou…

This study tested a new rapid test that checks for flu A, flu B, COVID-19, and RSV using one nasal swab. Over 1,100 people with respiratory symptoms took part. The goal was to see how well the test works compared to standard lab tests.

This study checked how well a new rapid test (iHealth COVID-19/Flu A&B) can detect COVID-19 and flu A and B in people with respiratory symptoms. About 588 people with two or more symptoms provided nose swabs. The test's results were compared to a standard lab test to see how accu…

This study looked at whether lung ultrasound (LUS) can accurately diagnose pneumonia in children in low-resource settings, where chest X-rays are often unavailable. Researchers compared LUS results to a 'gold standard' diagnosis based on clinical exams, imaging, and lab tests. Th…

This study tested a machine learning tool that uses routine medical data to predict pneumonia risk within the first week after brain tumor surgery. Researchers included over 1,800 adults having their first planned brain tumor removal. The goal was to see if the AI could help doct…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage eight common conditions (like pneumonia, kidney stones, and pregnancy issues) without needing extra tests. Over 160 patients took part, and researchers compared …

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study looked at a blood test called Beta-D-glucan (BDG) to see how well it detects invasive fungal infections in people with weak immune systems. Researchers tested 280 patients and checked if two positive results within 15 days confirmed an infection. The goal is to help do…

This study tested whether adding a rapid tuberculosis (TB) test to standard care for children hospitalized with severe pneumonia could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB countries were enrolled. The test, called Xpert MTB/RIF Ultra, was done on …

This study looked at 339 emergency room patients with suspected pneumonia to see if a chest CT scan could improve diagnosis. The goal was to find out if the CT scan changed the doctor's initial diagnosis, and if it led to changes in antibiotic treatment or hospital admission deci…

This study tested a new DNA test called the MycoGenie kit to see how well it can diagnose invasive aspergillosis, a serious fungal infection, in 350 blood cancer patients. The test looks for the fungus's DNA in blood samples and can also detect drug resistance. The goal is to fin…

This study tested whether a rapid molecular test using saliva can accurately diagnose strep throat in children aged 3-15. Researchers compared the saliva test to standard throat swab methods in 800 children visiting primary care. If accurate, this could replace uncomfortable thro…

This study looked at whether FebriDx, a rapid fingerstick test, can accurately tell bacterial from non-bacterial acute respiratory infections when used by people without lab training. Researchers compared results from untrained operators to trained ones in 800 patients with fever…

This study tested whether a smartwatch app called Hyfe can accurately count how often people cough. Researchers compared the app's cough counts to manual counts from audio recordings in 31 adults with various cough-related conditions. The goal is to see if the smartwatch can be a…

This large study tested whether an enhanced flu vaccine (Fluad) works better than standard flu shots in adults aged 65 and older. Over 38,000 participants received either Fluad or a regular vaccine. The goal was to see if Fluad prevents confirmed flu cases more effectively. Resul…

This study tested a new medicine called CD388, given as a single set of three shots, to see if it can prevent the flu in healthy adults aged 18 to 64. Over 5,000 participants received either CD388 or a placebo. Researchers measured how many people got the flu over the next 24 wee…

This study tested whether special UV light devices placed in common areas of nursing homes can reduce the number of severe respiratory infections (like pneumonia or COVID-19) in elderly residents. Over 1,600 residents in 12 French nursing homes took part. The devices were either …

This study tested whether a bacterial lysate (Broncho Vaxom) can prevent wheezing in infants who were hospitalized for severe bronchiolitis. 173 infants received either the lysate or a placebo for up to 24 months. The goal was to see if the treatment reduces the number of wheeze …

This study tested several types of flu vaccines in over 1,800 adults aged 65-82 in Hong Kong over four years. The goal was to see which vaccine or combination of vaccines provides the strongest and longest-lasting immune protection. Researchers measured antibody levels and immune…

This study looked at two new ways to prevent RSV, a serious lung infection in babies: a vaccine given to pregnant women and an antibody shot given to infants. Researchers wanted to see how well each method works alone or together. 181 mother-infant pairs took part, and the study …

This study tested a new medicine called clesrovimab in over 1,000 infants and children at high risk for severe RSV disease. The goal was to see if it is safe and works as well as or better than the current standard treatment, palivizumab. Participants received either clesrovimab …

This study tested whether specially built houses (Star Homes) could reduce malaria, respiratory infections, and diarrhea in children under 13 in rural Tanzania. Over 1,100 children lived either in a Star Home or a traditional mud house. The Star Homes have screened windows, solar…

This study tested whether giving families educational materials, alcohol-based hand sanitizers, and surgical face masks could reduce the spread of colds and flu among household members. Researchers followed 2,788 people in 450 households in Northern Manhattan for 15 months. They …

This study looked at how well the seasonal flu vaccine works in adults who are hospitalized with severe flu-like illness. Researchers compared vaccinated and unvaccinated patients across a network of French hospitals to see if the vaccine reduced confirmed flu cases. The goal is …

This study tested a new medicine called rezafungin to see if it can prevent serious fungal infections in adults getting a bone marrow transplant. About 600 participants received either rezafungin or the standard treatment. The goal was to see if rezafungin helps more people stay …

This study tested the drug letermovir to prevent CMV infection in 15 adults who had a lung transplant for idiopathic pulmonary fibrosis (IPF). Participants took letermovir daily for 6 or 12 months depending on their CMV risk. The goal was to see if the drug could prevent CMV infe…

This study tested whether a new vaccine against certain E. coli bacteria (ExPEC9V) can be given at the same time as a high-dose flu shot in adults aged 65 and older. The goal was to see if the immune response to both vaccines remains strong when given together. About 959 particip…

