New RNA flu vaccine could be a Game-Changer – early trial underway

NCT ID NCT05227001

Completed ⭐️ VACCINE ⭐️ Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

Pfizer is testing a new type of flu vaccine called a self-amplifying RNA (saRNA) vaccine. This early study involves 440 healthy adults aged 18 to 49. Participants receive either the saRNA vaccine, a licensed flu shot, or a placebo. The main goal is to check safety and side effects, with a secondary look at immune response. The trial is already completed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: self-amplifying RNA (saRNA) flu vaccine
What this could lead to: If successful, this could lead to a more effective flu vaccine that requires lower doses and provides stronger protection.
What could go wrong: This is an early Phase 1 trial focused on safety, not yet proving the vaccine works. The saRNA technology is new, and side effects or limited immune response are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLUENZA, HUMAN

Contacts and locations

Locations

Advanced Pharma CR, LLC

Miami, Florida, 33147, United States
Arizona Heart Rhythm Center

Phoenix, Arizona, 85016, United States
Benchmark Research

Austin, Texas, 78705, United States
CTI Clinical Research Center

Cincinnati, Ohio, 45212, United States
Coastal Carolina Research Center

North Charleston, South Carolina, 29405, United States
Comprehensive Cardiology Consultants

Pembroke Pines, Florida, 33028, United States
DM Clinical Research, Martin Diagnostic Clinic

Tomball, Texas, 77375, United States
Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States
Eric S. Tiblier, MD

Austin, Texas, 78705, United States
Finlay Medical Research

Greenacres City, Florida, 33467, United States
Great Lakes Clinical Trials - Andersonville

Chicago, Illinois, 60640, United States
Hope Research Institute

Phoenix, Arizona, 85018, United States
Miami Clinical Research

Miami, Florida, 33155, United States
Mount Sinai Hospital

Miami Beach, Florida, 33140, United States
NYU Langone Health

New York, New York, 10016, United States
Panax Clinical Research

Miami Lakes, Florida, 33014, United States
Pines Care Research Center, LLC

Pembroke Pines, Florida, 33024, United States
Pinnacle Health Care Center

Pembroke Pines, Florida, 33024, United States
Pioneer Heart Institute

Lincoln, Nebraska, 68506, United States
SUNY Upstate Medical University

Syracuse, New York, 13215, United States
SUNY Upstate Medical University Global Health Laboratory

Syracuse, New York, 13210, United States
SUNY Upstate Medical University Institute for Global Health

Syracuse, New York, 13215, United States
The Pain Center of Arizona

Phoenix, Arizona, 85018, United States
Velocity Clinical Research, Omaha

Omaha, Nebraska, 68134, United States

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