One shot for two viruses? new combo vaccine trial shows promise

NCT ID NCT06695130

Completed ⭐️ VACCINE ⭐️ Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a single combination vaccine that targets both COVID-19 and influenza in adults aged 50 and older. About 980 participants received either the combo shot, the flu vaccine alone, the COVID-19 vaccine alone, or separate shots in each arm. Researchers monitored safety and immune responses for one year. The goal is to see if one injection can effectively protect against both viruses.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Combination vaccine (recombinant influenza vaccine plus adjuvanted recombinant COVID-19 vaccine)
What this could lead to: If successful, this could lead to a single annual shot that protects against both COVID-19 and influenza, simplifying vaccination for older adults.
What could go wrong: This is an early-phase trial (Phase 1/2) with only 980 participants, so results may not confirm broad effectiveness or safety. The combination might not work as well as separate vaccines.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 IMMUNIZATION INFLUENZA IMMUNIZATION

Contacts and locations

Locations

Central Phoenix Medical Clinic- Site Number : 8400009

Phoenix, Arizona, 85020, United States
Optimal Research - Florida- Site Number : 8400006

Melbourne, Florida, 32934, United States
Optimal Research - Illinois- Site Number : 8400008

Peoria, Illinois, 61614, United States
Synexus Clinical Research US - Anderson- Site Number : 8400001

Anderson, South Carolina, 29621, United States
Synexus Clinical Research US - Cincinnati- Site Number : 8400003

Cincinnati, Ohio, 45236, United States
Synexus Clinical Research US - Evansville- Site Number : 8400004

Evansville, Indiana, 47714, United States
Synexus Clinical Research US - Minneapolis- Site Number : 8400011

Richfield, Minnesota, 55423, United States
Synexus Clinical Research US - Orlando- Site Number : 8400007

Orlando, Florida, 32806, United States
Synexus Clinical Research US - Vista- Site Number : 8400010

Vista, California, 92083, United States
Synexus Clinical Research US, Inc. - Cerritos- Site Number : 8400002

Cerritos, California, 90704, United States
Synexus-Las Vegas- Site Number : 8400005

Las Vegas, Nevada, 89113, United States
Walgreens Clinical Trials-Malden- Site Number : 8400012

Malden, Massachusetts, 02148, United States

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