This study tested a single dose of nirsevimab, a lab-made antibody, in 800 healthy preterm and term infants in China to see if it could prevent serious lung infections caused by RSV. The goal was to reduce doctor visits and hospital stays during the RSV season. Results showed the…

This study tested whether sending text message reminders to patients and nudging their doctors could increase flu vaccination rates. Over 26,000 adults aged 50 and older took part. The approach used simple, low-cost tools like pre-visit texts and automatic vaccine orders in the e…

This early-phase study tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein that can fuel cancer growth. Researchers checked for side effects and m…

This study tested whether a daily probiotic called LC-Plasma can prevent upper respiratory tract infections (like colds) in healthy adults aged 18-60 who often get sick. Over 600 participants took either the probiotic or a placebo pill every day for 24 weeks. Researchers tracked …

This study tested an injection called TNM001 in over 2,200 babies under 1 year old to see if it could prevent serious lung infections caused by RSV. The goal was to reduce the number of babies who get sick enough to need medical care. The study compared the shot to a placebo to c…

This study tested a new medicine called TNM001 to prevent severe RSV lung infections in high-risk infants under 1 year old. About 201 babies received either the antibody or a placebo, and were monitored for 270 days. The goal was to see if the antibody could safely reduce serious…

This large study tested a new medicine called clesrovimab to prevent RSV, a serious lung infection, in healthy babies born early or full-term. Over 3,600 infants received either the medicine or a placebo. The goal was to see if the medicine could reduce the number of babies who g…

This study looked at whether the drug posaconazole can prevent fungal lung infections in people who have had a stem cell transplant. 360 patients took the drug for 90 days after their transplant. Researchers checked drug levels in the blood and tracked how many patients got infec…

This study looked at whether a single shot of nirsevimab (Beyfortus) can prevent RSV and other respiratory infections in infants under 1 year old. Researchers reviewed medical records from 816 babies at seven hospitals in China, comparing those who got the shot to those who did n…

This completed study tested whether adding toothbrushing and oral gel to standard chlorhexidine mouthwash could prevent ventilator-associated pneumonia (VAP) in 100 ICU patients. The intervention group received comprehensive oral care, while the control group got mouthwash alone.…

This study tested how well two different 2023-2024 updated COVID-19 vaccines (Novavax and Pfizer mRNA) protect adults from getting sick with COVID-19. About 1,200 adults who had already received at least two mRNA vaccine doses were randomly assigned to get either the Novavax or P…

This study tested whether far-UVC light, a safe type of ultraviolet light, can reduce respiratory infections like flu and COVID-19 in long-term care facilities. The trial involved 550 elderly residents who are at higher risk due to age and health conditions. The light was used as…

This study checked the safety of a quadrivalent flu vaccine in over 42,800 people aged 3 and older. Researchers looked for side effects within 30 minutes, 7 days, and 28 days after vaccination. The goal was to find any very rare adverse reactions. Results help confirm the vaccine…

This study tested whether the dietary supplement MitoQ could prevent severe viral infections, like COVID-19, in adults who had close contact with a sick person. Eighty asymptomatic adults were given MitoQ or no treatment and monitored for illness. The goal was to see if the suppl…

This study tested different strategies to increase RSV vaccination among 50 pregnant people. The goal was to find the best way to encourage vaccination at the right time during pregnancy to protect newborns from severe RSV. The study compared early and late vaccination timing alo…

This study tested whether a high-dose flu vaccine works better than the standard dose in adults aged 50 to 64. About 1,180 participants received either the high-dose or standard-dose shot, and researchers measured their immune response 28 days later. The goal is to see if the str…

This study tested the H1N1 flu vaccine in 439 people with cystic fibrosis to see if it prevents the flu and is safe. Participants included adults, children, pregnant women, and lung transplant recipients. Researchers measured immune response and tracked flu symptoms, using antivi…

This study looked at over half a million older adults in Taiwan who were hospitalized for a bone fracture. Researchers compared those who had received a flu vaccine in the past year to those who had not. They found that vaccinated patients had fewer infections and a lower chance …

This study looked at how well a single dose of BEYFORTUS (nirsevimab) protects infants from serious RSV infections that require a doctor visit or hospital stay. Researchers followed nearly 50,000 babies during their first RSV season. The goal was to see if the shot reduces cases …

This study tested a new pneumococcal vaccine (V116) given at the same time as the seasonal flu shot in 1,080 adults aged 50 and older. The goal was to see if giving both vaccines together is safe and produces a strong immune response. Results help determine whether combining thes…

This study tested a new vaccine called AFX3772 in healthy infants about 2 months old. The goal was to see if it is safe and triggers a strong immune response against pneumococcal bacteria, which can cause pneumonia and other serious infections. Researchers compared AFX3772 with e…

This study tested a single injection of nirsevimab in over 8,000 healthy infants under 1 year old to see if it could prevent hospitalizations from RSV, a common respiratory virus. Babies received either the shot or no intervention and were followed for up to 6 months. The goal wa…

This study tested whether sending a one-time text reminder to parents could increase flu vaccination rates among children. Over 228,000 patients aged 6 months to 18 years at Children's Hospital of Philadelphia were included. Researchers compared vaccination rates 30 days after th…

This study tested a high-dose flu vaccine in 165 healthy adults aged 65 and older in Taiwan. Researchers compared the immune response and safety of the high-dose shot to a standard-dose flu vaccine. The goal was to see if the stronger dose could provide better protection against …

This study tested whether a teacher-led hygiene campaign in primary schools in Lagos, Nigeria, could improve handwashing and prevent diarrhea, undernutrition, and pneumonia in children. Over 3,500 children from schools with clean water and toilets took part. Researchers measured …

This study tested a high-dose flu vaccine against a standard-dose one in 2,100 adults aged 60 and older in Japan. The goal was to see if the high-dose version triggers a stronger immune response. Participants received one shot and were followed for 28 days to measure antibody lev…

