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New drug shows promise for severe pneumonia patients in ICU

NCT ID NCT05962606

Completed Disease control Sponsor: Aptarion Biotech AG Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called AON-D21 in 150 ICU patients with severe community-acquired pneumonia. The goal was to see if adding AON-D21 to standard care is safe and helps patients recover faster compared to a placebo. The trial focused on how quickly patients could stop needing breathing support and monitored side effects.

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Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia follicular lymphoma pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMMUNITY-ACQUIRED PNEUMONIA

Contacts and locations

Locations

  • Assistance Publique-Hopitaux de Paris (AP-HP)

    Paris, France

  • CHRU de Tours Hôpital Bretonneau

    Tours, France

  • CHU Dupuytren

    Limoges, France

  • Centre Hospitalier Argenteuil

    Argenteuil, France

  • Centre Hospitalier Départemental Vendée

    La Roche-sur-Yon, France

  • Centre Hospitalier de Melun

    Melun, France

  • Charité - Universitätsmedizin Berlin

    Berlin, Germany

  • Clinique Saint Pierre

    Ottignies, Belgium

  • Cliniques Universitaires Saint-Luc

    Brussels, Belgium

  • Cologne-Merheim Hospital Lung Clinic

    Cologne, Germany

  • Hospital Clinico San Carlos

    Madrid, Spain

  • Hospital Doctor Josep Trueta

    Girona, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, Spain

  • Hospital Universitari i Politecnic La Fe de Valencia

    Valencia, Spain

  • Hotel Dieu - CHU Nantes

    Nantes, France

  • Hôpital Nord Franche Comté

    Trévenans, France

  • Liverpool University Hospitals NHS Foundation Trust

    Liverpool, United Kingdom

  • Mid Yokshire Teaching NHS Trust

    Wakefield, United Kingdom

  • Nouvel Hôpital Civil

    Strasbourg, France

  • Royal Berkshire Foundation Trust

    Reading, United Kingdom

  • Universitaetsklinikum Giessen und Marburg GmbH

    Giessen, Germany

  • University College London

    London, United Kingdom

  • University Hospital Bristol and Weston NHS

    Bristol, United Kingdom

  • University Hospital of Wales

    Cardiff, United Kingdom

  • University Hospitals Plymouth NHS Trust, Derriford Hospital

    Plymouth, United Kingdom

  • University of Alabama at Birmingham Heersink School of Medicine

    Birmingham, Alabama, 35233, United States

  • York Hospital

    York, United Kingdom

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