Real-world data may reveal true effectiveness of leading breast cancer therapy

NCT ID NCT05043506

Completed Knowledge-focused Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study looks at medical records from across Europe to see how well a drug combination (palbociclib plus an aromatase inhibitor) works as a first treatment for people with a common type of advanced breast cancer (HR+/HER2-). Researchers want to understand how long the treatment keeps the cancer from getting worse and how long people live. The study does not give any new treatments—it simply observes what happens in real-world clinics.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Palbociclib plus an aromatase inhibitor
What this could lead to: If successful, this study could confirm that palbociclib plus an aromatase inhibitor works well in everyday clinical practice, not just in controlled trials.
What could go wrong: This is an observational study, not a controlled experiment, so results may be influenced by factors like patient selection or differences in care across countries.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CANCER

Contacts and locations

Locations

Airedale NHS Foundation Trust

Keighley, WEST Yorkshire, BD20 6TD, United Kingdom
Beatson West of Scotland Cancer Centre

Glasglow, Glasglow City, Scotland, G12 0YH, United Kingdom
Bethanien Center for Hematology and Oncology

Frankfurt, 60389, Germany
Borders General Hospital

Roxburghshire, Scotland, TD6 9BS, United Kingdom
Bradford Teaching Hospitals NHS Foundation Trust

Bradford, WEST Yorkshire, BD9 6RJ, United Kingdom
Buckinghamshire Healthcare NHS Trust, Stoke Mandeville Hospital

Buckinghamshire, Buckinghamshire, HP7 0JD, United Kingdom
Complejo Asistencial Universitario de Leon

León, 24007, Spain
Complejo Hospitalario Universitario de Vigo. Area Sanitaria de Vigo. Hospital Alvaro Cunqueiro

Vigo, Pontevedra, Cantabria Castilla Y LEON, 36211, Spain
Complejo Hospitalario de Navarra

Pamplona, Navarre, 31008, Spain
Complejo Universitario de Albacete

Albacete, 02006, Spain
Forth Valley Royal Hospital

Stirling, Scotland, FK9 4SW, United Kingdom
Frauenarztpraxis

Ilsede, Peine, D-31241, Germany
Glan Clwyd Hospital

Rhyl, Denbighshire, LL18 5UJ, United Kingdom
Group practice Goehler

Dresden, 01127, Germany
Gynäkologie Kompetenzzentrum Praxis Dr. med. Carsten Hielscher

Stralsund, 18439, Germany
Hospital Clínico de Santiago de Compostela

Santiago de Compostela, Santiago de Compostela/cantabria, 15706, Spain
Hospital General Universitario Morales Meseguer

Murcia, Comunidad de Murcia, 30008, Spain
Hospital Puerta de Hierro

Majadahonda, Madrid, 28222, Spain
Hospital San Jorge Huesca

Zaragoza, Huesca/ Aragon, 50009, Spain
Hospital Universitario Dr. Peset

Valencia, 46017, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Marques de Valdecilla

Santander, 39008, Spain
Hospital Universitario Quiron Madrid

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Virgen Del Rocio

Seville, Sevila, 41013, Spain
Hospital Universitario Virgen de Las Nieves

Granada, 18014, Spain
Hospital Universitario de Basurto

Bilbao, Bizkaia, 48013, Spain
Hospital Universitario de Puerto Real

Cadiz, Andalusia, 11510, Spain
Hospital de Sagunto

Sagunto, Valencia, Valencia/madrid Castilla LA Mancha, 46520, Spain
Hospital de Sant Pau i Santa Tecla

Tarragona, 43003, Spain
Hospital nuestra señora del prado de Toledo

Talavera de La Reina, Toledo, Madrid/castilla LA Mancha, 45600, Spain
Institut Catalâ Oncologia-L'Hospitalet

L'Hospitalet de Llobregat, Barcelona [barcelona], 08908, Spain
Institut für Versorgungsforschung GbR

Mainz, Rhineland-Palatinate, 55116, Germany
Kantonsspital Baden AG

Baden, 5404, Switzerland
Kantonsspital Baselland

Liestal, Switzerland
Kreisklinikum Böblingen gGmbH, Frauenklinik Böblingen

Sindelfingen, Landkreis Boblingen, 71065, Germany
Landesklinikum Krems

Krems, 3500, Austria
MediOnko-Institut GbR

Berlin, Brandenburg, 13597, Germany
Medizinische Studiengesellschaft NORD-WEST GmbH

Westerstede, 26655, Germany
Mälarsjukhuset

Eskilstuna, Södermanlands LÄN [se-04], 631 88, Sweden
Nottingham University Hospitals NHS Trust

Nottingham, GGS 1PB, United Kingdom
Priv. Doz. OA Dr. Michael Hubalek

Schwaz, 6130, Austria
Queen Elizabeth Hospital

Kings Lynn, Norfolk, PE30 4ET, United Kingdom
Royal Blackburn Hospital

Blackburn, BB2 3HH, United Kingdom
Royal Bournemouth Hospital

Bournemouth, BH7 7DW, United Kingdom
Royal Cornwall Hospital

Cornwall, TR1 3LJ, United Kingdom
Royal United Hospital Bath NHS Trust

Bath, BA1 3NG, United Kingdom
Ruppiner Kliniken GmbH

Neuruppin, Ostprignitz-ruppin, 16816, Germany
Sankt Josef Hospital Braunau

Braunau am Inn, 5280, Austria
Shrewsbury and Telford Hospital NHS Trust

Shrewsbury, Shropshire, SY3 8XQ, United Kingdom
St Goran Hospital

Bromma, 167 56, Sweden
St. Vincenz-Krankenhaus GmbH

Paderborn, 33098, Germany
Studienzentrum UnterEms

Emden, Saxony, 26721, Germany
UZ Leuven

Leuven, 3000, Belgium
Universitaetsklinikum Sankt Poelten

Sankt Pölten, 3100, Austria
Universitatsklinikum Essen

Essen, North Rhine-Westphalia, 45147, Germany
Universität des Saarlandes

Saarbrücken, Saarland, 66123, Germany
Universitätsklinikum Leipzig

Leipzig, Saxony, 04103, Germany
Universitätsklinikum Würzburg Frauenklinik und Poliklinik

Würzburg, Bavaria, 97080, Germany
Uppsala University Hospital

Uppsala, 751 85, Sweden
Western General Hospital

Waterloo Place, Edinburgh, EH1 3EG, United Kingdom
Wrexham Maelor Hospital

Wrexham, Wales, LL13 7TD, United Kingdom
Ysbyty Gwynedd Hospital

Bangor, Gwynedd, LL57 2PW, United Kingdom
Örebro University Hospital

Örebro, 70286, Sweden
Überörtliche Gemeinschaftspraxis

Hamburg, 48415, Germany

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