This phase 3 study tested a quadrivalent (four-strain) influenza vaccine against two trivalent (three-strain) vaccines in over 7,100 Chinese participants aged 6 months and older. The goal was to see if the quadrivalent vaccine triggers a stronger immune response and provides broa…

This study tested whether a high-dose flu vaccine (QIV-HD) works better than the standard-dose vaccine in adults aged 60 and older. Over 1,500 healthy volunteers received either the high-dose or standard shot. Researchers measured immune responses 28 days later to see if the high…

This study combines data from two large trials in Denmark and Spain involving over 466,000 older adults. It compares the high-dose flu vaccine (Efluelda/Fluzone High-Dose) to the standard-dose flu shot to see which better prevents severe outcomes like hospitalization for flu or p…

This study looked at whether it's safe and effective to give a high-dose flu vaccine and a Moderna COVID-19 booster at the same time to adults 65 and older. 306 volunteers who had already received two Moderna shots took part. Researchers measured side effects and antibody levels …

This study looked at whether giving antibiotics early to trauma patients on breathing machines can prevent ventilator-associated pneumonia. Researchers analyzed data from 2,143 adults admitted to intensive care after severe trauma. The goal was to see if early antibiotics reduce …

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This large study tested whether a high-dose flu vaccine works better than the standard-dose shot in adults 65 and older. Over 332,000 participants were randomly assigned to receive either the high-dose or standard-dose vaccine. Researchers tracked hospitalizations for flu, pneumo…

This study tested whether treating private well water with ultraviolet (UV) light can prevent stomach and respiratory infections in children under 5. Researchers gave 28 Pennsylvania households either a real UV device or a fake one and tracked illness symptoms via weekly texts. T…

This study in Blantyre, Malawi, compares two schedules of the pneumococcal conjugate vaccine (PCV13): the current 3-dose schedule without a booster (3+0) versus a 2-dose schedule with a booster at 9 months (2+1). The goal is to see if the booster reduces carriage of vaccine-type …

This study tests a personalized approach to giving the steroid dexamethasone to hospitalized adults with pneumonia. Instead of a standard dose, the amount is adjusted daily based on a blood marker called C-reactive protein (CRP). The goal is to reduce steroid side effects while s…

This study tested whether an extended-release form of nalbuphine, a pain medication, can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF). 165 participants received either different doses of the drug or a placebo for 6 weeks. The main goal was to see if …

This pilot study tested whether adding a vibrating chest vest to a standard cough-assist machine could reduce lung infections and hospital stays in people with ALS who use breathing support. Fourteen patients were randomly assigned to use either the vest plus cough assist or the …

This study looked at whether giving extra oxygen (40%) during exercise helps people with idiopathic pulmonary fibrosis (IPF) who do not have low oxygen at rest but do get low oxygen when active. Fifteen stable IPF patients completed exercise tests while breathing either oxygen or…

This study looked at whether taking a probiotic called LP28 can help older adults fight off colds and feel better. 102 people who had at least two colds in the past year took part. Researchers measured cold symptoms and immune cell levels to see if the probiotic made a difference…

This study looked at whether breathing 60% oxygen during exercise helps people with idiopathic pulmonary fibrosis (IPF) who are taking nintedanib. 78 participants exercised on a bike or walked while getting either high oxygen or standard care. The goal was to see if they could ex…

This study followed 18 people in Spain with idiopathic pulmonary fibrosis (IPF) or other progressive lung scarring who were taking nintedanib (OFEV) and had developed diarrhea. The goal was to see if the diarrhea could be controlled after 12 weeks while staying on the full dose. …

This study tested whether low-dose morphine can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. Forty-four participants received either morphine or a placebo for two weeks, then switched after a week off. The goal was to see if…

This study compared a single dose of baloxavir marboxil to a 5-day course of oseltamivir in 100 Chinese children aged 1 to 12 with flu symptoms. The main goal was to check safety, including side effects. Researchers also measured how quickly symptoms like cough and fever improved…

This study tested four different nasal aspirators (including electric and manual types) in 28 infants with colds. Caregivers rated how easy each device was to use and how it affected their baby's sleep, feeding, and breathing. The goal was to find which device parents prefer and …

This study compared two ways to fix a tight upper lip frenulum (lip-tie): using a scalpel or a diode laser. Some patients also got low-level laser therapy after surgery to help healing. The trial measured pain, speech, chewing, and quality of life in 94 adults. Results may help d…

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study tested a new device called the COMBO Endoscopy Oropharyngeal Airway in 104 adults undergoing a sedated lung procedure (fiberoptic bronchoscopy). The device combines oxygen delivery, airway support, and breathing monitoring into one tool. The goal was to see if it could…

This completed study looked at how two different Robitussin cough syrup regimens affect quality of life in 244 adults with coughs from the common cold. One group used a single daytime/nighttime syrup, while the other used separate daytime and nighttime syrups. Researchers measure…

This study looked at 200 children aged 2 to 12 with mild to moderate croup, a viral infection that causes a barking cough and breathing trouble. Researchers compared giving the steroid dexamethasone as a pill versus an injection to see which works better for easing symptoms. The …

This study looked at 80 children aged 1 month to 5 years with severe breathing problems from pneumonia or bronchiolitis. It compared two non-invasive breathing support methods: High Velocity Nasal Insufflation (HVNI) and Nasal Continuous Positive Airway Pressure (CPAP). The goal …

This study looked at whether taking probiotics can reduce a protein in the blood linked to acne inflammation. Researchers measured this protein in 50 adults with mild to moderate acne before and after probiotic treatment. The goal was to see if probiotics could help ease acne sym…

