New mRNA vaccine targets bird flu pandemic threat

NCT ID NCT06727058

Completed ⭐️ VACCINE ⭐️ Sponsor: Sanofi Pasteur, a Sanofi Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new mRNA vaccine designed to protect against H5 pandemic flu strains. Researchers gave 276 healthy adults one of three doses or a placebo to check safety and immune response. The goal is to find the right dose for future studies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pandemic flu H5 mRNA vaccine
What this could lead to: If successful, this could lead to a safe and effective vaccine against H5 pandemic flu strains, helping protect populations during future outbreaks.
What could go wrong: This is an early-phase trial with only 276 participants, so results may not apply to larger or more diverse groups. The vaccine may not produce strong enough immunity or could cause side effects.

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Conditions

The condition(s) this trial relates to.

avian influenza prevention target influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLUENZA IMMUNIZATION

Contacts and locations

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Locations

ARSN-Lakeland CRU- Site Number : 8400006

Lakeland, Florida, 33803, United States
Accel Research Site - NeuroStudies.net, LLC - ERN - PPDS- Site Number : 8400003

Decatur, Georgia, 30030-2627, United States
Accel Research Sites - St. Petersburg- Site Number : 8400004

Largo, Florida, 33777, United States
Accel Research Sites Network - DeLand Clinical Research Unit- Site Number : 8400002

DeLand, Florida, 32720, United States
Atlanta Clinical Research Center- Site Number : 8400007

Atlanta, Georgia, 30342, United States
Charlottesville Medical Research- Site Number : 8400005

Charlottesville, Virginia, 22911, United States
Coastal Carolina Research Center - North Charleston- Site Number : 8400001

North Charleston, South Carolina, 29405, United States
Olympus Clinical Research - Sugar Land- Site Number : 8400009

Sugar Land, Texas, 77479, United States
QUEST Research Institute- Site Number : 8400014

Bingham Farms, Michigan, 48334, United States
Velocity Clinical Research - Norfolk- Site Number : 8400015

Norfolk, Nebraska, 68701, United States
Velocity Clinical Research - Omaha- Site Number : 8400012

Omaha, Nebraska, 68134, United States
Velocity Clinical Research - San Diego- Site Number : 8400013

La Mesa, California, 91942, United States
Velocity Clinical Research - Springdale- Site Number : 8400010

Cincinnati, Ohio, 45246, United States
Velocity Clinical Research, Salt Lake City- Site Number : 8400011

West Jordan, Utah, 84088, United States

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