Breast disorder

This early-phase trial tests an experimental vaccine made from the alpha-lactalbumin protein, found in breast tissue, to see if it can safely train the immune system to fight triple-negative breast cancer cells. The study enrolls people who have completed treatment for non-metast…

This trial is testing whether choosing chemotherapy based on the genetic profile of a patient's breast tumor can improve treatment response compared to standard chemotherapy. Women with HER2-negative breast cancer that is not eligible for conservative surgery will be randomly ass…

This trial is testing whether a radioactive tracer, technetium Tc 99m sulfur colloid, can accurately locate sentinel lymph nodes in women with early-stage breast cancer. The sentinel node is the first lymph node cancer is likely to spread to, and finding it helps guide surgery. T…

This trial tests whether giving radiation to the nipple and areola after a nipple-sparing mastectomy is safe and feasible for women with early-stage breast cancer. The goal is to see if this extra radiation can reduce the risk of cancer returning in the preserved nipple area, all…

This phase III trial is investigating whether adding lapatinib to the standard combination of paclitaxel and trastuzumab before surgery can improve outcomes for patients with HER2-positive stage II or III breast cancer. The study aims to see if the three-drug regimen leads to a h…

This trial tests whether giving goserelin, a hormone-blocking drug, alongside chemotherapy can help preserve ovarian function and fertility in premenopausal women with breast cancer. Participants receive either chemotherapy plus goserelin or chemotherapy alone. Researchers will m…

This phase 2 trial compares three hormone therapies—fulvestrant, anastrozole, and tamoxifen—in women with invasive lobular breast cancer, a subtype that is often treated the same as more common breast cancers despite limited evidence. Participants take one of the drugs for about …

This phase III trial is testing whether a combination of docetaxel and cyclophosphamide works as well as or better than anthracycline-based chemotherapy (like doxorubicin) for women with HER2-negative breast cancer that has spread to lymph nodes or is high-risk. The study aims to…

This study tests whether a combination of ribociclib (a targeted pill) and hormone therapy can shrink tumors faster and more effectively than chemotherapy in women with a fast-growing type of advanced breast cancer (HR-positive, HER2-negative). Participants receive ribociclib plu…

This study looked at the safety and effectiveness of a drug called ribociclib combined with hormone therapy for people with a certain type of advanced breast cancer (HR+/HER2-). Researchers collected real-world data from 175 patients in the Middle East to track side effects and h…

This completed phase 3 trial tested whether a single, high-dose radiation boost (6 Gy in one session) is as good as the standard 5-session boost (10 Gy total) after whole-breast radiation in 132 breast cancer patients who had breast-conserving surgery. The main goal was to see if…

This phase II trial is testing whether adding two HER2-targeted drugs (trastuzumab and pertuzumab) to the chemotherapy gemcitabine can help people with metastatic HER2-positive breast cancer who have already received similar treatments. The study aims to see how long the cancer s…

This trial tests an experimental drug, RSO-021, given directly into the chest cavity of people with malignant pleural effusion—a buildup of fluid around the lungs caused by advanced solid tumors or mesothelioma. The study aims to find a safe dose and check for early signs that th…

This study monitors the safety and effectiveness of the drug olaparib (Lynparza) in people with ovarian, breast, prostate, or pancreatic cancer who are prescribed it as part of routine care in South Korea. Researchers will track side effects and how long the cancer stays under co…

This study follows women who received a REGENERA implant after having a non-cancerous breast lump removed. The goal is to see if the implant remains safe and performs well up to five years after the initial surgery. Researchers are tracking any side effects or complications linke…

This trial compares two chemotherapy drugs—cabazitaxel given every three weeks versus paclitaxel given weekly—as a first treatment for HER2-negative metastatic breast cancer. About 90 to 160 participants receive 18 weeks of one of the two drugs. The main goal is to see which drug…

This trial tests whether an accelerated radiation schedule of 5 sessions over 10-12 days works as well as the standard 15-session schedule for women who have had breast-conserving surgery for breast cancer. The study measures breast shape changes two years after treatment. If the…

This phase 2 trial is testing whether a combination of two chemotherapy drugs (nab-paclitaxel and cisplatin) plus an immunotherapy drug (camrelizumab) can help people with metastatic triple-negative breast cancer live longer without their disease getting worse. The study enrolls …

This phase 3 trial compares two treatment approaches for women aged 70 and older with estrogen-receptor-positive, HER2-negative breast cancer. Participants receive either hormone therapy alone for five years or chemotherapy followed by hormone therapy. The study aims to see if ad…

This study tests a precise type of radiation called proton therapy for women who have had a mastectomy for invasive breast cancer. Unlike standard radiation, proton beams stop at the target area, potentially reducing damage to nearby organs like the heart and lungs. The goal is t…

This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responde…

This study tests whether a program of motivational counseling to follow diet and exercise guidelines helps women newly diagnosed with breast cancer complete their chemotherapy and hormone therapy as planned. About 173 women scheduled for chemotherapy will be randomly assigned to …

This trial tests a new way to deliver radiation after breast cancer surgery. Instead of using a single treatment plan for the whole course, the Ethos system creates a new plan each day based on the patient's current anatomy. The goal is to avoid delays caused by changes in breast…

This trial is for women with advanced breast cancer that has both hormone receptors (HR-positive) and the HER2 protein (HER2-positive). It tests whether adding a CDK4/6 inhibitor called palbociclib to standard endocrine therapy and anti-HER2 antibodies (trastuzumab and pertuzumab…

This trial tests a device called SELENE that gives surgeons a detailed view of the tissue removed during breast-conserving surgery. The goal is to see if using this imaging helps surgeons remove all cancer cells the first time, reducing the chance that a patient needs another ope…

This trial investigates whether a structured exercise program can improve fitness and lower risk factors for heart disease, stroke, and type 2 diabetes in Latina women who have had breast cancer. Participants are randomly assigned to either an 8-month progressive exercise program…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This trial tests a surgical technique for breast reconstruction that uses a tiny camera (endoscope) to help the surgeon harvest muscle and skin from the back through a smaller cut. The goal is to rebuild the breast after cancer or burn injuries while leaving a less noticeable sca…

This trial tests an experimental drug called TQB2102 for people with HER2-positive breast cancer that has returned or spread to other parts of the body. TQB2102 is an antibody-drug conjugate—a targeted therapy that binds to HER2 on cancer cells and releases a potent chemotherapy …

This pilot study tests whether adding a special heat therapy (multimodal thermal therapy) to standard chemotherapy and immunotherapy can help the immune system better recognize and attack HER2-negative breast cancer. The study enrolls women aged 18–70 with certain subtypes of bre…

This trial tests whether freezing a small, low-risk breast tumor (cryoablation) can control the cancer as well as surgical removal. About 200 women with invasive ductal breast cancer tumors 1.5 cm or smaller will receive cryoablation and be followed for 5 years to check for local…

This study follows 66 women with stage II/III breast cancer who received a natural supplement called PG2 (from astragalus root) alongside their standard chemotherapy. Researchers want to see if PG2 helps delay cancer recurrence or spread, and whether it improves survival. The goa…

This trial investigates whether adding everolimus (RAD001) to trastuzumab (Herceptin) can help people with a specific type of advanced breast cancer that has stopped responding to trastuzumab alone. The study includes people with HER2-positive, PTEN-deficient metastatic breast ca…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This phase 2 trial tests a new drug called TVB-2640 (denifanstat) combined with trastuzumab and either chemotherapy (paclitaxel) or hormone therapy in 17 people with HER2+ metastatic breast cancer that no longer responds to trastuzumab. TVB-2640 blocks an enzyme cancer cells need…

This study tested whether Naderin, an immune-boosting drug, could prevent low white blood cell counts in 79 women with breast cancer receiving first-line chemotherapy. Participants either received Naderin alongside chemotherapy or chemotherapy alone. The results showed that only …

This Phase 2 trial tested whether disulfiram (Antabuse), a drug used for alcoholism, combined with copper supplements could help people with metastatic breast cancer who had run out of standard options. Only 9 patients took part, and researchers measured tumor response and surviv…

This phase 2 trial tested a combination of two drugs—paclitaxel (given intravenously and directly into the abdomen) and oral nilotinib—in 21 adults with cancers that had spread to the lining of the abdomen and could not be surgically removed. The goal was to see if the treatment …

This large phase III trial tests which of three chemotherapy drugs—paclitaxel, nab-paclitaxel, or ixabepilone—works best, with or without the targeted drug bevacizumab, for people with stage IIIC or IV breast cancer that has returned or spread. The study aims to find the most eff…

This trial investigates whether structured exercise—either aerobic cycling or resistance training—can improve health-related biomarkers in women with breast cancer undergoing neoadjuvant therapy (chemotherapy or endocrine therapy before surgery). The main focus is on changes in K…

This study tested whether atorvastatin, a cholesterol-lowering drug, can protect the heart in breast cancer patients receiving doxorubicin-based chemotherapy. 44 women with newly diagnosed breast cancer took atorvastatin daily for 3 months alongside their chemo. Researchers measu…

This Phase 1 trial tested an investigational oral drug called CFI-402257 in 52 people with advanced solid tumors, including breast cancer, that had stopped responding to standard treatments. The main goal was to find a safe dose and check how the drug moves through the body. It w…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This phase II trial tested whether combining the immunotherapy drug pembrolizumab (Keytruda) with the chemotherapy carboplatin could help people with HER2-negative metastatic breast cancer that has spread. The 12 participants had cancer cells in their blood and had already tried …

This study compares a new formulation of the chemotherapy drug doxorubicin (Doxopeg) to the standard version (Caelyx) in people with advanced ovarian cancer or metastatic breast cancer. The goal is to see if the two drugs are absorbed and processed by the body in the same way. Pa…

This trial compares a standard mastectomy closure to a technique that adds padding stitches between the skin and chest muscle, aiming to reduce lymphoceles (painful fluid pockets). About 90 women with breast cancer undergoing mastectomy will be randomly assigned to one of the two…

This phase II trial tested a combination of two targeted antibodies (pertuzumab and trastuzumab) plus a chemotherapy drug (nab-paclitaxel) in 63 patients with HER2-positive advanced breast cancer. The goal was to see how well the drugs work together to stop tumor growth and impro…

This study looked at whether using a blood test (NTproBNP) to guide heart-protecting medications can safely prevent heart damage in people with breast cancer or lymphoma receiving anthracycline chemotherapy. About 108 adults participated, and researchers measured how many joined,…

This study tested a new oral drug called BGB-43395 in 33 Chinese patients with advanced or metastatic HR+/HER2- breast cancer and other solid tumors. The drug blocks a protein (CDK4) that helps cancer cells grow. The goal was to find a safe dose and see if it can shrink tumors wh…

This trial studies whether breast-conserving surgery (lumpectomy) followed by radiation is a safe and effective option for women aged 40 and older who have two or more breast cancer tumors in the same breast. The goal is to see if this less invasive approach can control the cance…

