Gene-Tailored treatment shows promise for rare lung disease
NCT ID NCT04300920
First seen Apr 08, 2026 · Last updated May 07, 2026 · Updated 5 times
Summary
This study tested whether adding N-acetylcysteine (NAC) to standard care helps people with idiopathic pulmonary fibrosis (IPF) who have a specific gene variant (TOLLIP TT). The goal was to see if NAC could delay lung function decline, hospital stays, or death. 202 adults with IPF and the TT gene type took part. The approach uses genetics to personalize treatment for a serious lung condition.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Indiana University
Indianapolis, Indiana, 46202, United States
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Lisa Lancaster
Nashville, Tennessee, 37204, United States
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Loyola University
Maywood, Illinois, 60153, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Ohio State University
Columbus, Ohio, 43221, United States
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Piedmont Healthcare
Austell, Georgia, 30106, United States
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Stanford University
Stanford, California, 94305, United States
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Temple University
Philadelphia, Pennsylvania, 19140, United States
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Tulane University
New Orleans, Louisiana, 70112, United States
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University of Arizona
Tucson, Arizona, 85724, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
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University of Rochester
Rochester, New York, 14642, United States
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University of Southern California
Los Angeles, California, 90033, United States
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University of Texas Health San Antonio
San Antonio, Texas, 78229, United States
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University of Texas Southwestern
Dallas, Texas, 75390, United States
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University of Utah Health
Salt Lake City, Utah, 84108, United States
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University of Virginia
Charlottesville, Virginia, 22908, United States
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University of Washington
Seattle, Washington, 98195, United States
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Weill Cornell Medicine
New York, New York, 10016, United States
Conditions
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