Respiratory tract infectious disorder

This study tests a new vaccine called VAX-31 in adults aged 50 and older who have already received a pneumonia vaccine. The goal is to see if VAX-31 is safe and triggers a strong immune response. About 752 participants will receive either VAX-31 or an active comparator vaccine, a…

This early-stage trial is testing two mRNA vaccines in children aged 5 months to under 24 months. One vaccine targets RSV alone, and the other targets both RSV and hMPV. The main goals are to check safety and see how well the vaccines trigger an immune response. About 186 childre…

This study looks at health records of over 800,000 adults to see if the PCV20 vaccine reduces pneumonia cases. Researchers will compare pneumonia rates in people who got the vaccine versus those who did not. The goal is to measure how effective PCV20 is in adults aged 18 and olde…

This study tests a new pneumococcal vaccine (PG4) to see if it is safe and tolerable in adults. About 380 healthy adults will receive either the experimental vaccine, a similar vaccine, a standard vaccine, or a placebo. Participants will be monitored for side effects and give blo…

This study examines how well the ABRYSVO vaccine works when given during pregnancy to prevent RSV in infants. Researchers will compare health outcomes of babies born to vaccinated mothers versus unvaccinated mothers using electronic medical records. The goal is to see if the vacc…

This massive study is testing whether the Abrysvo RSV vaccine can prevent hospitalizations due to RSV in adults aged 18 and older. Half of the 690,000 participants will receive the vaccine, while the other half will not. Researchers will track how many in each group end up hospit…

This early-stage trial tests a new pneumococcal vaccine called PnMAPS30plus in 121 healthy adults aged 50 to 64. Participants receive a single shot of either the new vaccine or an approved one (PCV20) and are monitored for about six months. The goal is to check safety and whether…

This study looks at the best timing for a booster shot of the RSV vaccine in adults aged 60 and older. It will follow over 10,000 participants for up to 5 years to see how long protection lasts and whether a second dose is needed. The goal is to help prevent serious RSV infection…

This study tests two new vaccines (SCB-1022 and SCB-1033) designed to protect against RSV, human metapneumovirus, and parainfluenza virus. About 612 healthy adults aged 60-85 will receive either a vaccine or a placebo. The main goal is to check safety and how well the vaccines tr…

This early-stage study tests a new vaccine called VXB-241 in healthy adults aged 60-83, with a smaller group of younger adults (18-40) first. The vaccine is designed to protect against two viruses that can cause serious lung infections: RSV and HMPV. Researchers will check how sa…

This early-stage study tests a new vaccine called VXB-251 in 240 healthy adults aged 60-83. The vaccine is designed to protect against three viruses that can cause serious lung infections: RSV, hMPV, and PIV3. Researchers will check if the vaccine is safe and how well it triggers…

This study checks how well the ABRYSVO® vaccine protects infants from severe RSV when given to pregnant women. Researchers will look at hospital records from Argentina and Uruguay over several RSV seasons. The goal is to see if the vaccine reduces hospitalizations and severe illn…

This study looks at how getting the flu vaccine year after year changes your body's immune response. Researchers are testing two types of flu vaccines—a nasal spray (FluMist) and a shot (Flublok)—in 600 adults aged 22 to 50 in Hong Kong. They will measure antibodies and immune ce…

This study tests a new vaccine called VAX-31 to protect babies against pneumococcal disease, which can cause pneumonia and meningitis. About 900 healthy infants will receive four doses of VAX-31 or an existing vaccine starting at 2 months old. Researchers will check for side effe…

This study reviews medical records to see how effective Pfizer's ABRYSVO vaccine is at preventing severe RSV lung infections in adults 60 and older. Researchers will analyze existing health data from routine doctor visits over several years. No new treatments or active participat…

This phase 3 trial is testing a non-live, adjuvanted RSV vaccine (Arexvy) in 100 adults who have received a lung or stem cell transplant. The goal is to see if the vaccine is safe and helps their immune system fight RSV, a common virus that can be dangerous for them. Participants…

This study looks at how effective the Prevnar 20 (PCV20) vaccine is at preventing serious lung infections in people aged 65 and older. Researchers will analyze medical records from over 22 million Medicare beneficiaries, comparing those who got the vaccine to those who did not. T…

This early-stage study tests an experimental mRNA vaccine called JCXH-108 to see if it is safe and triggers an immune response against RSV, a common respiratory virus. About 75 healthy volunteers, split into two age groups (18-45 and 60+), will receive either the vaccine or a pla…

This study tests a nasal spray flu vaccine in 200 people aged 3 to 17. Researchers will measure specific antibodies in the nose to see how well the vaccine works. The goal is to understand the immune response and improve flu prevention.