This early-phase trial tested whether using mathematical models to schedule chemotherapy drugs docetaxel and epirubicin could reduce severe side effects in 17 patients with metastatic breast cancer. The goal was to find the safest dose and schedule while still giving six cycles o…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This early-phase study tested a new drug called ONO-4578 combined with standard hormone therapy and targeted drugs (letrozole plus palbociclib or abemaciclib) in 46 postmenopausal women with advanced or recurrent hormone receptor-positive, HER2-negative breast cancer. The main go…

This completed Phase 2 trial tested whether high-dose chemotherapy followed by a stem cell transplant could help people with breast cancer that responds to standard chemo. 203 patients with stage II, III, or IV breast cancer took part. The main goal was to see how long they survi…

This early-phase trial tested two oral drugs, dalpiciclib and chidamide, in 22 people with HR+/HER2- advanced breast cancer whose disease had worsened after CDK4/6 inhibitor therapy. The main goal was to find the safest dose. Researchers also looked at how well the combination sh…

This early-phase trial tested a new drug called SRG-514 in 25 people undergoing breast-conserving surgery for breast cancer. The drug was given directly into the area where the tumor was removed. The main goal was to find a safe dose and check for side effects. This is a first st…

This study looked at whether a special needle device (vacuum-assisted biopsy) can completely remove small breast cancers using ultrasound guidance, instead of traditional surgery. 45 women with small, early-stage breast cancers participated. The goal was to see if this less invas…

This study tested a new drug called nadunolimab, which blocks a protein that helps cancer grow, combined with standard chemotherapy for people with advanced triple-negative breast cancer. The trial had two parts: first to find a safe dose, then to see if the combination shrinks t…

This study tested whether taking oral chemotherapy pills (vinorelbine or capecitabine) along with the targeted drug trastuzumab can help prevent breast cancer from coming back in women with small, HER2-positive tumors that have not spread to lymph nodes. The 182 participants took…

This phase 2 study looked at women with invasive breast cancer who had a mastectomy with immediate prosthetic breast reconstruction, followed by TomoTherapy (a type of radiation) with or without chemotherapy. The goal was to see how often the reconstruction was successful. 66 pat…

This phase 2 trial tests BB-1701, a drug that targets HER2 on breast cancer cells, in 56 people with advanced breast cancer that is HER2-positive or HER2-low. The study has two parts: first to find the best dose, then to see how well it shrinks tumors. Participants receive the dr…

This early-phase trial tested a combination of four therapies to see if they could safely boost the immune system to fight cancer. 17 adults with non-Hodgkin's lymphoma, metastatic breast cancer, or head & neck cancer received low-dose radiation and two immune-boosting drugs inje…

This study tested an oral drug called (Z)-endoxifen in 240 premenopausal women with high breast density, a known risk factor for breast cancer. Over six months, researchers measured changes in breast density using mammogram software. The goal was to see if the drug could safely r…

This pilot study tested a 4-month program that combines weight loss strategies with stress management techniques for Black breast cancer survivors who have obesity and high stress. The program is based on the Diabetes Prevention Program and includes 16 sessions. Researchers measu…

This early-phase study tested a new radioactive drug called 177Lu-CTR-FAPI in 12 people with advanced solid tumors (breast cancer, sarcoma, or thyroid cancer) that had spread and no longer responded to standard treatments. The main goals were to see if the drug is safe and how it…

This pilot study tested a 12-week health behavior program for 50 breast cancer survivors to reduce their risk of heart disease. The program included individual coaching and group sessions focused on exercise and wellness. Researchers measured changes in walking distance and self-…

This study tested a new oral drug called OP-1250 in 153 adults with advanced or metastatic hormone-receptor-positive, HER2-negative breast cancer. The drug works by blocking estrogen receptors more completely than current therapies. The trial aimed to find the best dose, check sa…

This study tested a combination of enzalutamide (a hormone blocker) and paclitaxel (chemotherapy) given before surgery to 24 people with a specific type of triple-negative breast cancer that has androgen receptors. The goal was to see if this treatment could shrink tumors and red…

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This early-stage study tested a custom-made yeast vaccine designed to train the immune system to recognize and attack leftover cancer cells. Five adults with various cancers (like colorectal, breast, or lung) who had completed initial treatment received the vaccine. The goal was …

This phase 2 trial tested a drug called patritumab deruxtecan (HER3-DXd) in 63 patients with breast cancer, lung cancer, or other solid tumors that had spread to the brain or the lining of the brain and spinal cord. The drug is designed to seek out and destroy cancer cells carryi…

This study tested a new way to give radiation to people with early-stage breast cancer. Instead of many sessions, patients received just three doses aimed only at the tumor area. The goal was to see if this shorter treatment is safe and works well. 77 patients took part, and the …

This study tested whether cisplatin, a platinum-based chemo, works better than the standard doxorubicin/cyclophosphamide (AC) combo in women with newly diagnosed breast cancer who carry a BRCA mutation. 118 participants received either cisplatin or AC before surgery. The main goa…

This study tested a device that uses high-intensity focused ultrasound (HIFU) to treat breast fibroadenomas—noncancerous lumps. 113 women received the treatment, and researchers measured pain, anxiety, and lump size. The goal was to see if HIFU can safely shrink these lumps witho…

This study looked at how well older adults (70+) with advanced, hormone-sensitive breast cancer tolerate a combination of palbociclib and either letrozole or fulvestrant. The goal was to see if the treatment is safe and effective in this age group. 93 participants were enrolled, …

This early-stage trial tested a modified vaccinia virus (VV-GMCSF-Lact) injected directly into tumors of 34 women with recurrent or metastatic breast cancer that no longer responded to standard treatments. The main goal was to check safety and find the highest safe dose. Research…

This study tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy (bevacizumab and paclitaxel) helps people with a certain type of advanced breast cancer (HR-positive, HER2-negative). The trial enrolled 281 participants whose cancer had spread or could…

This phase 3 trial tested whether adding the immunotherapy drug toripalimab to standard chemotherapy (nab-paclitaxel) helps people with metastatic or recurrent triple-negative breast cancer live longer without their cancer growing. The study included 531 participants and compared…

This study tested a type of breast cancer surgery called nipple-sparing mastectomy, where the breast tissue is removed but the nipple and skin are kept. It involved 450 women with early-stage breast cancer who needed a full mastectomy. The goal was to see if this surgery keeps th…

This study tested whether a drug called ruxolitinib can reduce abnormal breast cells in people with high-risk or precancerous breast conditions like DCIS or atypical hyperplasia. Half of the 84 participants took ruxolitinib for about 15 days before surgery, and the other half too…

This early-phase trial tested a combination of two drugs—copanlisib and trastuzumab—in 26 women with advanced HER2-positive breast cancer that had worsened after prior treatment. The goal was to find the safest dose and see if the combination could shrink tumors or slow disease p…

This study tested a new drug (TQB3616) combined with fulvestrant in 122 people with a type of advanced breast cancer (HR-positive, HER2-negative). The goal was to see if the combination could shrink tumors or slow the cancer's growth. Participants had either received one prior tr…

This completed trial tested a mobile app called iGAME that gives tips to reduce sitting and encourage healthy habits. Researchers enrolled 48 adults with low back pain, cancer, or depression who were sedentary. The goal was to see if the app could increase physical activity and i…

This study tested a new drug called taselisib combined with standard anti-HER2 therapies in 68 people with advanced HER2+ breast cancer. The goal was to find the safest dose and see if the combination could shrink tumors or slow the disease. While not a cure, the approach aims to…

This early-phase study tested a new daily pill called TQB3616 in 40 adults with advanced breast cancer that had stopped responding to standard hormone therapy. The pill works by blocking a protein that helps cancer cells multiply. The main goals were to find a safe dose and under…

This phase 2 trial tested whether adding the drug veliparib to standard chemotherapy (cisplatin) helps people with metastatic triple-negative or BRCA-related breast cancer, including those with brain metastases. The study enrolled 344 participants to see if the combination slows …

This study tested whether adding the experimental drug TQB3616 to standard hormone therapy (fulvestrant) can help slow cancer growth in people with a common type of advanced breast cancer (HR-positive, HER2-negative). About 293 women took part, receiving either the drug combo or …

This study tested a new drug called STRO-002 in 19 Chinese adults with advanced ovarian, endometrial, or other solid tumors that had not responded to prior treatments. STRO-002 is an antibody-drug conjugate, meaning it combines a targeted antibody with a chemotherapy drug to deli…

This study tested a drug called hetrombopag in 60 advanced breast cancer patients whose platelets dropped too low from chemotherapy. The goal was to see if the drug could safely raise platelet counts and prevent treatment delays or dose reductions. Patients took the pill daily wh…

This completed study examined the safety and effectiveness of Ibrance (palbociclib) in women with advanced or metastatic breast cancer using a large real-world database. Researchers looked at side effects and how well the drug worked in everyday practice. The study included adult…

This early-phase trial tested an experimental drug called BAT8010 in 23 people with advanced or metastatic solid tumors who had no other standard treatment options. The main goals were to check safety, find the best dose, and see if the drug shows any sign of shrinking tumors. Pa…

This study tested a new ovarian stimulation protocol using degarelix (a drug typically used for prostate cancer) to help breast cancer patients preserve their fertility before chemotherapy. The goal was to keep estrogen levels low while still collecting enough eggs for freezing. …

This early-phase trial tested a personalized cancer vaccine (SV-BR-1-GM) combined with an immunotherapy drug (retifanlimab) in 36 people with advanced breast cancer that had stopped responding to standard treatments. The vaccine is made from the patient's own tumor cells and aims…

This study looked at whether taking letrozole, a hormone-blocking drug, could help prevent breast cancer from coming back in women who had already taken tamoxifen for at least 5 years. Over 5,000 women participated, and researchers measured how long they stayed cancer-free. The g…

This study tested whether giving higher doses of two chemotherapy drugs (epirubicin and docetaxel) along with a drug to boost immune recovery (pegfilgrastim) could help women with advanced or inflammatory breast cancer. 93 women took part. The goal was to see how well the treatme…

This study tested leflunomide, a pill usually used for arthritis, in 17 women with metastatic triple negative breast cancer (a fast-growing type). The goal was to see if it is safe and can help control the cancer. The drug works by blocking a protein the cancer needs to grow.

