Mushroom supplement shows promise for sinusitis sufferers

NCT ID NCT07460934

Completed Disease control Sponsor: Pleuran, s.r.o. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a dietary supplement called Imunoglukan P4H® (made from pleuran, a mushroom extract, plus vitamin C) could help people with chronic sinusitis. 85 patients over age 12 took the supplement alongside standard treatments like nasal sprays and saline rinses. Researchers tracked sinus flare-ups, infections, and antibiotic use to see if the supplement made a difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pleuran (Imunoglukan P4H®) with vitamin C
What this could lead to: If it works, this could offer a natural supplement to help prevent sinusitis flare-ups and reduce the need for antibiotics and nasal sprays.
What could go wrong: This is a small, completed study with only 85 participants. The supplement may not provide significant benefit over standard care alone, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic rhinosinusitis respiratory tract infectious disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIBIOTIC PROPHYLAXIS CHRONIC RHINOSINUSITIS (CRS) EXACERBATIONS RESPIRATORY TRACT INFECTIONS (RTI)

Contacts and locations

Locations

Department of Pediatric ENT, University Hospital Brno - Children's Hospital, Černopolní 9, Brno, Czechia 613 00

Brno, Czechia, 61300, Czechia
ORL department, F.D. Roosevelt University Hospital with Policlinic

Banská Bystrica, Slovensko, 97517, Slovakia
ORL department, University Hospital Brno, Jihlavská 25

Brno, Czechia, 62500, Czechia
ORL-HP s.r.o., Nemocničná - poliklinika 1

Veľký Krtíš, Slovensko, 99001, Slovakia
Sante s.r.o, Zdravomed 2, Cesta k nemocnici 1

Banská Bystrica, Slovensko, 97401, Slovakia

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