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Could a simple biopsy replace major surgery for multifocal breast cancer?

NCT ID NCT00417495

Completed Knowledge-focused Sponsor: Centre Oscar Lambret Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 2 trial looked at whether the sentinel lymph node technique—a less invasive way to check if cancer has spread—works for women with multifocal breast cancer (more than one tumor in the same breast). 216 women with early-stage, node-negative multifocal breast cancer took part. The goal was to see how often doctors could find and correctly identify the sentinel node, which could help avoid more extensive lymph node removal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could confirm that sentinel lymph node biopsy is a reliable option for women with multifocal breast cancer, potentially sparing them from more invasive lymph node removal.
What could go wrong
This is a completed Phase 2 trial, so results are not yet widely adopted. The technique may not be as accurate in multifocal cases as in single-tumor cases, and the study's findings need confirmation in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma breast cancer breast neoplasm invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

  • CRLC Val d'Aurelle

    Montpellier, 34298, France

  • Centre Claudius Regaud

    Toulouse, 31052, France

  • Centre Eugene Marquis

    Rennes, 35042, France

  • Centre Georges-Francois LECLERCQ

    Dijon, 21000, France

  • Centre Henri Becquerel

    Rouen, 76038, France

  • Centre Hospitalier

    Valenciennes, 59300, France

  • Centre Hospitalier Sud Léman Valsérine

    Saint-Julien-en-Genevois, 74167, France

  • Centre Hospitalier Universitaire

    Amiens, 80054, France

  • Centre Jean Perrin

    Clermont-Ferrand, 63011, France

  • Centre Leon Berard

    Lyon, 69373, France

  • Centre Oscar Lambret

    Lille, 59020, France

  • Centre Paul Papin

    Angers, 49933, France

  • Centre Rene Gauducheau

    Saint-Herblain, 44805, France

  • Clinique de Flandre

    Coudekerque-Branche, 59210, France

  • Hopital Tenon

    Paris, 75970, France

  • Hôpital Georges PIANTA

    Thonon-les-Bains, 74203, France

  • Hôpital Lariboisière

    Paris, 75010, France

  • Institut Bergonie

    Bordeaux, 33076, France

  • Institut Gustave Roussy

    Villejuif, 94808, France

  • Institut Paoli Calmettes

    Marseille, 130009, France

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