This study tested a new drug called giredestrant against the standard drug tamoxifen in 92 premenopausal women with a common type of early breast cancer. Participants took the medication for 15 days before their planned surgery. The goal was to see how well each drug slowed tumor…

This study tested a new drug called DF1001 in 270 adults with advanced solid tumors that have spread or cannot be removed. The drug works by helping the body's immune cells attack cancer cells. The trial first found the safest dose, then tested it alone or with other cancer drugs…

This early-phase trial tested a new drug, ipatasertib, added to two existing breast cancer medicines (trastuzumab and pertuzumab) in 17 people with advanced HER2-positive breast cancer that has a specific genetic change (PIK3CA mutation). The main goal was to find the safest dose…

This study tested whether adding the drug nintedanib to standard chemotherapy (docetaxel) helps people with advanced HER2-negative breast cancer live longer without their disease getting worse. Fifty-one adults who had already received some treatment took part. The goal was to se…

This study looked at whether a test called RAD51-foci can predict how well the drug olaparib works in people with advanced HER2-negative breast cancer who have certain gene mutations (BRCA1, BRCA2, PALB2, RAD51C, or RAD51D). About 65 participants received olaparib, and researcher…

This first-in-human trial tested personalized RNA vaccines designed to target each patient's unique tumor mutations in triple negative breast cancer (TNBC). 42 participants received two custom-made vaccines to stimulate their immune system. The main goal was to check safety and t…

This study tested whether giving vitamin D based on a patient's deficiency level works better than a standard dose. 215 breast cancer patients on chemotherapy received either a fixed daily supplement or a tailored dose. The goal was to see which method normalizes vitamin D levels…

This study tested a combination of two drugs—NT-I7 (efineptakin alfa) and pembrolizumab (Keytruda)—in 215 people with advanced solid tumors that had stopped responding to treatment. The goal was to check safety, find the right dose, and see if the combo could shrink tumors. The t…

This study tested whether montelukast, an asthma drug, can reduce heart damage caused by doxorubicin chemotherapy in breast cancer patients. Fifty adults with breast cancer were randomly assigned to receive either montelukast or a placebo alongside their treatment. Researchers me…

This study looked at whether a Mediterranean diet and increased physical activity could improve heart health in 150 breast cancer survivors taking hormone therapy. Participants received counseling on diet and exercise over three months. Researchers measured changes in waist size,…

This phase 2 study tested whether adding ganetespib, an experimental drug that blocks a protein called HSP90, to the standard hormone therapy fulvestrant could help people with hormone receptor-positive metastatic breast cancer that has stopped responding to hormone treatment. Th…

This study tested whether adding a low-dose chemotherapy pill (capecitabine) to standard hormone therapy (aromatase inhibitor) helps women with a common type of advanced breast cancer live longer without the disease getting worse. The trial involved 263 women who had not received…

This study looked at whether adding focused radiation to the cancer spots (metastases) can help people with breast cancer that has spread to a few places (up to 5 spots). 87 participants received either standard drug therapy alone or standard therapy plus radiation. The goal was …

This study tested whether applying tranexamic acid (TXA) directly into the wound during mastectomy surgery could reduce fluid buildup and infection. 62 women with breast cancer were split into two groups: one received TXA plus a special stitching technique, the other had stitchin…

This phase II trial tested a very strong chemotherapy regimen followed by a stem cell transplant in 41 people with stage IIIB inflammatory breast cancer. The goal was to see if this intense approach could help keep the cancer from coming back and improve survival. Participants re…

This study tested a breast reconstruction method for women who had a mastectomy, with or without radiation. Surgeons first used fat grafting to prepare the chest wall, then placed a breast implant just under the skin (not under the muscle) to reduce pain and animation. The study …

This study tested a supplement made from katuk leaves, torbangun leaves, and snakehead fish extract in 160 new mothers. For 15 days, half the moms took the supplement and half took a placebo. The main goal was to see if the supplement helped babies gain more weight, which would m…

This study tested a combination of chemotherapy (nab-paclitaxel) and immunotherapy (atezolizumab) given before surgery to women with triple-negative breast cancer. The goal was to shrink tumors and reduce the amount of breast tissue that needs to be removed. The trial involved 37…

This study tested whether a drug called T-DM1 causes fewer side effects than the standard treatment of paclitaxel plus trastuzumab in people with stage I HER2-positive breast cancer. About 500 participants were randomly assigned to one of the two treatments. The researchers also …

This Phase 3 trial compared the pill olaparib to standard chemotherapy in 302 people with metastatic breast cancer who have inherited BRCA1 or BRCA2 mutations. The goal was to see if olaparib could slow cancer growth better than chemo. Participants took olaparib twice daily or re…

This study tested a specific chemotherapy combination given before surgery for people with triple-negative breast cancer. The goal was to see if the treatment could completely eliminate the cancer from the breast and lymph nodes. 29 participants received the drugs, and the main o…

This study tested giving focused radiation before breast cancer surgery instead of the usual 5-6 weeks after surgery. 139 women with early-stage breast cancer received either one or three doses of radiation before their lumpectomy. The goal was to see if this approach can prevent…

This study tested whether adding the drug darsilide to standard hormone therapy (exemestane and goserelin) can shrink tumors in premenopausal women with HR-positive, HER2-negative breast cancer. The 119 participants had not responded fully to initial chemotherapy. The main goal w…

This study investigates whether a protein called FGF19, normally found in the intestine and gallbladder, appears at higher levels in the blood of people with breast or colorectal cancer compared to healthy individuals. Researchers will measure FGF19 and related markers in fasting…

This study tests two new radioactive imaging agents, 99mTc-ADAPT6 and 99mTc-DARPinG3, to see how well they can detect HER2-positive breast cancer using SPECT scans. Fifteen women with HER2-positive breast cancer will receive injections of each agent a few days apart, followed by …

This study tested a new radioactive tracer called 99mTc-ZHER2:41071 in 30 women with breast cancer. The tracer is designed to attach to HER2 proteins on cancer cells, allowing doctors to see them on a SPECT scan. The goal was to see how the tracer spreads in the body, how safe it…

This completed phase 1 trial tested a radioactive imaging agent called [99mTc]Tc-DB8 in 10 people with prostate or breast cancer. The goal was to see how the agent spreads in the body and whether it can help detect tumors using SPECT scans. Researchers also checked for safety and…

This completed study tested a new radioactive imaging agent called 99mTc-ADAPT6 to see if it can detect HER2 protein in breast cancer tumors using SPECT scans. Sixteen women with primary breast cancer received a single injection, followed by scans over six hours. The goal was to …

This study tested a special imaging tracer (99mTc-DARPinG3) to measure HER2 protein levels in breast cancer tumors using SPECT scans. Fifteen women with HER2-positive breast cancer received the tracer before and during chemotherapy plus targeted therapy. The goal was to see if th…

This completed phase 1 study tested a new radioactive imaging agent called 99mTc-RM26 in 10 people with prostate or breast cancer. The goal was to see how the agent spreads in the body and whether it can help spot tumors using SPECT scans. Researchers also checked for safety and …

This completed Phase 1 trial tested a new radioactive tracer called 99mTc-HE3-G3 to see if it can safely and accurately detect HER2 protein in breast cancer tumors using SPECT imaging. Thirty adults with primary breast cancer received one injection of the tracer, followed by scan…

This study tested a new imaging method that uses a radioactive tracer to detect HER2 protein in breast cancer tumors and nearby lymph nodes. 24 women with primary breast cancer received one injection followed by a scan. The goal was to see if the scan results matched standard tis…

This study tested a new imaging agent called 99mTc-ADAPT6 in 30 women with breast cancer that had spread to lymph nodes. The agent is designed to attach to HER2 proteins on cancer cells, allowing doctors to see them on a SPECT scan. The goal was to see if the scan results matched…

This study tested a new radioactive imaging agent that binds to the HER2 protein, which is important for guiding breast cancer treatment. Ten women with known HER2-positive or HER2-negative breast cancer received one injection of the agent, followed by several SPECT scans over 24…

This early study tested a new radioactive imaging agent, called [123I] I-(HE)3-G3, to see if it can safely detect HER2 protein in breast cancer tumors using SPECT scans. Ten people with either HER2-positive or HER2-negative breast cancer received one injection and were scanned ov…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study tested whether a gene test called MammaPrint can help doctors decide which breast cancer patients need chemotherapy before surgery. The goal is to shrink tumors enough so that patients can have less invasive surgery, like a lumpectomy instead of a mastectomy. The study…

This pilot study tested a new radioactive tracer called 89Zr-DFO*-trastuzumab in 6 people with HER2-positive breast or gastric cancer. The tracer is designed to attach to HER2 proteins on cancer cells and show up on PET scans. Participants received one injection and had up to 4 P…

This study aimed to create easy, non-invasive tests using blood and saliva to find markers of certain cancers, like breast and lung cancer. Researchers worked with 250 adults who had these cancers but hadn't started treatment yet. The goal was to improve early detection and monit…

This study tested whether specially trained dogs can identify breast, lung, prostate, or colorectal cancer by sniffing breath samples collected on masks. Over 1,300 people provided breath samples before their regular cancer screening or biopsy. The dogs' results were compared to …

This study tested a new way to tell breast cancer types apart using a special ultrasound, instead of a tissue biopsy. Researchers looked at blood vessel patterns in tumors from 94 patients and built a tool to predict whether the cancer was luminal or non-luminal. The goal is to h…

This study tested whether using contrast-enhanced mammography to guide breast biopsies is more accurate than the standard X-ray-guided method for suspicious calcifications. About 184 women with suspicious calcifications (BIRADS R3-R5) were randomly assigned to one of the two biop…

This study tested whether a low-dose contrast-enhanced breast CT (CE-BCT) can match the accuracy of contrast-enhanced MRI (CE-MRI) for diagnosing breast cancer. 293 women with various breast concerns received both scans, and three independent experts rated the images. The goal wa…

This study tested whether a newer type of PET scan (68Ga-FAPI) can better predict if breast cancer has been fully eliminated by chemotherapy compared to standard PET scans (18F-FDG) and MRI. Twenty-seven women with breast cancer had all three scans before and after chemotherapy, …

This study tested a new imaging technique called restriction spectrum imaging (RSI) to see if it can find breast cancer as well as standard breast MRI. About 460 women who were getting routine breast cancer screening took part. The goal was to compare how accurate RSI is versus c…

This completed study tested a special dye called TTP-ICG that sticks to breast cancer cells. After removing tissue, doctors soaked it in the dye and used a special camera to see if cancer cells were left at the edges or in lymph nodes. The goal was to help surgeons know right awa…

This study tested whether contrast-enhanced ultrasound (CEUS) can estimate the pressure inside breast tumors without using a needle. Twenty-five women scheduled for breast biopsy received an IV contrast agent and underwent ultrasound imaging. The goal was to see if the ultrasound…

This study looked at whether a small, portable ultrasound device can accurately tell the difference between benign (non-cancerous) and malignant (cancerous) breast lumps in women who had a positive clinical breast exam. Researchers tested the device on 150 women, using standard i…

This large study tested whether artificial intelligence (AI) can make mammography screening better. Over 100,000 women were randomly assigned to have their mammograms read with AI assistance or by the usual two radiologists. The goal was to see if AI could catch more cancers, red…

This study tested a new, noninvasive method called SAVE to help classify breast masses as benign or malignant. Researchers at Mayo Clinic enrolled 266 women with breast lesions to see how well the SAVE method could tell cancerous from non-cancerous masses. The goal is to provide …

This study tested whether a special PET scan (called 18F-DOPA PET-CT) can find brain metastases as well as or better than standard MRI in people with lung cancer, breast cancer, or melanoma. 32 adults with untreated brain metastases took part. The goal was to see if this PET meth…

