Can sound waves replace needles for breast cancer diagnosis?

NCT ID NCT04721886

Completed Diagnosis Sponsor: Thomas Jefferson University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether contrast-enhanced ultrasound (CEUS) can estimate the pressure inside breast tumors without using a needle. Twenty-five women scheduled for breast biopsy received an IV contrast agent and underwent ultrasound imaging. The goal was to see if the ultrasound pressure readings matched direct needle measurements, potentially offering a less invasive diagnostic option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Perflutren lipid microspheres (Definity) given intravenously
What this could lead to: If successful, this could lead to a noninvasive way to measure tumor pressure, helping doctors diagnose breast cancer without needles.
What could go wrong: This is a very early, small study (25 people) testing a method, not a treatment. It may not prove accurate enough for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast carcinoma breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CARCINOMA

Contacts and locations

Locations

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

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