This study follows women who previously received the GBS-NN/NN2 vaccine during pregnancy to see how long their immune protection lasts. It also tests whether a booster dose given in a new pregnancy is safe and boosts immunity, aiming to protect newborns from group B strep infecti…

This early-stage trial is testing a new mRNA vaccine called IN006 that targets respiratory syncytial virus (RSV). About 240 healthy adults aged 18 and older will receive either the vaccine or a placebo. The main goal is to check if the vaccine is safe and triggers an immune respo…

This large study enrolled over 15,000 U.S. military members to compare three types of licensed flu vaccines: egg-based, recombinant, and cell-culture-based. Participants were randomly assigned to one of the three vaccines over four flu seasons. The main goal is to see which vacci…

This study tests an experimental nasal vaccine made from a harmless virus (Sendai virus) that is similar to the one causing croup. The goal is to see if it is safe and helps children ages 1 to 5 build protection against croup. About 54 children will receive the vaccine as nose dr…

This phase 3 study tests a new quadrivalent seasonal influenza vaccine in healthy infants aged 6 months to under 3 years. The goal is to see if the vaccine triggers a strong immune response and is safe compared to an existing flu shot. About 245 children will take part, and resea…

This study tests two experimental vaccines, AZD4117 and AZD5315, designed to protect against certain strains of avian influenza (bird flu), specifically H5N1 and H7N9. Around 405 healthy adults will receive either a vaccine or a placebo to see if the vaccines are safe and trigger…

This study tests an experimental RSV vaccine in adults aged 60 and older. The goal is to see how well the vaccine triggers the immune system, how safe it is, and how long protection lasts—up to 5 years. About 1,720 participants will receive one or more doses of the vaccine at dif…

This study looks at how well a pneumonia vaccine (PCV20) works in people who have recovered from B-cell lymphoma and were treated with anti-CD20 therapy. Researchers want to see if a single dose or a boosted dose is safer and more effective at preventing pneumococcal infections. …

This early-stage trial is testing whether a new flu vaccine with an adjuvant (a booster ingredient) is safe for adults aged 65 and older. Eighty volunteers will receive a single shot and be monitored for side effects over a year. The study does not yet test if the vaccine prevent…

This early-stage trial is testing the safety of a new quadrivalent influenza vaccine with an adjuvant (a booster ingredient) in adults aged 65 and older. Eighty participants will receive either the new vaccine, a standard flu vaccine, or a placebo. The study monitors side effects…

This Phase 3 trial tests an updated COVID-19 vaccine (BNT162b2, 2025/2026 formulation) in 343 children aged 5 to 11 who have medical conditions that put them at high risk for severe COVID-19. All participants receive one dose and are monitored for about 6 months to check safety a…

This study tests a new vaccine called LYB005 against RSV, a virus that can cause serious lung infections in older adults. About 700 volunteers aged 60 and older will receive either the vaccine or a placebo. Researchers will check how well the vaccine boosts the immune system and …

This study looks at how well the ABRYSVO vaccine, given to pregnant women, protects their babies from RSV, a leading cause of severe lung infections in infants. Researchers will analyze medical records of infants up to 6 months old in western Pennsylvania over several RSV seasons…

This study is checking the safety of the Abrysvo RSV vaccine in adults aged 60 and older in everyday medical practice in Japan. About 1100 people who get the vaccine will be watched for side effects for 28 days. The goal is to confirm the vaccine is safe for older adults.

This Phase 3 study tests whether a single dose of Pfizer's RSV vaccine (RSVpreF) can prevent lower respiratory tract illness caused by RSV in adults aged 60 and older. Over 38,800 participants across multiple countries received either the vaccine or a placebo. The study also look…

This study compares high-dose and standard-dose flu vaccines in 396 adults who received a kidney, heart, or liver transplant within the past year. The goal is to see if a higher dose or two doses provide better protection against the flu. Results will help improve vaccine recomme…

This study tests a new mRNA vaccine designed to protect against a potential pandemic flu caused by the H5 virus. Healthy adults aged 18 and older will receive either a high, medium, or low dose of the vaccine or a placebo. The goal is to see if the vaccine is safe and triggers a …

This study is testing whether getting two doses of the H5N1 bird flu vaccine 3 weeks apart works as well as getting them 8 weeks apart. It involves 312 healthy adults aged 18-59. The goal is to see which schedule provides better protection against the virus.

This study tests a single dose of a new flu vaccine called OVX836 in about 2,850 healthy adults aged 18 to 59. The goal is to see if it can prevent confirmed influenza A and how safe it is. Participants will be randomly assigned to receive either the vaccine or a placebo.

This phase 2 trial is testing a new mRNA vaccine called ABO1105 against respiratory syncytial virus (RSV) in 420 healthy adults aged 50 and older. Participants receive either a low or high dose of the vaccine or a placebo. The study measures how well the vaccine boosts antibodies…

This early-stage trial tests a new mRNA vaccine called ABO1105 against respiratory syncytial virus (RSV). Around 96 healthy adults aged 18 and older will receive either the vaccine or a placebo. The main goal is to check if the vaccine is safe and triggers an immune response.

This study tests a new mRNA vaccine designed to protect adults aged 60 and older from two viruses that can cause serious lung infections: human metapneumovirus (hMPV) and respiratory syncytial virus (RSV). About 1,530 participants will receive either the vaccine or a placebo to c…

This study looks at how a nasal flu vaccine works in 60 healthy teenagers aged 14-17. Researchers will measure immune responses in the nose and blood before and after a single dose. The goal is to understand how the vaccine protects against the flu.