This study compared two MRI contrast agents, Dotarem and Gadavist, in 300 women undergoing breast MRI. The goal was to see if Dotarem is as effective as Gadavist at enhancing breast lesions for clearer images. Participants were randomly assigned to receive one of the two agents, …

This study compared contrast-enhanced mammography (CESM) and magnetic resonance imaging (MRI) for diagnosing suspicious breast lesions in 231 women. Both imaging methods were evaluated against biopsy or surgery results to see which is more accurate. The goal is to determine if CE…

This study tested whether a contrast-enhanced mammogram (angiomammography) can predict if breast cancer will fully disappear after chemotherapy. 67 women with breast cancer had imaging after two rounds of chemo. The goal was to see if this method could identify non-responders ear…

This study tested an artificial intelligence (AI) tool called Carebot AI MMG to see how well it can find breast lesions and measure breast density from mammograms. Researchers compared the AI's accuracy to that of human doctors using 122 mammogram studies. The goal was to see if …

This study looked at how many tissue samples are needed when doing a special type of breast biopsy called contrast-enhanced stereotactic biopsy (CESB). The biopsy is used for breast lesions that only show up on contrast-enhanced mammography. Researchers studied 77 women to find t…

This study looked at whether testing for certain gene changes (methylation) can help doctors tell if a breast lesion is cancerous or not. 301 women with suspicious breast lumps had standard biopsies plus extra gene testing. The goal was to see if the gene test could improve diagn…

This study tested whether adding two special ultrasound techniques—elastography and contrast-enhanced ultrasound—can better detect breast cancer spread to underarm lymph nodes. Researchers studied 180 women with breast cancer to see if these extra scans improve accuracy compared …

This study followed 40 women at high genetic risk for ovarian cancer due to BRCA mutations or strong family history. One group chose to have their ovaries and fallopian tubes removed to prevent cancer, while the other group opted for regular CA-125 blood tests every 3 months to c…

This trial tests whether memantine, a drug used for Alzheimer's disease, can prevent the chronic nerve pain that sometimes develops after breast cancer surgery. Half of the participants receive memantine for four weeks, starting two weeks before their operation, while the other h…

This trial investigates whether sulindac, an NSAID, can reduce breast density in postmenopausal women at elevated risk for breast cancer. High breast density is a known risk factor for the disease. Participants take sulindac or a placebo daily for 12 months, and changes in breast…

Breast cancer is the most common cancer among women in Singapore, yet only 30-40% attend regular mammograms. This trial enrolls 12,000 women aged 50-69 who haven't had a mammogram in two years. It compares five approaches: a simple reminder, a $10 voucher, a chance to win $5,000,…

This study tests whether simple nudges—like text message reminders for patients and automatic mammogram orders for doctors—can increase breast cancer screening among women aged 40 to 74 who are overdue for a mammogram. The trial involves over 21,000 women at two health systems. S…

This small pilot study tested whether an ice plant cream could prevent hand-foot syndrome (pain, redness, peeling on hands and feet) in 15 breast cancer patients receiving doxorubicin or docetaxel chemotherapy. The main goal was to see if a larger study is possible, not to prove …

This early-phase study tested whether losartan, a common blood pressure medication, could prevent early heart damage caused by radiation therapy in breast cancer patients. Five women with left-sided breast cancer who were scheduled for radiation took losartan. Researchers used he…

This study looked at whether teaching women simple self-massage and stretching exercises before and after breast cancer surgery could prevent long-term pain. 143 women took part. Half received standard care, and the other half also attended workshops to learn these techniques and…

This study tests whether training the muscles you use to breathe can improve how long obese breast cancer survivors can exercise. Researchers will compare breathing exercises plus aerobic exercise to aerobic exercise alone in 78 women who finished treatment. The goal is to see if…

This early-stage trial is testing whether a topical solution containing calcitriol, a form of vitamin D, can safely reduce hair loss in adults receiving taxane-based chemotherapy for breast, gynecologic, or other solid tumors. Participants apply the solution to their scalp twice …

This study tested short, digital exercises (called micro-interventions) designed to reduce distress and improve well-being in breast cancer survivors. 120 women who had been diagnosed with early-stage breast cancer in the past 5 years and had mild-to-moderate anxiety or depressio…

This study tests four different vaginal treatments (estrogen, DHEA, estrogen with probiotics, and a moisturizer) in 160 breast cancer patients who have vaginal atrophy due to hormone therapy. The goal is to see which treatment best relieves symptoms like dryness and pain, and imp…

This study looks at a breast reconstruction method that uses only a small part of a back muscle, aiming to reduce shoulder pain and stiffness. Researchers will compare this technique to standard implant reconstruction in about 190 women. The goal is to see which approach gives be…

This study tests if progressive resistance exercise can improve arm swelling and function in people who developed lymphedema after breast cancer treatment. Fifty adults aged 18-60 who are at least 3 months past surgery will be enrolled. Participants will do supervised exercises a…

This trial tests whether a cream made with mushroom extracts can help protect the skin of women undergoing radiation therapy for breast cancer. Participants use the cream or a standard moisturizer on the treated breast twice daily, starting before radiation and continuing for a m…

This study tests whether using virtual reality glasses or doing breathing exercises during chemotherapy can help reduce anxiety in breast cancer patients. Participants will be divided into three groups: one using VR glasses, one doing guided breathing exercises, and one receiving…

This trial tests whether myofascial chain release techniques—gentle manual therapy targeting the connective tissue around muscles—can improve shoulder range of motion in women who have had a mastectomy for breast cancer. Participants will receive either standard physiotherapy or …

This trial tests whether injecting a local anesthetic called bupivacaine under the chest muscle during breast reduction surgery can lower pain and reduce the need for narcotic painkillers afterward. About 52 female patients aged 13 to 25 will be randomly assigned to receive eithe…

This trial tests two types of nerve blocks for pain after breast cancer surgery. One method targets a deeper layer of muscle, while the other combines both superficial and deep layers. The goal is to see which approach better reduces pain, cuts down on opioid use, and improves co…

This trial tests whether applying a hyaluronic acid gel (Endotra Gel) to the breathing tube before general anesthesia can reduce sore throat, hoarseness, and coughing after breast cancer surgery. About 132 adults undergoing breast cancer surgery will be randomly assigned to recei…

This trial tests whether a web-based education program can improve body image, self-esteem, and quality of life in women with breast cancer who lose their hair during chemotherapy. The program provides information on hair loss, scalp care, wigs, and emotional coping strategies. R…

This trial tests whether a wearable sensor called the Alio Smart Patch can help catch early signs of febrile neutropenia, a serious infection risk from chemotherapy. Thirty adults with certain cancers will wear the patch and a glucose monitor at home, with a remote care team watc…

This trial tests whether a four-week mindfulness program, delivered by a nurse, can reduce psychological distress and increase hope and mindfulness in women with breast cancer receiving radiotherapy. One hundred women who had mastectomy and are now undergoing radiotherapy are ran…

This trial tests whether practicing Tai-Chi can help reduce fatigue in breast cancer patients receiving chemotherapy. Participants are randomly assigned to either routine care alone or routine care plus Tai-Chi practice five times a week for three weeks. Fatigue levels are measur…

This study tested whether bupropion, a medication that affects brain chemicals, can improve low sexual desire in women who have had breast or gynecologic cancer. About 230 women took either bupropion or a placebo pill for 9 weeks. The main goal was to see if their self-reported s…

This study tests whether a 12-week community program combining supervised physical exercise (Nordic walking and Tai Chi) with health education workshops can improve quality of life and reduce fatigue in women with metastatic breast cancer who are receiving active treatment. Parti…

This trial investigates whether a supervised program of aerobic and strength exercises can improve or prevent lymphedema—a painful arm swelling—in women who have had breast cancer treatment. Participants are assigned to either an exercise group or a no-exercise control group. Res…

This trial tests a digital application designed to help surgeons explain breast cancer surgery to patients. The goal is to see if using the app during the first consultation makes patients feel their doctor is more empathetic and empowers them in decision-making. The study involv…

This study explores whether a tablet-based cognitive stimulation program called HAPPYNeuron® is practical for breast cancer patients aged 70 and older. Cancer treatments, especially chemotherapy, can cause memory and thinking problems, and older patients may be at higher risk. Th…

This study explores whether a 12-week program combining cognitive stimulation sessions and adapted physical activity, done at home with remote supervision, is feasible for women who have cognitive difficulties after breast cancer treatment. The study includes 20 women with locali…

This trial tests whether a nurse-led communication support program delivered via mobile health tools can improve quality of life and reduce anxiety and depression in women with early-stage breast cancer starting chemotherapy. Participants are randomly assigned to receive either t…

This study tested whether ear acupressure (small pellets on specific ear points) plus basic breast care can reduce pain and blocked milk ducts in women after cesarean delivery. 72 new mothers with blocked ducts received either real ear acupressure or a sham version for 3 days, al…

This Phase 3 trial tested whether Nuvastatic, a plant extract, can reduce cancer-related fatigue in 180 women with breast cancer undergoing chemotherapy. Participants took Nuvastatic or a placebo three times daily for three chemo cycles. The study measured fatigue levels and qual…

This study tested whether EMDR (a therapy using guided eye movements) could help reduce anxiety and depression in women with breast cancer. Fifteen women who had mastectomy for invasive breast cancer received up to 8 sessions of EMDR during their cancer treatment. The main goal w…

This study tested whether a 20-minute virtual reality session before a planning CT scan could lower anxiety in 256 breast or pelvic cancer patients starting radiotherapy. Patients were randomly assigned to either the VR session or usual care. The goal was to see if VR could reduc…

This study tested whether an 8-week online positive psychology program could help women who finished breast cancer treatment feel less afraid of the cancer coming back. 38 women took part, with half attending weekly group sessions on gratitude, optimism, and savoring good moments…

This study tests whether PG2, a compound from the astragalus root, can reduce fatigue and low white blood cell counts caused by chemotherapy in women with stage II or III breast cancer. Participants receive either PG2 or a placebo alongside their standard chemotherapy. The goal i…

This study compared two ways to manage pain during breast cancer surgery: a nerve block (erector spinae plane block) and a lidocaine drip given through a vein. Researchers measured inflammation markers and pain levels in 40 women undergoing surgery. The goal was to see which meth…

This study tested whether a 12-week music listening program could help breast cancer patients with memory and thinking problems caused by chemotherapy. 90 women took part, with half listening to self-chosen music daily for at least 20 minutes plus usual care, and the other half r…

This study tested whether a nerve block (PECS II) or local anesthesia works better for pain after breast cancer surgery, without using opioids. 124 women undergoing breast surgery were randomly assigned to receive one of the two methods. Researchers measured pain, nausea, and opi…

This study looked at whether music therapy can lower anxiety in women with early-stage breast cancer during chemotherapy. Twenty-seven patients took part, with some receiving music therapy sessions while others did not. Researchers measured anxiety levels before and after each ch…

This study looked at whether fencing can help women who had surgery for breast cancer. Thirty patients took fencing lessons and were checked for improvements in arm function and quality of life. The results were encouraging, suggesting fencing may be a fun way to aid recovery.

