RSV booster shot shows promise for seniors

NCT ID NCT07117487

Completed Disease control Sponsor: ModernaTX, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new mRNA booster shot (mRNA-1345) in 507 adults aged 60 and older who had already received a licensed RSV vaccine at least a year earlier. The goal was to see if the booster is safe and boosts the immune system's ability to fight RSV. Researchers measured side effects and antibody levels in the blood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mRNA-1345 (an mRNA-based RSV vaccine booster)
What this could lead to: If successful, this could show that an mRNA booster safely strengthens protection against RSV in older adults who already received a different RSV vaccine.
What could go wrong: This is a completed phase 3 study, but results are not yet published. The booster may not provide significantly better immunity than the original vaccine, and side effects like injection site pain or fever are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

respiratory syncytial virus infectious disease viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATORY SYNCYTIAL VIRUS

Contacts and locations

Locations

Indago Research & Health Center, Inc.

Hialeah, Florida, 33012, United States
Velocity Clinical Research, Austin

Austin, Texas, 78759, United States
Velocity Clinical Research, Covington

Covington, Louisiana, 70433, United States
Velocity Clinical Research, Denver

Denver, Colorado, 80110, United States
Velocity Clinical Research, Hampton

Hampton, Virginia, 23666, United States
Velocity Clinical Research, Lincoln

Lincoln, Nebraska, 68510, United States
Velocity Clinical Research, Medford

Medford, Oregon, 97504, United States
Velocity Clinical Research, Rockville

Rockville, Maryland, 20854, United States
Velocity Clinical Research, Savannah

Savannah, Georgia, 31406, United States
Velocity Clinical Research, Spokane

Spokane, Washington, 99218, United States
Velocity Clinical Research, Valparaiso

Valparaiso, Indiana, 46383, United States

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