This early-stage trial is testing several doses of an experimental mRNA vaccine against RSV in 213 healthy adults aged 18-45. The goal is to check the vaccine's safety and how well it triggers an immune response. Participants receive two shots, and researchers monitor for side ef…

This study tests a new mRNA vaccine called IN006 against respiratory syncytial virus (RSV) in 500 healthy adults aged 60 and older. The vaccine is given as two different doses, with a booster after 12 or 24 months. Researchers will monitor safety and measure immune responses like…

This phase II trial tests whether combining the immunotherapy drug durvalumab (Imfinzi) with radiation therapy can effectively treat intermediate-risk head and neck cancer after surgery, while causing fewer serious side effects than the standard cisplatin-based chemo-radiation. T…

This study tests a new drug called verekitug in 666 people with moderate-to-severe COPD, a long-term lung disease that makes breathing hard. The goal is to see if it can reduce serious flare-ups and improve lung function compared to a placebo. Participants must be current or form…

This Phase 2 trial tests an oral drug called buloxibutid in 378 people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. Over 52 weeks, researchers compare two doses of buloxibutid against a placebo to see if it can slow lung function decline. The study is double…

This Phase 2 trial tests whether anlotinib, a drug currently used for cancer, can help people with idiopathic pulmonary fibrosis (IPF) or progressive fibrosis-interstitial lung disease. The study involves 30 adults aged 40-85 and measures changes in lung function over 52 weeks. P…

This study tests whether a single injection of peramivir can safely treat uncomplicated flu in adults. Participants receive either 150 mg, 300 mg of peramivir, or a placebo, and researchers measure how quickly symptoms improve. The goal is to see if this antiviral shot offers a f…

This study tests three different drug combinations in 430 adults with advanced head and neck cancer that has spread or returned after prior immunotherapy. The goal is to see if adding bevacizumab to standard chemo, or using atezolizumab plus bevacizumab, works better than the usu…

This study tests a special virus called a bacteriophage, combined with standard antibiotics, to treat a severe lung infection caused by Mycobacterium abscessus. The trial involves just one patient and aims to see if the virus can help clear the infection. It is an early, personal…

This phase II trial tests whether bevacizumab, a drug that blocks blood vessel growth, can lengthen the time between surgeries for adults with recurrent respiratory papillomatosis (RRP), a rare condition causing wart-like growths in the airways. Participants receive 11 doses of t…

This study looks at whether the antibiotic omadacycline can help people with a hard-to-treat lung infection caused by Mycobacterium abscessus. Researchers will review medical records of 200 patients to see how many get better or are cured. The goal is to find out which patients b…

This phase 3 trial tested whether adding bevacizumab to standard chemotherapy helps people with head and neck cancer that has returned or spread. About 403 adults took part. The main goal was to see if the combination improved overall survival compared to chemotherapy alone.

This study looks at the long-term safety of an inhaled medication called treprostinil for people with fibrotic lung diseases like idiopathic pulmonary fibrosis. About 1,850 adults who completed a prior related study will take the drug and be monitored for side effects. The goal i…

This study tests whether infusions of cord blood stem cells can help people with moderate to critical COVID-19 pneumonia. The trial includes 65 adults with COVID-19-related acute respiratory distress syndrome (ARDS). Researchers will compare stem cell treatment plus standard care…

This study tests a drug called rezafungin for people with a long-term lung infection caused by a fungus (chronic pulmonary aspergillosis) who have few other treatment choices. About 60 adults will receive the drug once a week for 6 months. Researchers will check if the treatment …

This study was designed to test whether adding an experimental drug and special immune cells to standard care could help critically ill adults with severe pneumonia, especially those with sepsis or lung failure. The trial was withdrawn before enrolling any participants, so no res…

This study was designed to see if adding two immune treatments (NAI and iNKT cells) to standard care could help critically ill adults with severe pneumonia, sepsis, or lung failure recover. It planned to enroll ICU patients and follow them for 90 days. However, the study was with…

This study is developing a new way to treat pulmonary fibrosis, a condition where the lungs become scarred and stiff. The approach uses tiny particles called liposomes, coated with hyaluronic acid, to deliver drugs directly to the cells that cause scarring. The research is being …

This study tests a drug called clofazimine for people with a chronic lung infection caused by Mycobacterium avium complex (MAC). The goal is to see if adding clofazimine to standard treatment helps clear the bacteria from sputum and improves walking ability and fatigue. About 102…

This trial tests an investigational drug called CAL101 in 150 adults with idiopathic pulmonary fibrosis, a disease that scars the lungs and makes breathing harder. Participants receive monthly IV infusions of CAL101 or a placebo for 6 months. The goal is to see if CAL101 can prev…

This study aims to find out if 5 days of antibiotics works as well as 10 days for children hospitalized with pneumonia, skin infections, or urinary tract infections. About 1,200 children will be randomly assigned to either a 5-day or 10-day course, with some receiving a placebo a…

This study tests an experimental tablet called HEC585 in 270 adults with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing harder. Participants receive either HEC585, a placebo (dummy pill), or an active comparator (Pirfenidone) to see if HEC…

This study tests whether online training and regular feedback reports can help doctors prescribe fewer antibiotics for common infections like ear infections, strep throat, sinusitis, and pneumonia in children. About 420 children aged 6 months to 12 years are included. The goal is…

This phase 2 trial tests whether a single, low dose of radiation to the chest can reduce lung inflammation in hospitalized COVID-19 pneumonia patients. Researchers compare two radiation doses (35 cGy and 100 cGy) to standard care. The goal is to see if this treatment lowers the n…

This study compares a shortened steroid regimen (8 days for moderate, 14 days for severe pneumonia) against the standard 21-day course in 196 HIV patients with Pneumocystis pneumonia. The goal is to see if the shorter treatment is non-inferior in preventing death and complication…

This study tests a drug called axatilimab in 145 people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The goal is to see if the drug can slow down the decline in lung function over 26 weeks compared to a placebo. Participants w…

