New drug tested to slow scarring in lungs

NCT ID NCT04308681

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This study tested whether an experimental drug called BMS-986278 could help people with pulmonary fibrosis, a condition that causes scarring in the lungs. 403 participants were randomly assigned to receive either the drug or a placebo for 26 weeks to see if it could slow the decline in their lung function. Researchers measured how much air participants could exhale and monitored for side effects to determine if the treatment was safe and effective.

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Contacts and locations

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Locations

Hopital Europeen Georges Pompidou

Paris, 75015, France
Local Institution

Phoenix, Arizona, 85006, United States
Local Institution

Hershey, Pennsylvania, 17033, United States
Local Institution

Nashville, Tennessee, 37232, United States
Local Institution

Falls Church, Virginia, 22042, United States
Local Institution

Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
Local Institution

São Paulo, São Paulo, 04266-010, Brazil
Local Institution

São Paulo, São Paulo, 04520-013, Brazil
Local Institution

Vancouver, British Columbia, V5Z 1M9, Canada
Local Institution

Freiburg im Breisgau, 79106, Germany
Local Institution

Mexico City, Mexico City, 06700, Mexico
Local Institution

Seoul, 06355, South Korea
Local Institution

Barcelona, 08035, Spain
Local Institution

Madrid, 28034, Spain
Local Institution

Marbella Málaga, 29603, Spain
Local Institution

London, WC1E 6JF, United Kingdom
Local Institution - 0003

Boston, Massachusetts, 02135, United States
Local Institution - 0006

Denver, Colorado, 80206, United States
Local Institution - 0021

Murdoch, Western Australia, 6150, Australia
Local Institution - 0022

Adelaide, South Australia, 5000, Australia
Local Institution - 0023

Heidelberg, Victoria, 3084, Australia
Local Institution - 0025

Westmead, New South Wales, 2145, Australia
Local Institution - 0026

Brisbane, Queensland, 4032, Australia
Local Institution - 0028

Los Angeles, California, 90024, United States
Local Institution - 0029

Cincinnati, Ohio, 45267, United States
Local Institution - 0030

Chesterfield, Missouri, 63017, United States
Local Institution - 0031

Kansas City, Kansas, 66160, United States
Local Institution - 0032

Birmingham, Alabama, 35294, United States
Local Institution - 0035

Gainesville, Florida, 32610, United States
Local Institution - 0036

St Louis, Missouri, 63110, United States
Local Institution - 0038

Quillota, Región de Valparaíso, 0, Chile
Local Institution - 0039

Pozuelo de Alarcón, 28223, Spain
Local Institution - 0041

London, SE1 9RT, United Kingdom
Local Institution - 0043

Stanford, California, 94305-528, United States
Local Institution - 0044

Nedlands, Western Australia, 6009, Australia
Local Institution - 0045

Camperdown, New South Wales, 2050, Australia
Local Institution - 0046

Greenslopes, Queensland, 4120, Australia
Local Institution - 0048

Buenos Aires, 1638, Argentina
Local Institution - 0049

Buenos Aires, Distrito Federal, 1425, Argentina
Local Institution - 0050

Cambridge, CB2 0AY, United Kingdom
Local Institution - 0051

Liège, 4000, Belgium
Local Institution - 0054

Talca, Maule Region, 3481349, Chile
Local Institution - 0064

Hamamatasu, Shizuoka, 431-3192, Japan
Local Institution - 0065

Leuven, 3000, Belgium
Local Institution - 0066

Bron, 69677, France
Local Institution - 0067

Rennes, 35033, France
Local Institution - 0071

Yokohama, Kanagawa, 236-0051, Japan
Local Institution - 0072

Roma, 00168, Italy
Local Institution - 0073

Catania, 95123, Italy
Local Institution - 0074

Brussels, 1200, Belgium
Local Institution - 0076

São Paulo, 01323020, Brazil
Local Institution - 0077

Modena, 41125, Italy
Local Institution - 0078

Atlanta, Georgia, 30309, United States
Local Institution - 0080

Bunkyo-ku, Tokyo, 113-8510, Japan
Local Institution - 0081

Monterrey, Nuevo León, 64718, Mexico
Local Institution - 0083

San Nicolás de los Garza, Nuevo León, 66465, Mexico
Local Institution - 0086

Seoul, 05505, South Korea
Local Institution - 0087

Seoul, 03722, South Korea
Local Institution - 0089

Monza, 20900, Italy
Local Institution - 0092

London, SW3 6HP, United Kingdom
Local Institution - 0093

Großhansdorf, 22927, Germany
Local Institution - 0094

Montreal, Quebec, H2X 3E4, Canada
Local Institution - 0095

Kobe, Hyōgo, 6500047, Japan
Local Institution - 0096

Charlottesville, Virginia, 22908, United States
Local Institution - 0097

San Miguel de Tucumán, Tucumán Province, T4000IAR, Argentina
Local Institution - 0103

