New mRNA flu shot enters human testing
NCT ID NCT05829356
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage trial tests a new mRNA-based flu vaccine in 159 adults aged 18-49 and 60+. The vaccine uses modified mRNA to target a specific flu strain (H3N2). Researchers compare its safety and immune response to a standard flu shot. The goal is to gather data to improve future mRNA flu vaccines.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
modified mRNA flu vaccine (H3 mRNA/LNP)
What this could lead to
If successful, this could lead to a more effective and adaptable flu vaccine using mRNA technology.
What could go wrong
This is a very early Phase 1 trial with only 159 participants, so safety and immune response are still being tested. It may not work better than existing vaccines.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Investigational Site Number : 0360001
Morayfield, Queensland, 4506, Australia
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Investigational Site Number : 0360002
Camberwell, Victoria, 3124, Australia
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Investigational Site Number : 0360003
Adelaide, 5000, Australia
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Investigational Site Number : 0360004
Herston, Queensland, 4006, Australia
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Investigational Site Number : 8260001
London, London, City of, SW10 9NH, United Kingdom
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Investigational Site Number : 8260002
Leicester, Leicestershire, LE1 5WW, United Kingdom
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Investigational Site Number : 8260003
Sheffield, Sheffield, S10 2JF, United Kingdom
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Investigational Site Number : 8260004
London, London, City of, W12 0HS, United Kingdom