New nasal spray vaccine shows promise against RSV in young children
NCT ID NCT04491877
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This study tested a live-attenuated RSV vaccine given as a nasal spray in 259 infants and toddlers aged 6 to 18 months. The main goals were to check safety and measure the immune response. Researchers also looked at how much vaccine virus was shed and how well the vaccine worked in children with and without prior RSV exposure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Live-attenuated respiratory syncytial virus (RSV) vaccine given as a nasal spray
- What this could lead to
- If successful, this could lead to a safe and effective nasal spray vaccine that protects infants and toddlers from RSV, a common cause of severe respiratory illness.
- What could go wrong
- This is an early-phase trial (Phase 1/2) with only 259 participants, so results may not apply to all children. The vaccine is live-attenuated, meaning there is a small risk of vaccine-related illness or shedding.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AMR - Newton-Site Number:8400002
Newton, Kansas, 67114, United States
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Alliance for Multispeciality Research-Site Number:8400014
El Dorado, Kansas, 67042, United States
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Be Well Clinical Studies-Site Number:8400054
Lincoln, Nebraska, 68516, United States
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Benchmark Research-Site Number:8400006
Covington, Louisiana, 70433, United States
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Boeson Research-Site Number:8400011
Missoula, Montana, 59804, United States
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California Research Foundation-Site Number:8400016
San Diego, California, 92123-1881, United States
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Clinical Research Institute-Site Number:8400053
Minneapolis, Minnesota, 55402, United States
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Coastal Pediatric Research-Site Number:8400031
Charleston, South Carolina, 29414, United States
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East Carolina University/Brody Medical Sciences Building-Site Number:8400043
Greenville, North Carolina, 27834, United States
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Elite Clinical Trials, Inc.-Site Number:8400001
Blackfoot, Idaho, 83221, United States
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FMC Science-Site Number:8400042
Lampasas, Texas, 76550-1820, United States
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Investigational Site Number :1520001
Santiago, Reg Metropolitana de Santiago, 8380453, Chile
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Investigational Site Number :1520004
Santiago, Reg Metropolitana de Santiago, 8420383, Chile
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Investigational Site Number :3400001
San Pedro Sula, 21104, Honduras
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Investigational Site Number :3400002
Tegucigalpa, 11101, Honduras
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JBR Clinical Research-Site Number:8400041
Salt Lake City, Utah, 84107, United States
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Leavitt Clinical Research-Site Number:8400036
Idaho Falls, Idaho, 83404, United States
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Matrix Clinical Research-Site Number:8400012
Gardena, California, 90247, United States
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Matrix Clinical Research-Site Number:8400032
Los Angeles, California, 90057, United States
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MedPharmics Inc-Site Number:8400040
Albuquerque, New Mexico, 87102, United States
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Meridian Clinical Research - Norfolk-Site Number:8400005
Norfolk, Nebraska, 68701, United States
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Michael W. Simon, MD, PSC-Site Number:8400013
Lexington, Kentucky, 40517, United States
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National Clinical Research Inc-Site Number:8400004
Richmond, Virginia, 23294, United States
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Nola Research Works-Site Number:8400017
New Orleans, Louisiana, 70125, United States
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Paradigm Clinical Research-Site Number:8400026
La Mesa, California, 91942, United States
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Pediatric Associates of Charlottesville North-Site Number:8400007
Charlottesville, Virginia, 22911, United States
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Snake River Research-Site Number:8400022
Idaho Falls, Idaho, 83404, United States
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The South Bend Clinic Center for Research-Site Number:8400024
South Bend, Indiana, 46617, United States
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Tribe Clinical Research-Site Number:8400027
Greenville, South Carolina, 29607, United States
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Other studies related to the condition(s) this trial covers.
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