This study tests an experimental drug called BMS-986278 in 1255 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. The goal is to see if the drug can slow the decline in lung function and is safe to take. Participants will receive ei…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study looks at whether a special team of doctors and nurses can treat adults with suspected infections at home, instead of sending them to the hospital. About 500 people will be randomly assigned to either standard hospital care or home-based care from a mobile response team…

This early-phase study planned to test whether injecting the seasonal flu vaccine directly into breast tumors could help the immune system attack the cancer. It was designed for women with triple-negative or HER2+ breast cancer who were already scheduled for chemotherapy before s…

This phase 2 trial tests an experimental drug called ENV-101 (taladegib) in 213 adults with idiopathic pulmonary fibrosis, a disease that causes lung scarring and makes breathing harder. Participants take either the drug or a placebo daily for several months. The main goal is to …

This early-stage study tests whether atezolizumab, a drug used for cancer, is safe for people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing problems. About 24 adults aged 50 and older with confirmed IPF will receive the drug. Research…

This early-stage study tests whether a person's own lung stem cells, grown from a small biopsy and given through an IV, are safe for treating idiopathic pulmonary fibrosis (IPF). Twenty-four adults with IPF will receive either a low or high dose of stem cells or standard care. Th…

This study tests whether adding CAL02 to standard antibiotics helps people with severe community-acquired bacterial pneumonia recover faster. CAL02 is designed to neutralize toxins released by bacteria. About 276 hospitalized adults in critical care will receive either CAL02 or a…

This study aimed to test whether giving antibody-rich plasma from recovered COVID-19 patients could help hospitalized adults with pneumonia caused by the virus. The trial was withdrawn before any participants were enrolled, so no data was collected. The approach was based on the …

This study tests a new drug called olorofim against a standard treatment (AmBisome followed by usual care) for a serious lung infection caused by Aspergillus fungus. About 225 adults with proven or probable infection will take part. The main goal is to see if olorofim reduces dea…

This study tests whether a piece of donated aorta (the body's largest artery) can be used as a patch to repair severe windpipe or bronchial defects in children. The surgery is for kids who cannot have standard windpipe repair. Only 5 children will be enrolled, and the main goal i…

This phase 2 trial tests a new drug called LYT-100 (deupirfenidone) in 240 adults with idiopathic pulmonary fibrosis (IPF), a lung disease that causes scarring and breathing difficulty. Participants receive either LYT-100, the existing drug pirfenidone, or a placebo. The main goa…

This study is testing a new diagnostic tool called RPIP, which uses advanced DNA sequencing to quickly identify the germs causing pneumonia and their drug resistance. The goal is to see if this method helps doctors choose the right treatment faster than current tests. The study w…

This study tests a lollipop-shaped device called CandyCollect to see if it can detect strep throat in children ages 5-17. Kids suck on the lollipop for a few minutes, and it captures bacteria in special channels. Researchers compare results to standard throat swabs to see if the …

This study looks for markers in blood, sputum, or urine that can help doctors decide if a lung nodule found on a CT scan is cancerous or harmless. The goal is to reduce the need for invasive biopsies. Researchers will also check if these markers return to normal after successful …

This study tests a simple, at-home smell test to see if it can detect COVID-19 infection and track how smell recovers over time. About 1000 adults, including those with known smell loss and healthy volunteers, will use smell cards to rate odor intensity, identification, and discr…

This study tests two new devices (imPulse Una and TOR) that use sound waves to detect COVID-19, flu, and RSV without needles or swabs. About 300 adults with or without symptoms will have a quick, painless scan. The goal is to see if these e-stethoscopes can accurately identify th…

This study compares lung ultrasound (LUS) with chest X-ray for diagnosing community-acquired pneumonia in emergency room patients. Researchers will enroll 47 adults with suspected pneumonia to see if LUS is as accurate as X-ray. If LUS proves reliable, it could offer a faster, ra…

This study tests a fast point-of-care PCR test (Spotfire) that quickly identifies whether a respiratory infection is caused by a virus. The goal is to give ER doctors results faster so they can avoid prescribing antibiotics when they won't help. The trial enrolls 200 adults with …

This study tests whether a new DNA-sequencing technique (metagenomic next-generation sequencing) can identify the cause of pneumonia faster than standard methods. About 114 ICU patients on ventilators will be randomly assigned to receive either the new test or usual care. The goa…

This study looks at two advanced genetic testing methods, mNGS and tNGS, to see how well they can identify the germs causing severe lung infections. Researchers will compare these tests to traditional methods in 80 patients. The goal is to find out if these newer technologies are…

This study tests a new vaccine called VAX-31, which protects against 31 types of pneumonia-causing bacteria. It is given together with the seasonal flu shot to healthy adults aged 50 and older. The goal is to see if giving both vaccines at the same time is safe and works as well …

This phase 3 trial is testing whether a single dose of CD388, a long-acting antiviral injection, can prevent the flu in 10,000 adults and teens at higher risk of complications. Participants receive either CD388 or a placebo and are monitored for flu-like illness over 24 weeks. Th…

This study tests whether a specially designed probiotic, Streptococcus salivarius eK12, can prevent repeated strep throat infections in children aged 3 to 10. The probiotic is given as a daily supplement and aims to crowd out the harmful bacteria without antibiotics. Researchers …

