Inhaled treprostinil aims to slow IPF lung damage in major trial

NCT ID NCT04708782

Completed Disease control Sponsor: United Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tested whether an inhaled drug called treprostinil (Tyvaso) could slow the loss of lung function in 598 adults with idiopathic pulmonary fibrosis (IPF), a progressive lung disease. Participants inhaled the drug or a placebo four times daily for 52 weeks. The main goal was to measure changes in forced vital capacity (FVC), a key breathing test. The study is complete, and results will show if treprostinil helps preserve lung function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: inhaled treprostinil (Tyvaso)
What this could lead to: If it works, this could offer a new inhaled treatment to slow lung function decline in people with idiopathic pulmonary fibrosis.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The drug may not significantly slow disease progression, and side effects from inhaled treprostinil can include cough, headache, and throat irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis interstitial lung disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC PULMONARY FIBROSIS INTERSTITIAL LUNG DISEASE

Contacts and locations

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Locations

A & A Research Consultants, LLC

McAllen, Texas, 78503, United States
Adventist Healthcare White Oak Medical CEnter

Silver Spring, Maryland, 20904, United States
Arizona Pulmonary Specialists, Ltd.

Phoenix, Arizona, 85012, United States
Ascension St. Vincent's

Jacksonville, Florida, 32204, United States
Banner University Medical Center-Phoenix

Phoenix, Arizona, 85006, United States
Baylor Clinic-Baylor College of Medicine

Houston, Texas, 77030, United States
Baylor University Medical Center

Dallas, Texas, 75246, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Central Florida Pulmonary Group, PA

Orlando, Florida, 32803, United States
Centre d'investigation Clinique Mauricie

Trois-Rivières, Quebec, G8T 7A1, Canada
Centro Respiratorio Integral LTDA. (CENRESIN)

Quillota, Valparaiso, 2260000, Chile
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cleveland Clinic Florida

Weston, Florida, 33331, United States
Clinical Research of Rock Hill

Rock Hill, South Carolina, 29732, United States
Coastal Pulmonary & Critical Care PLC

St. Petersburg, Florida, 33704, United States
Community Health Network

Indianapolis, Indiana, 46250, United States
Corewell Health William Beaumont Hospital

Royal Oak, Michigan, 48073, United States
Creighton University Clinical Research Office

Omaha, Nebraska, 68124, United States
David Geffen School of Medicine at UCLA

Los Angeles, California, 90095, United States
Dynamic Drug Advancement Limited

Ajax, Ontario, L1S 2J5, Canada
East Carolina University and Leo Jenkins Cancer Center

Greenville, North Carolina, 27834, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States
Fundacion Medica San Cristobal

Santiago, Santiago Metropolitan, 7630226, Chile
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Inova Fairfax Hospital

Falls Church, Virginia, 22042, United States
Institut Universitaire de Cardiologie et de Pneumologie de Quebec-Universite

Québec, G1V 4G5, Canada
Intermountain Medical Center

Murray, Utah, 84107, United States
Johns Hopkins Asthma & Allergy Center

Baltimore, Maryland, 21224, United States
LSU Health Science Center Shreveport

Shreveport, Louisiana, 71103, United States
LSU Health Sciences Center New Orleans

New Orleans, Louisiana, 70112, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55902, United States
Mayo Clinic Florida

Jacksonville, Florida, 32224, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Metroplex Pulmonary and Sleep Center PA

McKinney, Texas, 75069, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
National Jewish Health

Denver, Colorado, 80206, United States
NewportNativeMD, Inc

Newport Beach, California, 92663, United States
Northwell Health

New Hyde Park, New York, 11040, United States
Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States
Norton Pulmonary Specialists

Louisville, Kentucky, 40202, United States
Palmtree Clinical Research, Inc.

Palm Springs, California, 92262, United States
Penn State Milton S. Hershey Medical Center/Penn State College of Medicine

Hershey, Pennsylvania, 17033, United States
Piedmont Healthcare Atlanta

Atlanta, Georgia, 30309, United States
Premier Pulmonary Critical Care and Sleep Medicine

Denison, Texas, 75020, United States
Prisma Health Midlands

Columbia, South Carolina, 29203, United States
PulmonIx, LLC

Greensboro, North Carolina, 27403, United States
Pulmonary Associates of Richmond, Inc.

Richmond, Virginia, 23230, United States
Pulmonary Disease Specialists, PA d/b/a PDS Research

Kissimmee, Florida, 34741, United States
Renovatio Clinical Consultants, LLC

The Woodlands, Texas, 77380, United States
Rush University Medical Center Outpatient Pulmonary Clinic

Chicago, Illinois, 60612, United States
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Southeastern Research Center

Winston-Salem, North Carolina, 27103, United States
St Joseph's Physician's Pulmonary Health

Liverpool, New York, 13088, United States
St. Francis Sleep Allergy & Lung Institute

Clearwater, Florida, 33765, United States
St. Joseph's Healthcare Hamilton

Hamilton, Ontario, L8N 4A6, Canada
St. Joseph's Hospital and Medical Center - Norton Thoracic Institute

Phoenix, Arizona, 85013, United States
St.Paul's Hospital

Vancouver, British Columbia, V6Z1Y6, Canada
Stanford University Medical Center

Stanford, California, 94305, United States
Statecare Pulmonary Consultants

Knoxville, Tennessee, 37919, United States
Stony Brook Advanced Specialty Care

Stony Brook, New York, 11725, United States
Temple Lung Center

Philadelphia, Pennsylvania, 19140, United States
The Lung Research Center

Chesterfield, Missouri, 63017, United States
The Ohio State University Wexner Medical Center - Martha Morehouse Medical Pavilion

Columbus, Ohio, 43221, United States
The Oregon Clinic, PC

Portland, Oregon, 97220, United States
The Queen's Medical Center

Honolulu, Hawaii, 96813, United States
The University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
The University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
Thoams Jefferson,Hospital University

Philadelphia, Pennsylvania, 19107, United States
Toronto General Hospital

Toronto, Ontario, M5G 2C4, Canada
Tufts Medical Center

Boston, Massachusetts, 02111, United States
Tulane University Medical Center

New Orleans, Louisiana, 70112, United States
UC Davis Health Medical Center

Sacramento, California, 95817, United States
UC San Diego Health

La Jolla, California, 92037, United States
University of Arizona

Tucson, Arizona, 85724, United States
University of California - San Francisco

San Francisco, California, 94143, United States
University of California, Irvine

Orange, California, 92868, United States
University of Cincinnati

Cincinnati, Ohio, 45267, United States
University of Florida

Jacksonville, Florida, 32209, United States
University of Florida Health at Shands

Gainesville, Florida, 32610, United States
University of Louisville

Louisville, Kentucky, 40202, United States
University of Michigan Int Med Pulmonary and critical care

Ann Arbor, Michigan, 48109, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of New Mexico Health Sciences Center

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Rochester Medical center

Rochester, New York, 14642, United States
University of South Florida Health

Tampa, Florida, 33606, United States
University of Utah Health

Salt Lake City, Utah, 84108, United States
University of Virginia Health System

Charlottesville, Virginia, 22903, United States
University of Wisconsin School of Medicine and Public health

Madison, Wisconsin, 53792, United States
Univrsity of Texas Southwestern Medical Center

Dallas, Texas, 75390-8550, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37204, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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