Rosario, Santa Fe Province, S2000DTC, Argentina
Local Institution - 0106

Kōriyama, Fukushima, 963-0197, Japan
Local Institution - 0107

Essen, 45239, Germany
Local Institution - 0108

Curicó, Maule Region, 3341643, Chile
Local Institution - 0109

Monterrey, N.l., Nuevo León, 64460, Mexico
Local Institution - 0110

Heidelberg, 69126, Germany
Local Institution - 0111

Hanover, Lower Saxony, 30459, Germany
Local Institution - 0112

Sakai, Osaka, 591-8555, Japan
Local Institution - 0113

Haifa, 34362, Israel
Local Institution - 0114

Petah Tikva, 4941492, Israel
Local Institution - 0115

Buenos Aires, 1056, Argentina
Local Institution - 0116

Barcelona, 08036, Spain
Local Institution - 0117

Kumamoto, 861-4193, Japan
Local Institution - 0119

Stuttgart, 70736, Germany
Local Institution - 0120

Bobigny, 93000, France
Local Institution - 0121

Munich, 81377, Germany
Local Institution - 0122

Mendoza, 5500, Argentina
Local Institution - 0127

Québec, Quebec, G1V 2G5, Canada
Local Institution - 0128

Izumo, Shimane, 693-0021, Japan
Local Institution - 0132

Toulouse, 31059, France
Local Institution - 0134

Toronto, Ontario, M5T 3A9, Canada
Local Institution - 0136

Dijon, 21000, France
Local Institution - 0137

Madrid, 28040, Spain
Local Institution - 0140

L'Hospitalet de Llobregat, 08907, Spain
Local Institution - 0141

Vancouver, British Columbia, V5Z 1M9, Canada
Local Institution - 0143

Paris, 75018, France
Local Institution - 0144

Sherbrooke, Quebec, J1H 5N4, Canada
Local Institution - 0145

Tel Aviv, Tel Aviv, 6423906, Israel
Local Institution - 0146

Nagasaki, 852-8102, Japan
Local Institution - 0147

Santander, 39008, Spain
Local Institution - 0148

Ramat Gan, 5262100, Israel
Local Institution - 0149

Jerusalem, 9112001, Israel
Local Institution - 0153

Minato-ku, Tokyo, 1058470, Japan
Local Institution - 0154

Baltimore, Maryland, 21224, United States
Local Institution - 0155

Seto, Aichi-ken, 489-8642, Japan
Local Institution - 0156

Oaxaca City, Oaxaca, 68020, Mexico
Local Institution - 0162

Marseille, 13915, France
Local Institution - 0163

Edinburgh, EH16 4SA, United Kingdom
Local Institution - 0164

Columbus, Ohio, 43221, United States
Local Institution - 0166

Orlando, Florida, 32803, United States
Local Institution - 0169

Kobe, Hyōgo, 653-0013, Japan
Local Institution - 0170

Saitama, 330-8553, Japan
Local Institution - 0171

New Haven, Connecticut, 06520, United States
Local Institution - 0173

Tokyo, 143-8541, Japan
Local Institution - 0174

Taipei, 10002, Taiwan
Local Institution - 0175

Taipei, 11217, Taiwan
Local Institution - 0176

Kaohsiung City, 0, Taiwan
Local Institution - 0177

Shinjyuku-ku, Tokyo, 162-8655, Japan
Local Institution - 0180

Sapporo, Hokkaido, 060-8543, Japan
Local Institution - 0183

Beijing, Beijing Municipality, 100730, China
Local Institution - 0187

Beijing, Beijing Municipality, 100020, China
Local Institution - 0188

Wuhan, Hubei, 430022, China
Local Institution - 0189

Shanghai, Shanghai Municipality, 200030, China
University of Colorado Anschutz Medical Campus-Department of Medicine

Aurora, Colorado, 80045, United States

Conditions

Explore the condition pages connected to this study.

PULMONARY FIBROSIS