This completed trial tested three common cough treatments—levodropropizine, a codeine combination, and ivy leaf extract—against a placebo in 196 adults with acute cough from upper respiratory infections. Participants took the medicine three times a day for four days. The main goa…

This study tested whether a stellate ganglion block (an injection near nerves in the neck) can improve distorted sense of smell (parosmia) caused by COVID-19. 48 adults with long-term smell issues after COVID took part. Half received the nerve block, half got a placebo (saline). …

This study tested a drug called orvepitant to see if it can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a serious lung disease. About 80 adults with IPF and persistent cough took either orvepitant or a placebo in two separate periods, and researche…

This Phase 3 trial tested whether a single pill containing paracetamol (pain reliever/fever reducer), fexofenadine (antihistamine), and phenylephrine (decongestant) works better than a placebo for treating cold and flu symptoms. 567 adults in Brazil took the combo pill or a place…

This study tested whether a 25% lower dose of dexamethasone (0.15 mg/kg) works as well as the standard dose (0.6 mg/kg) for treating croup in children. Croup is a viral infection that causes airway swelling and breathing trouble. The trial involved 50 children and tracked return …

This study follows 31 people with progressive fibrosing interstitial lung disease (PF-ILD) for one year. Researchers compare imaging scans (CT and MRI) with standard breathing tests to see which method best tracks lung damage over time. The goal is to find better ways to measure …

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

This completed study looked at how genetic differences might change the way immune cells in the lungs respond to environmental triggers like dust and germs. Researchers collected blood and lung samples from 20 healthy adults to compare cell function between people with different …

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This study investigates how a specific strain of pneumococcus bacteria (serotype 3) colonizes the nose of healthy adults. Researchers will give volunteers nose drops containing the bacteria to see what dose leads to colonization and how long the bacteria stay before the immune sy…

This study looks at how regular winter swimming—bathing in cold open water during winter—affects blood cells, blood flow, and stress-fighting enzymes in healthy men. Researchers compare winter swimmers to a control group who never swim in cold water and have a sedentary lifestyle…

This completed study from France looked at health records of 2 million adults to see if having pneumonia increases the chance of later heart problems like heart attacks, strokes, or heart failure. Researchers compared people who had pneumonia with similar people who did not. The …

This study tested a drug called suzetrigine, which blocks a specific nerve channel (NaV1.8) involved in pain signaling. In 67 healthy volunteers, tiny amounts were injected into the skin alongside a placebo and lidocaine. Participants received six different types of brief pain (e…

This study measured levels of mannose-binding lectin (MBL), a protein involved in immune response, in 97 ICU patients with severe H1N1-related acute respiratory distress syndrome (ARDS). Researchers wanted to see if higher or lower MBL levels were linked to a higher risk of death…

This study tracks how many infants in Germany receive nirsevimab, a long-acting antibody that helps protect against severe RSV disease. Researchers will survey parents of babies born during three RSV seasons (2024–2027) to measure immunization rates. The goal is to see how well t…

This study looks at how common pneumococcus bacteria are in the noses and throats of healthy Vietnamese children aged 6 months to 5 years. Researchers will take a simple swab and interview parents about factors like vaccination history, antibiotic use, and living environment. The…

This pilot study looked at how well the antibiotic azithromycin kills Mycobacterium avium complex (MAC) bacteria in the lungs during the first 14 days of treatment. Ten adults with MAC lung disease took azithromycin daily, and researchers measured bacterial levels in their sputum…

This study tested whether a short animated video program could help first-graders learn how to prevent respiratory infections like colds. Forty-eight children in Turkey watched a 15-minute cartoon and practiced handwashing and coughing/sneezing etiquette over three weeks. Researc…

This study tracked 241 ICU patients with severe influenza to see how many developed a fungal lung infection called IAPA. Researchers collected blood and fluid samples to identify risk factors. The goal is to help doctors spot high-risk patients earlier.

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This observational study at Hospital H+ Querétaro looked at 150 patients with suspected or confirmed invasive aspergillosis, a serious fungal infection. Researchers measured a substance called galactomannan in lung fluid samples to see if higher levels were linked to worse outcom…

This completed study looked at 104 adults in the ICU with severe pneumonia caused by three common bacteria. Researchers checked whether the bacteria were sensitive to amoxicillin/clavulanic acid (AMC) or to third-generation cephalosporins (3GC), which are standard treatments. The…

This completed study looked at people with genetic conditions that affect how the lungs clear mucus, such as cystic fibrosis and primary ciliary dyskinesia. Researchers examined 87 participants, including healthy volunteers, to understand why these patients get repeated lung infe…

This study examined 41 patients treated for non-tuberculous mycobacteria (NTM) infections, comparing those with and without cancer. The goal was to count side effects from NTM treatment in each group to understand why cancer patients often stop therapy. Researchers hope this will…

This study looked at why some older adults (age 50 and up) maintain flu-fighting antibodies longer after getting the flu vaccine. Researchers enrolled 510 people and measured their immune response over time. The goal was to understand factors that help maintain protection, not to…

This study tested whether using a device that sends mild electrical pulses to the leg muscles (NMES) could help older adults recover strength and mobility after being hospitalized for a COPD flare-up or pneumonia. Seven participants used the device in the hospital and at home for…

This study looked at whether certain genes make people who are regularly around pigeons more likely to develop a type of lung disease called hypersensitivity pneumonitis. Researchers analyzed the DNA of 475 pigeon fanciers to find genetic markers linked to lung scarring. The goal…

This study looked at 537 patients with respiratory infection symptoms to see how the types of viruses and bacteria changed from the COVID-19 pandemic period to after it. Researchers used a special PCR test to detect multiple germs at once. The goal was to understand how pandemic …

This study looked at how the immune system of healthy adults aged 65-75 responds to RSV, a common cause of chest infections. Researchers gave volunteers a mild RSV infection and took blood and nose samples to find immune markers linked to protection. The goal is to use these find…

