Scientists infect older adults with RSV to unlock vaccine secrets
NCT ID NCT03728413
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at how the immune system of older adults (ages 60-75) responds to a controlled infection with respiratory syncytial virus (RSV). Researchers gave 28 healthy volunteers a weakened form of the virus via nasal drops and monitored their symptoms and immune reactions for 14 days. The goal was to identify which parts of the immune response are most important for protection, which could guide the development of better RSV vaccines for the elderly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RSV A Memphis 37 (a weakened respiratory syncytial virus given as nasal drops)
What this could lead to
If successful, this study could reveal which immune targets are most important for protecting older adults against RSV, helping design better vaccines.
What could go wrong
This is a very small, early-stage study (28 participants) that deliberately infects people with a virus. It is not testing a treatment or vaccine, so direct benefits are unlikely.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Imperial College London
London, W12 0NN, United Kingdom