New drug shows promise in slowing lung scarring
NCT ID NCT06132256
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called axatilimab in 145 people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The goal is to see if the drug can slow down the decline in lung function over 26 weeks compared to a placebo. Participants will be randomly assigned to receive either axatilimab or a dummy treatment, and their breathing will be closely monitored.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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A.O.U. Policlinico "G. Rodolico - San Marco"
Catania, 95123, Italy
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AOU Città della Salute e della Scienza di Torino - Molinette
Molinette, Italy
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AOU di Modena
Modena, 41124, Italy
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ASST Santi Paolo e Carlo
Milan, Lombardy, 20142, Italy
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AZ Groeninge
Kortrijk, West-Vlaanderen, 8500, Belgium
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Asian Medical Center
Seoul, Songpa-gu, 05505, South Korea
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Asklepios Lungenklinik Gauting
Gauting, 82131, Germany
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Azienda Ospedaliera Universitaria San Luigi Gonzaga
Torino, Orbassano, 10043, Italy
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Azienda Ospedaliera Universitaria Senese
Siena, Tuscany, 53100, Italy
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Azienda Ospedaliero Universitaria di Careggi
Florence, 50134, Italy
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CHU Amiens
Amiens, 80054, France
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CHU Dijon
Dijon, 21000, France
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CHU de Rennes
Rennes, 35033, France
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Centre de Recherche Clinique - CHUS
Sherbrooke, Quebec, J1H 5N4, Canada
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Chang-Geng Medical Foundation Linkou Chang-Geng Memorial Hospital
Linkou District, Taiwan
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China Medical University Hospital
Taichung, 40447, Taiwan
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Chonnam National University Hospital
Gwangju, Dong-gu, 61469, South Korea
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Chu Brest
Brest, 29200, France
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Chung-Ang University Gwangmyeong Hospital
Gyeonggi-do, Gwangmyeong-si, 14353, South Korea
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Clinica Lavinia Davidescu SRL
Oradea, 410163, Romania
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Clinical Hospital of Infectious Diseases and Pneumophysiology Dr.Victor Babeș Timișoara Department of Pneumology
Timișoara, 300310, Romania
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Dynamic Drug Advancement
Ajax, L1S 2J5, Canada
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E-Da Hospital
Kaohsiung City, 824005, Taiwan
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Gachon University Gil Medical Center
Incheon, Namdong-gu, 21565, South Korea
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Gannochy Trust Clinical Research Suite
Perth, Scotland, PH11NX, United Kingdom
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Giromed Institute
Girona, 17003, Spain
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Griffith University Clinical Trial Unit
Southport, Queensland, 4222, Australia
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital Gregorio Marañon
Madrid, 28007, Spain
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Hospital Universitari Son Espases
Palma de Mallorca, 07120, Spain
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Hospital Universitario Bellvitge
L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Hospital Universitario Central de Asturias
Oviedo, Principality of Asturias, 33011, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, 39008, Spain
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Hospital Universitario Parc Tauli
Sabadell, Barcelona, 08208, Spain
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Hospital Universitario Puerta de Hierro
Majadahonda, Madrid, 28222, Spain
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Hospital Universitario Puerta del Mar - Pneumology and Thoracic Surgery Department
Cadiz, 11009, Spain
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Hospital Universitario Santiago de Compostela
Santiago de Compostela, 15706, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, 29010, Spain
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Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
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ISMETT
Palermo, 90127, Italy
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Inje University Haeundae Paik Hospital
Haeundae, Busan, 48108, South Korea
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Institute for Respiratory Health
Perth, Western Australia, 6009, Australia
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Jeonbuk National University Hospital
Jeonju, 54907, South Korea
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Klinikum Chemnitz - Zentrum für klinische Studien
Chemnitz, 09116, Germany
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Klinikum Konstanz, Innere Medizin, Pneumologie
Konstanz, Baden-Wurttemberg, 78464, Germany
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Konkuk University Medical Center
Seoul, Gwangjin-gu, 05030, South Korea
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Korea University ANAM Hospital
Seoul, 02841, South Korea
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Leeds Teaching Hospitals NHS Trust
Leeds, W York, LS9 7TF, United Kingdom
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Mackay Hospital & Health Service
West Mackay, Queensland, 4740, Australia
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Makowskie Centrum medyczne Hamernia Sp zz
Maków Podhalański, 34-220, Poland
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Mater Misericordiae Ltd
South Brisbane, Queensland, 4101, Australia
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Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625, Germany
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Mics Centrum Medyczne Bydgoszcz
Bydgoszcz, Poland
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Monash Health
Clayton, Victoria, 3168, Australia
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National Taiwan University Hospital
Taipei, Taiwan
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Norfolk and Norwich University Hospital
Norwich, Norfolk, NR4 7UY, United Kingdom
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OLV Hospital Aalst
Aalst, Oost-Vlaanderen, 9300, Belgium
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Ospedale Colonnello D'Avanzo
Foggia, Apulia, 71122, Italy
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Oxford University Hospitals NHS Trust
Oxford, Oxforshire, OX3 7LE, United Kingdom
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Pneumologisches Studienzentrum München-West
Munich, Bavaria, 81241, Germany
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RoMed Klinikum Rosenheim
Rosenheim, 83022, Germany
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Royal Papworth Hospital - Clincial Research Facility
Cambridge, Cambridgehsire, CB2 0AY, United Kingdom
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Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia
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Samsung Medical Center
Seoul, 06351, South Korea
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San Gerardo
Monza, MB, 20900, Italy
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SoonChunHyang University Hospital
Seoul, 04401, South Korea
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Studienzentrum Dr. Keller
Frankfurt am Main, 60389, Germany
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Sunshine Coast University Hospital
Birtinya, Queensland, 4575, Australia
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Taichung Veterans General Hospital
Taichung, 40705, Taiwan
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The Catholic University of Korea, Eunpyeong St. Mary's Hospital
Seoul, Eunpyeong-gu, 03312, South Korea
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Thomayer University Hospital
Prague, 140 00, Czechia
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University Hospital Vall d'Hebron
Barcelona, 08035, Spain
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University Hospitals Birmingham NHS Foundation Trust
Birmingham, West Midlands, B15 2WB, United Kingdom
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University of Padua
Padova, Padua, 35128, Italy
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Vitamed Galaj I Cichomski sp.j.
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-079, Poland
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Wallace Street Specialist Centre
Brisbane, Queensland, 4032, Australia
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Warmia and Mazury Center for Lung Diseases
Olsztyn, 10-357, Poland
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