This study tested whether wearing special light glasses for 30 minutes each morning could help breast cancer patients feel less tired, sleep better, and think more clearly during treatment. The trial included 260 women with early-stage breast cancer, plus a healthy comparison gro…

This study looked at whether walking, with or without a grounding stick, can reduce pain, fatigue, and improve sleep in women with breast cancer. Fifty-five women who were on chemotherapy took part. They walked for 30 minutes at least three times a week for eight weeks. The goal …

This study looked at 157 women with breast cancer who had a mastectomy. It compared two ways to drain fluid after surgery: active drainage (using suction) and passive drainage (gravity). The goal was to see which method led to less fluid buildup (seroma), shorter drain time, and …

This study tested three different ways to prescribe and monitor resistance training intensity in 61 breast cancer survivors who had finished treatment. The goal was to see which method best improves muscle strength, body composition, and psychological well-being. Participants per…

This study tested whether taking a daily probiotic supplement could reduce inflammation caused by chemotherapy or immunotherapy in women with breast cancer. Sixty women took either a probiotic or a placebo for eight weeks while receiving treatment. Researchers measured changes in…

This study looked at whether adding magnesium sulfate to a standard numbing medicine (bupivacaine) in a nerve block could improve pain control after a mastectomy. Seventy women having breast cancer surgery received either the standard nerve block or one with added magnesium. The …

This study looked at whether a stress management program called Pythagorean Self-Awareness Intervention could help breast cancer survivors. 120 women who had finished their main cancer treatments (but could still be on hormone therapy) took part. The researchers measured stress, …

This study tested a hybrid (online and in-person) group education program based on psychodynamic nursing theory for women who had a mastectomy. The goal was to see if it could improve how they value their bodies, reduce anxiety about their appearance, and enhance their sexual qua…

This study looked at whether a 12-week aerobic exercise program can improve quality of life, thinking skills, and physical function in women who have finished breast cancer treatment. 69 survivors were split into three groups: one did moderate aerobic exercise three times a week,…

This study tested whether Daflon, a medication usually used for vein problems, can reduce seroma — a common fluid buildup after breast cancer surgery. 190 patients took Daflon or a placebo for four weeks after surgery. The goal was to see if it lowers the chance of seroma forming…

This study looked at 80 women with breast abscesses (pus pockets) to see if a newer, less invasive suction drainage method works better than the standard cut-and-drain surgery. The goal was to compare pain, hospital stay, healing time, and complications. Results could help doctor…

This study tested two non-drug treatments—kinesio taping and low-level laser therapy—on 66 women with arm swelling (lymphedema) after mastectomy for stage II breast cancer. The goal was to see which method better reduced arm size, improved hand grip strength, and eased shoulder p…

This study looked at whether a program of exercise before surgery and a special recovery plan after surgery could help women leave the hospital sooner after a mastectomy. Twenty-four women with breast cancer took part. The program included walking, cycling, and strength exercises…

This study looked at whether adding nerve mobilization (gentle stretching exercises for nerves) to early physical therapy can reduce long-term shoulder disability in women after breast cancer surgery. 140 women who had surgery for breast cancer took part. The results help underst…

This study looked at whether taking omega-3 fatty acid supplements can reduce joint pain and stiffness caused by aromatase inhibitors, a common hormone therapy for breast cancer. 77 postmenopausal women with early-stage breast cancer or at high risk took omega-3 supplements soon …

This study tested whether a capsaicin skin patch (made from chili peppers) works better than oral pregabalin for treating nerve pain that starts soon after breast cancer surgery. 140 women who had surgery for breast cancer and developed nerve pain within 2 months were enrolled. T…

This study looked at whether it's possible to test a program that combines different approaches to help breast cancer survivors with sexual health issues. 18 women who had finished their main cancer treatment took part. The goal was to see if women would join, stay, and follow th…

This study tested whether cognitive education activities could help breast cancer patients who experience memory, attention, and thinking problems after chemotherapy, often called 'chemobrain'. 108 patients took part. The activities were designed to support memory, attention, and…

This study looked at whether a 6-month physical activity program using a fitness tracker could help women with metastatic breast cancer feel better and less tired. 124 women with hormone receptor-positive, HER2-negative metastatic breast cancer who were starting chemotherapy took…

This early-phase study tested whether a 2-week very low-carbohydrate (ketogenic) diet combined with the drug letrozole is feasible and tolerable for people with early-stage estrogen receptor-positive (ER+) breast cancer. 31 postmenopausal women participated before surgery. The go…

This study tested whether wearing special cold caps (Penguin caps) during chemotherapy could prevent or reduce hair loss in people with early-stage breast cancer. Twelve participants used the caps while getting one of four common chemo regimens. The goal was to see if at least ha…

This study tested whether two nurse phone calls during the first three cycles of chemotherapy could improve the emotional state and quality of life of patients with breast, colon, or rectal cancer. 274 patients were randomly assigned to receive either standard care or standard ca…

This study looked at whether taking fat from one part of the body and moving it to a breast that was damaged by radiation can help the tissue heal. Ten women who had radiation for breast cancer took part. The goal was to see if this fat transfer could make the skin softer and les…

This study looked at whether a special vacuum-assisted wound dressing (ciNPWT) helps reduce complications after breast reconstruction surgery using the patient's own tissue. Researchers reviewed records of 253 women who had this surgery between 2012 and 2025. They compared those …

This study tested a silver-plated wound dressing (Silverlon) in 17 breast cancer patients receiving radiation therapy. The goal was to see if the dressing could reduce the severity of acute radiation dermatitis, a common skin reaction that causes redness, peeling, and pain. Patie…

This study tested whether an online exercise and education program could help cancer patients and survivors feel better during the COVID-19 pandemic. Thirty adults with metastatic breast or gynecological cancer, or breast cancer survivors, took part. The program aimed to reduce f…

This study tested whether a gentle arm massage with sesame-lavender oil can reduce acute pain and anxiety in women after mastectomy surgery. 90 women were randomly assigned to receive massage with either sesame-lavender oil, plain sesame oil, or paraffin oil (a placebo). The goal…

This pilot study tested whether acupuncture could reduce tingling, numbness, and pain in the hands and feet caused by chemotherapy in breast cancer survivors. Fifty-seven women who had completed taxane-based chemotherapy were randomly assigned to receive acupuncture immediately o…

This completed study tested a culturally adapted program to help breast cancer patients manage joint and muscle pain caused by hormone therapy. 289 women on aromatase inhibitors received either the tailored program (health education, monitoring, and nursing guidance) or standard …

This study looked at whether mild to moderate aerobic exercise, done three times a week for three weeks, could improve quality of life and blood levels of zinc, copper, and iron in 28 post-menopausal women who had radiotherapy for breast cancer. The goal was to see if a simple ex…

This pilot study looked at whether a 12-week supervised exercise program could improve body composition and physical function in 62 breast cancer patients. Participants exercised 2-3 times per week for 90 minutes. The study measured changes in fat mass, lean mass, bone density, a…

This study tested whether a program that combines behavioral activation (a type of counseling that helps people engage in meaningful activities) with medication optimization (reviewing and adjusting current medications) can reduce anxiety and depression in adults aged 60 and olde…

This study tested whether a personalized telephone-based weight loss program could help reduce fatigue in overweight or obese breast cancer survivors. 220 participants who had finished active treatment for early-stage breast cancer were enrolled. The program provided motivational…

This study tested whether using virtual reality (VR) and music during chemotherapy sessions is practical and helpful for breast cancer patients. Sixty patients were offered VR headsets with calming music and videos while receiving chemo. The goal was to see if patients would use …

This study compared two types of nipple-sparing mastectomy for breast cancer: one done with a robot and the other with traditional open surgery. 82 women took part, and the main goal was to see which approach led to higher patient satisfaction. The trial also looked at recovery t…

This study tested whether a digital physiotherapy platform (Trak) helps women recover shoulder movement better than standard paper-based exercises after lymph node removal for breast cancer. Forty women participated in a 4-week home program. Researchers measured shoulder mobility…

This study looked at whether mindfulness exercises can lower stress and improve communication between patients with liver disease and their doctors. 56 adults took part, answering surveys about their stress, anxiety, and how well they felt they could share decisions with their he…

This study tested a home-use helmet that shines low-level light on the scalp to help hair regrow after chemotherapy. 106 women with breast cancer who had just finished chemo used the device three times a week for four weeks. Researchers measured hair count and width, and tracked …

This study compared two surgical techniques for treating gynecomastia (enlarged male breasts) in 64 men with mild to moderate severity. Participants were randomly assigned to receive either periareolar excision or pull-through surgery, and their satisfaction with chest appearance…

This study tested whether listening to positive affirmations along with classical music during a cesarean section could lower anxiety and improve breastfeeding. 99 women were split into three groups: one listened to affirmations with music, one listened to music only, and one had…

This study looked at whether giving a specific type of numbing medicine (called PECS) during mastectomy surgery can lower the chance of having chronic pain 6 months later. It included 194 women having a breast removed, with or without lymph node removal or reconstruction. The goa…

This pilot study tested a smartphone app that lets breast cancer patients on oral chemotherapy report side effects and get basic advice. Hospital pharmacists were alerted when needed. The goal was to see if the app could improve monitoring and reduce phone calls. Only 28 patients…

This study tested a web-based dance movement therapy program for women with breast cancer undergoing chemotherapy. 67 participants were asked to dance at home three times a week for at least 70 minutes per session. Researchers measured changes in alexithymia (difficulty identifyi…

This study tested two different doses of lidocaine given through an IV to women who had nerve pain after mastectomy for breast cancer. Thirty women took part, and researchers measured how the pain felt (like burning or stinging) using a special scale. The goal was to see if lidoc…

This study tested whether a technique called ischemic preconditioning, which is used to protect organs during transplants, could reduce fat tissue damage after breast reconstruction surgery. 18 women who had breast reconstruction using their own belly fat were included. The appro…

This study looked at whether an 8-week virtual program focused on healthy eating and exercise could reduce stress and improve quality of life for breast cancer survivors. Twenty-two adults who had been diagnosed with breast cancer took part in weekly 90-minute online sessions. Re…

This study tested a group video app that guides breast cancer survivors through yogic breathing exercises at home. The goal was to see if the app helps reduce stress and other long-term side effects from cancer treatment. Forty survivors who finished radiation therapy within the …

This study tested whether a specific meditation technique, Twin Hearts Meditation, could reduce nausea and vomiting caused by chemotherapy in women with breast cancer. 102 women were split into two groups: one practiced meditation for 30 minutes at least three times a week, while…

This study tested whether a 7-day supervised fast (max 350 calories per day) could reduce muscle and joint pain in 54 breast cancer patients taking aromatase inhibitors. The goal was to see if fasting is feasible and improves physical well-being and quality of life. Researchers a…

This study tested whether a combination of physiotherapy techniques—including dry needling, nerve gliding exercises, and scapula strengthening—works better than exercise alone for women with ongoing shoulder pain after breast cancer treatment. Ninety women were randomly assigned …