This study looked at 56 patients in a French hospital who had infections from a rare type of Klebsiella pneumoniae bacteria that can be treated with the common antibiotic amoxicillin. Researchers used genetic sequencing to understand why these bacteria are sensitive to amoxicilli…

This study from the University of Sao Paulo looked at whether measuring blood pressure during an exercise test can help predict outcomes in adults with flu-like symptoms, especially those who are unvaccinated. Researchers enrolled 62 participants and followed them for 30 days. Th…

This completed study tested whether an AI system could improve how ventilators are set for children (ages 1 month to 18 years) in the pediatric ICU with breathing problems like pneumonia or respiratory failure. Researchers compared AI-generated recommendations to the actual adjus…

This completed study in Hong Kong enrolled 977 adults aged 18-45 to understand how getting the flu vaccine year after year changes the body's immune response. Participants received either the Flublok vaccine or a saline placebo. Researchers measured antibody levels and looked for…

This study looked at how a new drug called HEC585 interacts with two existing medicines for idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. Thirty-three healthy adults took part to measure drug levels and safety. The goal was to see if combining these drugs cause…

This study looked at how the COVID-19 pandemic and related public health measures changed asthma control in children aged 3 to 16. Researchers compared asthma control and flare-ups in 577 children during the pandemic to data from before the pandemic. The goal was to see if lockdo…

This study followed 241 adults hospitalized with the flu to see how the infection impacts the heart. Researchers tracked heart complications like new or worsening heart failure, heart attacks, and cardiac arrest. The goal was to better understand the link between influenza and he…

This study tested a program where rural hospitals connect with an infectious disease expert through video calls to improve antibiotic use. The goal was to reduce unnecessary antibiotics and fight drug-resistant infections. Eight VA medical centers participated, and the approach h…

This completed study gave 11 healthy adults a specially made H3N2 flu virus via nasal spray to see how their immune systems reacted. Participants were quarantined for at least 8 days in a hospital-like setting. The goal was to learn more about flu infection and immune response, n…

This study tested whether a tool called the ARISCAT score can predict lung complications (like pneumonia or collapsed lung) after major abdominal cancer surgery. Researchers followed 410 adults who had surgery under general anesthesia. The goal was to see if the score could help …

This study tested a new way to decide if patients with lower respiratory tract infections need antibiotics. Instead of relying on standard methods, doctors used a step-by-step approach: a clinical score, a lung ultrasound, and a blood test for procalcitonin. The goal was to reduc…

This completed study from France compared over 1,500 ICU patients on ventilators to see if those with COVID-19 develop more lung infections than patients with influenza or no viral pneumonia. Researchers tracked cases of ventilator-associated pneumonia and tracheobronchitis. The …

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This completed study tested different doses of an influenza A H3N2 virus in 33 healthy adults aged 18 to 55. The goal was to find a dose that safely causes mild flu symptoms, so this virus strain can be used in future trials to test new vaccines or treatments. Participants were m…

This study looked at whether a set of care guidelines (called a pathway) could help doctors and nurses in community hospitals use the best treatments for children hospitalized with asthma, pneumonia, or bronchiolitis. Over 11,000 children took part across many hospitals. The goal…

This study tested whether a new type of PET scan can measure how the supplement EGCG (found in green tea) affects collagen buildup in the lungs of people with idiopathic pulmonary fibrosis (IPF). Twelve participants who were already in a larger EGCG study received an injection of…

This completed study in France tracked over 10,000 people with idiopathic pulmonary fibrosis to see how long they continued taking antifibrotic drugs (nintedanib or pirfenidone). The goal was to measure the percentage still on treatment after 30 months and identify factors linked…

This study looked at how bacteria living in the nose and gut influence the immune response to a nasal flu vaccine in 201 children aged 6 to 17. Half got the vaccine right away, half waited 28 days. Researchers collected samples before and after vaccination to measure antibodies a…

This study tested whether electronic alerts and structured messages from an antibiotic stewardship team could reduce antibiotic use in hospitalized patients with suspected pneumonia. 107 adults were enrolled, and those with test results suggesting viral infection were randomly as…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study looked at how children's immune systems respond to the seasonal flu vaccine. Researchers collected nasal and finger-prick blood samples from 65 kids aged 2-17 before and after they got their flu shot. The goal was to understand both systemic and nasal immunity, which c…

This study looked at how adults aged 18 and older experienced a trivalent recombinant influenza vaccine. Over 1,000 participants completed a short online survey about their injection experience, side effects, and willingness to get vaccinated again. The goal was to better underst…

This study followed 51 people with idiopathic pulmonary fibrosis (IPF) for 6 months to understand how their shortness of breath changes over time. Researchers measured both the physical sensation and the emotional impact of breathlessness, and looked at how these relate to lung f…

This study tested whether a rapid test called Unyvero could help doctors choose the right antibiotic sooner for patients with pneumonia who are on breathing machines in the ICU. The test looks for bacteria and their resistance genes in just a few hours, compared to standard lab c…

This study surveyed 418 respiratory doctors in the Asia-Pacific region to understand how they diagnose tuberculous pleuritis, a type of TB that affects the lining around the lungs. The goal was to see which tests are used, how available they are, and how doctors decide to start t…

This study looked at why the live attenuated influenza vaccine (LAIV), given as a nasal spray, is less effective in adults than in children. Researchers measured antibody levels in 51 healthy adults after vaccination to understand the immune response. The goal is to use these ins…

This study examined whether giving ICU patients the same antibiotic they had before, versus a different one, affects the development of drug-resistant bacteria. Researchers looked at 197 adults with Gram-negative infections. The goal was to understand how antibiotic choice impact…

This study checked how accurate a new test (Xpert Expanded Respiratory Panel) is at finding respiratory infections. Researchers tested nose swabs from 3,200 people with symptoms and compared results to other tests. The goal was to see if the new test works well enough for routine…

This study tested whether adding infectious disease experts to primary care teams helps reduce unnecessary antibiotic use. Over 1,300 patients from six clinics in Spain took part. Doctors in the expert-advised group could call or meet with specialists to discuss tricky cases. The…

This study aimed to find biomarkers in patients with pneumonia. Researchers enrolled 272 participants and tracked outcomes like death in the hospital and whether the pneumonia got worse. The goal was to better understand the disease, not to test a new treatment.

