New inhaled antifungal shows promise for lung transplant patients
NCT ID NCT05037851
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new drug called opelconazole, given as a mist through a nebulizer, to prevent a serious fungal lung infection (aspergillosis) in people who had a lung transplant. The trial involved 102 participants and compared the drug to standard care. The main goal was to see how safe and tolerable the treatment was over 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Opelconazole (nebulized antifungal drug)
- What this could lead to
- If successful, this could provide a safer, more effective way to prevent dangerous fungal infections in lung transplant patients.
- What could go wrong
- This is a small, early-phase trial focused on safety and tolerability, not yet proving the drug prevents infections. Results may not apply to all transplant patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clinical Research Site
Phoenix, Arizona, 85013, United States
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Clinical Research Site
La Jolla, California, 92037, United States
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Clinical Research Site
Los Angeles, California, 90095, United States
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Clinical Research Site
Jacksonville, Florida, 32224, United States
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Clinical Research Site
Tampa, Florida, 33606, United States
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Clinical Research Site
Maywood, Illinois, 60153, United States
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Clinical Research Site
New York, New York, 10016, United States
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Clinical Research Site
The Bronx, New York, 10467, United States
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Clinical Research Site
Philadelphia, Pennsylvania, 19104, United States
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Clinical Research Site
Philadelphia, Pennsylvania, 19140, United States
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Clinical Research Site
Pittsburgh, Pennsylvania, 15213, United States
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Clinical Research Site
Nashville, Tennessee, 37232, United States
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Clinical Research Site
Dallas, Texas, 75246, United States
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Clinical Research Site
Edmonton, T6G 1Z1, Canada
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Clinical Research Site
Toronto, M5G 2N2, Canada
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Clinical Research Site 1
Houston, Texas, 77030, United States
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Clinical Research Site 2
Houston, Texas, 77030, United States
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Clinical Research Site 3
Houston, Texas, 77030, United States
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Research Site
St Louis, Missouri, 63110, United States
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