This Phase 3 study is testing a new vaccine called VAX-31 in about 4,000 healthy adults aged 50 and older. The goal is to see if VAX-31 provides better immune protection against more strains of pneumococcal bacteria compared to two current vaccines, Prevnar 20 and Capvaxive. Rese…

This early-stage study tests whether a single injection of a new antibody, JST-010, is safe in healthy adults aged 18 to 55. The goal is to prevent pneumonic plague, a rare but serious lung infection. Researchers compare the antibody to a placebo and monitor participants for one …

This study compares a 5-day versus a 10-day course of oseltamivir (Tamiflu) to prevent influenza in people exposed to the virus while in the hospital. About 200 adults with flu risk factors will be randomly assigned to one of the two treatment lengths. The goal is to see if the s…

This study tests whether a community-based communication program can increase flu vaccination rates among people over 65 in Can Tho City, Vietnam. The program includes direct counseling, weekly health tips via the Zalo app, and printed leaflets. Researchers will compare vaccinati…

This study tests several new mRNA-based flu vaccines in about 971 healthy adults aged 18 and older. The goal is to see how well they trigger an immune response and how safe they are compared to standard flu shots. Participants receive one dose of an experimental vaccine or a comp…

This study tests whether OM-85 (Broncho-Vaxom), a bacterial extract taken by mouth for 10 days each month, can reduce the number of respiratory infections in children aged 6 months to 5 years who have a history of wheezing. About 525 children will receive either OM-85 or a placeb…

This early-stage trial is testing whether a new long-acting antiviral medicine called CD388 can be safely given at the same time as the high-dose flu vaccine. About 100 healthy adults aged 18 to 49 will receive either the vaccine plus CD388 or the vaccine plus a placebo. Research…

This study looks at how safe and effective nirsevimab is at preventing severe RSV in babies and young children. About 110 infants and toddlers up to 24 months old will receive the medicine as part of their regular care. Researchers will track side effects and how many children ge…

This study tests whether training school personnel in vaccine communication and providing promotional materials can increase flu vaccination rates among students. About 6,000 students from participating schools will be tracked. The goal is to see if these simple steps lead to mor…

This study tests whether sending a short, encouraging letter from a pharmacist can motivate more adults to get their flu and travel vaccines. Researchers will track vaccination rates and also check if vaccinated people have fewer strokes in the following six months. About 20,000 …

This study tests different text message reminders to see which ones work best at getting people to get their flu vaccine. About 100,000 patients who haven't had their flu shot yet will receive a reminder text before a doctor's visit. The goal is to find simple, effective ways to …

This study tests the safety of giving repeated annual doses of an experimental drug called CD388 to healthy adults. About 400 people who already tolerated one dose without serious side effects will receive two more doses over two years. Researchers will monitor for side effects a…

This study compares two methods to prevent RSV, a common virus that can cause serious breathing problems in babies. One method is a vaccine given to pregnant women, which passes protection to the baby before birth. The other is an antibody shot given directly to the newborn. The …

This study tests a propolis throat spray to see if it can reduce how often and how long healthy adults get sick. One hundred people aged 18 to 65 will use the spray or a placebo daily for 16 weeks and report any illnesses. The goal is to find a simple way to prevent common colds …

This study checks how well the RSV vaccine (ABRYSVO) works when given to pregnant women to protect their babies from severe RSV illness. Researchers will look at health records of infants hospitalized with breathing problems in Australia. They want to see if vaccinated moms' babi…

This study tests whether placing HEPA air purifiers in primary school classrooms can reduce student absences caused by respiratory infections like colds and flu. About 72 schools in Norway will be randomly assigned to receive either working purifiers or sham devices. Researchers …

This study tests whether a pill made from dead bacteria (OM 85) can prevent lower respiratory tract infections in people aged 75+ living in nursing homes. Participants take the pill or a placebo for 10 days each month over 3 months. The goal is to see if the treatment reduces inf…

This study tests whether a virtual reality (VR) game can teach primary schoolchildren aged 6-12 better hygiene habits to prevent the spread of COVID-19 and other respiratory viruses. Over 2,000 children will either play the VR game for two weeks or receive standard education. Res…

This study planned to test a single IV dose of peramivir against placebo in teens and adults with uncomplicated flu. The goal was to see if it could shorten flu symptoms like cough, sore throat, and fever. However, the trial was withdrawn before any participants were enrolled, so…

This study tests whether virtual reality (VR) can improve how caregivers learn chest percussion techniques for children with pneumonia. About 60 caregivers will be randomly assigned to VR training or standard teaching. The goal is to see if VR boosts skill accuracy, knowledge, an…

This study planned to test whether osteopathic manipulative treatment (OMT) — a hands-on technique to improve chest movement — could reduce lung inflammation and improve breathing in adults with asthma. Researchers intended to measure inflammation using a nitric oxide breath test…

This study tests whether giving a thyroid hormone (T3) directly into the lungs can safely improve oxygen levels in adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 68 critically ill patients on ventilators will either receive the hormone or s…

This study tests whether a mix of two probiotics (Lactobacillus rhamnosus and Bifidobacterium breve) can reduce the severity and duration of cold symptoms in children aged 3 months to 6 years. 120 children with mild to moderate upper respiratory infections will receive either the…

This early-stage study tests different doses of an experimental flu medicine called TRX-100, taken alongside standard care, in 105 people with mild to moderate influenza. The main goals are to check safety and find the best dose. Researchers will also track how well it eases flu …

This pilot study tests whether home-based or video-supervised exercise programs are acceptable and helpful for people with chronic lung diseases like IPF, sarcoidosis, bronchiectasis, asthma, and other interstitial lung diseases. Fifty participants will be randomly assigned to on…

This study tests a procedure called RhinAer that uses heat to treat the nerves in the nose for people with chronic rhinitis (long-term stuffy or runny nose). Researchers want to see if it reduces inflammation and improves symptoms like cough and post-nasal drip. About 25 adults a…

This study tests a new medicine called ZSP1273 in children aged 2 to 11 who have influenza A. The goal is to see if it can shorten flu symptoms and is safe. About 119 children in China will take either ZSP1273 or the standard flu drug oseltamivir.