This study observed over 1,800 children hospitalized for serious breathing problems like bronchiolitis, pneumonia, or asthma. It aimed to track how many children were hospitalized for bronchiolitis after a new immunization became available. The study did not test any new treatmen…

This study followed over 3,800 women who had received an RSV vaccine or a placebo in a previous pregnancy to see if it was safe in later pregnancies. No new vaccine was given—researchers just tracked pregnancy outcomes and baby health up to 42 days after birth. The goal was to de…

This completed early-phase study tested a new way to study Strep A bacteria, which causes strep throat and can lead to serious heart disease. Researchers safely exposed 40 healthy adults aged 18-40 to a specific strain of Strep A under controlled conditions. The goal was to see h…

This study gave healthy adults a mild dose of respiratory syncytial virus (RSV) in a controlled hospital setting to learn how the body fights the infection. Thirty-two volunteers aged 18 to 50 stayed in isolation for about 10 days while researchers monitored symptoms, viral shedd…

This study tested three different oximeters (Masimo, Nellcor, Nonin) at various oxygen targets in 40 patients with and without COPD. The goal was to see how the choice of oximeter and target affects the amount of oxygen needed. Results could help guide safer oxygen therapy.

This study looked at whether new RSV prevention medicines given to infants or pregnant women reduced hospitalizations for RSV in children under 2. Researchers analyzed health records from over 2,700 children in the Australian Capital Territory. The goal was to see if the 2025 pre…

This study tested whether measuring a protein called MxA in the blood can help doctors decide when to stop antiviral drugs in patients with flu or COVID-19. Researchers enrolled 86 adults and compared standard care to MxA-guided treatment. The goal was to see if the test could re…

This study surveyed 5,000 German adults to find out how many people got their flu shot during the current respiratory season. The focus was on adults aged 60 and older, as well as those with chronic illnesses. By collecting this data, researchers hope to help public health offici…

This study tested a simple questionnaire to help match newly diagnosed idiopathic pulmonary fibrosis (IPF) patients to the right level of palliative care. Researchers asked 30 patients a few questions to see if the tool could predict their needs as accurately as a doctor's judgme…

This study looked at 21 adults with idiopathic pulmonary fibrosis (IPF) to see how a simple arm test (the 6-minute pegboard and ring test) relates to their exercise ability, fatigue, daily activities, and quality of life. Participants performed several physical tests, including w…

This study created and tested a risk score called RESPIRE to predict whether a patient's pneumonia is caused by multidrug-resistant bacteria. Researchers looked at data from 300 adults with community-acquired pneumonia in the emergency department. The goal is to help doctors quic…

This study gave healthy adults a nasal flu vaccine to safely mimic a mild flu infection. Researchers then measured virus levels and immune responses in nasal samples. A small group also had lung function tests. The goal was to create a reliable model for studying flu without caus…

This completed study analyzed over 230,000 adults in France who had lower respiratory tract infections like pneumonia, bronchitis, or flu. Researchers used anonymous electronic health records from 2015 to 2024 to describe patient characteristics, how often antibiotics were prescr…

This study looked at how well the 2023 and 2024 flu vaccines protect against influenza A. Researchers gave the 2023 vaccine to 23 healthy adults between May and June 2024, when the vaccine was about to expire, to compare their immune responses with people who got the 2023 vaccine…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…

This study tested a Turkish version of the Respiratory Distress Observation Scale (RDOS) in 100 adult palliative care patients who cannot describe their breathing trouble. The scale uses eight physical signs like heart rate and restlessness to rate distress. The goal was to see i…

This study looked at how fat (lipid) metabolism is linked to severe pneumonia caused by COVID-19 versus other germs. Researchers measured cholesterol and other fat-related substances in 62 adults with severe pneumonia. The goal was to understand these differences, not to test a t…

This study looked at 76 ICU patients with severe pneumonia who were placed on a lung machine (ECMO) and given minimal ventilator support. Researchers wanted to see if this approach changed how well the kidneys worked. They reviewed medical records from 2019 to 2023, comparing uri…

This completed study looked at 179 ICU patients with pneumonia to figure out the best doses of common antibiotics. Researchers took blood and lung fluid samples to measure how the drugs move through the body. The goal was to create personalized dosing plans that ensure enough ant…

This study looked at how the immune system of older adults (ages 60-75) responds to a controlled infection with respiratory syncytial virus (RSV). Researchers gave 28 healthy volunteers a weakened form of the virus via nasal drops and monitored their symptoms and immune reactions…

This study looked at how the flu virus changes the types of bacteria living in the nose and throat, and how the body's immune system reacts. Researchers gave 17 healthy adults either a flu vaccine nasal spray or a saltwater mist, then tracked bacterial changes and immune response…

This study looked at 150 adults who had severe COVID-19 pneumonia to find out how many develop long-term lung issues. Researchers used CT scans to check for lung scarring and other damage months after infection. The goal is to better understand the lasting effects of severe COVID…

This study looked at 688 adults hospitalized with pneumonia in 11 hospitals in Colombia to find out how many cases were caused by pneumococcal bacteria. Researchers also identified which bacterial strains were most common and whether current vaccines cover them. The goal is to he…

