New pill aims to slow lung damage in scarring disease

NCT ID NCT06422884

Ongoing Disease control Sponsor: Endeavor Biomedicines, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 2 trial tests an experimental drug called ENV-101 (taladegib) in 213 adults with idiopathic pulmonary fibrosis, a disease that causes lung scarring and makes breathing harder. Participants take either the drug or a placebo daily for several months. The main goal is to see if the drug improves lung function and is safe to use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ENV-101 (taladegib)

What this could lead to

If successful, this could point toward a new treatment option to slow lung function decline in people with idiopathic pulmonary fibrosis.

What could go wrong

This is a mid-stage trial with 213 participants, so results may not confirm benefit. The drug may cause side effects or fail to improve lung function compared to placebo.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC PULMONARY FIBROSIS PROGRESSIVE FIBROSING INTERSTITIAL LUNG DISEASE

Contacts and locations

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Locations

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Quilmes, Buenos Aires, B1878FNR, Argentina
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Buenos Aires, 1888, Argentina
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Buenos Aires, C1426ABP, Argentina
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Mendoza, 5501, Argentina
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Mendoza, CP 5500, Argentina
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Camperdown, New South Wales, 2050, Australia
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Macquarie Park, New South Wales, 2109, Australia
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Brisbane, Queensland, 4032, Australia
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South Brisbane, Queensland, 4101, Australia
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Box Hill, Victoria, 3128, Australia
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Nedlands, Western Australia, 6009, Australia
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Graz, Styria, 8036, Austria
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Vienna, 1090, Austria
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Dinant, Namur, 5500, Belgium
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Brussels, 1070, Belgium
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Brussels, 1200, Belgium
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Edmonton, Alberta, T6G 2C8, Canada
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Vancouver, British Columbia, V6Z 2K5, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Trois-Rivières, Quebec, G8T 7A1, Canada
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Angers, 49933, France
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Bordeaux, 33604, France
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Caen, 14033, France
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Dijon, 21000, France
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Montpellier, 34090, France
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Nantes, 44093, France
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Paris, 75014, France
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Paris, 94270, France
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Rennes, 35033, France
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Tours, 37044, France
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Giessen, Hesse, 35398, Germany
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Immenhausen, Hesse, 34376, Germany
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Hanover, Lower Saxony, 30625, Germany
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Essen, North Rhine-Westphalia, 45239, Germany
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Berlin, 13125, Germany
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Leipzig, 4103, Germany
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Dublin, Leinster, D05 AT88, Ireland
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Dublin, Leinster, D07 A8NN, Ireland
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Cork, Munster, T12 DC4A, Ireland
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Dublin, D04 T6F4, Ireland
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Bologna, Forli-Cesena, 47121, Italy
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Padova, Padua, 35128, Italy
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Florence, Tuscany, 50314, Italy
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Catania, 95123, Italy
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Milan, 20123, Italy
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Turin, 10126, Italy
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Kuala Lumpur, Selangor, 42300, Malaysia
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Kuala Lumpur, Selangor, 50590, Malaysia
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Kuala Lumpur, Selangor, 56000, Malaysia
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Monterrey, Nuevo León, 64060, Mexico
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Monterrey, Nuevo León, 64718, Mexico
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San Nicolás de los Garza, Nuevo León, 66465, Mexico
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San Juan del Río, Querétaro, 76800, Mexico
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Chihuahua City, 31230, Mexico
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Mexico City, 14080, Mexico
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Oaxaca City, 68000, Mexico
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Puebla City, 72180, Mexico
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Auckland, New Zealand
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Christchurch, 8011, New Zealand
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Hamilton, New Zealand
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Seoul, (Deogyang District), 10475, South Korea
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Ulsan, (Dong District), 44033, South Korea
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Busan, (Haeundae District), 48108, South Korea
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Seoul, (Seongbuk District), 02841, South Korea
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Seoul, (Songpa District), 05505, South Korea
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Seoul, (Yongsan District), 04401, South Korea
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Seoul, 16499, South Korea
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Belfast, BT9 7AB, United Kingdom
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Birmingham, B15 2GW, United Kingdom
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Birmingham, B9 5SS, United Kingdom
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Cambridge, CB2 0AY, United Kingdom
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Edinburgh, EH1 3EG, United Kingdom
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Exeter, EX2 5DW, United Kingdom
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Leicester, LE3 9QP, United Kingdom
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London, SW3 6NP, United Kingdom
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Londonderry, BT47 6SB, United Kingdom