This phase 3 trial tests whether the experimental drug ZSP1273 can shorten flu symptoms in teenagers aged 12-17 with uncomplicated influenza A. About 157 participants in China will receive either the drug or a placebo. The main goal is to see how quickly symptoms like cough, feve…

This study looks at whether training one leg at a time on a bike can help people with idiopathic pulmonary fibrosis (IPF) exercise longer. IPF makes it hard to breathe, so using fewer muscles may allow a better workout. The trial will compare one-legged cycling to the usual two-l…

This study looks at HIV-negative people who get opportunistic infections—illnesses that usually only affect those with weak immune systems. Researchers want to find out if these patients have unusual antibodies that block a key immune signal. Up to 224 adults in Thailand and Taiw…

This study collects and analyzes blood, DNA, and tissue samples from 315 adults with pulmonary fibrosis, their relatives, and healthy volunteers. The goal is to learn more about the disease's causes, not to test a new treatment. Researchers hope the findings will guide future the…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study tests a new AI-powered toolkit designed to help public health officials at local CDC offices respond more quickly to emerging infectious diseases such as COVID-19, mpox, influenza, and dengue. The toolkit combines data analysis, risk assessment, decision support, and e…

This early-stage study is testing a new tablet version of the COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood when taken as a whole tablet, dispersed in water, or with food. The goal is to compare the new tablet to…

This study looks for biological markers in blood and lung samples from people with idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases. The goal is to find markers that can predict how the disease will progress and to group patients into subtypes. Researchers…

This study tests whether training primary care providers on how to talk to patients about vaccines can increase flu and COVID-19 vaccination rates. Over 24,500 patients and their doctors at multiple clinics will take part. Doctors in some clinics will receive special communicatio…

This study looks at whether using a UV light filter on private well water can lower the chance of stomach infections in children under 5. About 900 families in Pennsylvania and New Jersey will either get a working UV filter or a fake one. Researchers will track how often kids get…

This study at Duke University tests whether a special MRI scan using inhaled xenon gas can detect changes in lung function over time in people with progressive pulmonary fibrosis. Sixty adults with various types of lung scarring will have MRI scans before starting anti-fibrotic m…

This study looks at whether air samplers placed in homes can detect viruses that cause colds and flu, and how that compares to standard nasal swabs. About 422 students and their families will participate. The goal is to better understand how respiratory viruses spread through hou…

This study looks at whether a high-protein diet helps patients on breathing machines with severe pneumonia recover faster. Researchers will compare patients getting a high-protein diet to those on a standard-protein diet, tracking how long they need the ventilator and whether the…

This study follows 300 pregnant women who had respiratory infections to see if RSV can pass from mother to baby before birth. Researchers will test blood from mothers and umbilical cords for RSV antibodies and viruses. Babies will be tracked for up to 4 years to monitor respirato…

This study looks at blood samples from 400 people with and without HIV to understand how aging and HIV infection change the body's immune response to the flu vaccine. Researchers will measure antibody levels and immune cell types to see who responds well to the vaccine and who do…

This study is testing two new types of pulse oximeters—simple devices that measure oxygen levels—for babies and toddlers with pneumonia in Cape Town, South Africa. Researchers want to see if these devices help healthcare workers correctly identify children with low oxygen and ref…

This study looks at 500 elderly patients (65 and older) with severe pneumonia to understand why some recover and others don't. Researchers will review medical records from hospitals across Europe, focusing on death rates and complications. No new drugs or treatments are being tes…

This pilot study is testing whether two natural dietary supplements—taxifolin (found in apples and onions) and ergothioneine (found in mushrooms)—can improve immune function in healthy adults aged 50 to 65. Researchers will measure how well immune cells engulf and destroy threats…

This study looks at how four different FDA-approved flu vaccines affect the immune system in 50 adults aged 18-50 and 65-80. Researchers will measure antibody levels and memory B cells to see how age and past vaccination history influence the body's response. The goal is to under…

This study looks at how things in the environment and at work might affect people with interstitial lung diseases (a group of lung conditions). Researchers will ask 1,000 adults with a new diagnosis about their exposures to things like pollution, chemicals, and dust. The goal is …

This study follows 250 Italian adults with genetic forms of pulmonary fibrosis to see how their lung function changes over time. Researchers will track breathing tests and compare patients who receive immune-modulating drugs with those who do not. The goal is to understand how in…

This study looks at 109 people in Virginia with nontuberculous mycobacterial (NTM) lung disease. Researchers use genetic sequencing to tell if a repeat infection is a relapse or a new infection from the environment. The goal is to better understand how the disease comes back and …