This study tested whether taking the statin drug atorvastatin changes the body's immune response to the flu vaccine. 63 adults took either a statin or a placebo for four weeks before and after getting the flu shot. Researchers measured antibody levels and checked for side effects…

This study looked at 760 children under 8 years old who had surgery with a breathing tube. Some had cold symptoms, others did not. Researchers tested five simple signs—like facial grimace and eye opening—to see if they could predict a safe breathing tube removal. The goal was to …

This study aimed to create a way for doctors to predict which children with Mycoplasma pneumonia might become severely ill. Researchers looked at data from 964 children to build and test a prediction model. The goal is to help doctors act faster and improve outcomes for kids at r…

This completed Phase 1 trial studied how deupirfenidone (LYT-100) and nintedanib interact in 24 healthy adults aged 18-65. Participants took both drugs over several weeks to measure drug levels and check for side effects. The goal was to understand potential drug-drug interaction…

This study reviewed the medical records of 239 patients aged 65 and older who had major abdominal surgery. The goal was to find out what factors increase the risk of lung complications like pneumonia or respiratory failure after surgery. By understanding these risks, doctors may …

This study reviewed records from 542 adults in 20 ICUs across China who had severe flu (Influenza A) and breathing failure. Researchers divided patients into those who also developed a fungal lung infection (aspergillosis) and those who did not, to understand risk factors and sur…

This study tested whether a special belt that creates images of the lungs (Electrical Impedance Tomography) can safely help doctors choose the best pressure settings on a breathing machine for infants under 3 years old. The study included 14 children with various serious conditio…

This study looked at 32 adults in the ICU on ECMO life support who had severe influenza or COVID-19 and a serious fungal lung infection called aspergillosis. Researchers measured how the antifungal drug voriconazole behaves in the body to find the best dose for these very ill pat…

This study tested a computer tool that helps nurses decide when antibiotics are needed for common respiratory infections like colds and sore throats. The tool, built into the electronic health record, calculates a patient's risk and suggests appropriate care. Researchers measured…

This study looked at 263 adults on breathing machines who had signs of pneumonia. Researchers tested their blood and lung fluid to see how many had a serious fungal infection called invasive pulmonary aspergillosis. The goal was to find out how common this infection is in this gr…

This study looked at 250 people to understand why some smokers develop a rare lung condition called combined pulmonary fibrosis and emphysema (CPFE). Researchers compared telomere length and genetic mutations in patients with CPFE, those with only fibrosis or emphysema, and healt…

This study tracked 289 healthcare workers in short-stay hospital wards to see how often they caught the flu, both with and without symptoms. Participants gave blood samples and nasal swabs to confirm infections. The goal is to understand how many silent flu cases occur among staf…

This study tested whether a device called MYOTRACE, which measures how hard a person's breathing muscles are working, can help doctors assess patients with respiratory diseases. 56 adults with conditions like COPD or asthma were included. The goal was to see if the device's readi…

This early-stage study tested a new drug called AZD8965 in 147 healthy adults, including Japanese and Chinese participants. The main goal was to check if the drug is safe and how the body processes it, both with and without food. No treatment was given for any disease, so this st…

This completed study looked at medical records of 307 adults in five European countries who were treated with the antifungal drug isavuconazole for serious fungal infections (invasive aspergillosis or mucormycosis). Researchers tracked how well the drug worked (clinical, radiolog…

This study looked at how well different licensed flu vaccines trigger an immune response in adults aged 65 to 74. About 179 participants received one of four flu vaccines over two flu seasons, and researchers measured their antibody levels at several time points. The goal was to …

This completed study looked at how the antibiotics amoxicillin and clavulanic acid get into the infected fluid around the lungs in people with pleural infections. Eleven adults with complicated infections had chest tubes placed and received the antibiotics. Researchers measured a…

This study looked at how the antibiotic ceftobiprole moves through the blood and lungs of 12 adults with severe pneumonia who were on breathing machines. Researchers gave a high dose continuously through a vein and took blood and lung fluid samples to measure drug levels. The goa…

This completed study observed 178 patients with advanced cancer, chronic kidney failure, or chronic lung diseases to assess their palliative care needs and survival factors. Researchers used two scoring tools to evaluate when and how to best introduce palliative care alongside re…

This study followed 919 pregnant women in Paris to see how often they caught H1N1 flu during the 2009 pandemic and what happened to their pregnancies. Researchers also checked if the flu vaccine was safe. The goal was to better understand the risks of flu during pregnancy.

This early-phase study involved 36 healthy Thai adults to see if getting a COVID-19 booster and flu vaccine together is as effective and safe as getting them separately. Researchers measured immune responses and side effects over one month. The goal was to gather information to p…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study looked at 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers collected fluid from the lungs to study the virus and the body's immune response. The goal was to learn more about what causes severe illness, not to test a new treatment.

This completed study looked at 227 adults and children in the intensive care unit with severe flu. Researchers wanted to see if a specific blood marker (soluble HLA-G5) could predict which patients would develop severe breathing failure. They also collected respiratory samples to…

This study followed over 1,000 adults with confirmed or suspected COVID-19 who were admitted to intensive care units (ICUs) across France. Researchers tracked their treatments, complications, and survival at 28 days. The goal was to learn how these patients are managed and what f…

This study tested whether inhaling iloprost, a drug that widens blood vessels in the lungs, can improve oxygen levels in obese patients during one-lung ventilation for lung surgery. 78 participants were randomly assigned to receive either iloprost or a saltwater placebo. The rese…

This study looked at whether a device that delivers rapid puffs of air (intrapulmonary percussive ventilation) can help inhaled medication reach scarred lung areas in people with idiopathic pulmonary fibrosis (IPF). Nine participants inhaled a radioactive tracer with and without …

