Flu vaccine mystery: why some shots work better than others

NCT ID NCT07240922

Ongoing ⭐️ VACCINE ⭐️ Sponsor: The University of Hong Kong Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how getting the flu vaccine year after year changes your body's immune response. Researchers are testing two types of flu vaccines—a nasal spray (FluMist) and a shot (Flublok)—in 600 adults aged 22 to 50 in Hong Kong. They will measure antibodies and immune cells in the blood and nose to understand why some people get better protection than others.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Live attenuated influenza vaccine (FluMist) and recombinant hemagglutinin influenza vaccine (Flublok)
What this could lead to: If successful, this could help explain why some people respond better to flu vaccines than others, potentially leading to more effective vaccination strategies.
What could go wrong: This is a phase 4 study focused on immune response measurements, not on preventing flu itself. Results may not directly improve vaccine effectiveness or apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLUENZA

Contacts and locations

Locations

School of Public Health, The University of Hong Kong

Hong Kong, Hong Kong, 00000, Hong Kong

More trials for these conditions

Other studies related to the condition(s) this trial covers.