This study tested an online educational program for cancer patients receiving chemotherapy. The program included video sessions, peer discussions, and digital materials to help with symptom management and emotional coping. Researchers compared 212 patients who used the program to…

This study looked at 60 women having breast cancer surgery (mastectomy). Doctors gave them a nerve block with either bupivacaine alone or bupivacaine plus magnesium sulfate to see which provided longer pain relief after surgery. The goal was to find a better way to manage post-op…

This study tested whether acupuncture can reduce hot flashes in women with hormone-positive breast cancer who are on hormonal therapy. 84 participants were randomly assigned to receive either acupuncture or usual care. The main goal was to see if acupuncture lowered hot flash sco…

This study tested three different nerve block methods to manage pain after a double mastectomy with immediate reconstruction. Over 1,500 women received either a paravertebral block, a serratus+PECS-1 block, or a combination. The goal was to see which approach reduces the need for…

This study tested whether a mobile app helps cancer patients undergoing chemotherapy or radiation therapy report their symptoms more effectively. Over 200 participants used the app to track side effects for 8 weeks. The goal was to see if the app improves how patients recognize a…

This study tested a stepped-care telehealth program for cancer survivors living in rural areas who experience anxiety, depression, or sleep problems. Participants received either low-intensity check-ins or high-intensity phone therapy with a licensed therapist, depending on sympt…

This study looked at whether giving a tiny amount of the opioid remifentanil right after surgery could prevent a condition called opioid-induced hyperalgesia, where opioids actually make pain worse. It involved 41 women with breast cancer having breast surgery under total intrave…

This study tested whether acupuncture can help prevent or reduce nerve pain, numbness, and tingling caused by chemotherapy in people with early-stage breast cancer. 89 participants were split into two groups: one received acupuncture, the other watched nature videos and did relax…

This study compared two types of nerve blocks—serratus posterior superior intercostal plane block and thoracic paravertebral block—for pain relief after mastectomy. Sixty women received one of the blocks along with standard painkillers. Researchers measured pain scores and opioid…

This study tested a brief, nurse-led videoconference program designed to help breast cancer survivors who were hesitant or delayed in starting recommended hormone therapy. The program aimed to address cultural and personal concerns. Researchers measured how many people enrolled, …

This study tested a program to help young couples cope with reproductive and sexual health problems after breast or gynecologic cancer. 158 survivors and their partners took part in a videoconference intervention. The goal was to reduce distress and improve communication about fe…

This study looked at whether giving a lower dose of the steroid dexamethasone before the chemotherapy drug docetaxel can prevent allergic reactions with fewer side effects. The standard high dose can cause problems like high blood sugar, mood changes, and weakened immunity. Resea…

This study looked at side effects from a special radiotherapy technique called simultaneous integrated boost (SIB) given after breast-conserving surgery for breast cancer. 93 women were followed to see how well they tolerated the treatment. The goal was to compare side effects wi…

This pilot study looked at whether a supervised or distance-supervised brisk walking program could help manage fatigue in breast cancer patients currently on hormone therapy. Seventeen women who had completed chemotherapy and/or radiation took part in a 6-week program, walking tw…

This study tested a cognitive training program to help breast cancer patients manage 'chemobrain'—memory and thinking problems caused by chemotherapy. Fifty women with newly diagnosed breast cancer took part, with half receiving the training plus educational materials, and the ot…

This study tested whether adding dexmedetomidine (a sedative) to a standard numbing medicine (bupivacaine) in a chest nerve block could improve pain control after breast cancer surgery. Sixty women received either the standard block or the block with added dexmedetomidine. The ma…

This study looked at breast reconstruction using only a patient's own fat (lipomodulin) after mastectomy for breast cancer. Researchers wanted to see how often the procedure works, how the breast looks afterward, and how it affects quality of life. The study included 118 women wh…

This study tested whether listening to audio-guided meditation during a breast biopsy helps reduce pain and anxiety. 225 women having a breast biopsy were offered meditation or standard care. Researchers measured their pain and anxiety levels before and after the procedure using …

This study tested a virtual reality program to help breast cancer patients who have memory or concentration problems after treatment. 23 patients used the VR program for 10-15 minutes each week for 6 weeks. The goal was to see if patients would stick with the program and if it co…

This study looked at why some women have dense breasts on mammograms and why that increases their risk of breast cancer. Researchers collected tissue samples, medical records, and health updates from 466 women aged 40-65 who were having a breast biopsy. The goal was to understand…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study is testing whether certain markers in the blood can predict how well the drug trastuzumab shrinks tumors in women with early HER2-positive breast cancer. Participants receive trastuzumab before breast-conserving surgery, and researchers compare blood marker levels with…

This study is watching nearly 3,000 people newly diagnosed with breast cancer in Latin America. It does not test a new treatment but instead collects information on how the cancer is diagnosed, what treatments are used, and how patients do over time. The goal is to better underst…

This study looks back at medical records to see how ribociclib, a CDK4/6 inhibitor used for hormone receptor-positive, HER2-negative metastatic breast cancer, is prescribed and tolerated in older adults (65 and over) and Black/African American patients. These groups are often und…

This study looks at whether having a patient navigator—a person who helps guide you through the healthcare system—can help women get timely follow-up care after an abnormal mammogram. The COVID-19 pandemic caused many delays in cancer diagnosis, especially for at-risk groups. Res…

This study tested new screening methods like MRI, duct lavage, and PET scans in 200 women with BRCA gene mutations who are at high risk for breast cancer. The goal was to see if these tools can find cancer earlier than standard mammograms. Participants were followed for three yea…

This study observed over 2,400 women in Russia with advanced HR+/HER2- breast cancer to see how well different treatments work in everyday medical practice. Researchers tracked how long patients stayed on their therapy before it stopped working or caused side effects. The goal wa…

This study tests whether sending text message reminders to patients and alerts to doctors can increase the number of women who get their recommended mammograms. About 8,490 women aged 40-74 who are overdue for screening will take part. The goal is to see if these simple 'nudges' …

This completed study looked at why some women reject personalized breast cancer risk estimates. Researchers gave 781 Black or African American women aged 39-74 a personal risk score based on the Gail Model and asked if they agreed with it. The goal was to understand risk rejectio…

This study tests whether a direct meeting between breast cancer patients and a pathologist—where the pathologist reviews the patient's own pathology slides—can improve the patient's understanding of their disease and sense of empowerment. Participants complete questionnaires befo…

This study explores the experiences of women who saw their GP with a breast health concern and were referred to a specialist. Through interviews and focus groups, researchers aim to uncover what helped or hindered the referral process. The goal is to inform medical education and …

This study looked at tissue samples from 2751 early breast cancer patients who had already completed chemotherapy. Researchers wanted to see if tumors with low levels of HER2 protein are biologically different from those with no HER2 at all. They used genetic testing and protein …

This study looks back at medical records of women with triple-negative breast cancer who had chemotherapy and radiation before surgery. It focuses on those who still had cancer cells left after treatment (residual disease) and tracks how long they lived without the cancer coming …

This study gives women over 70 being treated for breast cancer a wrist-worn activity tracker to wear for a year. Researchers will analyze daily step counts and sleep duration to describe different physical activity and sleep profiles. They will also see how these profiles relate …

This study looks at how breast cancer patients' predictions of their quality of life after surgery compare to what they actually experience. Researchers will ask women before and after surgery about their physical and emotional well-being. The goal is to understand if patients' e…

This study observes how Canadian women with a specific type of advanced breast cancer (HR+/HER2-) use the drug palbociclib (Ibrance) as their first treatment. Researchers will measure how long patients stay on the drug and look at treatment patterns in real-world settings, outsid…

This study looks at the risk of interstitial lung disease (ILD) in people with inoperable or recurrent breast cancer who take the drug palbociclib (Ibrance) combined with fulvestrant. Researchers will compare this group to patients taking fulvestrant alone, using data from over 4…

This study investigates whether tumor DNA found in the blood (called plasma tumor DNA or ptDNA) can predict how well breast cancer responds to chemotherapy given before surgery. Researchers will collect blood samples from 228 people with early-stage, high-risk breast cancer (HER2…

This study follows women who had breast cancer surgery to see if the type of anesthesia they received—propofol or sevoflurane—affects cancer recurrence and survival 5 and 10 years later. Only patients from an earlier trial are included. The goal is to understand whether anesthesi…

This study follows 600 Chinese women with early-stage HER2-positive breast cancer to see how anti-HER2 treatment affects their quality of life over a year. Participants fill out questionnaires about physical, emotional, and social well-being. The goal is to understand real-world …

This pilot study tests a near-infrared (NIR) imaging device that measures oxygen levels in breast skin flaps during and after mastectomy with immediate reconstruction. The goal is to see if the device can reliably detect areas with poor blood flow that might lead to healing probl…

This observational study looks at how anthracycline chemotherapy affects inflammation, oxidative stress, and heart function in adult women who had breast cancer. Researchers measure blood markers and use echocardiograms to assess heart changes about 10 years after treatment. The …

This study investigates whether women who have completed breast cancer treatment have a higher chance of developing colorectal polyps or colon cancer. Researchers will perform screening colonoscopies in 216 asymptomatic breast cancer survivors and check for abnormal growths. The …

This study looks at whether breast cancer patients with mild, moderate, or severe liver problems face a higher risk of a serious side effect—grade 4 neutropenia (a dangerous drop in infection-fighting white blood cells)—when taking the drug palbociclib. Researchers analyzed medic…

This study looks at medical records from across Europe to see how well a drug combination (palbociclib plus an aromatase inhibitor) works as a first treatment for people with a common type of advanced breast cancer (HR+/HER2-). Researchers want to understand how long the treatmen…

This study looked at whether using a physical activity screener, along with exercise coaching and self-monitoring, could help breast and colon cancer survivors become more active and spend less time sitting. Twenty survivors who had finished their main cancer treatment at least t…

This completed study looked at whether a simple blood test (liquid biopsy) can help track breast, ovarian, and endometrial cancers. Researchers analyzed circulating tumor cells in 150 women to see if these cells could predict the risk of cancer spreading or how well treatment wor…

This study looked at two ways to help breast and ovarian cancer survivors get genetic counseling: a mailed brochure or a phone call with a health coach. About 668 women took part. The goal was to see which method led more people to actually get genetic counseling or testing. The …

This early-phase trial tested a precise, high-dose radiation technique called stereotactic body radiotherapy (SBRT) in 42 patients with breast, lung, or prostate cancer that had spread to several places in the body. The main goal was to find the safest dose and check for side eff…

This completed study from Semmelweis University looked at whether the breast cancer drug trastuzumab (Herceptin) causes dry eye or other eye surface problems. 35 adults with HER2-positive breast cancer took the drug as prescribed and visited the clinic every 3 months for eye exam…

This study tested whether a short video featuring cancer survivors and local leaders could encourage more people in rural Tamil Nadu to get screened for oral, breast, and cervical cancer. Over 1,200 adults aged 30-59 who had not been screened recently were randomly assigned to se…

This completed study analyzed tissue samples from 108 breast cancer patients to identify proteins linked to early cancer invasion. The goal was to find markers that could help assess the risk of tumor spread in patients without lymph node involvement. Researchers focused on listi…

This study looks at medical records from 750 people with a common type of early breast cancer (HR+/HER2-). It aims to understand how doctors treat these patients in real life, especially after newer targeted drugs called CDK4/6 inhibitors became available. By analyzing treatment …

This study explored whether a simple blood test measuring the neutrophil-to-lymphocyte ratio (NLR) can help predict how well women with advanced breast cancer respond to a common treatment (CDK4/6 inhibitors plus hormone therapy). Researchers followed 165 patients starting this t…

This completed study from the University of Central Florida involved 24 women diagnosed with breast cancer. Through online questionnaires and focus groups on Zoom, researchers explored how the disease and its treatment affect sexual health, intimacy, and relationships. The goal i…

This study measured levels of a protein called IP3R3 in breast cancer tissue from 42 women. The goal was to see if this protein is involved in how cancer cells migrate and invade nearby tissues. Researchers hope this could lead to better understanding of what makes breast cancer …

This study collected information from 93 men who have had breast cancer. Participants filled out a questionnaire about their life, work, family, and health history. The goal is to find patterns that might help explain why some men develop breast cancer. No treatments or drugs wer…

This study looked back at 1,030 breast cancer patients to see how radiotherapy affected their chances of staying cancer-free and living longer. The goal was to understand radiotherapy's real benefits and help doctors design better treatment plans in the future.