This study compares how well two FDA-approved COVID-19 vaccines—Novavax (a protein-based vaccine) and Pfizer (an mRNA vaccine)—trigger the immune system. Researchers will measure antibody levels against several virus variants in 54 healthy adults aged 18-79 who have risk factors …

This study follows 1,423 adults with idiopathic pulmonary fibrosis (IPF) for two years to learn how the disease progresses naturally. Researchers will track events like sudden worsening, hospital stays, and deaths. The goal is to better understand IPF patterns, not to test a new …

This study follows 75 adults aged 65 and older over three to four flu seasons to learn why the flu vaccine becomes less effective as people age. Participants will receive a different FDA-approved flu vaccine each year, and researchers will collect blood, nasal swab, and stool sam…

This study follows 500 children under 18 who tested positive for flu, RSV, or COVID-19. Each child takes a daily nose swab for 14 days to measure how the virus levels change over time. Researchers also check if family members get sick. The goal is to understand when kids are most…

This study aims to understand how the immune system responds to a second infection with a mild bird flu virus (H10N7). Healthy adults who were infected with H10N7 in a previous study will be infected again and monitored closely in the hospital for 9 days. The goal is to learn mor…

This study compares new, less invasive ways to collect samples for respiratory virus testing—like a nasal wash or saliva—against the standard deep nose swab. Researchers want to see if these gentler methods work just as well and cause less pain. About 1,000 adults in the emergenc…

This study looks at whether vitamin D levels are linked to certain immune markers in people with active tuberculosis (TB), with or without a chronic fungal lung infection called aspergillosis. Researchers will compare blood samples from 300 adults—including healthy volunteers—to …

This study follows 200 people who have had the flu to see how their immune system changes over two years. Participants give blood and nasal samples every three months. The goal is to learn how long antibodies last and how they change, which could help create more effective flu va…

This study compares immune responses to flu and COVID-19 vaccines between people with chronic spinal cord injuries and healthy individuals. Researchers will analyze blood samples to see if gene activity and antibody levels differ between the groups. The goal is to understand why …

This study follows about 1,000 adults in the U.S. who test positive for COVID-19 or influenza. Participants fill out surveys about their symptoms and quality of life over six months. The goal is to understand how these illnesses affect daily activities and whether COVID-19 vaccin…

This project works to make sure children with common respiratory infections get the right antibiotics for the right amount of time. It involves over 259,000 kids across many clinics. The goal is to learn the best ways to help doctors follow antibiotic guidelines and reduce unnece…

This study compares two flu vaccines: a nasal spray and a standard shot. Researchers will measure immune responses in the nose and blood of 60 healthy adults aged 18-49. The goal is to understand how each vaccine triggers protection and find ways to improve future flu vaccines.

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This trial is studying a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works and its safety. Participants will be monitored closely. The study sponsor and current status are not publicly available.

This study follows 100 adults hospitalized in intensive care units with severe pneumonia caused by Mycoplasma or Chlamydia bacteria. Researchers will track how patients are treated, how long they stay in the hospital, and how many survive. They will also check for antibiotic resi…

This study looks at 1,800 adults hospitalized with pneumonia in Hong Kong. Researchers use a simple urine test to identify which types of pneumococcus bacteria are causing the infections. The goal is to understand which strains are most common, which can help improve future vacci…

This study is testing whether an artificial intelligence model can more accurately diagnose the cause of severe pneumonia compared to traditional methods. Researchers will collect data from 1,000 ICU patients, including medical images, lab tests, and immune system information. Th…

This study looks at why people with severe liver disease who are in the intensive care unit (ICU) are at risk for a dangerous fungal lung infection called invasive pulmonary aspergillosis. Researchers will study 450 patients to find better ways to predict, diagnose, and treat thi…

This study looks at whether eating a high-fiber diet (rich in fruits, vegetables, and whole grains) can change the bacteria in your gut and improve how well the flu vaccine works. Researchers will give 31 adults special meals and snacks before they get their flu shot. The main go…

This study looks at whether the bacteria in your gut and what you eat can influence how well the flu vaccine works. Researchers will collect blood and stool samples from 74 adults before and after they get their flu shot. The goal is to find links between gut microbiome diversity…

This study looks at a new way of paying for healthcare called bundled payments, where providers get a single payment for an entire episode of care. Researchers will analyze Medicare data from 440 provider organizations to see if this approach improves quality and reduces costs fo…

This study looks at whether a procedure called flexible bronchoscopy can help doctors find the exact germ causing pneumonia in children who are not getting better with standard antibiotics. The study will include 58 children in the intensive care unit at a hospital in Cairo. If i…

This study places a rapid testing device in primary care clinics to help doctors quickly identify whether a cold-like illness is caused by a virus or bacteria. About 8,000 adults with symptoms like cough or runny nose will get a nasal swab, with results in 15 minutes. The goal is…

This study follows over 2,000 people and their pets in the Canton of Bern to learn how infections like COVID-19 spread and what social and environmental factors influence transmission. Participants provide samples and answer questionnaires over time. The goal is to improve pandem…

This registry is following 867 people with idiopathic interstitial pneumonias (IIPs), a group of rare lung diseases. The goal is to learn how these diseases behave over time, how they are diagnosed, and what treatments doctors currently use. No new drugs or procedures are being t…

This study looks at how the RSV vaccine affects the immune system in adults aged 60 and older. Researchers will take blood samples before and after vaccination to find early signs of protection. The goal is to understand why some people respond better than others. 14 volunteers w…

