Military study aims to find the best flu shot
NCT ID NCT03734237
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This large study enrolled over 15,000 U.S. military members to compare three types of licensed flu vaccines: egg-based, recombinant, and cell-culture-based. Participants were randomly assigned to one of the three vaccines over four flu seasons. The main goal is to see which vaccine best prevents lab-confirmed flu. Results could help guide flu shot choices in the military.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
influenza vaccines (egg-based, recombinant, and cell-culture-based)
What this could lead to
If successful, this study could show which flu vaccine type is most effective for military personnel, helping to reduce flu illness in this population.
What could go wrong
This is a pragmatic trial, not a placebo-controlled one, so results may be influenced by real-world factors. Also, flu viruses change each year, so effectiveness may vary across seasons.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brooke Army Medical Center
Fort Sam Houston, Texas, 78234, United States
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Lackland Airforce Base
San Antonio, Texas, 78243, United States
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Madigan Army Medical Center
Tacoma, Washington, 98431, United States
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Naval Medical Center Portsmouth
Portsmouth, Virginia, 23704, United States
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Naval Medical Center San Diego
San Diego, California, 34800, United States
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USU
Bethesda, Maryland, 20307, United States
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United States Naval Academy
Annapolis, Maryland, 21402, United States
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Walter Reed National Military Medical Center
Bethesda, Maryland, 20814, United States
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Womack Army Medical Center
Fort Bragg, North Carolina, 28310, United States