This study reviewed medical records of about 3,500 patients with phyllodes tumors, a rare type of breast tumor, treated at 8 top hospitals in China between 2001 and 2023. Researchers aim to describe the tumor features, treatments used, and long-term outcomes like recurrence and s…

This study looked at how two common drugs (ritonavir and itraconazole) change the way the body processes a new experimental drug called SHR-A1811 in people with advanced HER2-positive breast cancer. Seventeen participants received the drug alone and then with each of the other me…

This study examined the vaginal microbiome—the community of bacteria and other microbes—in 35 women with breast cancer who were receiving hormone therapy. The goal was to see if certain bacteria are linked to vaginal dryness and sexual health. Researchers collected vaginal swabs …

This completed study looked at medical records of over 1,100 people in Australia who took CDK4/6 inhibitors (like palbociclib) for advanced or metastatic breast cancer. Researchers wanted to understand patient characteristics, dosing, and how long people stayed on treatment in re…

This completed study looked at 121 women in Brazil with a certain type of advanced breast cancer (HR+/HER2-). Researchers tracked how doctors prescribed palbociclib combined with other drugs in everyday practice, not in a strict trial setting. The goal was to describe patient bac…

This study looked at medical records from over 1,300 breast cancer patients in Japan who took the drug palbociclib. The goal was to find out which patients are more likely to develop a severe drop in white blood cells (grade 4 neutropenia), a known side effect. Researchers compar…

This completed study looked at medical records of 258 adults in Saudi Arabia, UAE, and other Gulf countries who received palbociclib (a targeted cancer pill) combined with hormone therapy for advanced HR+/HER2- breast cancer. Researchers aimed to describe patient characteristics,…

This study tested whether a two-hour, peer-led workshop with religious messages could encourage Muslim women in North East England and Scotland to get screened for breast, bowel, and cervical cancer. 169 women aged 25-74 who were not up-to-date with all eligible screenings took p…

This early-phase study tested the drug HRS-8080 in 24 healthy adults to see how well it is absorbed and whether food changes its levels in the body. Participants took single doses under different conditions, including fasting and with low- or high-fat meals. The results will help…

This study tested a custom-made device called the Breast Cancer Locator (BCL) in 35 women with non-palpable breast cancer. The device helps surgeons see exactly where the tumor is during breast-conserving surgery, with the goal of removing all cancer in one go and reducing the ne…

This study looked at whether nerve signals (called sympathetic skin response) are linked to how well women respond to standard lymphedema therapy after breast cancer surgery. Thirty women with lymphedema and thirty healthy women had nerve tests and filled out symptom questionnair…

This study looked at whether breast cancer survivors have reduced arm exercise capacity and oxygen use compared to healthy people. Researchers tested 60 women (30 survivors and 30 healthy) using an arm bike and muscle oxygen monitor. The goal was to better understand long-term ef…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This study looked at 220 women with HER2-low advanced breast cancer whose disease progressed after antibody-drug conjugate (ADC) therapy. Researchers compared different follow-up treatments, such as other ADCs, chemotherapy, hormone therapy, or immunotherapy, to see which worked …

This study tested a digital health platform to help people with a hereditary risk of breast and ovarian cancer share their genetic test results with family members. Researchers worked with 128 participants in Switzerland and Korea to see if the tool reduced distress and improved …

This study examined blood samples from 49 women with metastatic breast cancer to find genetic markers that predict side effects from trastuzumab (Herceptin). The goal was to understand why some patients experience heart or allergic reactions. It did not test a new treatment, but …

This study offered a rapid hepatitis C test to 1,500 women aged 50-74 who were already coming in for breast cancer screening in Montpellier, France. The goal was to see how many women would agree to the extra test and how many had undiagnosed hepatitis C. Women who tested positiv…

This study tested whether implanting tiny gold markers near spinal tumors helps deliver radiation more accurately. Researchers also checked if giving slightly more radiation to the nearby esophagus is safe, which might improve tumor control. The study involved 41 adults with vari…

This study tested whether an extract of American ginseng root (LEAG) could change certain markers in breast cancer tumors. Sixteen women took ginseng tablets for 5–14 days before their surgery. Researchers measured changes in inflammation and growth-related proteins in the tumor …

This study tested a website and mobile app called BC-Navigate, designed to help Black women and other women of color start chemotherapy on time after breast cancer surgery. The goal was to see if the app was easy to use and could reduce racial inequities in cancer care. Researche…

This completed study followed 830 women who had early or locally advanced breast cancer and finished their main treatment (except hormone therapy). The goal was to understand their health-related quality of life using several questionnaires. No new treatment was tested; instead, …

This study surveyed 385 women aged 35 or younger with early-stage breast cancer to learn their attitudes about the risk of infertility from adjuvant therapy. The goal was to understand how concerns about having children might influence their treatment choices. The results could h…

This study tested a new cone-beam CT scanner that takes clearer pictures during radiation therapy for lung, liver, and breast cancers. 31 people participated to see if the new scanner reduces image blurring and improves accuracy. The goal is to help doctors target tumors more pre…

This study examined whether specific gene variations influence how well metastatic breast cancer patients respond to chemotherapy with or without the drug bevacizumab. Researchers enrolled 307 women from Italy to compare outcomes and analyze genetic interactions. The goal was to …

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at whether a special, graph-based genetic counseling method helps newly diagnosed breast cancer patients better understand their risk of cancer in the other breast and make more informed surgery choices. About 400 patients participated, comparing this new approa…

This completed study looked at whether a deficiency in the DPD enzyme can predict severe side effects from the chemotherapy drug capecitabine in women with metastatic breast cancer. Researchers analyzed blood samples from 303 participants to see if genetic differences could help …

This completed study surveyed over 500 breast cancer patients from low-income and minority groups in Northern California to find out what stops them from getting genomic testing. Researchers used an online survey and phone interviews to gather information. The goal was to identif…

This study tested a community-based program to help homeless women complete mammograms for breast cancer screening. Researchers surveyed 203 women living in shelters and provided a brief educational session on breast health. The goal was to identify and overcome barriers to scree…

This study tested whether a flexible, personalized exercise program is practical for cancer patients receiving chemotherapy. Twenty-one adults with breast, ovarian, or colorectal cancer took part. The main goal was to see if patients would join, attend, and stick with the exercis…

This study looked at 120 women having mastectomy for breast cancer to see if the gender of their anesthesiologist affected their pain and need for painkillers after surgery. Researchers compared pain scores and medication use between patients treated by male versus female anesthe…

This study tested whether a simulation-based breast health class could improve breast cancer awareness and self-exam habits among Afghan refugee women. 46 women aged 20-65 who spoke Turkish or Dari took part. The goal was to see if this teaching method helps them recognize sympto…

This completed pilot study looked at how the drug tamoxifen affects breast cancer tumors at a molecular level. Researchers studied 59 patients with a specific type of breast cancer to see how tamoxifen changes the interaction between two key proteins. The goal was to gather infor…

This completed study analyzed medical records of 1,170 advanced breast cancer patients in Japan to see how they used the drug palbociclib (Ibrance). Researchers looked at blood test frequency and how long patients stayed on treatment. The goal was to describe real-world treatment…

This study examined tumor samples from 3,646 women with early-stage breast cancer who had already received chemotherapy after surgery. Researchers measured specific immune cells (tumor-infiltrating lymphocytes and CD8+ T cells) to see if their presence was linked to how long pati…

This completed study looked at 470 women with breast cancer in Paris to understand how their background affects their experience. It compared women born in France with those born in sub-Saharan Africa, focusing on diagnosis timing, treatment access, and social impacts. The goal i…

This study aims to develop and validate a scoring system to identify which patients with metastatic breast cancer are likely to live longer with third-line chemotherapy. Researchers will collect clinical, histological, and biological data from 267 women starting a third line of t…

This completed study analyzed health records from over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer diagnoses for up to 12 ye…

This study looked at how a person's genes and drug levels in the blood affect hormone therapy for breast cancer. It included 2000 women with hormone-sensitive breast cancer who were already scheduled for adjuvant hormone therapy. Researchers measured drug levels and genetic marke…

This study tested a program called REASSURE to help low-risk breast cancer survivors feel more prepared for their follow-up care. About 104 survivors took part for up to 18 months. The goal was to see if the program improved their confidence and reduced unnecessary care.