This study tests whether using rapid, advanced lab tests to identify the exact bacteria causing a severe infection can help doctors choose the right antibiotics faster. About 190 adults with sepsis in Greek ICUs will either get standard care or the new testing strategy. The goal …

This study tests whether a hospital-customized plan (ROAD Home) reduces unnecessary antibiotic use at discharge for adults with pneumonia or urinary tract infections. Forty hospitals are randomly assigned to either use this tailored approach or continue their usual practices. The…

This study looks at 500 patients with severe breathing failure due to pneumonia who are using a non-invasive breathing mask. Researchers will measure their energy needs, muscle function, and blood markers to identify different patient types. The goal is to better understand how t…

This study tests a 'discharge stewardship bundle' to help doctors prescribe the right antibiotics for the right duration when children leave the hospital. Over 1,100 children with pneumonia, urinary tract infections, or skin infections will be followed. Doctors receive feedback r…

This study was designed to track how the immune system recovers after CAR-T cell therapy and to test a pneumococcal vaccine (PCV-21) in these patients. It planned to enroll 50 adults with blood cancers or solid tumors. However, the study was withdrawn before any participants were…

This study tests whether a special MRI using inhaled xenon gas can show changes in lung function over time in people with idiopathic pulmonary fibrosis (IPF) who are starting approved treatments. About 34 participants will have an MRI before starting therapy and again at 3, 6, an…

This study looks at how the flu vaccine changes immune cells in the nose and blood. Researchers will collect samples from 30 healthy adults before and after they get the flu shot. The goal is to understand if the vaccine creates 'resident memory' immune cells in the nose, which c…

This study looks at whether a molecule called miR200 in the blood can help detect idiopathic pulmonary fibrosis (IPF), a lung-scarring disease, at an early stage. Researchers will compare miR200 levels in 450 people: those with IPF, those with other lung diseases, and healthy vol…

This study observes 100 adults with idiopathic pulmonary fibrosis (IPF) who are taking the drug nintedanib. The goal is to understand who is more likely to get diarrhea as a side effect and to see if lowering the dose helps. Researchers will track diarrhea severity and how dose c…

This study tests whether temperature sensors placed inside a Venturi mask can monitor breathing patterns in 82 patients hospitalized with pneumonia and respiratory failure. The goal is to see if these patterns can detect early signs of deterioration before patients need a breathi…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…

This study tracks how long the flu virus stays in the upper airways of 18 hospitalized adults who are taking oseltamivir (Tamiflu). The goal is to see if antiviral treatment can safely shorten the time patients need to stay in isolation, freeing up hospital rooms during flu seaso…

This study was designed to see if a harmless marker (quinine) placed in the mouth could show up in lung secretions, indicating that fluid is leaking past the breathing tube's cuff. It aimed to help detect aspiration in critically ill patients on ventilators. However, the study wa…

This study examines medical records of 1,100 children under 18 from hospitals across China who were hospitalized with RSV-positive bronchiolitis or pneumonia between 2017 and 2021. Researchers aim to understand how the disease is diagnosed and treated, and what it costs families …

This study looks at 120 adults getting a left ventricular assist device (LVAD) to see how often infections happen and how their immune system changes after surgery. The goal is to find what makes some patients more likely to get infections. This research does not test a new treat…

This study measures how well certain antibiotics penetrate the lungs in patients with pneumonia. Researchers will compare antibiotic levels in the blood and in lung fluid from 101 adults who need a bronchoscopy. The goal is to find factors that predict good lung penetration, whic…

This study follows 1,500 healthy infants from birth to age 4 to understand how their first encounter with the flu—either through vaccination or natural infection—affects their immune system's response to later flu exposures. Pregnant mothers are enrolled before delivery, and thei…

This study looks at lung tissue from 80 people with pulmonary fibrosis to find unique genetic markers linked to scarring. By analyzing gene activity, researchers hope to better understand the disease and pave the way for new diagnostic tools and treatments. Participants must be 1…

This study from the University of Pennsylvania looks at whether simply asking people about their intentions to do a health behavior—like getting a flu shot—makes them more likely to actually do it. Researchers are tracking 350 participants to see if measuring intention changes be…

This study looks at how well cancer patients respond to common vaccines like flu, COVID-19, and shingles. Researchers will measure antibody levels before and after vaccination in 250 adults with cancer. The goal is to understand immune responses in this group, not to test a new t…

This study aims to understand how nontuberculous mycobacteria (NTM) spread among people with cystic fibrosis (CF). NTM infections are hard to treat and common in CF, but their sources are unclear. Researchers will track 100 participants with CF and NTM, testing dust and water in …

This study looks back at 100 newborns who had a flexible bronchoscopy (a thin, flexible tube with a camera) to diagnose breathing problems in the neonatal intensive care unit over the past 10 years. Researchers want to see how often this procedure helped doctors find the exact ca…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…

This study follows 2,500 people who visit freshwater beaches in Ontario, Manitoba, and Nova Scotia to see if contact with water containing blue-green algae (cyanobacteria) leads to stomach bugs, respiratory issues, or skin/eye infections. Researchers will also track illness in pe…

This study is testing whether a questionnaire originally designed for COPD patients can be adapted to measure self-care in people with idiopathic pulmonary fibrosis (IPF). Researchers will enroll 156 adults with IPF to see if the tool accurately captures how well patients manage …