This study looked at 73 people who were hospitalized with severe COVID-19 pneumonia to see if their lungs still had problems 4 months later. The main focus was on how well oxygen moves from the lungs into the blood. The goal was to better understand these lasting issues so doctor…

This study looked at whether a special type of scan (PET/CT) can help doctors see if treatment for a serious fungal lung infection is working earlier than usual. It involved 51 adults with blood cancer and invasive pulmonary aspergillosis. The goal was to see if the scan results …

This study tested how well the flu vaccine works and if it's safe for people with inflammatory bowel disease (IBD). Researchers compared 228 adults with IBD who were either taking immunosuppressive drugs or not. The goal was to see if the vaccine triggers a strong immune response…

This study looked at over 2,300 children aged 0-12 who had mild cold symptoms before elective non-cardiac surgery. Researchers wanted to see if the COVID-19 pandemic changed the risks of complications like breathing problems or infections. The goal is to help doctors decide the s…

This study looked at whether the seasonal flu vaccine works as well in people with sarcoidosis as it does in healthy people. Researchers gave the flu shot to 190 adults with sarcoidosis and compared their immune response to a group of healthy volunteers. The goal was to see if th…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with lung conditions like COPD, asthma, or COVID-19. Researchers compared the app's cough counts to patients' own reports and expert listening. The goal was to improve …

This study tested ways to reduce unnecessary antibiotic use in hospitalized patients being treated for pneumonia, but who had normal breathing and oxygen levels. Over 600 patients were randomly assigned to usual care, an electronic alert, or pharmacist outreach. The goal was to s…

This study looked at 1000 patients who needed extra tools to place a breathing tube during surgery. Researchers wanted to see if these patients had a higher chance of lung problems like pneumonia afterward. The goal was to better understand risks and improve patient safety.

This study tested whether giving doctors automated reports on their antibiotic prescribing habits could improve how often they follow official guidelines. Researchers looked at over 26,000 patients with pneumonia, ear infections, or sore throat. They compared antibiotic use befor…

This study looked at whether a dietary fiber from baker's yeast (beta-glucan) can improve how well the flu vaccine works in healthy adults aged 50 and older. 78 participants took either the supplement or a placebo before getting their flu shot. Researchers measured antibody level…

This study followed 158 adults with chronic fibrosing interstitial lung disease (a type of progressive lung scarring) who were starting treatment with nintedanib. Researchers wanted to see if changes in lung function (measured by forced vital capacity) over 52 weeks were linked t…

This study followed 38 adults who survived severe breathing failure from the 2009 H1N1 flu. Researchers compared those who needed a machine to oxygenate their blood (ECMO) with those who did not. They measured lung function, quality of life, and mental health at least 9 months af…

This study looked at how a new medicine called nirsevimab affected RSV infections and hospital stays in children under 2 years old in the Australian Capital Territory. Researchers used routine health data from over 2,300 kids to compare RSV cases and emergency visits before and a…

This completed study looked at 60 people with idiopathic pulmonary fibrosis (IPF) to see how common muscle loss (sarcopenia) is and how it affects their quality of life and disease progression. Researchers measured muscle strength, walking speed, lung function, and used a questio…

This study tested a patient engagement tool (PET) designed to encourage COVID-19 and flu vaccination among underserved populations in East London, including minority ethnic groups, migrants, and low-income individuals. Over 5,900 adults from six GP practices were randomly assigne…

This completed study collected blood, urine, and nasal swab samples from 249 adults—some with COVID-19, some with the flu, and healthy controls—at two time points. Researchers used a systems biology approach to analyze the data, aiming to understand why people respond differently…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults aged 65 and older who received the 2020-2021 flu vaccine. The samples were sent to experts at the WHO, CDC, and FDA to help decide which flu strains to include in future vaccines. T…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults 65 and older after they received their seasonal flu vaccines. The samples were sent to health authorities to help decide which flu strains to include in future vaccines. The study d…

This study collected blood samples from 90 children (6 months to under 9 years) and adults 65 and older after they received the 2019-2020 flu vaccine. The samples were sent to health agencies like the WHO and CDC to help them decide which flu strains to include in future vaccines…

This completed study looked at 143 people with two types of lung scarring diseases (IPF and hypersensitivity pneumonitis). Researchers compared three different scoring systems (GAP, ILD-GAP, and CPI) to see which one best predicts how long patients might live. The goal was to fin…

This study tested a new AI system (Janus Pro 1B-CXR) designed to help radiologists interpret chest X-rays. The AI was developed using public data and evaluated in 296 patients with suspected chest diseases. Researchers compared report quality, reading time, and agreement between …

This completed study looked at 234 patients with severe staph pneumonia to see if a toxin called PVL makes the disease worse. Researchers compared survival rates between patients infected with PVL-producing bacteria and those without. They also collected blood samples to explore …

This study tracked nearly 2,500 adults who came to the emergency room during flu season to see how many actually had the flu. By testing everyone with a nasal swab, researchers aimed to find flu cases that might otherwise go unnoticed. The goal is to give hospitals a clearer pict…

This pilot study tested a noninvasive wearable device that measures breathing, heart rate, body temperature, and oxygen levels. Researchers wanted to see if it could help screen for and monitor respiratory infections like COVID-19. Forty healthy adults performed breathing tasks w…

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…

This completed study looked at how 147 healthy hospital workers responded to the seasonal flu vaccine and the H1N1 pandemic vaccine. Researchers measured antibody and cellular immune responses, focusing on how age and previous flu vaccinations affected those responses. The goal w…

This completed study looked at how well the seasonal flu vaccine worked during the 2012-2013 flu season in adults who were hospitalized with flu-like symptoms. Researchers compared vaccinated and unvaccinated patients across a network of French hospitals to see if the vaccine red…