This study looked at whether it's possible to measure certain substances called oxysterols in the blood of breast cancer patients. 29 women taking hormonal therapy (tamoxifen or anti-aromatase drugs) had their blood tested before and 28 days after starting treatment. The goal was…

This study looked at whether tiny molecules called microRNAs in the blood can help predict if hormone therapy will work for women with advanced breast cancer. Researchers tested blood samples from 39 women before and after one month of treatment with tamoxifen or an aromatase inh…

This completed study looked at 480 patients with HR+, HER2- metastatic breast cancer who were treated with CDK4/6 inhibitors as their first therapy. Researchers examined patient profiles, treatment patterns, and outcomes in everyday clinical practice. The goal was to understand h…

This study looked at whether a tumor gene test called the 21 gene Recurrence Score (OncotypeDx) changes doctors' recommendations for chemotherapy in women with early-stage, hormone receptor-positive breast cancer that has spread to lymph nodes. Researchers tracked how often chemo…

This study looked at whether using a special ultrasound ruler during breast-conserving surgery helps surgeons remove all cancer the first time. Researchers reviewed records from 273 patients who had this ultrasound-guided surgery. The goal was to see if it lowered the rate of inc…

This study looked back at medical records of 693 Japanese patients with a certain type of advanced breast cancer (HR+/HER2-) who received palbociclib plus endocrine therapy as their first or second treatment. Researchers measured how long patients lived without the cancer getting…

This study combined data from over 5,300 people with early-stage breast cancer who received a specific type of chemotherapy. Researchers wanted to see how long patients lived without the cancer coming back and what side effects they had. The goal is to learn from past treatments …

This study tested whether a personalized psychological program given before and after breast cancer surgery could lower stress and change certain markers in the tumor linked to cancer spread. Forty women with early-stage breast cancer took part. Half received the psychological su…

This completed early study tested a special clip-on electrode with fiber optics that detects light signals during breast cancer surgery. The goal was to see if the device is safe and can help surgeons identify different tissue types in real time. Twenty-four women with invasive b…

This study observed 440 adults in Poland with advanced HR+ HER2- breast cancer to understand how doctors treat the disease in everyday practice. Researchers tracked treatment choices, changes over one year, and how they relate to patient characteristics and guidelines. The goal w…

This study looked at medical records from over 218,000 adults in England with a common type of breast cancer (HR+/HER2-). Researchers tracked which treatments people received, how the disease progressed over time, and how healthcare resources were used. The goal was to understand…

This study looked at 20 women who had radiation therapy for node-positive breast cancer years earlier. Researchers used cardiac MRI to check heart function and see if radiation dose levels were linked to heart damage. The goal was to better understand safe radiation limits to pro…

This study looked at skin samples from 20 breast cancer patients receiving radiation therapy to understand why some develop radiation dermatitis—itchy, red, swollen skin. Researchers took small skin biopsies from areas showing signs of irritation. The goal was to identify molecul…

This study looked at 35 women with early-stage breast cancer who do not currently qualify for genetic testing under standard guidelines. It compared the use of an artificial intelligence program for pre-test genetic counseling versus traditional in-person counseling. The goal was…

This study looked at how women aged 65 and older with early-stage breast cancer choose among three options after surgery: standard weeks-long whole-breast radiotherapy, a single dose of radiation during surgery, or no radiation at all. Researchers surveyed 104 patients to underst…

This study looked back at medical records of over 1,000 people with rare breast conditions called florid and pleomorphic lobular carcinoma in situ (FLCIS and PLCIS). The goal was to understand how doctors currently diagnose and treat these conditions, since there are no official …

This completed study looked at the medical records of 8 men diagnosed with breast cancer at Methodist Health System. Researchers wanted to understand their demographics, how their disease progressed, and what complications they faced. Because male breast cancer is very rare, this…

Breast cancer in men is rare, making up only 1% of cases, and most research has focused on women. This study aims to develop a questionnaire specifically for men with breast cancer to measure their quality of life. Researchers interviewed 65 patients and healthcare professionals …

This study looked at nearly 1,000 cancer survivors to find out which follow-up care model works best for their quality of life and satisfaction. Participants were breast, prostate, or colorectal cancer survivors who had finished active treatment. Researchers compared different ca…

This completed study looked at whether sampling just a few lymph nodes under the arm can tell if breast cancer has spread, instead of removing many nodes. Twenty patients with advanced breast cancer at diagnosis took part. The goal was to see if this targeted approach could reduc…

This study examined how well CDK4/6 inhibitors (a type of targeted therapy) work for people with advanced breast cancer in Egypt. Researchers looked at 206 patients to measure how long the drugs kept cancer from growing, side effects, and overall costs. The goal was to see if the…

This study measured how much physical activity 507 breast cancer patients in Spain get and what types of exercise they prefer. Researchers used questionnaires to understand current activity levels and exercise likes and dislikes. The goal is to use this information to design bett…

This study used functional MRI (fMRI) to see how the brain's sensory map changes after breast reconstruction in women treated for breast cancer. Researchers compared brain activity when touching the reconstructed breast versus the natural breast. The goal was to objectively measu…

This completed study looked at how emotional skills affect the way young women (45 or younger) with non-metastatic breast cancer and their partners adjust to the disease. 391 couples filled out questionnaires at several points during treatment, from before chemotherapy to after r…

This completed Phase 3 study looked at how four different hormone therapies (anastrozole, exemestane, letrozole, and tamoxifen) affect memory in postmenopausal women with breast cancer. The 44 participants took one of these drugs for 6 to 12 months, and researchers tested their v…

This completed Phase 2 trial enrolled 61 postmenopausal women with operable, hormone-sensitive breast cancer. Participants took letrozole for 7 to 30 days before their scheduled surgery. The goal was to measure changes in a tumor marker called Ki67 to see which cancers are highly…

This study looked at 28 women with breast cancer that spread to their bones. Researchers compared two types of scans—PET-CT and whole-body MRI—to see if they agree on whether the bone tumors are stable, improving, or getting worse. The goal is to find a reliable way to monitor tr…

This study looked at whether sending a culturally and linguistically tailored reminder letter could increase breast cancer screening among women aged 50-69 who had never been screened before. About 8,000 women were split into two groups: one got the standard invitation only, the …

This study tested a new questionnaire designed to measure quality of life in young women (under 45) with non-metastatic breast cancer and their partners. Over 1,000 couples completed the survey at home. The goal was to see if the questionnaire accurately captures the emotional an…

This completed Phase 2 trial looked at whether the sentinel lymph node technique—a less invasive way to check if cancer has spread—works for women with multifocal breast cancer (more than one tumor in the same breast). 216 women with early-stage, node-negative multifocal breast c…

This study looked at spinal fluid from 51 breast cancer patients whose cancer may have spread to the lining of the brain and spinal cord (leptomeningeal metastases). Researchers compared a new blood test technique (CellSearch) with standard spinal fluid analysis to see which bett…

This completed study looked at blood and tumor samples from 66 women with breast cancer who were about to receive chemotherapy before surgery. Researchers searched for unique protein patterns that might show whether the tumor would shrink with treatment. The goal was to find a wa…

This study looked back at medical records of over 1,600 adults in Russia with HER2-low breast cancer that had spread or could not be removed by surgery. Researchers wanted to understand how common this type is, what patient characteristics are, and how doctors actually diagnose a…

This study looked at how breast cancer affects the quality of life of young women (under 45) and their life partners. Researchers interviewed 171 couples at different times during medical follow-up to understand emotional, social, and relationship challenges. The goal was to crea…

This study looked at whether a special PET scan (FDG-PET) can detect early whether breast cancer is responding to chemotherapy. 63 women with breast cancer had a PET scan before and after their first chemo cycle. The goal was to see if the scan could tell responders from non-resp…

This study tested whether a mobile app-based education program could improve women's understanding of HPV and their attitudes toward breast cancer screening. Seventy women aged 30-65 used the app and completed surveys before and after the program. The goal was to see if the app c…

This study looked at how calcium and vitamin markers change in 146 breast cancer patients receiving standard adjuvant chemotherapy. Researchers measured these markers before, during, and after treatment to understand metabolic effects. The goal was to see how often patients devel…

This completed study looked at over 4,400 women to compare long-term quality of life between those whose breast cancer was found through screening and those whose cancer was found through symptoms. Researchers measured quality of life at different times after diagnosis and also c…

This study looked at whether automated planning tools can be used with MRI scans to guide radiation therapy for breast cancer. The goal was to make treatment faster and more precise while avoiding extra radiation from X-rays. 63 female breast cancer patients took part to help ref…

This observational study enrolled 94 women with breast cancer to see if it's possible to collect blood, stool, and survey data from older patients taking aromatase inhibitors (a type of hormone therapy). The main goal was to test the feasibility of gathering this information for …

This study looked at how breast cancer-related lymphedema (arm swelling) affects the way women walk. Researchers compared 40 women with lymphedema to healthy volunteers, measuring arm swelling, shoulder movement, grip strength, and walking patterns. The goal was to understand if …

This study reviewed medical records of women with advanced or metastatic HR+/HER2- breast cancer who received Palbociclib combined with hormone therapy in community clinics. The goal was to see how doctors actually prescribe these drugs, how long patients stay on treatment, and w…

This study tested whether an educational video series about sexual health is acceptable and useful for women undergoing breast cancer treatment. 32 women with early-stage breast cancer watched the videos over six months. Researchers measured how well the videos were received and …

This study looked at whether the ratio of index to ring finger length (2D:4D) is different in women with breast cancer compared to healthy women. Researchers measured the fingers of 132 women (79 with breast cancer, 53 without) and checked if the ratio related to tumor markers in…

This study looked at 105 babies born to mothers who smoked during pregnancy, comparing those whose mothers quit versus those who continued. Researchers checked health indicators like birth weight, Apgar scores, and developmental milestones up to 24 months. The goal is to understa…

This completed study from the University of Alabama at Birmingham involved 200 women with metastatic or early-stage breast cancer. Researchers conducted interviews and focus groups with patients, nurses, and doctors to understand how treatment decisions are made, including the op…

This study looked at data from 298 breast cancer patients to build a computer model that predicts whether chemotherapy before surgery will completely eliminate the cancer. The model uses routine clinical and lab information to estimate the chance of a complete response. It is not…

This study followed 67 women with breast cancer to see how chemotherapy given before surgery (neoadjuvant chemotherapy) affects their physical abilities. Researchers measured muscle strength, balance, and fatigue before and after treatment. The goal was to better understand the p…

This study looked at 171 women with early breast cancer to see if immune cells inside tumors are linked to how well chemotherapy works. Researchers also checked if certain markers in the blood could help predict cancer return. The goal was to better understand which patients migh…

This study looked at how well anti-HER2 drugs work in Egyptian women with HER2-positive breast cancer. Researchers followed 80 patients who received either one drug (trastuzumab) or a combination (trastuzumab plus pertuzumab or lapatinib) as part of their regular care. The goal w…

This study looked at 97 women with early-stage breast cancer who were getting strong chemotherapy. They were given one of two types of G-CSF (a drug that helps the body make more white blood cells) to see which one better prevented dangerously low white blood cell counts. The goa…

This study looked back at the records of 471 women who had breast cancer surgery with immediate implant reconstruction. It compared a newer method using a tiny camera through small cuts (endoscopic) to the traditional method with a larger cut. The goal was to see which approach l…

This study tested a mobile health app designed to help Black women with breast cancer learn about clinical trials and decide whether to join. Eighty Black women with newly diagnosed breast cancer who had a smartphone or computer took part. The app provided education and a way to …

This study looked at 27 women with breast cancer who had a mastectomy and immediate breast reconstruction with an implant. The implant was placed either above the chest muscle (prepectoral) or below it (subpectoral). Researchers measured pain, arm function, quality of life, and c…

This study tested whether mental exercises or a slowed clock can help people hold their breath longer during breast cancer radiation therapy. 36 healthy volunteers were asked to hold their breath while doing a simple mental task on a tablet. The goal was to see if these tricks co…

This study looked at 3000 cancer patients to see which treatments work best for preventing dangerously low white blood cell counts after chemotherapy. It compared different approaches to see how well they prevent infections and improve quality of life. The goal is to give doctors…