Nasal spray vs. needle: which flu vaccine works better?
NCT ID NCT05921448
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two flu vaccines: a nasal spray and a standard shot. Researchers will measure immune responses in the nose and blood of 60 healthy adults aged 18-49. The goal is to understand how each vaccine triggers protection and find ways to improve future flu vaccines.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Influenza vaccines (nasal spray and injection)
What this could lead to
If successful, this study could reveal which flu vaccine type triggers stronger nasal immunity, potentially leading to more effective vaccines.
What could go wrong
This is a very early, small study (60 people) focused on immune markers, not on preventing flu. Results may not apply to the general population.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Copenhagen Hospital Biobank Unit, Department of Clinical Immunology, Rigshospitalet, Denmark
Copenhagen, Copenhagen, 2100, Denmark
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Department of Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital
Gentofte Municipality, Copenhagen, 2900, Denmark
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Diagnostic Immunology, Department of Clinical Immunology, Rigshospitalet, Denmark
Copenhagen, Copenhagen, 2100, Denmark
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Imperial College
London, W12 0NN, United Kingdom
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Institute for Immunology and Microbiology (ISIM), Panum Institute, University of Copenhagen
Copenhagen, Copenhagen, 2100, Denmark
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National Influenza Center for WHO at Statens Serum Institut (SSI)
Copenhagen, 2300, Denmark
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Technical University of Denmark (DTU)
Kongens Lyngby, 2800, Denmark