Could a simple biopsy replace major surgery for multifocal breast cancer?
NCT ID NCT00417495
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 2 trial looked at whether the sentinel lymph node technique—a less invasive way to check if cancer has spread—works for women with multifocal breast cancer (more than one tumor in the same breast). 216 women with early-stage, node-negative multifocal breast cancer took part. The goal was to see how often doctors could find and correctly identify the sentinel node, which could help avoid more extensive lymph node removal.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could confirm that sentinel lymph node biopsy is a reliable option for women with multifocal breast cancer, potentially sparing them from more invasive lymph node removal.
What could go wrong
This is a completed Phase 2 trial, so results are not yet widely adopted. The technique may not be as accurate in multifocal cases as in single-tumor cases, and the study's findings need confirmation in larger trials.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CRLC Val d'Aurelle
Montpellier, 34298, France
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Centre Claudius Regaud
Toulouse, 31052, France
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Centre Eugene Marquis
Rennes, 35042, France
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Centre Georges-Francois LECLERCQ
Dijon, 21000, France
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Centre Henri Becquerel
Rouen, 76038, France
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Centre Hospitalier
Valenciennes, 59300, France
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Centre Hospitalier Sud Léman Valsérine
Saint-Julien-en-Genevois, 74167, France
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Centre Hospitalier Universitaire
Amiens, 80054, France
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Centre Jean Perrin
Clermont-Ferrand, 63011, France
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Centre Leon Berard
Lyon, 69373, France
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Centre Oscar Lambret
Lille, 59020, France
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Centre Paul Papin
Angers, 49933, France
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Centre Rene Gauducheau
Saint-Herblain, 44805, France
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Clinique de Flandre
Coudekerque-Branche, 59210, France
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Hopital Tenon
Paris, 75970, France
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Hôpital Georges PIANTA
Thonon-les-Bains, 74203, France
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Hôpital Lariboisière
Paris, 75010, France
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Institut Bergonie
Bordeaux, 33076, France
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Institut Gustave Roussy
Villejuif, 94808, France
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Institut Paoli Calmettes
Marseille, 130009, France