New 24-Strain pneumonia vaccine shows promise in infant trial

NCT ID NCT05844423

Completed ⭐️ VACCINE ⭐️ Sponsor: Vaxcyte, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a new vaccine called VAX-24, which targets 24 types of pneumococcal bacteria, in 802 healthy infants. The babies received four doses at 2, 4, 6, and 12-15 months old, alongside routine vaccines. The goal was to check safety and how well the vaccine triggers an immune response compared to current vaccines that cover fewer strains.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 24-valent pneumococcal conjugate vaccine (VAX-24)
What this could lead to: If successful, this vaccine could protect infants against more strains of pneumococcal bacteria than current vaccines, potentially preventing more cases of pneumonia, meningitis, and ear infections.
What could go wrong: This is a phase 2 dose-finding study, so it is still early. The vaccine may not prove more effective or as safe as existing vaccines, and side effects like injection-site reactions or fever are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pneumonia pneumococcal infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PNEUMOCOCCAL VACCINES

Contacts and locations

Locations

ACC Pediatric Research

Haughton, Louisiana, 71037, United States
Allegheny Health and Wellness Pavilion

Erie, Pennsylvania, 16506, United States
Alliance for Multispecialty Research

Layton, Utah, 84041, United States
Alliance for Multispecialty Research

Murray, Utah, 84107, United States
Alliance for Multispecialty Research

Provo, Utah, 84604, United States
Alliance for Multispecialty Research

Roy, Utah, 84067, United States
Alliance for Multispecialty Research

Syracuse, Utah, 84075, United States
Coastal Pediatric Research

Summerville, South Carolina, 29486, United States
Holston Medical Group

Kingsport, Tennessee, 37660, United States
Jedidiah Clinical Research

Tampa, Florida, 33617, United States
Kentucky Pediatric/ Adult Research

Bardstown, Kentucky, 40004, United States
Kool Kids Pediatrics

Houston, Texas, 77065, United States
Madera Family Medical Group

Madera, California, 93637, United States
Meridian Clinical Research

Hastings, Nebraska, 68901, United States
Midwest Children's Health Research Institute

Lincoln, Nebraska, 68504, United States
Midwest Children's Health Research Institute

Lincoln, Nebraska, 68505, United States
Midwest Children's Health Research Institute

Lincoln, Nebraska, 68516, United States
Midwest Children's Health Research Institute

Lincoln, Nebraska, 68522, United States
Ohio Pediatric Research Assn.

Dayton, Ohio, 45414, United States
Palmetto Pediatrics, PA

North Charleston, South Carolina, 29406, United States
Pediatric Associates

Houston, Texas, 77087, United States
Pediatric Center

Richmond, Texas, 77469, United States
Pediatric Research of Charlottesville, LLC

Charlottesville, Virginia, 22902, United States
The Children's Clinic of Jonesboro, P.A.

Jonesboro, Arkansas, 72401, United States
Tribe Clinical Research at Parkside Pediatrics

Simpsonville, South Carolina, 29680, United States
UPMC Bass Wolfson Cranberry

Cranberry Township, Pennsylvania, 16066, United States
UPMC Children's Community Pediatrics Bass Wolfson-Squirrel Hill

Pittsburgh, Pennsylvania, 15217, United States
UPMC Children's Community Pediatrics South Hills-Jefferson Hills

Jefferson Hills, Pennsylvania, 15025, United States
UPMC Children's Community Pediatrics-Castle Shannon

Pittsburgh, Pennsylvania, 15234, United States
UPMC Primary Care Center Oakland

Pittsburgh, Pennsylvania, 15213, United States
Ventavia

Houston, Texas, 77008, United States
Ventavia Research Group

Burleson, Texas, 76028, United States

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