Could morphine finally silence the hacking cough of IPF?
NCT ID NCT04429516
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether low-dose morphine can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. Forty-four participants received either morphine or a placebo for two weeks, then switched after a week off. The goal was to see if morphine lowered cough counts and improved quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
morphine sulfate
What this could lead to
If it works, this could provide a new option to ease chronic coughing in people with IPF, improving their daily comfort and quality of life.
What could go wrong
This is a small, early-phase trial with only 44 participants. Morphine may cause side effects like drowsiness or constipation, and the cough relief might not be better than placebo.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for IDIOPATHIC PULMONARY FIBROSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Royal Brompton Hospital
London, SW3 6NP, United Kingdom