New mRNA flu shot shows promise in early trial
NCT ID NCT06436703
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
Pfizer completed a study testing a new modified RNA (mRNA) flu vaccine in 1,202 healthy adults aged 18 and older. The goal was to see if the vaccine is safe and triggers a strong immune response. Participants received either the experimental mRNA vaccine or a licensed flu shot, and were followed for about 6 months. This early research helps determine whether mRNA technology can improve flu protection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
modified RNA influenza vaccine
What this could lead to
If successful, this could lead to a more effective or faster-to-update flu vaccine, potentially offering better protection each season.
What could go wrong
This was an early-phase study focused on safety and immune response, not on preventing flu illness. The vaccine may not work better than existing flu shots, and side effects like injection-site pain or fever are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AMR Clinical
Mobile, Alabama, 36608, United States
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AMR Clinical
Norfolk, Virginia, 23502, United States
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Alliance for Multispecialty Research, LLC
New Orleans, Louisiana, 70119, United States
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Alliance for Multispecialty Research, LLC
Kansas City, Missouri, 64114, United States
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Anaheim Clinical Trials, LLC
Anaheim, California, 92801, United States
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Artemis Institute for Clinical Research
San Diego, California, 92103, United States
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Charlottesville Medical Research
Charlottesville, Virginia, 22911, United States
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Clinical Neuroscience Solutions, Inc.
Orlando, Florida, 32801, United States
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Clinical Research Consulting
Milford, Connecticut, 06460, United States
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Clinical Research Professionals
Chesterfield, Missouri, 63005, United States
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Clinical Trials of Texas, LLC
San Antonio, Texas, 78229, United States
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Clinical Trials of Texas, LLC dba Flourish Research
San Antonio, Texas, 78229, United States
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DM Clinical Research - Philadelphia
Philadelphia, Pennsylvania, 19107, United States
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Diablo Clinical Research, Inc.
Walnut Creek, California, 94598, United States
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Duke Vaccine and Trials Unit
Durham, North Carolina, 27703, United States
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Dynamed Clinical Research, LP d/b/a DM Clinical Research
Tomball, Texas, 77375, United States
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East-West Medical Research Institute
Honolulu, Hawaii, 96814, United States
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Headlands Horizons LLC
Brownsville, Texas, 78526, United States
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Headlands Research - Scottsdale
Scottsdale, Arizona, 85260, United States
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Headlands Research Orlando
Orlando, Florida, 32819, United States
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Indago Research & Health Center, Inc
Hialeah, Florida, 33012, United States
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J. Lewis Research, Inc. / Foothill Family Clinic
Salt Lake City, Utah, 84109, United States
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J. Lewis Research, Inc. / Foothill Family Clinic South
Salt Lake City, Utah, 84121, United States
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M3 Wake Research, Inc.
Raleigh, North Carolina, 27612, United States
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Orange County Research Center
Lake Forest, California, 92630, United States
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Palm Springs Community Health Center
Miami Lakes, Florida, 33014, United States
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Prism Research LLC dba Nucleus Network
Saint Paul, Minnesota, 55114, United States
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Qps-Mra, Llc
South Miami, Florida, 33143, United States
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Research Centers of America
Hollywood, Florida, 33024, United States
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Research Centers of America ( Hollywood )
Hollywood, Florida, 33024, United States
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Rochester Clinical Research, LLC
Rochester, New York, 14609, United States
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SMS Clinical Research
Mesquite, Texas, 75149, United States